{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:32:38Z","timestamp":1788255158198,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2008,5,8]],"date-time":"2008-05-08T00:00:00Z","timestamp":1210204800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1007\/s00383-008-2167-z","type":"journal-article","created":{"date-parts":[[2008,5,7]],"date-time":"2008-05-07T15:35:57Z","timestamp":1210174557000},"page":"803-808","source":"Crossref","is-referenced-by-count":46,"title":["Evaluation of the levels of folate, vitamin B12, homocysteine and fluoride in the parents and the affected neonates with neural tube defect and their matched controls"],"prefix":"10.1007","volume":"24","author":[{"given":"Simmi K.","family":"Ratan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal Nain","family":"Rattan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra Mohan","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savita","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simmi","family":"Kharab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Bala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Jhanwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,5,8]]},"reference":[{"key":"2167_CR1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000066335","volume":"5","author":"IC Verma","year":"2002","unstructured":"Verma IC, Bijharnia S (2002) The burden of genetic disorders in India and a framework for community control. Community Genet 5:192\u2013196","journal-title":"Community Genet"},{"key":"2167_CR2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0020-7292(92)90260-P","volume":"39","author":"JB Sharma","year":"1992","unstructured":"Sharma JB, Gulati N (1992) Potential relationship between dengue fever and neural tube defects in a Northern District of India. Int J Gynecol Obstet 39:291\u2013295","journal-title":"Int J Gynecol Obstet"},{"key":"2167_CR3","first-page":"223","volume":"99","author":"AK Sharma","year":"1994","unstructured":"Sharma AK, Upreti M, Kamboj M, Mewhra P, Das K, Mura A, Dhasmana S, Agarwal SS (1994) Incidence of neural tube defects at Lucknow over a 10\u00a0year period from 1982\u20131991. Indian J Med Res 99:223\u2013226","journal-title":"Indian J Med Res"},{"issue":"8069","key":"2167_CR4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0140-6736(78)90225-8","volume":"1","author":"IC Verma","year":"1978","unstructured":"Verma IC (1978) High frequencyof neural tube defects in North India. Lancet 1(8069):879\u2013880","journal-title":"Lancet"},{"issue":"5","key":"2167_CR5","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/00007691-200210000-00008","volume":"24","author":"B Kapur","year":"2002","unstructured":"Kapur B, Soldin OP, Koren G (2002) Potential prevention of neural tube defects by assessment of women of child bearing age through monitoring of folate. Ther Drug Monit 24(5):628\u2013630","journal-title":"Ther Drug Monit"},{"issue":"9448","key":"2167_CR6","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/S0140-6736(04)17445-X","volume":"364","author":"LE Mitchell","year":"2004","unstructured":"Mitchell LE, Adzick NS, Melchionne J, Pasquariello PS, Sutton LN, Whitehead AS (2004) Spina bifida. Lancet 364(9448):1885\u20131895","journal-title":"Lancet"},{"issue":"21","key":"2167_CR7","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1001\/jama.1995.03530210052030","volume":"274","author":"LE Daly","year":"1995","unstructured":"Daly LE, Kirke PN, Molloy A, weir DG, Scott JM (1995) Folate levels and neural tube defects. JAMA 274(21):1698\u20131702","journal-title":"JAMA"},{"key":"2167_CR8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1079\/NRR19910006","volume":"4","author":"CJ Schorah","year":"1991","unstructured":"Schorah CJ, Smithells RW (1991) Maternal vitamin nutrition and malformations of the neural tube. Nutr Res Rev 4:33\u201349","journal-title":"Nutr Res Rev"},{"issue":"11","key":"2167_CR9","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1093\/jn\/129.11.2070","volume":"129","author":"JH Shin","year":"1999","unstructured":"Shin JH, Shiota K (1999) Folic acid suppression of pregnant mice suppresses heat induced NTD in the offspring. J Nutr 129(11):2070\u20132073","journal-title":"J Nutr"},{"key":"2167_CR10","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s004310050850","volume":"157","author":"J Hall","year":"1998","unstructured":"Hall J, Soleholin F (1998) Folic acid for the prevention of congenital anomalies. Eur J Pediatr 157:445\u2013450","journal-title":"Eur J Pediatr"},{"key":"2167_CR11","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/adc.78.3.288","volume":"78","author":"N Akar","year":"1998","unstructured":"Akar N (1998) Neural tube defects and zinc. Arch Dis Child 78:288\u2013291","journal-title":"Arch Dis Child"},{"key":"2167_CR12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0301-2115(02)00305-6","volume":"107","author":"C Mdela","year":"2003","unstructured":"Mdela C, Usandizaga R, Sancha M, Magdaleno F, Herranz A, Cabrillo E (2003) Homocysteine, folic acid and B group vitamins in obstetrics and gynaecology Eur J Obstet Gynecol 107:125\u2013134","journal-title":"Eur J Obstet Gynecol"},{"key":"2167_CR13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/bdra.10040","volume":"67","author":"LA Afman","year":"2003","unstructured":"Afman LA, Blom HJ, Vander Put NMJ, Van Straaten HWM (2003) Homocysteine interference in neurulation: a chick embryo model. Birth Defects Res 67:421\u2013428","journal-title":"Birth Defects Res"},{"key":"2167_CR14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ymgme.2003.12.010","volume":"81","author":"CL Relton","year":"2004","unstructured":"Relton CL, Wilding CS, Laffling AJ, Jonas PA, Burgess T, Binks K, Tawn EJ, Burn J (2004) Low erythrocyte folate status and polymorphic variation in folate related genes are associated with risk of neural tube defect pregnancy. Mol Genet Metab 81:273\u2013281","journal-title":"Mol Genet Metab"},{"key":"2167_CR15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/qjmed\/90.8.519","volume":"90","author":"M Ward","year":"1997","unstructured":"Ward M, McNulty H, McPartlin J, Strain JJ, Weir DG, Scott JM (1997) Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. Q J Med 90:519\u2013524","journal-title":"Q J Med"},{"key":"2167_CR16","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/adc.51.12.944","volume":"51","author":"RW Smithlells","year":"1976","unstructured":"Smithlells RW, Sheppard S, Schoral LJ (1976) Vitamin deficiences and neural tube defects. Arch Dis Child 51:944\u2013950","journal-title":"Arch Dis Child"},{"key":"2167_CR17","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/S0140-6736(96)91236-2","volume":"347","author":"DL Posey","year":"1996","unstructured":"Posey DL, Khoury MJ, Mulinare J, Adams MJ Jr, Ou C-Y (1996) Is mutated M T H F R a risk factor for neural tube defects. Lancet 347:686\u2013687","journal-title":"Lancet"},{"issue":"21","key":"2167_CR18","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/S0140-6736(95)91743-8","volume":"346","author":"NM Vander Put","year":"1995","unstructured":"Vander Put NM, Steegers-Theunissen RPM, Frosst P, Trijbels FJM, Eskes TKAM, Van de Heuvel LP, Mariman ECM, Den Heyer M, Rozen R, Blom HJ (1995) Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346(21):1070\u20131071","journal-title":"Lancet"},{"key":"2167_CR19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/ajmg.1320160109","volume":"16","author":"PA Baird","year":"1983","unstructured":"Baird PA (1983) Neural tube defects in the sikhs. Am J Med Genet 16:49\u201356","journal-title":"Am J Med Genet"},{"issue":"4","key":"2167_CR20","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1442-200X.1995.tb03363.x","volume":"37","author":"SK Gupta","year":"1995","unstructured":"Gupta SK, Gupta RC, Seth AK, Chaturvedi CS (1995) Increased incidence of Spina bifida occulta in fluorosis prone areas. Acta Paediatr Jpn 37(4):503\u2013506","journal-title":"Acta Paediatr Jpn"},{"key":"2167_CR21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/pd.1970100303","volume":"10","author":"RG Vergel","year":"1990","unstructured":"Vergel RG, Sauche ZLR, Jeredero BL, Rodrignez PL, Martinez AJ (1990) Primary prevention of neural tube defects with folic acid supplementation: Cuban experience. Prenat Diagn 10:149\u2013152","journal-title":"Prenat Diagn"},{"key":"2167_CR22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/ajmg.a.20230","volume":"123A","author":"EE Castilla","year":"2003","unstructured":"Castilla EE, Orioli IM, Lopez Camelo JS, deGracaDutra M, Nazer Horrera J (2003) Preliminary data on changes in neural tube defect prevalence rates after folic acid fortification in South Africa. Am J Med Genet 123A:123\u2013128","journal-title":"Am J Med Genet"},{"key":"2167_CR23","first-page":"2042","volume":"360","author":"JG Ray","year":"2002","unstructured":"Ray JG, Meier C, Vermeulen MJ, Boss Sheila, Wyatt PR, Cole DEC (2002) Association Of neural tube defects and folic acid food fortification in Canada. Lancet 360:2042\u201320243","journal-title":"Lancet"},{"key":"2167_CR24","first-page":"1257","volume-title":"Chemistry and biology of pteridines","author":"N Habibzadeh","year":"1990","unstructured":"Habibzadeh N, Smithells RW, Schorah CJ (1990) Folic acid metabolism in placental cells associated with neural tube defects. In: Curtius HC, Hisla SG, Blau W (eds) Chemistry and biology of pteridines. Walter de Gruyter, Berlin, pp 1257\u20131261"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-008-2167-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00383-008-2167-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-008-2167-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T15:52:10Z","timestamp":1559058730000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00383-008-2167-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,8]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["2167"],"URL":"https:\/\/doi.org\/10.1007\/s00383-008-2167-z","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,8]]}}}