{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:24:54Z","timestamp":1788344694975,"version":"build-2803163510"},"reference-count":114,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T00:00:00Z","timestamp":1216252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1007\/s00383-008-2188-7","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T17:28:55Z","timestamp":1216315735000},"page":"873-883","source":"Crossref","is-referenced-by-count":57,"title":["Down syndrome and the enteric nervous system"],"prefix":"10.1007","volume":"24","author":[{"given":"S. W.","family":"Moore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,7,17]]},"reference":[{"key":"2188_CR1","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/bjc.1998.662","volume":"78","author":"AE Altmann","year":"1998","unstructured":"Altmann AE, Halliday JL, Giles GG (1998) Associations between congenital malformations and childhood cancer\u2014a register-based case\u2013control study. Br J Cancer 78:1244\u20131249","journal-title":"Br J Cancer"},{"issue":"2","key":"2188_CR2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/15216540600644853","volume":"58","author":"F Argellati","year":"2006","unstructured":"Argellati F, Massone S, d\u2019Abramo C, Marinari UM, Pronzato MA, Domenicotti C, Ricciarelli R (2006) Evidence against the overexpression of APP in Down syndrome 2. IUBMB Life 58(2):103\u2013106","journal-title":"IUBMB Life"},{"issue":"7093","key":"2188_CR3","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nature04678","volume":"441","author":"JR Arron","year":"2006","unstructured":"Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR et al (2006) NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 441(7093):595\u2013600","journal-title":"Nature"},{"key":"2188_CR4","first-page":"568","volume":"46","author":"JA Badner","year":"1990","unstructured":"Badner JA, Sieber WK, Garver KL, Chakravarti A (1990) A genetic study of Hirschsprung disease. Am J Hum Genet 46:568\u2013580","journal-title":"Am J Hum Genet"},{"key":"2188_CR5","doi-asserted-by":"crossref","unstructured":"Barlow GM, Lyons GE, Richardson JA, Sarnat HB, Korenberg JR (2002) DSCAM: an endogenous promoter drives expression in the developing CNS and neural crest. Biochem Biophys Res Commun 299 (1):1\u20136","DOI":"10.1016\/S0006-291X(02)02548-2"},{"issue":"1","key":"2188_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/PDR.0b013e31811ead83","volume":"62","author":"J Baumann","year":"2007","unstructured":"Baumann J (2007) Down syndrome cell adhesion molecule\u2014a common determinant of brain and heart wiring. Pediatr Res 62(1):1","journal-title":"Pediatr Res"},{"key":"2188_CR7","doi-asserted-by":"crossref","unstructured":"Behar TN, Colton CA (2003) Redox regulation of neuronal migration in a Down syndrome model 1. Free Radic Biol Med 35(6):566\u2013575","DOI":"10.1016\/S0891-5849(03)00329-0"},{"issue":"2","key":"2188_CR8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pneurobio.2004.08.001","volume":"74","author":"R Benavides-Piccione","year":"2004","unstructured":"Benavides-Piccione R, Ballesteros-Yanez I, de Lagran MM, Elston G, Estivill X, Fillat C, Defelipe J, Dierssen M (2004) On dendrites in Down syndrome and DS murine models: a spiny way to learn. Prog Neurobiol 74(2):111\u2013126","journal-title":"Prog Neurobiol"},{"key":"2188_CR9","doi-asserted-by":"crossref","unstructured":"Berto G, Camera P, Fusco C, Imarisio S, Ambrogio C, Chiarle R, Silengo L, Di Cunto F. (6-1-2007) The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase. J Cell Sci 120(Pt. 11):1859\u20131867","DOI":"10.1242\/jcs.000703"},{"key":"2188_CR10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1161\/01.CIR.73.2.360","volume":"73","author":"WT Besson","year":"1986","unstructured":"Besson WT, Kirby ML, Van Mierop LHS, Teabeaut JR (1986) Effects of the size of lesions of the cardiac neural crest at various embryonic ages on incidence and type of cardiac defects. Circulation 73:360\u2013364","journal-title":"Circulation"},{"key":"2188_CR11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ng868","volume":"1","author":"S Bolk-Gabriel","year":"2002","unstructured":"Bolk-Gabriel S, Salomon R, Pelet A et al (2002) Segregation at three loci explains familial and population risk in Hirschsprung disease. Nat Genet 1:89\u201393","journal-title":"Nat Genet"},{"issue":"7","key":"2188_CR12","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s003830050652","volume":"15","author":"J Bozinovski","year":"2006","unstructured":"Bozinovski J, Poenaru D, Paterson W, Kamal I (2006) Esophageal aperistalsis following fundoplication in a patient with trisomy 21. Pediatr Surg Int 15(7):510\u2013511","journal-title":"Pediatr Surg Int"},{"issue":"2","key":"2188_CR13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00004836-198604000-00002","volume":"8","author":"PJ Buchin","year":"1986","unstructured":"Buchin PJ, Levy JS, Schullinger JN (1986) Down\u2019s syndrome and the gastrointestinal tract. J Clin Gastroenterol 8(2):111\u2013114","journal-title":"J Clin Gastroenterol"},{"key":"2188_CR14","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0002-9610(05)81281-4","volume":"159","author":"DA Caniano","year":"1990","unstructured":"Caniano DA, Teitelbaum DH, Qualman SJ (1990) Management of Hirschsprungs disease in children with Trisomy 21. Am J Surg 159:402\u2013404","journal-title":"Am J Surg"},{"key":"2188_CR15","unstructured":"Carrascosa-Romero MC, Fern\u00e1ndez-C\u00f3rdoba MS, Gonz\u00e1lvez-Pi\u00f1era J, Guti\u00e9rrez-Junquera C, Pardal-Fern\u00e1ndez JM (2007) Neurocristopathies: a high incidence of cerebral dysgenesis in patients with Hirschsprung\u2019s disease. Rev Neurol 45(12):707\u2013712"},{"issue":"4","key":"2188_CR16","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/j.1440-1746.2005.03996.x","volume":"21","author":"AG Catto-Smith","year":"2006","unstructured":"Catto-Smith AG, Trajanovska M, Taylor RG (2006) Long-term continence in patients with Hirschsprung\u2019s disease and Down syndrome. J Gastroenterol Hepatol 21(4):748\u2013753","journal-title":"J Gastroenterol Hepatol"},{"issue":"3","key":"2188_CR17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4067\/S0716-97602006000300009","volume":"39","author":"P Caviedes","year":"2006","unstructured":"Caviedes P, Caviedes R, Rapoport SI (2006) Altered calcium currents in cultured sensory neurons of normal and trisomy 16 mouse fetuses, an animal model for human trisomy 21 (Down syndrome). Biol Res 39(3):471\u2013481","journal-title":"Biol Res"},{"issue":"1\u20132","key":"2188_CR18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00726-002-0337-1","volume":"24","author":"MS Cheon","year":"2003","unstructured":"Cheon MS, Bajo M, Kim SH, Claudio JO, Stewart AK, Patterson D, Kruger WD, Kondoh H, Lubec G (2003) Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part II). Amino Acids 24(1\u20132):119\u2013125","journal-title":"Amino Acids"},{"issue":"12","key":"2188_CR19","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/S0022-3468(99)90337-8","volume":"34","author":"SA Clarke","year":"1999","unstructured":"Clarke SA, Van der Avoirt A (1999) Imperforate anus, Hirschsprung\u2019s disease, and trisomy 21: a rare combination. J Pediatr Surg 34(12):1874","journal-title":"J Pediatr Surg"},{"key":"2188_CR20","doi-asserted-by":"crossref","first-page":"d723","DOI":"10.2741\/1020","volume":"8","author":"DO Clegg","year":"2003","unstructured":"Clegg DO, Wingerd KL, Hikita ST, Tolhurst EC (2003) Integrins in the development, function and dysfunction of the nervous system. Front Biosci 8:d723\u2013d750","journal-title":"Front Biosci"},{"issue":"9","key":"2188_CR21","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/bdra.20393","volume":"79","author":"MA Cleves","year":"2007","unstructured":"Cleves MA, Hobbs CA, Cleves PA, Tilford JM, Bird TM, Robbins JM (2007) Congenital defects among liveborn infants with Down syndrome. Birth Defects Res A Clin Mol Teratol 79(9):657\u2013663","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"2188_CR22","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/1471-2164-8-268","volume":"8","author":"A Conti","year":"2007","unstructured":"Conti A, Fabbrini F, D\u2019Agostino P, Negri R, Greco D, Genesio R, D\u2019Armiento M, Olla C, Paladini D, Zannini M, Nitsch L (2007) Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy. BMC Genomics 8:268","journal-title":"BMC Genomics"},{"issue":"21","key":"2188_CR23","doi-asserted-by":"crossref","first-page":"10405","DOI":"10.1073\/pnas.89.21.10405","volume":"89","author":"JD Crapo","year":"1992","unstructured":"Crapo JD, Oury T, Rabouille C, Slot JW, Chang LY (1992) Copper, zinc superoxide dismutase is primarily a cytosolic protein in human cells. Proc Natl Acad Sci USA 89(21):10405\u201310409","journal-title":"Proc Natl Acad Sci USA"},{"key":"2188_CR24","doi-asserted-by":"crossref","unstructured":"Deutsch S, Lyle R, Dermitzakis ET, Attar H, Subrahmanyan L, Gehrig C, Parand L, Gagnebin M, Rougemont J, Jongeneel CV, Antonarakis SE (2005) Gene expression variation and expression quantitative trait mapping of human chromosome 21 genes. Hum Mol Genet 14(23):3741\u20133749","DOI":"10.1093\/hmg\/ddi404"},{"issue":"4","key":"2188_CR25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF00712843","volume":"10","author":"RJ Donnelly","year":"1990","unstructured":"Donnelly RJ, Friedhoff AJ, Beer B, Blume AJ, Vitek MP (1990) Interleukin-1 stimulates the beta-amyloid precursor protein promoter. Cell Mol Neurobiol 10(4):485\u2013495","journal-title":"Cell Mol Neurobiol"},{"key":"2188_CR26","doi-asserted-by":"crossref","unstructured":"Dowjat WK, Adayev T, Kuchna I, Nowicki K, Palminiello S, Hwang YW, Wegiel J (2007) Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome. Neurosci Lett 413(1):77\u201381","DOI":"10.1016\/j.neulet.2006.11.026"},{"key":"2188_CR27","unstructured":"Engidawork E, Baiic N, Fountoulakis M, Dierssen M, Greber-Platzer S, Lubec G (2001) Beta-amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect. J Neural Transm Suppl 2001(61):335\u2013346"},{"issue":"7093","key":"2188_CR28","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/441582a","volume":"44","author":"CJ Epstein","year":"2006","unstructured":"Epstein CJ (2006) Down\u2019s syndrome: critical genes in a critical region. Nature 44(7093):582\u2013583","journal-title":"Nature"},{"issue":"6","key":"2188_CR29","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0022-3468(96)90125-6","volume":"31","author":"H Flageole","year":"1996","unstructured":"Flageole H, Fecteau A, Laberge JM, Guttman FM (1996) Hirschsprung\u2019s disease, imperforate anus, and Down\u2019s syndrome: a case report. J Pediatr Surg 31(6):759\u2013760","journal-title":"J Pediatr Surg"},{"key":"2188_CR30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1399-0004.1985.tb00417.x","volume":"28","author":"K Garver","year":"1985","unstructured":"Garver K, Law J, Garver B (1985) Hirschsprung disease: a genetic study. Clin Genet 28:503\u2013508","journal-title":"Clin Genet"},{"issue":"12","key":"2188_CR31","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1046\/j.1440-1681.1999.03176.x","volume":"26","author":"MD Gershon","year":"1999","unstructured":"Gershon MD (1999) Endothelin and the development of the enteric nervous system. Clin Exp Pharmacol Physiol 26(12):985\u2013988","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"2","key":"2188_CR32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/neu.480240207","volume":"24","author":"MD Gershon","year":"1993","unstructured":"Gershon MD, Chalazonitis A, Rothman TP (1993) From neural crest to bowel: development of the enteric nervous system. J Neurobiol. 24(2):199\u2013214","journal-title":"J Neurobiol."},{"issue":"4","key":"2188_CR33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/ije\/13.4.479","volume":"13","author":"EL Goldberg","year":"1984","unstructured":"Goldberg EL (1984) An epidemiological study of Hirschsprung\u2019s disease. Int J Epidemiol 13(4):479\u2013485","journal-title":"Int J Epidemiol"},{"key":"2188_CR34","doi-asserted-by":"crossref","unstructured":"Goyal RK, Hirano I (1996) The enteric nervous system. N Engl J Med 334(17):1106\u20131115","DOI":"10.1056\/NEJM199604253341707"},{"key":"2188_CR35","first-page":"458","volume":"60","author":"L Graivier","year":"1966","unstructured":"Graivier L, Sieber WK (1966) Hirschsprungs disease and mongolism. Surgery 60:458\u2013461","journal-title":"Surgery"},{"issue":"1","key":"2188_CR36","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/ajmg.a.30312","volume":"131","author":"CY Gregory-Evans","year":"2004","unstructured":"Gregory-Evans CY, Vieira H, Dalton R, Adams GG, Salt A, Gregory-Evans K (2004) Ocular coloboma and high myopia with Hirschsprung disease associated with a novel ZFHX1B missense mutation and trisomy 21. Am J Med Genet A 131(1):86\u201390","journal-title":"Am J Med Genet A"},{"key":"2188_CR37","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/archsurg.1978.01370160112019","volume":"113","author":"J Grosfeld","year":"1978","unstructured":"Grosfeld J, Ballantine T, Csicsko J (1978) A critical evaluation of the Duhamel operation for HSCR. Arch Surg 113:454\u2013459","journal-title":"Arch Surg"},{"key":"2188_CR38","doi-asserted-by":"crossref","unstructured":"Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, R\u00fclicke T, von Kretzschmar H, von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, M\u00fcller U (2000) Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci 20(21):7951\u20137963","DOI":"10.1523\/JNEUROSCI.20-21-07951.2000"},{"issue":"534","key":"2188_CR39","first-page":"50","volume":"57","author":"A Henderson","year":"2007","unstructured":"Henderson A, Lynch SA, Wilkinson S, Hunter M (2007) Adults with Down\u2019s syndrome: the prevalence of complications and health care in the community. Br J Gen Pract. 57(534):50\u201355","journal-title":"Br J Gen Pract."},{"issue":"1","key":"2188_CR40","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00005176-198201010-00017","volume":"1","author":"C Hillemeier","year":"1982","unstructured":"Hillemeier C, Buchin PJ, Gryboski J (1982) Esophageal dysfunction in Down\u2019s syndrome. J Pediatr Gastroenterol Nutr 1(1):101\u2013104","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2188_CR41","first-page":"279","volume":"41","author":"K Ikeda","year":"1986","unstructured":"Ikeda K, Goto S (1986) Additional anomalies in Hirschsprungs disease: an analysis based on a nationwide survey in Japan. Z Kinderchir 41:279\u2013281","journal-title":"Z Kinderchir"},{"issue":"3","key":"2188_CR42","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1086\/520000","volume":"81","author":"E A\u00eft Yahya-Graison","year":"2007","unstructured":"A\u00eft Yahya-Graison E, Aubert J, Dauphinot L, Rivals I, Prieur M, Golfier G, Rossier J, Personnaz L, Creau N, Blehaut H, Robin S, Delabar JM, Potier MC (2007) Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes. Am J Hum Genet 81(3):475\u2013491","journal-title":"Am J Hum Genet"},{"issue":"1","key":"2188_CR43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1189\/jlb.0804459","volume":"78","author":"SL Jones","year":"2005","unstructured":"Jones SL, Sharief Y (2005) Asymmetrical protein kinase A activity establishes neutrophil cytoskeletal polarity and enables chemotaxis. J Leukoc Biol 78(1):248\u2013245","journal-title":"J Leukoc Biol"},{"issue":"11\u201312","key":"2188_CR44","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bbadis.2006.03.006","volume":"1762","author":"JP Julien","year":"2006","unstructured":"Julien JP, Kriz J (2006) Transgenic mouse models of amyotrophic lateral sclerosis. Biochim Biophys Acta 1762(11\u201312):1013\u20131024","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"2188_CR45","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/sj.ejhg.5200650","volume":"9","author":"MG Julies","year":"2001","unstructured":"Julies MG, Moore SW, Kotze MJ, du Plessis L (2001) Novel RET mutations in Hirschsprung\u2019s disease patients from the diverse South African population. Eur J Hum Genet 9(6):419\u2013423","journal-title":"Eur J Hum Genet"},{"key":"2188_CR46","doi-asserted-by":"crossref","unstructured":"Kallen B, Mastroiacovo P, Robert E (1996) Major congenital malformations in Down syndrome. Am J Med Genet 65(2):160\u2013166","DOI":"10.1002\/(SICI)1096-8628(19961016)65:2<160::AID-AJMG16>3.0.CO;2-O"},{"key":"2188_CR47","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1073\/pnas.91.11.4997","volume":"91","author":"JR Korenberg","year":"1994","unstructured":"Korenberg JR, Chen X, Schipper R, Sun Z, Gonsky R, Gerwehr S et al (1994) Down syndrome phenotypes: the consequence of chromosomal imbalance. Proc Natl Acad Sci 91:4997\u20135001","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"2188_CR48","first-page":"236","volume":"47","author":"JR Korenberg","year":"1990","unstructured":"Korenberg JR, Kawashima H, Pulst SM, Ikeuchi T, Ogasawara N, Yamamoto K, Schonberg SA, West R, Allen L, Magenis E (1990) Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype. Am J Hum Genet 47(2):236\u2013246","journal-title":"Am J Hum Genet"},{"issue":"6","key":"2188_CR49","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1055\/s-2008-1072288","volume":"9","author":"A Leffler","year":"1999","unstructured":"Leffler A, Wedel T, Busch LC (1999) Congenital colonic hypoganglionosis in murine trisomy 16\u2014an animal model for Down\u2019s syndrome. Eur J Pediatr Surg 9(6):381\u2013388","journal-title":"Eur J Pediatr Surg"},{"key":"2188_CR50","first-page":"245","volume":"373","author":"J Levy","year":"1991","unstructured":"Levy J (1991) The gastrointestinal tract in Down syndrome. Prog Clin Biol Res 373:245\u2013256","journal-title":"Prog Clin Biol Res"},{"issue":"2","key":"2188_CR51","first-page":"159","volume":"22","author":"J Li","year":"2000","unstructured":"Li J, Busch LC, Kuhnel W (2000) PGP 9.5 immunohistochemical study on the development of the enteric nervous system of trisomy 16 mouse embryos and their normal littermates. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 22(2):159\u2013164","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"issue":"5","key":"2188_CR52","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2174\/156720506779025305","volume":"3","author":"IT Lott","year":"2006","unstructured":"Lott IT, Head E, Doran E, Busciglio J (2006) Beta-amyloid, oxidative stress and down syndrome. Curr Alzheimer Res 3(5):521\u2013528","journal-title":"Curr Alzheimer Res"},{"issue":"2","key":"2188_CR53","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1179\/016164103101201193","volume":"25","author":"Y Manabe","year":"2003","unstructured":"Manabe Y, Nagano I, Gazi MS, Murakami T, Shiote M, Shoji M, Kitagawa H, Abe K (2003) Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis. Neurol Res 25(2):195\u2013200","journal-title":"Neurol Res"},{"issue":"13","key":"2188_CR54","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/gb-2005-6-13-r107","volume":"6","author":"R Mao","year":"2005","unstructured":"Mao R, Wang X, Spitznagel EL Jr, Frelin LP, Ting JC, Ding H, Kim JW, Ruczinski I, Downey TJ, Pevsner J (2005) Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart. Genome Biol 6(13):R107","journal-title":"Genome Biol"},{"key":"2188_CR55","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1084\/jem.164.3.855","volume":"164","author":"SD Marlin","year":"1986","unstructured":"Marlin SD, Morton CC, Anderson DC, Springer TA (1986) LFA-1 Immunodeficiency disease. J Exp Med 164:855\u2013867","journal-title":"J Exp Med"},{"issue":"1","key":"2188_CR56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1440-1789.2006.00649.x","volume":"26","author":"H Matsuda","year":"2006","unstructured":"Matsuda H, Hirato J, Kuroiwa M, Nakazato Y (2006) Histopathological and immunohistochemical study of the enteric innervations among various types of aganglionoses including isolated and syndromic Hirschsprung disease. Neuropathology 26(1):8\u201323","journal-title":"Neuropathology"},{"issue":"1","key":"2188_CR57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1385\/BTER:81:1:21","volume":"81","author":"NA Meguid","year":"2001","unstructured":"Meguid NA, Kholoussi NM, Afifi HH (2001) Evaluation of superoxide dismutase and glutathione peroxidase enzymes and their cofactors in Egyptian children with Down\u2019s syndrome. Biol Trace Elem Res 81(1):21\u201328","journal-title":"Biol Trace Elem Res"},{"key":"2188_CR58","unstructured":"Meijers C, Mulder M (1995) Anteroposterior differences within caudal hindbrain neural crest cell populations and the development of the enteric nervous system. Presented at the Second International Meeting: Hirschsprung disease and related neurocristopathies. Cleveland, OH, October 1995"},{"issue":"3","key":"2188_CR59","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.ju.0000112915.69436.91","volume":"171","author":"ES Mercer","year":"2004","unstructured":"Mercer ES, Broecker B, Smith EA, Kirsch AJ, Scherz HC A, Massad C (2004) Urological manifestations of Down syndrome. J Urol 171(3):1250\u20131253","journal-title":"J Urol"},{"issue":"4","key":"2188_CR60","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1515\/IJDHD.2006.5.4.369","volume":"5","author":"SW Moore","year":"2006","unstructured":"Moore SW (2006) Down syndrome and Hirschsprungs disease: a significant relationship? Int J Disabil Hum Dev 5(4):369\u2013375","journal-title":"Int J Disabil Hum Dev"},{"issue":"4","key":"2188_CR61","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00383-006-1655-2","volume":"22","author":"SW Moore","year":"2006","unstructured":"Moore SW (2006) The contribution of associated congenital anomalies in understanding Hirschsprung\u2019s disease. Pediatr Surg Int 22(4):305\u2013315","journal-title":"Pediatr Surg Int"},{"key":"2188_CR62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-3-540-33935-9_9","volume-title":"Hirschsprungs disease and Allied disorders","author":"SW Moore","year":"2008","unstructured":"Moore SW (2008) Congenital anomalies and genetic associations in Hirschsprungs Disease. In: Holschneider AM, Puri P (eds) Hirschsprungs disease and Allied disorders, 3rd edn. Springer, Berlin, pp 115\u2013131","edition":"3"},{"issue":"3","key":"2188_CR63","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S1055-8586(98)70011-3","volume":"7","author":"SW Moore","year":"1998","unstructured":"Moore SW, Johnson GA (1998) Hirschsprung\u2019s disease: Genetic and functional associations of Down and Waardenburghs Syndromes. Semin Pediatr Surg 7(3):156\u2013161","journal-title":"Semin Pediatr Surg"},{"key":"2188_CR64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1055\/s-2008-1042468","volume":"1","author":"SW Moore","year":"1991","unstructured":"Moore SW, Rode H, Millar AJ, Albertyn R, Cywes S (1991) Familial Aspects of Hirschsprungs Disease. Eur J Pediat Surg 1:97\u2013107","journal-title":"Eur J Pediat Surg"},{"key":"2188_CR65","doi-asserted-by":"crossref","unstructured":"Moore SW and Zaahl MG (2008) The ITGB2 immunomodulatory gene (CD18), enterocolitis and Hirschsprung\u2019s disease (HSCR). J Pediatr Surg (in press)","DOI":"10.1016\/j.jpedsurg.2007.12.057"},{"issue":"7","key":"2188_CR66","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.jpedsurg.2007.02.019","volume":"42","author":"SW Moore","year":"2007","unstructured":"Moore SW, Zaahl MG (2007) Association of endothelin-beta receptor (EDNRB) gene variants in anorectal malformations. J Pediatr Surg 42(7):1266\u20131270","journal-title":"J Pediatr Surg"},{"issue":"2","key":"2188_CR67","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00383-005-1617-0","volume":"22","author":"A Morabito","year":"2006","unstructured":"Morabito A, Lall A, Gull S, Mohee A, Bianchi A (2006) The impact of Down\u2019s syndrome on the immediate and long-term outcomes of children with Hirschsprung\u2019s disease. Pediatr Surg Int 22(2):179\u2013181","journal-title":"Pediatr Surg Int"},{"issue":"7","key":"2188_CR68","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/jnen\/63.7.679","volume":"63","author":"RE Mrak","year":"2004","unstructured":"Mrak RE, Griffin WS (2004) Trisomy 21 and the brain. J Neuropathol Exp Neurol 63(7):679\u2013685","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"2188_CR69","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/jnr.490320216","volume":"32","author":"S Murtomaki","year":"1992","unstructured":"Murtomaki S, Risteli J, Risteli L, Koivisto UM, Johansson S, Liesi P (1992) Laminin and its neurite outgrowth-promoting domain in the brain in Alzheimer\u2019s disease and Down\u2019s syndrome patients. J Neurosci Res 32(2):261\u2013273","journal-title":"J Neurosci Res"},{"issue":"1","key":"2188_CR70","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/15513818609068848","volume":"5","author":"Y Nakazato","year":"1986","unstructured":"Nakazato Y, Landing BH (1986) Reduced number of neurons in esophageal plexus ganglia in Down syndrome: additional evidence for reduced cell number as a basic feature of the disorder. Pediatr Pathol 5(1):55\u201363","journal-title":"Pediatr Pathol"},{"issue":"5","key":"2188_CR71","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.clinbiochem.2004.12.014","volume":"38","author":"CB Netto","year":"2005","unstructured":"Netto CB, Portela LV, Ferreira CT, Kieling C, Matte U, Felix T, da Silveira TR, Souza DO, Goncalves CA, Giugliani R (2005) Ontogenetic changes in serum S100B in Down syndrome patients. Clin Biochem 38(5):433\u2013435","journal-title":"Clin Biochem"},{"issue":"2","key":"2188_CR72","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.clinbiochem.2003.09.010","volume":"37","author":"CB Netto","year":"2004","unstructured":"Netto CB, Siqueira IR, Fochesatto C, Portela LV, da Purificacao Tavares M, Souza DO, Giugliani R, Goncalves CA (2004) S100B content and SOD activity in amniotic fluid of pregnancies with Down syndrome. Clin Biochem 37(2):134\u2013137","journal-title":"Clin Biochem"},{"issue":"12","key":"2188_CR73","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s00383-005-1528-0","volume":"21","author":"M Okawada","year":"2005","unstructured":"Okawada M, Okazaki T, Yamataka A, Lane GJ, Miyano T (2005) Down\u2019s syndrome and esophageal achalasia: a rare but important clinical entity. Pediatr Surg Int 21(12):997\u20131000","journal-title":"Pediatr Surg Int"},{"key":"2188_CR74","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/ajmg.1320030302","volume":"3","author":"GS Omenn","year":"1979","unstructured":"Omenn GS, McKusick VA (1979) The association of Waardenburgh syndrome and Hirschsprungs megacolon. Am J Med Genet 3:217\u2013223","journal-title":"Am J Med Genet"},{"issue":"1","key":"2188_CR75","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ridd.2006.02.006","volume":"28","author":"FJ Ordonez","year":"2007","unstructured":"Ordonez FJ, Rosety-Rodriguez M (2007) Correlation between glutathione peroxidase activity and anthropometrical parameters in adolescents with Down syndrome. Res Dev Disabil 28(1):105\u2013108","journal-title":"Res Dev Disabil"},{"key":"2188_CR76","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJM196701192760303","volume":"276","author":"E Passarge","year":"1967","unstructured":"Passarge E (1967) The genetics of Hirschsprungs Disease. N Engl J Med 276:138\u2013143","journal-title":"N Engl J Med"},{"issue":"1\u20132","key":"2188_CR77","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0006-8993(95)00251-K","volume":"680","author":"R Pearce","year":"1995","unstructured":"Pearce R, Galdzicki Z, Rapoport SI (1995) Decreased sensitivity to nerve growth factor of dorsal root ganglion neurons cultured from mouse trisomy 16, a model of Down\u2019s syndrome. Brain Res 680(1\u20132):108\u2013116","journal-title":"Brain Res"},{"key":"2188_CR78","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0888-7543(91)90406-5","volume":"9","author":"MB Petersen","year":"1991","unstructured":"Petersen MB, Slaugenhaupt SA, Lewis JG, Warren AC, Chakravarti A, Antonarakis SE (1991) A genetic linkage map of 27 markers on human chromosome 21. Genomics 9:407\u2013419","journal-title":"Genomics"},{"issue":"2","key":"2188_CR79","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00004836-199409000-00005","volume":"19","author":"HG Preiksaitis","year":"1994","unstructured":"Preiksaitis HG, Miller L, Pearson FG, Diamant NE (1994) Achalasia in Down\u2019s syndrome. J Clin Gastroenterol 19(2):105\u2013107","journal-title":"J Clin Gastroenterol"},{"key":"2188_CR80","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/hmg\/3.8.1217","volume":"3","author":"E Puffenberger","year":"1994","unstructured":"Puffenberger E, Kauffman E, Bolk S et al (1994) Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22. Hum Mol Genet 3:1217\u20131225","journal-title":"Hum Mol Genet"},{"key":"2188_CR81","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0022-3468(94)90369-7","volume":"29","author":"FM Quinn","year":"1994","unstructured":"Quinn FM, Surana R, Puri P (1994) The influence of trisomy 21 on outcome in children with Hirschsprung\u2019s disease. J Pediatr Surg 29:781\u2013783","journal-title":"J Pediatr Surg"},{"issue":"4","key":"2188_CR82","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neures.2007.08.007","volume":"59","author":"M Rachidi","year":"2007","unstructured":"Rachidi M, Lopes C (2007) Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms. Neurosci Res. 59(4):349\u2013369","journal-title":"Neurosci Res."},{"key":"2188_CR83","doi-asserted-by":"crossref","unstructured":"Reeves RH, Yao J, Crowley MR, Buck S, Zhang X, Yarowsky P, Gearhart JD, Hilt DC (1994) Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice. Proc Natl Acad Sci USA 91(12):5359\u20135363","DOI":"10.1073\/pnas.91.12.5359"},{"issue":"5","key":"2188_CR84","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0022-3476(95)70169-9","volume":"127","author":"I Rivera-Matos","year":"1995","unstructured":"Rivera-Matos I, Rakita R, Mariscalco M, Elder F, Dreyer S, Cleary T (1995) Leukocyte adhesion deficiency mimicking Hirschsprung disease. J Pediatr 127(5):755\u2013757","journal-title":"J Pediatr"},{"issue":"3","key":"2188_CR85","first-page":"197","volume":"20","author":"GD Ross","year":"2000","unstructured":"Ross GD (2000) Regulation of the adhesion versus cytotoxic functions of the Mac-1\/CR3\/alphaMbeta2-integrin glycoprotein. Crit Rev Immunol 20(3):197\u2013222","journal-title":"Crit Rev Immunol"},{"issue":"2","key":"2188_CR86","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1006\/dbio.1996.0234","volume":"178","author":"TP Rothman","year":"1996","unstructured":"Rothman TP, Chen J, Howard MJ, Costantini F, Schuchardt A, Pachnis V, Gershon MD (1996) Increased expression of laminin-1 and collagen (IV) subunits in the aganglionic bowel of ls\/ls, but not c-ret \u2212\/\u2212 mice. Dev Biol 178(2):498\u2013513","journal-title":"Dev Biol"},{"issue":"2","key":"2188_CR87","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1006\/dbio.1993.1264","volume":"159","author":"TP Rothman","year":"1993","unstructured":"Rothman TP, Goldowitz D, Gershon MD (1993) Inhibition of migration of neural crest-derived cells by the abnormal mesenchyme of the presumptive aganglionic bowel of ls\/ls mice: analysis with aggregation and interspecies chimeras. Dev Biol 159(2):559\u2013573","journal-title":"Dev Biol"},{"issue":"1","key":"2188_CR88","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1620\/tjem.187.43","volume":"187","author":"T Sakai","year":"1999","unstructured":"Sakai T, Wakizaka A, Nirasawa Y, Ito Y (1999) Point nucleotidic changes in both the RET proto-oncogene and the endothelin-B receptor gene in a Hirschsprung disease patient associated with Down syndrome. Tohoku J Exp Med 187(1):43\u201347","journal-title":"Tohoku J Exp Med"},{"issue":"1","key":"2188_CR89","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2006.05.022","volume":"51","author":"A Salehi","year":"2006","unstructured":"Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K et al (2006) Increased App expression in a mouse model of Down\u2019s syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 51(1):29\u201342","journal-title":"Neuron"},{"issue":"3","key":"2188_CR90","first-page":"448","volume":"58","author":"D Satge","year":"1998","unstructured":"Satge D, Sasco AJ, Carlsen NL, Stiller CA, Rubie H et al (1998) A lack of neuroblastoma in Down syndrome: a study from 11 European countries. Cancer Res 58(3):448\u2013452","journal-title":"Cancer Res"},{"issue":"2\u20133","key":"2188_CR91","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jphysparis.2005.12.013","volume":"99","author":"K Saud","year":"2006","unstructured":"Saud K, Arriagada C, Cardenas AM, Shimahara T, Allen DD, Caviedes R, Caviedes P (2006) Neuronal dysfunction in Down syndrome: contribution of neuronal models in cell culture. J Physiol Paris 99(2\u20133):201\u2013210","journal-title":"J Physiol Paris"},{"issue":"20","key":"2188_CR92","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1056\/NEJM199105163242001","volume":"24","author":"T Siddique","year":"1991","unstructured":"Siddique T, Figlewicz DA, Pericak-Vance MA, Haines JL, Rouleau G, Jeffers AJ, Sapp P, Hung WY, Bebout J, McKenna-Yasek D et al (1991) Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity. N Engl J Med 24(20):1381\u20131384","journal-title":"N Engl J Med"},{"issue":"Pt 2","key":"2188_CR93","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1469-1809.1988.tb01087.x","volume":"52","author":"E Solomon","year":"1988","unstructured":"Solomon E, Palmer RW, Hing S, Law SK (1988) Regional localization of CD18, the beta-subunit of the cell surface adhesion molecule LFA-1, on human chromosome 21 by in situ hybridization. Ann Hum Genet. 52(Pt 2):123\u2013128","journal-title":"Ann Hum Genet"},{"issue":"2","key":"2188_CR94","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/(SICI)1096-8628(19990625)89:2<96::AID-AJMG7>3.0.CO;2-4","volume":"89","author":"JK Spahis","year":"1999","unstructured":"Spahis JK, Wilson GN (1999) Down syndrome: perinatal complications and counseling experiences in 216 patients. Am J Med Genet 89(2):96\u201399","journal-title":"Am J Med Genet"},{"key":"2188_CR95","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/tera.1420320204","volume":"32","author":"D Spouge","year":"1985","unstructured":"Spouge D, Baird PA (1985) Hirschsprungs Disease in a large birth cohort. Teratology 32:171\u2013177","journal-title":"Teratology"},{"issue":"1","key":"2188_CR96","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ydbio.2006.03.031","volume":"295","author":"L Stanchina","year":"2006","unstructured":"Stanchina L, Baral V, Robert F, Pingault V, Lemort N, Pachnis V, Goossens M, Bondurand N (2006) Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development. Dev Biol 295(1):232\u2013249","journal-title":"Dev Biol"},{"issue":"9","key":"2188_CR97","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1523\/JNEUROSCI.15-09-06046.1995","volume":"15","author":"T Takahashi","year":"1995","unstructured":"Takahashi T, Nowakowski RS, Caviness VS Jr (1995) The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall. J Neurosci 15(9):6046\u20136057","journal-title":"J Neurosci"},{"issue":"1","key":"2188_CR98","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0168-0102(01)00259-0","volume":"41","author":"N Tamamaki","year":"2001","unstructured":"Tamamaki N, Nakamura K, Okamoto K, Kaneko T (2001) Radial glia is a progenitor of neocortical neurons in the developing cerebral cortex. Neurosci Res 41(1):51\u201360","journal-title":"Neurosci Res"},{"issue":"1","key":"2188_CR99","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1055\/s-2008-1071042","volume":"7","author":"FC Tanyel","year":"1997","unstructured":"Tanyel FC, Muftuoglu SF, Dagdeviren A, Unsal I, Buyukpamukcu N, Hicsonmez A (1997) Expression of beta-1 integrins in ganglionic and aganglionic segments of patients with Hirschsprung\u2019s disease. Eur J Pediatr Surg 7(1):16\u201320","journal-title":"Eur J Pediatr Surg"},{"issue":"3","key":"2188_CR100","first-page":"451","volume":"64","author":"GM Taylor","year":"1988","unstructured":"Taylor GM, Haigh H, Williams A, D\u2019Souza SW, Harris R (1988) Down\u2019s syndrome lymphoid cell lines exhibit increased adhesion due to the over-expression of lymphocyte function-associated antigen (LFA-1). Immunology 64(3):451\u2013456","journal-title":"Immunology"},{"key":"2188_CR101","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/00000658-198803000-00003","volume":"207","author":"DH Teitelbaum","year":"1988","unstructured":"Teitelbaum DH, Qualman SJ, Caniano DA (1988) Hirschsprungs disease: identification of risk factors for enterocolitis. Ann Surg 207:240\u2013244","journal-title":"Ann Surg"},{"issue":"1 Pt 1","key":"2188_CR102","first-page":"G136","volume":"270","author":"RM Thomas","year":"1996","unstructured":"Thomas RM, Fang S, Leichus LS, Oberley LW, Christensen J, Murray JA, Ledlow A, Conklin JL (1996) Antioxidant enzymes in intramural nerves of the opossum esophagus. Am J Physiol 270(1 Pt 1):G136\u2013G142","journal-title":"Am J Physiol"},{"issue":"4","key":"2188_CR103","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1542\/peds.2006-1136","volume":"118","author":"AS Trotsenburg van","year":"2006","unstructured":"van Trotsenburg AS, Heymans HS, Tijssen JG, de Vijlder JJ, Vulsma T (2006) Comorbidity, hospitalization, and medication use and their influence on mental and motor development of young infants with Down syndrome. Pediatrics 118(4):1633\u20131639","journal-title":"Pediatrics"},{"issue":"8","key":"2188_CR104","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/j.1460-9568.2005.04389.x","volume":"22","author":"AS Vlug","year":"2006","unstructured":"Vlug AS, Teuling E, Haasdijk ED, French P, Hoogenraad CC, Jaarsma D (2006) ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation. Eur J Neurosci 22(8):1881\u20131894","journal-title":"Eur J Neurosci"},{"issue":"1","key":"2188_CR105","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/13668250601146761","volume":"32","author":"RA Wallace","year":"2007","unstructured":"Wallace RA (2007) Clinical audit of gastrointestinal conditions occurring among adults with Down syndrome attending a specialist clinic. J Intellect Dev Disabil 32(1):45\u201350","journal-title":"J Intellect Dev Disabil"},{"issue":"11","key":"2188_CR106","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/ppul.20687","volume":"42","author":"K Weir","year":"2007","unstructured":"Weir K, McMahon S, Barry L, Ware R, Masters IB, Chang AB (2007) Oropharyngeal aspiration and pneumonia in children. Pediatr Pulmonol. 42(11):1024\u20131031","journal-title":"Pediatr Pulmonol."},{"issue":"4","key":"2188_CR107","first-page":"185","volume":"33","author":"WD Wilson-Storey","year":"1988","unstructured":"Wilson-Storey WD, Scobie WG, Raeburn JA (1988) Defective white blood cell function in Hirschsprungs disease: a possible predisposing factor for enterocolitis. J Roy Coll Surg Edin 33(4):185\u2013188","journal-title":"J Roy Coll Surg Edin"},{"key":"2188_CR108","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1073\/pnas.81.8.2426","volume":"81","author":"TC Wright","year":"1984","unstructured":"Wright TC, Orkin RW, Destrempes M, Kurnit D (1984) Increased adhesiveness of Down syndrome fetal fibroblasts in vitro. Proc Natl Acad Sci USA 81:2426\u20132430","journal-title":"Proc Natl Acad Sci USA"},{"key":"2188_CR109","doi-asserted-by":"crossref","unstructured":"Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ (2007) A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci 27(52):14459\u201314469","DOI":"10.1523\/JNEUROSCI.4701-07.2007"},{"issue":"1","key":"2188_CR110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0890-8508(03)00003-3","volume":"17","author":"MG Zaahl","year":"2003","unstructured":"Zaahl MG, du Plessis L, Warnich L, Kotze MJ, Moore SW (2003) Significance of novel endothelin-B receptor gene polymorphisms in Hirschsprung\u2019s disease: Predominance of a novel variant (561C\/T) in patients with co-existing Down\u2019s syndrome. Mol Cell Probes 17(1):49\u201354","journal-title":"Mol Cell Probes"},{"key":"2188_CR111","unstructured":"Zaahl MG, van Huyssteen B, Strickland N, Panton NA, and Moore SW (2006) Hirschsprung\u2019s disease (HSCR) and Chromosome 21: Investigating two possible modifier loci, superoxide dismutase (SOD1) and integrin-\u00e22 gene (ITGB2) (in press)"},{"issue":"6","key":"2188_CR112","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1111\/j.1572-0241.2001.03864.x","volume":"96","author":"N Zarate","year":"2001","unstructured":"Zarate N, Mearin F, Hidalgo A, Malagelada JR (2001) Prospective evaluation of esophageal motor dysfunction in Down\u2019s syndrome. Am J Gastroenterol 96(6):1718\u20131724","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"2188_CR113","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1111\/j.1572-0241.1999.01161.x","volume":"94","author":"N Zarate","year":"1999","unstructured":"Zarate N, Mearin F, Gil-Vernet JM, Camarasa F, Malagelada JR (1999) Achalasia and Down\u2019s syndrome: coincidental association or something else? Am J Gastroenterol 94(6):1674\u20131677","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"2188_CR114","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/neu.20269","volume":"66","author":"J Zhang","year":"2006","unstructured":"Zhang J, Huang EJ (2006) Dynamic expression of neurotrophic factor receptors in postnatal spinal motoneurons and in mouse model of ALS. J Neurobiol 66(8):882\u2013895","journal-title":"J Neurobiol"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-008-2188-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00383-008-2188-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-008-2188-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T02:21:06Z","timestamp":1588818066000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00383-008-2188-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,17]]},"references-count":114,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["2188"],"URL":"https:\/\/doi.org\/10.1007\/s00383-008-2188-7","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,17]]}}}