{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:51:04Z","timestamp":1789869064714,"version":"4.0.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T00:00:00Z","timestamp":1278806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1007\/s00383-010-2654-x","type":"journal-article","created":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T22:18:16Z","timestamp":1278886696000},"page":"1011-1015","source":"Crossref","is-referenced-by-count":17,"title":["Prenatal retinoic acid upregulates pulmonary gene expression of PI3K and AKT in nitrofen-induced pulmonary hypoplasia"],"prefix":"10.1007","volume":"26","author":[{"given":"Takashi","family":"Doi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Ruttenstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Dingemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,7,11]]},"reference":[{"key":"2654_CR1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1053\/j.semperi.2004.03.009","volume":"28","author":"NM Doyle","year":"2004","unstructured":"Doyle NM, Lally KP (2004) The CDH Study Group and advance in the clinical care of the patient with congenital diaphragmatic hernia. Semin Perinatol 28:174\u2013184","journal-title":"Semin Perinatol"},{"key":"2654_CR2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1053\/j.semperi.2004.03.011","volume":"28","author":"FA Ivascu","year":"2004","unstructured":"Ivascu FA, Hirschl RB (2004) New approaches to managing congenital diaphragmatic hernia. Semin Perinatol 28:185\u2013198","journal-title":"Semin Perinatol"},{"key":"2654_CR3","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.amjsurg.2005.05.035","volume":"190","author":"JR Grosche","year":"2005","unstructured":"Grosche JR, Islam S, Boulanger SC (2005) Congenital diaphragmatic hernia. Am J Surg 190:324\u2013332","journal-title":"Am J Surg"},{"key":"2654_CR4","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/0022-3468(90)90190-K","volume":"25","author":"D Kluth","year":"1990","unstructured":"Kluth D, Kangah R, Reich P et al (1990) Nitrofen-induced diaphragmatic hernias in rats: an animal model. J Pediatr Surg 25:850\u2013854","journal-title":"J Pediatr Surg"},{"key":"2654_CR5","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.jpedsurg.2009.07.069","volume":"44","author":"T Doi","year":"2009","unstructured":"Doi T, Puri P (2009) Up-regulation of Wnt5a gene expression in the nitrofen-induced hypoplastic lung. J Pediatr Surg 44:2302\u20132306","journal-title":"J Pediatr Surg"},{"key":"2654_CR6","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1016\/j.jpedsurg.2009.02.068","volume":"44","author":"T Doi","year":"2009","unstructured":"Doi T, Hajduk P, Puri P (2009) Upregulation of Slit-2 and Slit-3 gene expressions in the nitrofen-induced hypoplastic lung. J Pediatr Surg 44:2092\u20132095","journal-title":"J Pediatr Surg"},{"key":"2654_CR7","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00383-009-2452-5","volume":"25","author":"H Sato","year":"2009","unstructured":"Sato H, Murphy P, Hajduk P (2009) Sonic hedgehog gene expression in nitrofen induced hypoplastic lungs in mice. Pediatr Surg Int 25:967\u2013971","journal-title":"Pediatr Surg Int"},{"key":"2654_CR8","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1152\/physrev.2000.80.3.1021","volume":"80","author":"PJ McCaffery","year":"2000","unstructured":"McCaffery PJ, Drager UC et al (2000) Retinoids in embryonal development. Physiol Rev 80:1021\u20131054","journal-title":"Physiol Rev"},{"key":"2654_CR9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0070-2153(04)61007-6","volume":"61","author":"M Maden","year":"2004","unstructured":"Maden M (2004) Retinoids in lung development and regeneration. Curr Top Dev Biol 61:153\u2013189","journal-title":"Curr Top Dev Biol"},{"key":"2654_CR10","doi-asserted-by":"crossref","first-page":"L1079","DOI":"10.1152\/ajplung.00286.2007","volume":"293","author":"BR Noble","year":"2007","unstructured":"Noble BR, Babiuk RP, Clugston RD et al (2007) Mechanisms of action of the congenital diaphragmatic hernia-inducing teratogen nitrofen. Am J Physiol Lung Cell Mol Physiol 293:L1079\u2013L1087","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2654_CR11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00383-006-1848-8","volume":"23","author":"N Nakazawa","year":"2007","unstructured":"Nakazawa N, Takayasu H, Montedonico S et al (2007) Altered regulation of retinoic acid synthesis in nitrofen-induced hypoplastic lung. Pediatr Surg Int 23:391\u2013396","journal-title":"Pediatr Surg Int"},{"key":"2654_CR12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jpedsurg.2006.10.028","volume":"42","author":"N Nakazawa","year":"2007","unstructured":"Nakazawa N, Montedonico S, Takayasu H et al (2007) Disturbance of retinol transportation causes nitrofen induced hypoplastic lung. J Pediatr Surg 42:345\u2013349","journal-title":"J Pediatr Surg"},{"key":"2654_CR13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jpedsurg.2008.10.079","volume":"44","author":"T Doi","year":"2009","unstructured":"Doi T, Sugimoto K, Puri P (2009) Up-regulation of COUP-TFII gene expression in the nitrofen-induced hypoplastic lung. J Pediatr Surg 44:321\u2013324","journal-title":"J Pediatr Surg"},{"key":"2654_CR14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00383-005-1571-x","volume":"22","author":"S Montedonico","year":"2006","unstructured":"Montedonico S, Nakazawa N, Puri P (2006) Retinoic acid rescues lung hypoplasia in nitrofen-induced hypoplastic foetal rat lung explants. Pediatr Surg Int 22:2\u20138","journal-title":"Pediatr Surg Int"},{"key":"2654_CR15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jpedsurg.2007.10.030","volume":"43","author":"S Montedonico","year":"2008","unstructured":"Montedonico S, Sugimoto K, Felle P et al (2008) Prenatal treatment with retinoic acid promotes pulmonary alveologenesis in the nitrofen model of congenital diaphragmatic hernia. J Pediatr Surg 43:500\u2013507","journal-title":"J Pediatr Surg"},{"key":"2654_CR16","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.jpedsurg.2009.04.027","volume":"44","author":"T Doi","year":"2009","unstructured":"Doi T, Sugimoto K, Puri P (2009) Prenatal retinoic acid up-regulates pulmonary gene expression of COUP-TFII, FOG2, and GATA4 in pulmonary hypoplasia. J Pediatr Surg 44:1933\u20131937","journal-title":"J Pediatr Surg"},{"key":"2654_CR17","doi-asserted-by":"crossref","first-page":"8347","DOI":"10.1074\/jbc.274.13.8347","volume":"274","author":"LE Rameh","year":"1999","unstructured":"Rameh LE, Cantley LC (1999) The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 274:8347\u20138350","journal-title":"J Biol Chem"},{"key":"2654_CR18","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1042\/bj3150709","volume":"315","author":"SR James","year":"1996","unstructured":"James SR, Downes CP, Gigg R et al (1996) Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3, 4, 5-trisphosphate without subsequent activation. Biochem J 315:709\u2013713","journal-title":"Biochem J"},{"key":"2654_CR19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tice.2004.09.002","volume":"37","author":"J Wang","year":"2005","unstructured":"Wang J, Ito T, Udaka N et al (2005) PI3K\u2013AKT pathway mediates growth and survival signals during development of fetal mouse lung. Tissue Cell 37:25\u201335","journal-title":"Tissue Cell"},{"key":"2654_CR20","unstructured":"Doi T, Ruttenstock E, Dingemann J et al (2009) Spatio-temporal alteration in PI3K\u2013AKT signalling in the nitrofen induced hypoplastic lung. J Pediatr Surg (in press)"},{"key":"2654_CR21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/CIRCULATIONAHA.104.500959","volume":"112","author":"A Uruno","year":"2005","unstructured":"Uruno A, Sugawara A, Kanatsuka H (2005) Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase\/Akt pathway. Circulation 112:727\u2013736","journal-title":"Circulation"},{"key":"2654_CR22","first-page":"L305","volume":"270","author":"GD Massaro","year":"1996","unstructured":"Massaro GD, Massaro D (1996) Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats. Am J Physiol 270:L305\u2013L310","journal-title":"Am J Physiol"},{"key":"2654_CR23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1183\/09031936.03.00119103","volume":"23","author":"M Hind","year":"2004","unstructured":"Hind M, Maden M (2004) Retinoic acid induces alveolar regeneration in the adult mouse lung. Eur Respir J 23:20\u201327","journal-title":"Eur Respir J"},{"key":"2654_CR24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s003830050399","volume":"13","author":"D Major","year":"1998","unstructured":"Major D, Cadenas M, Fournier L et al (1998) Retinol status of newborn infants with congenital diaphragmatic hernia. Pediatr Surg Int 13:547\u2013549","journal-title":"Pediatr Surg Int"},{"key":"2654_CR25","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1038\/sj.onc.1208347","volume":"24","author":"EF Farias","year":"2005","unstructured":"Farias EF, Marzan C, Mira-y-Lopez R (2005) Cellular retinol-binding protein-I inhibits PI3K\/Akt signaling through a retinoic acid receptor-dependent mechanism that regulates p85\u2013p110 heterodimerization. Oncogene 24:1598\u20131606","journal-title":"Oncogene"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-010-2654-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00383-010-2654-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-010-2654-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T15:52:21Z","timestamp":1559058741000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00383-010-2654-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,11]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["2654"],"URL":"https:\/\/doi.org\/10.1007\/s00383-010-2654-x","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,11]]}}}