{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:54:14Z","timestamp":1792083254136,"version":"4.4.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,11,17]],"date-time":"2012-11-17T00:00:00Z","timestamp":1353110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s00383-012-3209-0","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T16:53:49Z","timestamp":1353084829000},"page":"3-8","source":"Crossref","is-referenced-by-count":13,"title":["Increased activation of NADPH oxidase 4 in the pulmonary vasculature in experimental diaphragmatic hernia"],"prefix":"10.1007","volume":"29","author":[{"given":"Jan-H","family":"Gosemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Friedmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Hunziker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolae","family":"Corcionivoschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,17]]},"reference":[{"issue":"3","key":"3209_CR1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1053\/j.sempedsurg.2010.03.001","volume":"19","author":"R Keijzer","year":"2010","unstructured":"Keijzer R, Puri P (2010) Congenital diaphragmatic hernia. Semin Pediatr Surg 19(3):180\u2013185","journal-title":"Semin Pediatr Surg"},{"issue":"1","key":"3209_CR2","doi-asserted-by":"crossref","first-page":"L184","DOI":"10.1152\/ajplung.90455.2008","volume":"297","author":"RJ Teng","year":"2009","unstructured":"Teng RJ, Eis A, Bakhutashvili I, Arul N, Konduri GG (2009) Increased superoxide production contributes to the impaired angiogenesis of fetal pulmonary arteries with in utero pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 297(1):L184\u2013L195","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3209_CR3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1465-9921-12-119","volume":"12","author":"P Dorfmuller","year":"2011","unstructured":"Dorfmuller P, Chaumais MC, Giannakouli M, Durand-Gasselin I, Raymond N, Fadel E, Mercier O, Charlotte F, Montani D, Simonneau G, Humbert M, Perros F (2011) Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension. Respir Res 12:119","journal-title":"Respir Res"},{"issue":"2","key":"3209_CR4","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0022-3468(98)90468-7","volume":"33","author":"Y Taira","year":"1998","unstructured":"Taira Y, Yamataka T, Miyazaki E, Puri P (1998) Adventitial changes in pulmonary vasculature in congenital diaphragmatic hernia complicated by pulmonary hypertension. J Pediatr Surg 33(2):382\u2013387","journal-title":"J Pediatr Surg"},{"issue":"4","key":"3209_CR5","doi-asserted-by":"crossref","first-page":"L559","DOI":"10.1152\/ajplung.00090.2010","volume":"299","author":"X Lu","year":"2010","unstructured":"Lu X, Murphy TC, Nanes MS, Hart CM (2010) PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B. Am J Physiol Lung Cell Mol Physiol 299(4):L559\u2013L566","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"12","key":"3209_CR6","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1161\/01.CIR.0000012917.74432.66","volume":"105","author":"D Sorescu","year":"2002","unstructured":"Sorescu D, Weiss D, Lassegue B, Clempus RE, Szocs K, Sorescu GP, Valppu L, Quinn MT, Lambeth JD, Vega JD, Taylor WR, Griendling KK (2002) Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation 105(12):1429\u20131435","journal-title":"Circulation"},{"issue":"3","key":"3209_CR7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/CIRCRESAHA.107.148015","volume":"101","author":"M Mittal","year":"2007","unstructured":"Mittal M, Roth M, Konig P, Hofmann S, Dony E, Goyal P, Selbitz AC, Schermuly RT, Ghofrani HA, Kwapiszewska G, Kummer W, Klepetko W, Hoda MA, Fink L, Hanze J, Seeger W, Grimminger F, Schmidt HH, Weissmann N (2007) Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature. Circ Res 101(3):258\u2013267","journal-title":"Circ Res"},{"issue":"4","key":"3209_CR8","doi-asserted-by":"crossref","first-page":"C899","DOI":"10.1152\/ajpcell.00474.2004","volume":"288","author":"J Hwang","year":"2005","unstructured":"Hwang J, Kleinhenz DJ, Lassegue B, Griendling KK, Dikalov S, Hart CM (2005) Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. Am J Physiol Cell Physiol 288(4):C899\u2013C905","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"3209_CR9","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1165\/rcmb.2008-0132OC","volume":"42","author":"RE Nisbet","year":"2010","unstructured":"Nisbet RE, Bland JM, Kleinhenz DJ, Mitchell PO, Walp ER, Sutliff RL, Hart CM (2010) Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model. Am J Respir Cell Mol Biol 42(4):482\u2013490","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"3209_CR10","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1165\/rcmb.4912","volume":"29","author":"AM Barlier-Mur","year":"2003","unstructured":"Barlier-Mur AM, Chailley-Heu B, Pinteur C, Henrion-Caude A, Delacourt C, Bourbon JR (2003) Maturational factors modulate transcription factors CCAAT\/enhancer-binding proteins alpha, beta, delta, and peroxisome proliferator-activated receptor-gamma in fetal rat lung epithelial cells. Am J Respir Cell Mol Biol 29(5):620\u2013626","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"10","key":"3209_CR11","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1161\/01.RES.0000073585.50092.14","volume":"92","author":"S Ameshima","year":"2003","unstructured":"Ameshima S, Golpon H, Cool CD, Chan D, Vandivier RW, Gardai SJ, Wick M, Nemenoff RA, Geraci MW, Voelkel NF (2003) Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. Circ Res 92(10):1162\u20131169","journal-title":"Circ Res"},{"issue":"5","key":"3209_CR12","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1172\/JCI32503","volume":"118","author":"G Hansmann","year":"2008","unstructured":"Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M (2008) An antiproliferative BMP-2\/PPARgamma\/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest 118(5):1846\u20131857","journal-title":"J Clin Invest"},{"issue":"5","key":"3209_CR13","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jpedsurg.2012.01.038","volume":"47","author":"JH Gosemann","year":"2012","unstructured":"Gosemann JH, Doi T, Kutasy B, Friedmacher F, Dingemann J, Puri P (2012) Alterations of peroxisome proliferator-activated receptor gamma and monocyte chemoattractant protein 1 gene expression in the nitrofen-induced hypoplastic lung. J Pediatr Surg 47(5):847\u2013851","journal-title":"J Pediatr Surg"},{"issue":"10","key":"3209_CR14","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.jpedsurg.2010.06.014","volume":"45","author":"J Dingemann","year":"2010","unstructured":"Dingemann J, Doi T, Ruttenstock E, Puri P (2010) Abnormal platelet-derived growth factor signaling accounting for lung hypoplasia in experimental congenital diaphragmatic hernia. J Pediatr Surg 45(10):1989\u20131994","journal-title":"J Pediatr Surg"},{"issue":"1","key":"3209_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tiv.2004.04.010","volume":"19","author":"DE Kling","year":"2005","unstructured":"Kling DE, Aidlen JT, Fisher JC, Kinane TB, Donahoe PK, Schnitzer JJ (2005) Nitrofen induces a redox-dependent apoptosis associated with increased p38 activity in P19 teratocarcinoma cells. Toxicol In Vitro 19(1):1\u201310","journal-title":"Toxicol In Vitro"},{"issue":"11","key":"3209_CR16","doi-asserted-by":"crossref","first-page":"L1159","DOI":"10.1152\/ajplung.00325.2010","volume":"302","author":"YT Chang","year":"2012","unstructured":"Chang YT, Ringman Uggla A, Osterholm C, Tran PK, Eklof AC, Lengquist M, Hedin U, Tran-Lundmark K, Frenckner B (2012) Antenatal imatinib treatment reduces pulmonary vascular remodeling in a rat model of congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol 302(11):L1159\u2013L1166","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"9368","key":"3209_CR17","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/S0140-6736(03)13167-4","volume":"361","author":"JR Runo","year":"2003","unstructured":"Runo JR, Loyd JE (2003) Primary pulmonary hypertension. Lancet 361(9368):1533\u20131544","journal-title":"Lancet"},{"issue":"4","key":"3209_CR18","doi-asserted-by":"crossref","first-page":"e35364","DOI":"10.1371\/journal.pone.0035364","volume":"7","author":"HJ Corbett","year":"2012","unstructured":"Corbett HJ, Connell MG, Fernig DG, Losty PD, Jesudason EC (2012) ANG-1 TIE-2 and BMPR signalling defects are not seen in the nitrofen model of pulmonary hypertension and congenital diaphragmatic hernia. PLoS ONE 7(4):e35364","journal-title":"PLoS ONE"},{"issue":"19","key":"3209_CR19","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1161\/CIRCULATIONAHA.108.845909","volume":"123","author":"C Luong","year":"2011","unstructured":"Luong C, Rey-Perra J, Vadivel A, Gilmour G, Sauve Y, Koonen D, Walker D, Todd KG, Gressens P, Kassiri Z, Nadeem K, Morgan B, Eaton F, Dyck JR, Archer SL, Thebaud B (2011) Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation 123(19):2120\u20132131","journal-title":"Circulation"},{"issue":"6","key":"3209_CR20","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1161\/01.RES.0000063424.28903.BB","volume":"92","author":"LA Brennan","year":"2003","unstructured":"Brennan LA, Steinhorn RH, Wedgwood S, Mata-Greenwood E, Roark EA, Russell JA, Black SM (2003) Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase. Circ Res 92(6):683\u2013691","journal-title":"Circ Res"},{"issue":"1","key":"3209_CR21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.chom.2012.05.018","volume":"12","author":"N Corcionivoschi","year":"2012","unstructured":"Corcionivoschi N, Alvarez LA, Sharp TH, Strengert M, Alemka A, Mantell J, Verkade P, Knaus UG, Bourke B (2012) Mucosal reactive oxygen species decrease virulence by disrupting campylobacter jejuni phosphotyrosine signaling. Cell Host Microbe 12(1):47\u201359","journal-title":"Cell Host Microbe"},{"issue":"5","key":"3209_CR22","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1165\/2008-0145OC","volume":"40","author":"RE Nisbet","year":"2009","unstructured":"Nisbet RE, Graves AS, Kleinhenz DJ, Rupnow HL, Reed AL, Fan TH, Mitchell PO, Sutliff RL, Hart CM (2009) The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. Am J Respir Cell Mol Biol 40(5):601\u2013609","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"10","key":"3209_CR23","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1089\/ars.2008.2035","volume":"10","author":"S Li","year":"2008","unstructured":"Li S, Tabar SS, Malec V, Eul BG, Klepetko W, Weissmann N, Grimminger F, Seeger W, Rose F, Hanze J (2008) NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts. Antioxid Redox Signal 10(10):1687\u20131698","journal-title":"Antioxid Redox Signal"},{"key":"3209_CR24","doi-asserted-by":"crossref","unstructured":"Gosemann JH, Friedmacher F, Fujiwara N, Alvarez L, Corcionivoschi N, Puri P (2012) Disruption of the bone morphogenetic protein receptor 2 pathway in nitrofen induced congenital diaphragmatic hernia. Paper presented at the American Academy of Pediatrics, New Orleans","DOI":"10.1002\/bdrb.21065"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-012-3209-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00383-012-3209-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-012-3209-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T18:24:10Z","timestamp":1562351050000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00383-012-3209-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,17]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["3209"],"URL":"https:\/\/doi.org\/10.1007\/s00383-012-3209-0","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,17]]}}}