{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:40:15Z","timestamp":1791225615284,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T00:00:00Z","timestamp":1403913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s00383-014-3525-7","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T07:27:55Z","timestamp":1403854075000},"page":"1017-1022","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nitrofen increases total retinol levels in placenta during lung morphogenesis in the nitrofen model of congenital diaphragmatic hernia"],"prefix":"10.1007","volume":"30","author":[{"given":"Balazs","family":"Kutasy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Pes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Friedmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Paradisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,28]]},"reference":[{"issue":"3","key":"3525_CR1","doi-asserted-by":"crossref","first-page":"e356","DOI":"10.1542\/peds.2004-2845","volume":"116","author":"J Colvin","year":"2005","unstructured":"Colvin J, Bower C, Dickinson JE, Sokol J (2005) Outcomes of congenital diaphragmatic hernia: a population-based study in Western Australia. Pediatrics 116(3):e356\u2013e363","journal-title":"Pediatrics"},{"issue":"3 Pt 1","key":"3525_CR2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1542\/peds.112.3.532","volume":"112","author":"G Stege","year":"2003","unstructured":"Stege G, Fenton A, Jaffray B (2003) Nihilism in the 1990s: the true mortality of congenital diaphragmatic hernia. Pediatrics 112(3 Pt 1):532\u2013535","journal-title":"Pediatrics"},{"issue":"2","key":"3525_CR3","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.amjsurg.2005.05.035","volume":"190","author":"JR Gosche","year":"2005","unstructured":"Gosche JR, Islam S, Boulanger SC (2005) Congenital diaphragmatic hernia: searching for answers. Am J Surg 190(2):324\u2013332","journal-title":"Am J Surg"},{"issue":"4","key":"3525_CR4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.prrv.2007.08.004","volume":"8","author":"PD Robinson","year":"2007","unstructured":"Robinson PD, Fitzgerald DA (2007) Congenital diaphragmatic hernia. Paediatr Respir Rev 8(4):323\u2013334 (quiz 334\u2013325)","journal-title":"Paediatr Respir Rev"},{"issue":"7","key":"3525_CR5","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00383-008-2140-x","volume":"24","author":"S Montedonico","year":"2008","unstructured":"Montedonico S, Nakazawa N, Puri P (2008) Congenital diaphragmatic hernia and retinoids: searching for an etiology. Pediatr Surg Int 24(7):755\u2013761","journal-title":"Pediatr Surg Int"},{"issue":"4","key":"3525_CR6","doi-asserted-by":"crossref","first-page":"L1079","DOI":"10.1152\/ajplung.00286.2007","volume":"293","author":"BR Noble","year":"2007","unstructured":"Noble BR, Babiuk RP, Clugston RD, Underhill TM, Sun H, Kawaguchi R, Walfish PG, Blomhoff R, Gundersen TE, Greer JJ (2007) Mechanisms of action of the congenital diaphragmatic hernia-inducing teratogen nitrofen. Am J Physiol Lung Cell Mol Physiol 293(4):L1079\u2013L1087","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3525_CR7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.nutr.22.010402.102745E","volume":"22","author":"M Clagett-Dame","year":"2002","unstructured":"Clagett-Dame M, DeLuca HF (2002) The role of vitamin A in mammalian reproduction and embryonic development. Annu Rev Nutr 22:347\u2013381","journal-title":"Annu Rev Nutr"},{"issue":"37","key":"3525_CR8","doi-asserted-by":"crossref","first-page":"32198","DOI":"10.1074\/jbc.M111.253070","volume":"286","author":"L Wassef","year":"2011","unstructured":"Wassef L, Quadro L (2011) Uptake of dietary retinoids at the maternal-fetal barrier: in vivo evidence for the role of lipoprotein lipase and alternative pathways. J Biol Chem 286(37):32198\u201332207","journal-title":"J Biol Chem"},{"issue":"1","key":"3525_CR9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bbalip.2011.05.003","volume":"1821","author":"E Spiegler","year":"2012","unstructured":"Spiegler E, Kim YK, Wassef L, Shete V, Quadro L (2012) Maternal-fetal transfer and metabolism of vitamin A and its precursor beta-carotene in the developing tissues. Biochim Biophys Acta 1821(1):88\u201398","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"3525_CR10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1203\/00006450-200010000-00024","volume":"48","author":"V Sapin","year":"2000","unstructured":"Sapin V, Chaib S, Blanchon L, Alexandre-Gouabau MC, Lemery D, Charbonne F, Gallot D, Jacquetin B, Dastugue B, Azais-Braesco V (2000) Esterification of vitamin A by the human placenta involves villous mesenchymal fibroblasts. Pediatr Res 48(4):565\u2013572","journal-title":"Pediatr Res"},{"issue":"5213","key":"3525_CR11","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.7754382","volume":"268","author":"HL Monaco","year":"1995","unstructured":"Monaco HL, Rizzi M, Coda A (1995) Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein. Science 268(5213):1039\u20131041","journal-title":"Science"},{"issue":"6","key":"3525_CR12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0098-2997(03)00038-4","volume":"24","author":"L Quadro","year":"2003","unstructured":"Quadro L, Hamberger L, Colantuoni V, Gottesman ME, Blaner WS (2003) Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models. Mol Asp Med 24(6):421\u2013430","journal-title":"Mol Asp Med"},{"issue":"5","key":"3525_CR13","doi-asserted-by":"crossref","first-page":"E844","DOI":"10.1152\/ajpendo.00556.2003","volume":"286","author":"L Quadro","year":"2004","unstructured":"Quadro L, Hamberger L, Gottesman ME, Colantuoni V, Ramakrishnan R, Blaner WS (2004) Transplacental delivery of retinoid: the role of retinol-binding protein and lipoprotein retinyl ester. Am J Physiol Endocrinol Metab 286(5):E844\u2013E851","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"3525_CR14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0074-7696(08)61566-1","volume":"188","author":"GM Morriss-Kay","year":"1999","unstructured":"Morriss-Kay GM, Ward SJ (1999) Retinoids and mammalian development. Int Rev Cytol 188:73\u2013131","journal-title":"Int Rev Cytol"},{"issue":"2","key":"3525_CR15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/(SICI)1097-0177(199702)208:2<199::AID-AJA7>3.0.CO;2-D","volume":"208","author":"V Sapin","year":"1997","unstructured":"Sapin V, Ward SJ, Bronner S, Chambon P, Dolle P (1997) Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse. Dev Dyn 208(2):199\u2013210","journal-title":"Dev Dyn"},{"issue":"1","key":"3525_CR16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2045-3701-2-11","volume":"2","author":"RK Kam","year":"2012","unstructured":"Kam RK, Deng Y, Chen Y, Zhao H (2012) Retinoic acid synthesis and functions in early embryonic development. Cell Biosci 2(1):11","journal-title":"Cell Biosci"},{"issue":"2","key":"3525_CR17","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jpedsurg.2006.10.028","volume":"42","author":"N Nakazawa","year":"2007","unstructured":"Nakazawa N, Montedonico S, Takayasu H, Paradisi F, Puri P (2007) Disturbance of retinol transportation causes nitrofen-induced hypoplastic lung. J Pediatr Surg 42(2):345\u2013349","journal-title":"J Pediatr Surg"},{"issue":"1","key":"3525_CR18","doi-asserted-by":"crossref","first-page":"276S","DOI":"10.1093\/jn\/134.1.276S","volume":"134","author":"J Paik","year":"2004","unstructured":"Paik J, Vogel S, Quadro L, Piantedosi R, Gottesman M, Lai K, Hamberger L, Vieira Mde M, Vieira Mde M, Blaner WS (2004) Vitamin A: overlapping delivery pathways to tissues from the circulation. J Nutr 134(1):276S\u2013280S","journal-title":"J Nutr"},{"issue":"1","key":"3525_CR19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1210\/endo-128-1-401","volume":"128","author":"Y Kato","year":"1991","unstructured":"Kato Y, Braunstein GD (1991) Retinoic acid stimulates placental hormone secretion by choriocarcinoma cell lines in vitro. Endocrinology 128(1):401\u2013407","journal-title":"Endocrinology"},{"issue":"5","key":"3525_CR20","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00383-006-1848-8","volume":"23","author":"N Nakazawa","year":"2007","unstructured":"Nakazawa N, Takayasu H, Montedonico S, Puri P (2007) Altered regulation of retinoic acid synthesis in nitrofen-induced hypoplastic lung. Pediatr Surg Int 23(5):391\u2013396","journal-title":"Pediatr Surg Int"},{"issue":"42","key":"3525_CR21","doi-asserted-by":"crossref","first-page":"35647","DOI":"10.1074\/jbc.M507924200","volume":"280","author":"SM O\u2019Byrne","year":"2005","unstructured":"O\u2019Byrne SM, Wongsiriroj N, Libien J, Vogel S, Goldberg IJ, Baehr W, Palczewski K, Blaner WS (2005) Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J Biol Chem 280(42):35647\u201335657","journal-title":"J Biol Chem"},{"issue":"8","key":"3525_CR22","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/bdra.20151","volume":"73","author":"D Gallot","year":"2005","unstructured":"Gallot D, Marceau G, Coste K, Hadden H, Robert-Gnansia E, Laurichesse H, Dechelotte PJ, Labbe A, Dastugue B, Lemery D et al (2005) Congenital diaphragmatic hernia: a retinoid-signaling pathway disruption during lung development? Birth Defects Res A Clin Mol Teratol 73(8):523\u2013531","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"4","key":"3525_CR23","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1542\/peds.2010-0521","volume":"126","author":"LW Beurskens","year":"2010","unstructured":"Beurskens LW, Tibboel D, Lindemans J, Duvekot JJ, Cohen-Overbeek TE, Veenma DC, de Klein A, Greer JJ, Steegers-Theunissen RP (2010) Retinol status of newborn infants is associated with congenital diaphragmatic hernia. Pediatrics 126(4):712\u2013720","journal-title":"Pediatrics"},{"issue":"2","key":"3525_CR24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00383-011-2995-0","volume":"28","author":"B Kutasy","year":"2012","unstructured":"Kutasy B, Gosemann JH, Doi T, Fujiwara N, Friedmacher F, Puri P (2012) Nitrofen interferes with trophoblastic expression of retinol-binding protein and transthyretin during lung morphogenesis in the nitrofen-induced congenital diaphragmatic hernia model. Pediatr Surg Int 28(2):143\u2013148","journal-title":"Pediatr Surg Int"},{"issue":"1\u20132","key":"3525_CR25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1570-0232(03)00233-2","volume":"791","author":"K Hosotani","year":"2003","unstructured":"Hosotani K, Kitagawa M (2003) Improved simultaneous determination method of beta-carotene and retinol with saponification in human serum and rat liver. J Chromatogr B Anal Technol Biomed Life Sci 791(1\u20132):305\u2013313","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"3525_CR26","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1081\/JLC-120017902","volume":"26","author":"ANZI Moulas","year":"2003","unstructured":"Moulas ANZI, Taitzoglou IA, Tsantarliotou MP, Botsoglou NA (2003) Simultaneous determination of retinoic acid, retinol, and retinyl palmitate in ram plasma by liquid chromatography. J Liq Chromatogr 26:559\u2013572","journal-title":"J Liq Chromatogr"},{"issue":"1","key":"3525_CR27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00383-012-3203-6","volume":"29","author":"B Kutasy","year":"2013","unstructured":"Kutasy B, Gosemann JH, Duess JW, Puri P (2013) Increased trophoblastic apoptosis mediated by neutrophil gelatinase-associated lipocalin (NGAL) activation in the nitrofen model of congenital diaphragmatic hernia. Pediatr Surg Int 29(1):25\u201331","journal-title":"Pediatr Surg Int"},{"issue":"2","key":"3525_CR28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1293\/tox.24.95","volume":"24","author":"S Furukawa","year":"2011","unstructured":"Furukawa S, Hayashi S, Usuda K, Abe M, Hagio S, Ogawa I (2011) Toxicological pathology in the rat placenta. J Toxicol Pathol 24(2):95\u2013111","journal-title":"J Toxicol Pathol"},{"issue":"10","key":"3525_CR29","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1210\/en.2005-0158","volume":"146","author":"L Quadro","year":"2005","unstructured":"Quadro L, Hamberger L, Gottesman ME, Wang F, Colantuoni V, Blaner WS, Mendelsohn CL (2005) Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency. Endocrinology 146(10):4479\u20134490","journal-title":"Endocrinology"},{"issue":"2","key":"3525_CR30","first-page":"112","volume":"52","author":"SD Ismadi","year":"1982","unstructured":"Ismadi SD, Olson JA (1982) Dynamics of the fetal distribution and transfer of vitamin A between rat fetuses and their mother. Int J Vitam Nutr Res 52(2):112\u2013119","journal-title":"Int J Vitam Nutr Res"},{"issue":"9","key":"3525_CR31","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1074\/jbc.M708885200","volume":"283","author":"YK Kim","year":"2008","unstructured":"Kim YK, Wassef L, Hamberger L, Piantedosi R, Palczewski K, Blaner WS, Quadro L (2008) Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. J Biol Chem 283(9):5611\u20135621","journal-title":"J Biol Chem"},{"issue":"2","key":"3525_CR32","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1073\/pnas.96.2.547","volume":"96","author":"O Wendling","year":"1999","unstructured":"Wendling O, Chambon P, Mark M (1999) Retinoid X receptors are essential for early mouse development and placentogenesis. Proc Natl Acad Sci USA 96(2):547\u2013551","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"3525_CR33","doi-asserted-by":"crossref","first-page":"L1159","DOI":"10.1152\/ajplung.2000.279.6.L1159","volume":"279","author":"TW Guilbert","year":"2000","unstructured":"Guilbert TW, Gebb SA, Shannon JM (2000) Lung hypoplasia in the nitrofen model of congenital diaphragmatic hernia occurs early in development. Am J Physiol Lung Cell Mol Physiol 279(6):L1159\u2013L1171","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"3525_CR34","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ydbio.2006.09.050","volume":"301","author":"PY Jay","year":"2007","unstructured":"Jay PY, Bielinska M, Erlich JM, Mannisto S, Pu WT, Heikinheimo M, Wilson DB (2007) Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol 301(2):602\u2013614","journal-title":"Dev Biol"},{"issue":"11","key":"3525_CR35","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1016\/j.jpedsurg.2009.02.068","volume":"44","author":"T Doi","year":"2009","unstructured":"Doi T, Hajduk P, Puri P (2009) Upregulation of Slit-2 and Slit-3 gene expressions in the nitrofen-induced hypoplastic lung. J Pediatr Surg 44(11):2092\u20132095","journal-title":"J Pediatr Surg"},{"issue":"12","key":"3525_CR36","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.jpedsurg.2009.07.069","volume":"44","author":"T Doi","year":"2009","unstructured":"Doi T, Puri P (2009) Up-regulation of Wnt5a gene expression in the nitrofen-induced hypoplastic lung. J Pediatr Surg 44(12):2302\u20132306","journal-title":"J Pediatr Surg"},{"issue":"2","key":"3525_CR37","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/bdrb.20293","volume":"92","author":"E Ruttenstock","year":"2011","unstructured":"Ruttenstock E, Doi T, Dingemann J, Puri P (2011) Prenatal administration of retinoic acid upregulates insulin-like growth factor receptors in the nitrofen-induced hypoplastic lung. Birth Defects Res B Dev Reprod Toxicol 92(2):148\u2013151","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"issue":"3","key":"3525_CR38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/bdrb.20247","volume":"89","author":"DE Kling","year":"2010","unstructured":"Kling DE, Cavicchio AJ, Sollinger CA, Schnitzer JJ, Kinane TB, Newburg DS (2010) Nitrofen induces apoptosis independently of retinaldehyde dehydrogenase (RALDH) inhibition. Birth Defects Res B Dev Reprod Toxicol 89(3):223\u2013232","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"key":"3525_CR39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1289\/ehp.8670137","volume":"70","author":"JM Manson","year":"1986","unstructured":"Manson JM (1986) Mechanism of nitrofen teratogenesis. Environ Health Perspect 70:137\u2013147","journal-title":"Environ Health Perspect"},{"issue":"2","key":"3525_CR40","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/tera.1420340202","volume":"34","author":"TJ Brown","year":"1986","unstructured":"Brown TJ, Manson JM (1986) Further characterization of the distribution and metabolism of nitrofen in the pregnant rat. Teratology 34(2):129\u2013139","journal-title":"Teratology"},{"issue":"1","key":"3525_CR41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/bdra.20613","volume":"88","author":"RD Clugston","year":"2010","unstructured":"Clugston RD, Zhang W, Greer JJ (2010) Early development of the primordial mammalian diaphragm and cellular mechanisms of nitrofen-induced congenital diaphragmatic hernia. Birth Defects Res A Clin Mol Teratol 88(1):15\u201324","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"2","key":"3525_CR42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00383-013-3449-7","volume":"30","author":"B Kutasy","year":"2014","unstructured":"Kutasy B, Friedmacher F, Duess JW, Puri P (2014) Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia. Pediatr Surg Int 30(2):137\u2013142","journal-title":"Pediatr Surg Int"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-014-3525-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00383-014-3525-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-014-3525-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T02:27:49Z","timestamp":1716863269000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00383-014-3525-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,28]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["3525"],"URL":"https:\/\/doi.org\/10.1007\/s00383-014-3525-7","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,28]]}}}