{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T02:56:51Z","timestamp":1780887411024,"version":"3.54.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s00383-016-3979-x","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T12:43:44Z","timestamp":1474375424000},"page":"1193-1200","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fenofibrate reduces intestinal damage and improves intestinal recovery following intestinal ischemia\u2013reperfusion injury in a rat"],"prefix":"10.1007","volume":"32","author":[{"given":"I.","family":"Sukhotnik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Nissimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ben Shahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Moati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bitterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Berkowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Coran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bitterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,20]]},"reference":[{"key":"3979_CR1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00000658-199208000-00002","volume":"216","author":"EA Deitch","year":"1992","unstructured":"Deitch EA (1992) Multiple organ failure. Pathophysiology and potential future therapy. Ann Surg 216:117\u2013134","journal-title":"Ann Surg"},{"key":"3979_CR2","first-page":"47","volume":"548","author":"DN Granger","year":"1986","unstructured":"Granger DN, Hollwarth ME, Park DA (1986) Ishemia reperfusion injury: role of oxygen-derived free radicals. Acta Physiol Scand Suppl 548:47\u201356","journal-title":"Acta Physiol Scand Suppl"},{"key":"3979_CR3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6","volume":"190","author":"DL Carden","year":"2000","unstructured":"Carden DL, Granger DN (2000) Pathophysiology of ischaemia\u2013reperfusion injury. J Pathol 190:255\u2013266","journal-title":"J Pathol"},{"key":"3979_CR4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1006\/cryo.1996.0040","volume":"33","author":"MJ Mangino","year":"1996","unstructured":"Mangino MJ, Mangino JE, Murphy MK, Anderson CB (1996) Arachidonic acid metabolism in intestinal hypothermic preservation injury. Cryobiology 33:404\u2013412","journal-title":"Cryobiology"},{"key":"3979_CR5","first-page":"H2976","volume":"272","author":"I Kurose","year":"1997","unstructured":"Kurose I, Argenbright LW, Wolf R, Lianxi L, Granger DN (1997) Ischemia\/reperfusion-induced microvascular dysfunction: role of oxidants and lipid mediators. Am J Physiol 272:H2976\u2013H2982","journal-title":"Am J Physiol"},{"key":"3979_CR6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/jsre.2001.6106","volume":"99","author":"S Yamamoto","year":"2001","unstructured":"Yamamoto S, Tanabe M, Wakabayashi G, Shimazu M, Matsumoto K, Kitajima M (2001) The role of tumor necrosis factor-alpha and interleukin-1beta in ischemia\u2013reperfusion injury of the rat small intestine. J Surg Res 99:134\u2013141","journal-title":"J Surg Res"},{"key":"3979_CR7","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/gut.32.8.905","volume":"32","author":"MH Schoenberg","year":"1991","unstructured":"Schoenberg MH, Poch B, Younes M, Schwarz A, Baczako K, Lundberg C, Haglund U, Beger HG (1991) Involvement of neutrophils in postischaemic damage to the small intestine. Gut 32:905\u20131112","journal-title":"Gut"},{"key":"3979_CR8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00024382-200003000-00007","volume":"13","author":"Z Sun","year":"2000","unstructured":"Sun Z, Wang X, Deng X, Boriesson A, Wallen R, Hallberg E, Andersson R (2000) Phagocytic and intestinal endothelial and epithelial barrier function during the early stage of small intestinal ischemia and reperfusion injury. Shock 13:209\u2013216","journal-title":"Shock"},{"key":"3979_CR9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/0022-4804(92)90145-P","volume":"52","author":"K Koike","year":"1992","unstructured":"Koike K, Moore FA, Moore EE, Poggetti RS, Tuder RM, Banerjee A (1992) Endotoxin after gut ischemia\/reperfusion causes irreversible lung injury. J Surg Res 52:656\u2013662","journal-title":"J Surg Res"},{"key":"3979_CR10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0140-6736(98)10364-1","volume":"354","author":"J Vamecq","year":"1999","unstructured":"Vamecq J, Latruffe N (1999) Medical significance of peroxisome proliferator-activated receptors. Lancet 354:141\u2013148","journal-title":"Lancet"},{"key":"3979_CR11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/bcpt.12003","volume":"112","author":"R Krysiak","year":"2013","unstructured":"Krysiak R, Gdula-Dymek A, Okopien B (2013) The effect of\u00a0fenofibrate\u00a0on lymphocyte release of\u00a0proinflammatory\u00a0cytokines\u00a0and systemic inflammation in simvastatin-treated patients with atherosclerosis and early glucose metabolism disturbances. Basic Clin Pharmacol Toxicol 112:198\u2013202","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"3979_CR12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/jnr.20518","volume":"81","author":"J Xu","year":"2005","unstructured":"Xu J, Storer PD, Chavis JA, Racke MK, Drew PD (2005) Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia. J Neurosci Res 81:403\u2013411","journal-title":"J Neurosci Res"},{"key":"3979_CR13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.14701\/kjhbps.2013.17.3.89","volume":"17","author":"TW Won","year":"2013","unstructured":"Won TW (2013) Fenofibrate, a peroxisome proliferator-activated receptor \u03b1-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver. Korean J Hepatobiliary Pancreat Surg 17:89\u2013108","journal-title":"Korean J Hepatobiliary Pancreat Surg"},{"key":"3979_CR14","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4103\/2231-4040.101016","volume":"3","author":"GS Sugga","year":"2012","unstructured":"Sugga GS, Khan MU, Khanam R (2012) Protective role of fibrates in cardiac ischemia\/reperfusion. J Adv Pharm Technol Res 3:188\u2013192","journal-title":"J Adv Pharm Technol Res"},{"key":"3979_CR15","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3109\/0886022X.2010.504911","volume":"32","author":"Y Bhalodia","year":"2010","unstructured":"Bhalodia Y, Sheth N, Vaghasiya J, Jivani N (2010) Role of fenofibrate alone and in combination with telmisartan on renal ischemia\/reperfusion injury. Ren Fail 32:1088\u20131094","journal-title":"Ren Fail"},{"key":"3979_CR16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10735-011-9313-y","volume":"42","author":"V Boshra","year":"2011","unstructured":"Boshra V, Moustafa AM (2011) Effect of preischemic treatment with fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, on hepatic ischemia\/reperfusion injury in rats. J Mol Histol 42:113\u2013122","journal-title":"J Mol Histol"},{"key":"3979_CR17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1477-5956-12-24","volume":"12","author":"P Gel\u00e9","year":"2014","unstructured":"Gel\u00e9 P, Vingtdeux V, Potey C, Drobecq H, Ghestem A, Melnyk P, Bu\u00e9e L, Sergeant N, Bordet R (2014) Recovery of brain biomarkers following peroxisome proliferator-activated receptor agonist neuroprotective treatment before ischemic stroke. Proteome Sci 12:24\u201334","journal-title":"Proteome Sci"},{"key":"3979_CR18","first-page":"532","volume":"15","author":"P Chromszynski","year":"1993","unstructured":"Chromszynski P (1993) A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 15:532\u2013536","journal-title":"Biotechniques"},{"key":"3979_CR19","first-page":"574","volume":"107","author":"PO Park","year":"1990","unstructured":"Park PO, Haglund U, Bulkley GB (1990) The sequence of development of intestinal tissue injury after strangulation ischemia and reperfusion. Surgery 107:574\u2013580","journal-title":"Surgery"},{"key":"3979_CR20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00383-015-3828-3","volume":"32","author":"I Sukhotnik","year":"2016","unstructured":"Sukhotnik I, Aranovich I, Ben Shahar Y, Bitterman N, Pollak Y, Berkowitz D, Chepurov D, Coran AG, Bitterman A (2016) Effect of taurine on intestinal recovery following intestinal ischemia\u2013reperfusion injury in a rat. Pediatr Surg Int 32:161\u2013168","journal-title":"Pediatr Surg Int"},{"key":"3979_CR21","first-page":"47","volume":"26","author":"Y Ben Shahar","year":"2016","unstructured":"Ben Shahar Y, Sukhotnik I, Bitterman N, Pollak Y, Bejar J, Chepurov D, Coran A, Bitterman A (2016) Effect of N-acetylserotonin on intestinal recovery following intestinal ischemia\u2013reperfusion injury in a rat. Eur J Pediatr Surg 26:47\u201353","journal-title":"Eur J Pediatr Surg"},{"key":"3979_CR22","first-page":"153","volume":"22","author":"G Pearson","year":"2001","unstructured":"Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22:153\u2013183","journal-title":"Endocr Rev"},{"key":"3979_CR23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00418-013-1113-x","volume":"140","author":"J Chen","year":"2013","unstructured":"Chen J, Terada N, Saitoh Y, Huang Z, Ohno N, Ohno S (2013) Detection of MAPK signal transduction proteins in an ischemia\/reperfusion model of mouse intestine using in vivo cryotechnique. Histochem Cell Biol 140:491\u2013505","journal-title":"Histochem Cell Biol"},{"key":"3979_CR24","first-page":"G270","volume":"274","author":"T Noda","year":"1998","unstructured":"Noda T, Iwakiri R, Fujimoto K, Matsuo S, Aw TY (1998) Programmed cell death induced by ischemia\u2013reperfusion in rat intestinal mucosa. Am J Physiol 274:G270\u2013G278","journal-title":"Am J Physiol"},{"key":"3979_CR25","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/jcbfm.2013.233","volume":"34","author":"T Ouk","year":"2014","unstructured":"Ouk T, Gautier S, P\u00e9trault M, Montaigne D, Mar\u00e9chal X, Masse I, Devedjian JC, Deplanque D, Bastide M, Nevi\u00e8re R, Duriez P, Staels B, Pasquier F, Leys D, Bordet R (2014) Effects of the PPAR-\u03b1 agonist fenofibrate on acute and short-term consequences of brain ischemia. J Cereb Blood Flow Metab 34:542\u2013551","journal-title":"J Cereb Blood Flow Metab"},{"key":"3979_CR26","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00204-010-0572-2","volume":"84","author":"CR Elcombe","year":"2010","unstructured":"Elcombe CR, Elcombe BM, Foster JR, Farrar DG, Jung R, Chang SC, Kennedy GL, Butenhoff JL (2010) Hepatocellular hypertrophy and cell proliferation in Sprague\u2013Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPAR\u03b1 and CAR\/PXR. Arch Toxicol 84:787\u2013798","journal-title":"Arch Toxicol"},{"key":"3979_CR27","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1365-2133.2010.10037.x","volume":"164","author":"M Schuster","year":"2011","unstructured":"Schuster M, Zouboulis CC, Ochsendorf F, M\u00fcller J, Tha\u00e7i D, Bernd A, Kaufmann R, Kippenberger S (2011) Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne? Br J Dermatol 164:182\u2013186","journal-title":"Br J Dermatol"},{"key":"3979_CR28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11626-015-9979-7","volume":"52","author":"M Hong","year":"2016","unstructured":"Hong M, Song KD, Lee HK, Yi S, Lee YS, Heo TH, Jun HS, Kim SJ (2016) Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential. Vitro Cell Dev Biol Anim 52:349\u2013355","journal-title":"Vitro Cell Dev Biol Anim"},{"key":"3979_CR29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00109-007-0257-3","volume":"86","author":"M Zanetti","year":"2008","unstructured":"Zanetti M, Stocca A, Dapas B, Farra R, Uxa L, Bosutti A, Barazzoni R, Bossi F, Giansante C, Tedesco F, Cattin L, Guarnieri G, Grassi G (2008) Inhibitory effects of\u00a0fenofibrate\u00a0on\u00a0apoptosis\u00a0and cell proliferation in human endothelial cells in high glucose. J Mol Med (Berl) 86:185\u2013195","journal-title":"J Mol Med (Berl)"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-016-3979-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00383-016-3979-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-016-3979-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T19:15:49Z","timestamp":1498331749000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00383-016-3979-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,20]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["3979"],"URL":"https:\/\/doi.org\/10.1007\/s00383-016-3979-x","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,20]]}}}