{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:47:19Z","timestamp":1783439239645,"version":"3.54.6"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T00:00:00Z","timestamp":1482796800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00383-016-4042-7","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T01:59:36Z","timestamp":1482803976000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pathophysiology, prevention, treatment, and outcomes of intestinal failure-associated liver disease"],"prefix":"10.1007","volume":"33","author":[{"given":"Noora H.","family":"Al-Shahwani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Sigalet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,27]]},"reference":[{"issue":"4","key":"4042_CR1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jpeds.2012.03.062","volume":"161","author":"RH Squires","year":"2012","unstructured":"Squires RH, Duggan C, Teitelbaum DH, Wales PW, Balint J, Venick R et al (2012) Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure Consortium. J Pediatr 161(4):723\u2013728","journal-title":"J Pediatr"},{"issue":"1","key":"4042_CR2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1053\/j.sempedsurg.2009.11.003","volume":"19","author":"SA Kocoshis","year":"2010","unstructured":"Kocoshis SA (2010) Medical management of pediatric intestinal failure. Semin Pediatr Surg 19(1):20\u201326","journal-title":"Semin Pediatr Surg"},{"issue":"1","key":"4042_CR3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jpedsurg.2010.09.083","volume":"46","author":"D Sigalet","year":"2011","unstructured":"Sigalet D, Boctor D, Brindle M, Lam V, Robertson M (2011) Elements of successful intestinal rehabilitation. J Pediatr Surg 46(1):150\u2013156","journal-title":"J Pediatr Surg"},{"key":"4042_CR4","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jpedsurg.2013.02.070","volume":"48","author":"JD Stanger","year":"2013","unstructured":"Stanger JD, Oliveira C, Blackmore C, Avitzur Y (2013) Wales PA The impact of multi-disciplinary intestinal rehabilitation programs on the outcome of pediatric patients with intestinal failure: a systematic review and meta-analysis. J Pediatr Surg 48:983\u2013992","journal-title":"J Pediatr Surg"},{"issue":"1","key":"4042_CR5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1177\/0148607113496280","volume":"38","author":"G Lauriti","year":"2014","unstructured":"Lauriti G, Zani A, Aufieri R, Cananzi M, Chiesa PL, Eaton S, Pierro A (2014) Incidence, prevention, and treatment of parenteral nutrition-associated cholestasis and intestinal failure-associated liver disease in infants and children: a systematic review. JPEN J Parenter Enteral Nutr 38(1):70\u201385. doi: 10.1177\/0148607113496280","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"4042_CR6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0095-5108(03)00069-1","volume":"29","author":"SJ Karpen","year":"2002","unstructured":"Karpen SJ (2002) Update on the etiologies and management of neonatal cholestasis. Clin Perinat. 29:159\u2013180","journal-title":"Clin Perinat."},{"key":"4042_CR7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbamcr.2006.04.014","volume":"1773","author":"A Geier","year":"2007","unstructured":"Geier A, Mb Wagner, Dietrich CG, Trauner M (2007) Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Biochim et Biophys Acta 1773:283\u2013308","journal-title":"Biochim et Biophys Acta"},{"key":"4042_CR8","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S0022-3468(96)90507-2","volume":"31","author":"SV Beath","year":"1996","unstructured":"Beath SV, Davies P, Papadopolou A et al (1996) Parenteral nutrition-related cholestasis in postsurgical neonates: multivariate analysis of risk factors. J Pediatr Surg 31:604\u2013606","journal-title":"J Pediatr Surg"},{"issue":"2","key":"4042_CR9","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/MPG.0000000000000586","volume":"60","author":"Lacaille F, Gupte G, Colomb V, D\u2019Antiga L, Hartman C, Hojsak I, Kolacek S, Puntis J, Shamir R; ESPGHAN Working Group of Intestinal Failure and Intestinal Transplantation","year":"2015","unstructured":"Lacaille F, Gupte G, Colomb V, D\u2019Antiga L, Hartman C, Hojsak I, Kolacek S, Puntis J, Shamir R; ESPGHAN Working Group of Intestinal Failure and Intestinal Transplantation (2015) Intestinal failure-associated liver disease: a position paper of the ESPGHAN Working Group of Intestinal Failure and Intestinal Transplantation. J Pediatr Gastroenterol Nutr 60(2):272\u2013283. doi: 10.1097\/MPG.0000000000000586","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"4042_CR10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jhep.2009.05.012","volume":"51","author":"M Wagner","year":"2009","unstructured":"Wagner M, Zollner G (2009) Trauner M New molecular insights into the mechanisms of cholestasis J. Hepatology 51:565\u2013580","journal-title":"Hepatology"},{"key":"4042_CR11","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3945\/an.113.004796","volume":"5","author":"DG Burrin","year":"2014","unstructured":"Burrin DG, Ng K, Stoll B, Pipa\u00f3n MSG (2014) Impact of new-generation lipid emulsions on cellular mechanisms of parenteral nutrition-associated liver disease. Adv Nutr 5:82\u201391. doi: 10.3945\/an.113.004796","journal-title":"Adv Nutr"},{"key":"4042_CR12","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.3945\/jn.110.125799","volume":"140","author":"B Stoll","year":"2010","unstructured":"Stoll B, Horst DA, Cui L, Chang X, Ellis KJ, Hadsell DL, Suryawan A, Kurundkar A, Maheshwari A, Davis TA et al (2010) Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs. J Nutr 140:2193\u20132200","journal-title":"J Nutr"},{"key":"4042_CR13","doi-asserted-by":"crossref","first-page":"8988","DOI":"10.1074\/jbc.M212633200","volume":"278","author":"MS Kim","year":"2003","unstructured":"Kim MS, Shigenaga J, Moser A, Feingold K, Grunfeld C (2003) Repression of farnesoid X receptor during the acute phase response. J Biol Chem 278:8988\u20138995","journal-title":"J Biol Chem"},{"key":"4042_CR14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1203\/PDR.0b013e3181256492","volume":"62","author":"BA Carter","year":"2007","unstructured":"Carter BA, Taylor OA, Prendergast DR, Zimmerman TL, Von Furstenberg R, Moore DD, Karpen SJ (2007) Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatr Res 62:301\u2013306","journal-title":"Pediatr Res"},{"key":"4042_CR15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s11745-009-3371","volume":"45","author":"ML Forchielli","year":"2010","unstructured":"Forchielli ML, Bersani G, Tala S et al (2010) The spectrum of plant and animal sterols in different oil-derived intravenous emulsions. Lipids 45:63. doi: 10.1007\/s11745-009-3371","journal-title":"Lipids"},{"issue":"206","key":"4042_CR16","first-page":"206137","volume":"5","author":"CEK Karim","year":"2013","unstructured":"Karim CEK, Anderson AL, Devereaux MW et al (2013) Phytosterols promote liver injury and kupffer cell activation in parenteral nutrition-associated liver disease. Sci Transl Med 5(206):206137","journal-title":"Sci Transl Med"},{"key":"4042_CR17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.clnu.2012.09.007","volume":"32","author":"O Goulet","year":"2013","unstructured":"Goulet O, Olieman J, Ksiazyk J, Spolidoro J, Tibboe D, K\u00f6hler H, Vural Yagci R, Falconer J, Grimble G, Beattie RM (2013) Neonatal short bowel syndrome as a model of intestinal failure: physiological background for enteral feeding. Clinical Nutrition 32:162\u2013171","journal-title":"Clinical Nutrition"},{"key":"4042_CR18","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.jpeds.2013.07.011","volume":"163","author":"EA Cristofalo","year":"2013","unstructured":"Cristofalo EA, Schanler RJ, Blanco CL et al (2013) Randomized trial of exclusive human milk versus preterm formula diets in extremely premature infants. J Pediatr 163:1592\u20131595","journal-title":"J Pediatr"},{"issue":"3","key":"4042_CR19","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/MPG.0000000000001158","volume":"63","author":"DA Stamm","year":"2016","unstructured":"Stamm DA, Hait E, Litman HJ, Mitchell PD, Duggan C (2016) High prevalence of eosinophilic gastrointestinal disease in children with intestinal failure. J Pediatr Gastroenterol Nutr 63(3):336\u2013339","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"4042_CR20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1399-3038.2007.00591.x","volume":"19","author":"A Mazon","year":"2008","unstructured":"Mazon A, Solera E, Alentado N et al (2008) Frequent IgE sensitization to latex, cow\u2019s milk, and egg in children with short bowel syndrome. Pediatr Allergy Immunol 19:180\u2013183","journal-title":"Pediatr Allergy Immunol"},{"key":"4042_CR21","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jpedsurg.2005.03.019","volume":"40","author":"PJ Javid","year":"2005","unstructured":"Javid PJ, Collier S, Richardson D, Iglesias J, Gurac K, Lob C, Kim HB, Duggan C, Tom Jaksic T (2005) The role of enteral nutrition in the reversal of parenteral nutrition-associated liver dysfunction in infants. J Pediatr Surg 40:1015\u20131018","journal-title":"J Pediatr Surg"},{"key":"4042_CR22","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1542\/peds.2004-1014","volume":"115","author":"DH Teitelbaum","year":"2005","unstructured":"Teitelbaum DH, Tracy TF Jr, Aouthmany MM, Llanos A, Brown MB, Yu S et al (2005) Use of cholecystokinin-octapeptide for the prevention of parenteral nutrition-associated cholestasis. Pediatrics 115:1332\u20131340","journal-title":"Pediatrics"},{"key":"4042_CR23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1067\/mpd.2002.125802","volume":"141","author":"JE Heubi","year":"2002","unstructured":"Heubi JE, Wiechmann DA, Creutzinger V, Setchell KD, Squires R Jr, Couser R et al (2002) Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease. J Pediatr 141:237\u2013242","journal-title":"J Pediatr"},{"key":"4042_CR24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0022-3468(97)90609-6","volume":"32","author":"JJ Meehan","year":"1997","unstructured":"Meehan JJ, Georgeson KE (1997) Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome. J Pediatr Surg 32:473\u2013475","journal-title":"J Pediatr Surg"},{"key":"4042_CR25","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1053\/j.gastro.2007.03.043","volume":"132","author":"PC Ng","year":"2007","unstructured":"Ng PC, Lee CH, Wong SPS et al (2007) High-dose oral erythromycin decreased the incidence of parenteral nutrition-associated cholestasis in preterm infants. Gastroenterology 132:1726\u20131739","journal-title":"Gastroenterology"},{"key":"4042_CR26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pedneo.2011.11.007","volume":"53","author":"YY Ng","year":"2012","unstructured":"Ng YY, Su PH, Chen JY et al (2012) Efficacy of intermediate-dose oral erythromycin on very low birth weight infants with feeding intolerance. Pediatr Neonatol. 53:34\u201340","journal-title":"Pediatr Neonatol."},{"key":"4042_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009172.pub2","author":"V Kapoor","year":"2015","unstructured":"Kapoor V, Glover R, Malviya MN (2015) Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants. Cochrane Database Syst Rev. doi: 10.1002\/14651858.CD009172.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"4042_CR28","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1177\/0884533612439896","volume":"27","author":"VW Vanek","year":"2012","unstructured":"Vanek VW, Seidner DL, Allen P, Bistrian B, Collier S, Gura K, Miles JM, Valentine CJ, Kochevar M, Novel Nutrient Task Force, Intravenous Fat Emulsions Workgroup, American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors (2012) A.S.P.E.N. position paper: clinical role for alternative intravenous fat emulsions. Nutr Clin Pract. 27(2):150\u2013192","journal-title":"Nutr Clin Pract."},{"issue":"2","key":"4042_CR29","doi-asserted-by":"publisher","first-page":"629S","DOI":"10.3945\/ajcn.114.103986","volume":"103","author":"P Nandivada","year":"2016","unstructured":"Nandivada P, Fell GL, Gura KM, Puder M (2016) Lipid emulsions in the treatment and prevention of parenteral nutrition-associated liver disease in infants and children. Am J Clin Nutr 103(2):629S\u2013634S. doi: 10.3945\/ajcn.114.103986","journal-title":"Am J Clin Nutr"},{"issue":"Supplement","key":"4042_CR30","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1097\/MPG.0b013e31819773cf","volume":"48","author":"S Innes","year":"2009","unstructured":"Innes S (2009) Omega-3 fatty acids and neural development to 2\u00a0years of age: do we know enough for dietary recommendations? J Pediatr Gastroenterol Nutr 48(Supplement):S16\u2013S24","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"4042_CR31","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1177\/0148607114542515","volume":"39","author":"KL Finn","year":"2015","unstructured":"Finn KL, Chung M, Rothpletz-Puglia P (2015) Byham-Gray L impact of providing a combination lipid emulsion compared with a standard soybean oil lipid emulsion in children receiving parenteral nutrition: a systematic review and meta-analysis. JPEN J Parenter Enteral Nutr 39(6):656\u2013667","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"2","key":"4042_CR32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/MPG.0000000000000948","volume":"62","author":"G Lam","year":"2016","unstructured":"Lam G, Strogach IG, Baron N, Thompson JF (2016) Normal growth and essential fatty acid status in children with intestinal failure on lipid limitation. J Pediatr Gastroenterol Nutr 62(2):335\u2013340","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"4042_CR33","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115626921","author":"IR Diamond","year":"2016","unstructured":"Diamond IR, Grant RC, Pencharz PB, de Silva N, Feldman BM, Fitzgerald P, Sigalet D, Dicken B, Turner J, Marchand V, Ling SC, Moore AM, Avitzur Y, Wales PW (2016) Preventing the progression of intestinal failure-associated liver disease in infants using a composite lipid emulsion: a pilot randomized controlled trial of SMOFlipid. JPEN J Parenter Enteral Nutr. doi: 10.1177\/0148607115626921","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"1 Suppl","key":"4042_CR34","doi-asserted-by":"crossref","first-page":"81S","DOI":"10.1177\/0148607111424411","volume":"36","author":"M Rayyan","year":"2012","unstructured":"Rayyan M, Devlieger H, Jochum F, Allegaert K (2012) Short-term use of parenteral nutrition with a lipid emulsion containing a mixture of soybean oil, olive oil, medium-chain triglycerides, and fish oil: a randomized double-blind study in preterm infants. JPEN J Parenter Enteral Nutr 36(1 Suppl):81S\u201394S PMID: 22237883","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"4042_CR35","first-page":"e679","volume":"121","author":"KM Gura","year":"2008","unstructured":"Gura KM, Lee S, Valim C, Zhou J, Kim S, Modi BP, Arsenault DA, Strijbosch RAM, Lopes S, Duggan C (2008) Puder M safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease. Pediatrics 121:e679\u2013e686","journal-title":"Pediatrics"},{"key":"4042_CR36","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1159\/000358267","volume":"105","author":"HS Lam","year":"2014","unstructured":"Lam HS, Tam YH, Poon TC, Cheung HM, Yu X, Chan BP, Lee KH, Lee BS, Ng PC (2014) A double-blind randomised controlled trial of fish oil-based versus soy-based lipid preparations in the treatment of infants with parenteral nutrition-associated cholestasis. Neonatology 105:290\u2013296. doi: 10.1159\/000358267","journal-title":"Neonatology"},{"issue":"2","key":"4042_CR37","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3945\/jn.114.204974","volume":"145","author":"HW Park","year":"2015","unstructured":"Park HW, Lee NM, Kim JH, Kim KS, Kim SN (2015) Parenteral fish oil-containing lipid emulsions may reverse parenteral nutrition-associated cholestasis in neonates: a systematic review and meta-analysis. J Nutr 145(2):277\u2013283. doi: 10.3945\/jn.114.204974","journal-title":"J Nutr"},{"issue":"3","key":"4042_CR38","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/MCO.0b013e3283385407","volume":"13","author":"B Koletzko","year":"2010","unstructured":"Koletzko B, Goulet O (2010) Fish oil containing intravenous lipid emulsions in parenteral nutrition-associated cholestatic liver disease. Curr Opin Clin Nutr Metab Care 13(3):321\u2013326. doi: 10.1097\/MCO.0b013e3283385407","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"4042_CR39","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.204974","author":"HW Park","year":"2014","unstructured":"Park HW, Lee NM, Kim JH, Kim KS, Kim SN (2014) Parenteral fish oil\u2014containing lipid emulsions may reverse parenteral nutrition\u2013associated cholestasis in neonates: a systematic review and meta-analysis. J Nutr Dis. doi: 10.3945\/jn.114.204974","journal-title":"J Nutr Dis"},{"issue":"4","key":"4042_CR40","doi-asserted-by":"crossref","first-page":"e680","DOI":"10.1542\/peds.2005-1273","volume":"117","author":"ML Blakely","year":"2006","unstructured":"Blakely ML, Tyson JE, Lally KP et al (2006) Laparotomy versus peritoneal drainage for necrotizing enterocolitis or isolated intestinal perforation in extremely low birth weight infants: outcomes through 18\u00a0months adjusted age. Pediatrics 117(4):e680\u2013e687","journal-title":"Pediatrics"},{"key":"4042_CR41","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1001\/archpedi.161.6.583","volume":"161","author":"SM Schulzke","year":"2007","unstructured":"Schulzke SM, Deshpande CG, Patole SK (2007) Neurodevelopmental outcomes of very low-birth-weight infants with necrotizing enterocolitis a systematic review of observational studies. Arch Pediatr Adolesc Med 161:583\u2013590","journal-title":"Arch Pediatr Adolesc Med"},{"key":"4042_CR42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jpedsurg.2009.10.020","volume":"45","author":"SC Fitzgibbons","year":"2010","unstructured":"Fitzgibbons SC, Jones BA, Hulla MA, Zurakowskic D, Duro D, Duggan C, Boctor D, Sigalet DL, Jaksic T (2010) Relationship between biopsy-proven parenteral nutrition-associated liver fibrosis and biochemical cholestasis in children with short bowel syndrome. J Ped Surg 45:95\u201399","journal-title":"J Ped Surg"},{"issue":"1","key":"4042_CR43","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1097\/SLA.0000000000000445","volume":"261","author":"P Nandivada","year":"2015","unstructured":"Nandivada P, Chang MI, Potemkin AK, Carlson SJ, Cowan E, O\u02bcloughlin AA, Mitchell PD, Gura KM, Puder M (2015) The natural history of cirrhosis from parenteral nutrition-associated liver disease after resolution of cholestasis with parenteral fish oil therapy. Ann Surg 261(1):172\u2013179. doi: 10.1097\/SLA.0000000000000445","journal-title":"Ann Surg"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-016-4042-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00383-016-4042-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-016-4042-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T02:50:26Z","timestamp":1498359026000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00383-016-4042-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,27]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["4042"],"URL":"https:\/\/doi.org\/10.1007\/s00383-016-4042-7","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,27]]}}}