{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T19:27:35Z","timestamp":1771961255145,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T00:00:00Z","timestamp":1561766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T00:00:00Z","timestamp":1561766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s00383-019-04505-1","type":"journal-article","created":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T09:02:49Z","timestamp":1561798969000},"page":"929-934","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Altered expression of caveolin-1 in the colon of patients with Hirschsprung\u2019s disease"],"prefix":"10.1007","volume":"35","author":[{"given":"Hiroki","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Marie","family":"O\u2019Donnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Tomuschat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Coyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prem","family":"Puri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,29]]},"reference":[{"key":"4505_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-3-540-33935-9_10","volume-title":"Hischsprung\u2019s disease and allied disorders","author":"FM Murphy","year":"2008","unstructured":"Murphy FM, Puri MP (2008) Enterocolitis complicating Hirschsprung\u2019s disease. In: Puri P (ed) Hischsprung\u2019s disease and allied disorders. Springer, Berlin, pp 133\u2013143"},{"key":"4505_CR2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s00383-016-3862-9","volume":"32","author":"A Gosain","year":"2016","unstructured":"Gosain A (2016) Established and emerging concepts in Hirschsprung\u2019s-associated enterocolitis. Pediatr Surg Int 32:313\u2013320","journal-title":"Pediatr Surg Int"},{"key":"4505_CR3","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s00383-013-3353-1","volume":"29","author":"FR Demehri","year":"2013","unstructured":"Demehri FR, Halaweish IF, Coran AG, Teitelbaum DH (2013) Hirschsprung-associated enterocolitis: pathogenesis, treatment and prevention. Pediatr Surg Int 29:873\u2013881","journal-title":"Pediatr Surg Int"},{"key":"4505_CR4","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1053\/j.semperi.2008.01.002","volume":"32","author":"NK Chokshi","year":"2008","unstructured":"Chokshi NK, Guner YS, Hunter CJ, Upperman JS, Grishin A, Ford HR (2008) The role of nitric oxide in intestinal epithelial injury and restitution in neonatal necrotizing enterocolitis. Semin Perinatol 32:92\u201399","journal-title":"Semin Perinatol"},{"key":"4505_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jpedsurg.2015.10.006","volume":"51","author":"A Grishin","year":"2016","unstructured":"Grishin A, Bowling J, Bell B, Wang J, Ford HR (2016) Roles of nitric oxide and intestinal microbiota in the pathogenesis of necrotizing enterocolitis. J Pediatr Surg 51:13\u201317","journal-title":"J Pediatr Surg"},{"key":"4505_CR6","first-page":"431","volume":"46","author":"E Kolb","year":"1991","unstructured":"Kolb E (1991) Current knowledge on the formation of nitric oxide in endothelial cells of blood vessels, in nerve cells and macrophages as well as its significance in vascular dilatation, information transmission and damage of tumor cells. Z Gesamte Inn Med 46:431\u2013436","journal-title":"Z Gesamte Inn Med"},{"key":"4505_CR7","doi-asserted-by":"publisher","first-page":"G865","DOI":"10.1152\/ajpgi.00187.2004","volume":"287","author":"BA Vallance","year":"2004","unstructured":"Vallance BA, Dijkstra G, Qiu B, van der Waaij LA, van Goor H, Jansen PL et al (2004) Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity. Am J Physiol Gastrointest Liver Physiol 287:G865\u2013G874","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4505_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4077\/CJP.2011.AMK011","volume":"54","author":"H Krauss","year":"2011","unstructured":"Krauss H, Sosnowski P, Biczysko M, Biczysko W, Majewski P, Jablecka A et al (2011) Effects of l-arginine and NG-nitro l-arginine methyl ester (L-NAME) on ischemia\/reperfusion injury of skeletal muscle, small and large intestines. Chin J Physiol 54:7\u201318","journal-title":"Chin J Physiol"},{"key":"4505_CR9","doi-asserted-by":"publisher","first-page":"G225","DOI":"10.1152\/ajpgi.00447.2002","volume":"286","author":"C Hierholzer","year":"2004","unstructured":"Hierholzer C, Kalff JC, Billiar TR, Bauer AJ, Tweardy DJ, Harbrecht BG (2004) Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 286:G225\u2013G233","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4505_CR10","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.jhep.2013.01.038","volume":"58","author":"J Du Plessis","year":"2013","unstructured":"Du Plessis J, Vanheel H, Janssen CE, Roos L, Slavik T, Stivaktas PI et al (2013) Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function. J Hepatol 58:1125\u20131132","journal-title":"J Hepatol"},{"key":"4505_CR11","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1097\/CCM.0b013e31822661ad","volume":"39","author":"DJ Hackam","year":"2011","unstructured":"Hackam DJ (2011) Danger at the doorstep: regulation of bacterial translocation across the intestinal barrier by nitric oxide. Crit Care Med 39:2189\u20132190","journal-title":"Crit Care Med"},{"key":"4505_CR12","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1161\/ATVBAHA.107.151167","volume":"27","author":"JD Erusalimsky","year":"2007","unstructured":"Erusalimsky JD, Moncada S (2007) Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. Arterioscler Thromb Vasc Biol 27:2524\u20132531","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4505_CR13","doi-asserted-by":"publisher","first-page":"G1347","DOI":"10.1152\/ajpgi.00375.2006","volume":"292","author":"S Cetin","year":"2007","unstructured":"Cetin S, Leaphart CL, Li J, Ischenko I, Hayman M, Upperman J et al (2007) Nitric oxide inhibits enterocyte migration through activation of RhoA-GTPase in a SHP-2-dependent manner. Am J Physiol Gastrointest Liver Physiol 292:G1347\u2013G1358","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4505_CR14","doi-asserted-by":"publisher","first-page":"3602","DOI":"10.1128\/IAI.70.7.3602-3610.2002","volume":"70","author":"CF Benjamim","year":"2002","unstructured":"Benjamim CF, Silva JS, Fortes ZB, Oliveira MA, Ferreira SH, Cunha FQ (2002) Inhibition of leukocyte rolling by nitric oxide during sepsis leads to reduced migration of active microbicidal neutrophils. Infect Immun 70:3602\u20133610","journal-title":"Infect Immun"},{"key":"4505_CR15","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S0891-5849(00)00391-9","volume":"29","author":"DG Binion","year":"2000","unstructured":"Binion DG, Rafiee P, Ramanujam KS, Fu S, Fisher PJ, Rivera MT et al (2000) Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Free Radic Biol Med 29:881\u2013888","journal-title":"Free Radic Biol Med"},{"key":"4505_CR16","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.jpedsurg.2005.11.003","volume":"41","author":"HR Ford","year":"2006","unstructured":"Ford HR (2006) Mechanism of nitric oxide-mediated intestinal barrier failure: insight into the pathogenesis of necrotizing enterocolitis. J Pediatr Surg 41:294\u2013299","journal-title":"J Pediatr Surg"},{"key":"4505_CR17","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1203\/PDR.0b013e3181d4ff2b","volume":"67","author":"A D\u2019Souza","year":"2010","unstructured":"D\u2019Souza A, Fordjour L, Ahmad A, Cai C, Kumar D, Valencia G et al (2010) Effects of probiotics, prebiotics, and synbiotics on messenger RNA expression of caveolin-1, NOS, and genes regulating oxidative stress in the terminal ileum of formula-fed neonatal rats. Pediatr Res 67:526\u2013531","journal-title":"Pediatr Res"},{"key":"4505_CR18","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1007\/s10753-017-0566-9","volume":"40","author":"M Yan","year":"2017","unstructured":"Yan M, Hou M, Liu J, Zhang S, Liu B, Wu X et al (2017) Regulation of iNOS-derived ROS generation by HSP90 and Cav-1 in porcine reproductive and respiratory syndrome virus-infected swine lung injury. Inflammation 40:1236\u20131244","journal-title":"Inflammation"},{"key":"4505_CR19","doi-asserted-by":"publisher","first-page":"e0119004","DOI":"10.1371\/journal.pone.0119004","volume":"10","author":"CR Weiss","year":"2015","unstructured":"Weiss CR, Guan Q, Ma Y, Qing G, Bernstein CN, Warrington RJ et al (2015) The potential protective role of caveolin-1 in intestinal inflammation in TNBS-induced murine colitis. PLoS One 10:e0119004","journal-title":"PLoS One"},{"key":"4505_CR20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1161\/01.ATV.0000101182.89118.E5","volume":"24","author":"PG Frank","year":"2004","unstructured":"Frank PG, Lee H, Park DS, Tandon NN, Scherer PE, Lisanti MP (2004) Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arterioscler Thromb Vasc Biol 24:98\u2013105","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4505_CR21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00418-001-0367-x","volume":"117","author":"RD Minshall","year":"2002","unstructured":"Minshall RD, Tiruppathi C, Vogel SM, Malik AB (2002) Vesicle formation and trafficking in endothelial cells and regulation of endothelial barrier function. Histochem Cell Biol 117:105\u2013112","journal-title":"Histochem Cell Biol"},{"key":"4505_CR22","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1172\/JCI27100","volume":"116","author":"J Yu","year":"2006","unstructured":"Yu J, Bergaya S, Murata T, Alp IF, Bauer MP, Lin MI et al (2006) Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. J Clin Invest 116:1284\u20131291","journal-title":"J Clin Invest"},{"key":"4505_CR23","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1161\/01.RES.0000129178.56294.17","volume":"94","author":"JP Gratton","year":"2004","unstructured":"Gratton JP, Bernatchez P, Sessa WC (2004) Caveolae and caveolins in the cardiovascular system. Circ Res 94:1408\u20131417","journal-title":"Circ Res"},{"key":"4505_CR24","doi-asserted-by":"publisher","first-page":"13273","DOI":"10.1074\/jbc.M113.528695","volume":"289","author":"AE Trane","year":"2014","unstructured":"Trane AE, Pavlov D, Sharma A, Saqib U, Lau K, van Petegem F et al (2014) Deciphering the binding of caveolin-1 to client protein endothelial nitric-oxide synthase (eNOS): scaffolding subdomain identification, interaction modeling, and biological significance. J Biol Chem 289:13273\u201313283","journal-title":"J Biol Chem"},{"key":"4505_CR25","first-page":"195","volume":"9","author":"WM Krajewska","year":"2004","unstructured":"Krajewska WM, Maslowska I (2004) Caveolins: structure and function in signal transduction. Cell Mol Biol Lett 9:195\u2013220","journal-title":"Cell Mol Biol Lett"},{"key":"4505_CR26","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1080\/07853890410018899","volume":"36","author":"TM Williams","year":"2004","unstructured":"Williams TM, Lisanti MP (2004) The Caveolin genes: from cell biology to medicine. Ann Med 36:584\u2013595","journal-title":"Ann Med"},{"key":"4505_CR27","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1084\/jem.20061536","volume":"203","author":"XM Wang","year":"2006","unstructured":"Wang XM, Zhang Y, Kim HP, Zhou Z, Feghali-Bostwick CA, Liu F et al (2006) Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J Exp Med 203:2895\u20132906","journal-title":"J Exp Med"},{"key":"4505_CR28","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1038\/82176","volume":"6","author":"M Bucci","year":"2000","unstructured":"Bucci M, Gratton JP, Rudic RD, Acevedo L, Roviezzo F, Cirino G et al (2000) In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nat Med 6:1362\u20131367","journal-title":"Nat Med"},{"key":"4505_CR29","doi-asserted-by":"publisher","first-page":"5760","DOI":"10.1074\/jbc.M701572200","volume":"283","author":"CJ Le Saux","year":"2008","unstructured":"Le Saux CJ, Teeters K, Miyasato SK, Hoffmann PR, Bollt O, Douet V et al (2008) Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. J Biol Chem 283:5760\u20135768","journal-title":"J Biol Chem"},{"key":"4505_CR30","doi-asserted-by":"publisher","first-page":"3809","DOI":"10.4049\/jimmunol.0712437","volume":"182","author":"XM Wang","year":"2009","unstructured":"Wang XM, Kim HP, Nakahira K, Ryter SW, Choi AM (2009) The heme oxygenase-1\/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. J Immunol 182:3809\u20133818","journal-title":"J Immunol"},{"key":"4505_CR31","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.jpedsurg.2017.01.046","volume":"52","author":"C Tomuschat","year":"2017","unstructured":"Tomuschat C, O\u2019Donnell AM, Coyle D, Dreher N, Kelly D, Puri P (2017) NOS-interacting protein (NOSIP) is increased in the colon of patients with Hirschsprungs\u2019s disease. J Pediatr Surg 52:772\u2013777","journal-title":"J Pediatr Surg"},{"key":"4505_CR32","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1001\/archsurg.1996.01430230037007","volume":"131","author":"DL Sorrells","year":"1996","unstructured":"Sorrells DL, Friend C, Koltuksuz U, Courcoulas A, Boyle P, Garrett M et al (1996) Inhibition of nitric oxide with aminoguanidine reduces bacterial translocation after endotoxin challenge in vivo. Arch Surg 131:1155\u20131163","journal-title":"Arch Surg"},{"key":"4505_CR33","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.bbrc.2009.04.091","volume":"384","author":"YS Guner","year":"2009","unstructured":"Guner YS, Ochoa CJ, Wang J, Zhang X, Steinhauser S, Stephenson L et al (2009) Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes. Biochem Biophys Res Commun 384:221\u2013225","journal-title":"Biochem Biophys Res Commun"},{"key":"4505_CR34","doi-asserted-by":"publisher","first-page":"G861","DOI":"10.1152\/ajpgi.00412.2002","volume":"285","author":"DA Potoka","year":"2003","unstructured":"Potoka DA, Upperman JS, Zhang XR, Kaplan JR, Corey SJ, Grishin A et al (2003) Peroxynitrite inhibits enterocyte proliferation and modulates Src kinase activity in vitro. Am J Physiol Gastrointest Liver Physiol 285:G861\u2013G869","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4505_CR35","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/s10354-010-0766-5","volume":"160","author":"M Wendel","year":"2010","unstructured":"Wendel M, Heller AR (2010) Mitochondrial function and dysfunction in sepsis. Wien Med Wochenschr 160:118\u2013123","journal-title":"Wien Med Wochenschr"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-019-04505-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00383-019-04505-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-019-04505-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T23:29:14Z","timestamp":1593300554000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00383-019-04505-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,29]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["4505"],"URL":"https:\/\/doi.org\/10.1007\/s00383-019-04505-1","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,29]]},"assertion":[{"value":"20 June 2019","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}