{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:32:26Z","timestamp":1762867946746,"version":"3.37.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200266","81270441"],"award-info":[{"award-number":["81200266","81270441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00383-019-04555-5","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T12:17:36Z","timestamp":1568981856000},"page":"81-91","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dual roles of commensal bacteria after intestinal ischemia and reperfusion"],"prefix":"10.1007","volume":"36","author":[{"given":"Hong-yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinrao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenzhao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie-xiong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"4555_CR1","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1002\/cphy.c150007","volume":"5","author":"DNHL Granger","year":"2015","unstructured":"Granger DNHL, Kvietys P (2015) The gastrointestinal circulation: physiology and pathophysiology. Compr Physiol 5:1541\u20131583. \nhttps:\/\/doi.org\/10.1002\/cphy.c150007","journal-title":"Compr Physiol"},{"key":"4555_CR2","doi-asserted-by":"publisher","first-page":"520","DOI":"10.2741\/1816","volume":"1","author":"E Deitch","year":"2006","unstructured":"Deitch E, Xu D, Kaise V (2006) Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review. Front Biosci 1:520\u2013528. \nhttps:\/\/doi.org\/10.2741\/1816","journal-title":"Front Biosci"},{"key":"4555_CR3","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.surge.2012.03.003","volume":"10","author":"E Deitch","year":"2012","unstructured":"Deitch E (2012) Gut-origin sepsis: evolution of a concept. Surgeon 10:350\u2013356. \nhttps:\/\/doi.org\/10.1016\/j.surge.2012.03.003","journal-title":"Surgeon"},{"key":"4555_CR4","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/SHK.0000000000000431","volume":"44","author":"J Yi","year":"2015","unstructured":"Yi J, Slaughter A, Kotter C, Moore E, Hauser C, Itagaki K, Wohlauer M, Frank D, Silliman C, Banerjee A, Peltz E (2015) A \"clean case\" of systemic injury: mesenteric lymph after hemorrhagic shock elicites a sterile inflammatory response. Shock 44:336\u2013340. \nhttps:\/\/doi.org\/10.1097\/SHK.0000000000000431","journal-title":"Shock"},{"key":"4555_CR5","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1172\/JCI75225","volume":"124","author":"M Kagnoff","year":"2014","unstructured":"Kagnoff M (2014) The intestinal epithelium is an integral component of a communications network. J Clin Invest 124:2841\u20132843. \nhttps:\/\/doi.org\/10.1172\/JCI75225","journal-title":"J Clin Invest"},{"key":"4555_CR6","doi-asserted-by":"publisher","first-page":"G1020","DOI":"10.1152\/ajpgi.00239.2011","volume":"301","author":"K Yoshiya","year":"2011","unstructured":"Yoshiya K, Lapchak P, Thai T, Kannan L, Rani P, Dalle Lucca J, Tsokos G (2011) Depletion of gut commensal bacteria attenuates intestinal ischemia\/reperfusion injury. Am J Physiol Gastrointest Liver Physiol 301:G1020\u20131030. \nhttps:\/\/doi.org\/10.1152\/ajpgi.00239.2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4555_CR7","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.4049\/jimmunol.173.6.4137","volume":"173","author":"D Souza","year":"2004","unstructured":"Souza D, Vieira A, Soares A, Pinho V, Nicoli J, Vieira L, Teixeira M (2004) The essential role of the intestinal microbiota in facilitating acute inflammatory responses. J Immunol 173:4137\u20134146. \nhttps:\/\/doi.org\/10.4049\/jimmunol.173.6.4137","journal-title":"J Immunol"},{"key":"4555_CR8","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1378\/chest.112.2.491","volume":"112","author":"P Sorkine","year":"1997","unstructured":"Sorkine P, Szold O, Halpern P, Gutman M, Greemland M, Rudick V, Goldman G (1997) Gut decontamination reduces bowel ischemia-induced lung injury in rats. Chest 112:491\u2013495. \nhttps:\/\/doi.org\/10.1378\/chest.112.2.491","journal-title":"Chest"},{"key":"4555_CR9","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1097\/SHK.0b013e31816a3458","volume":"30","author":"L Chen","year":"2008","unstructured":"Chen L, Chang W, Chen P, Liu W, Hsu C (2008) TLR ligand decreases mesenteric ischemia and reperfusion injury-induced gut damage through TNF-alpha signaling. Shock 30:563\u2013570. \nhttps:\/\/doi.org\/10.1097\/SHK.0b013e31816a3458","journal-title":"Shock"},{"key":"4555_CR10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/00024382-200116010-00006","volume":"16","author":"B van der Hoven","year":"2001","unstructured":"van der Hoven B, Nabuurs M, van Leengoed L, Groeneveld A, Thijs L (2001) Gut luminal endotoxin reduces ischemia-reperfusion injury of the small gut in germ-free pigs. Shock 16:28\u201332","journal-title":"Shock"},{"key":"4555_CR11","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.jpedsurg.2010.02.093","volume":"45","author":"PM Tatum Jr","year":"2010","unstructured":"Tatum PM Jr, Lorenz RG, Dimmitt RA (2010) Toll-like receptor 4 is protective against neonatal murine ischemia\u2013reperfusion intestinal injury. J Pediatr Surg 45:1246\u20131255. \nhttps:\/\/doi.org\/10.1016\/j.jpedsurg.2010.02.093","journal-title":"J Pediatr Surg"},{"key":"4555_CR12","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1111\/j.1365-2036.2006.03174.x","volume":"25","author":"M Gatt","year":"2007","unstructured":"Gatt M, Reddy B, MacFie J (2007) Review article: bacterial translocation in the critically ill-evidence and methods of prevention. Aliment Pharmacol Ther 25:741\u2013757. \nhttps:\/\/doi.org\/10.1111\/j.1365-2036.2006.03174.x","journal-title":"Aliment Pharmacol Ther"},{"key":"4555_CR13","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","volume":"118","author":"SPJ Rakoff-Nahoum","year":"2004","unstructured":"Rakoff-Nahoum SPJ, Eslami-Varzaneh F, Edberg S, Medzhitov R (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118:229\u2013241. \nhttps:\/\/doi.org\/10.1016\/j.cell.2004.07.002","journal-title":"Cell"},{"key":"4555_CR14","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/j.surg.2015.12.013","volume":"159","author":"H Zhang","year":"2016","unstructured":"Zhang H, Besner G, Feng J (2016) Antibody blockade of mucosal addressing cell adhesion molecule-1 attenuates proinflammatory activity of mesenteric lymph after hemorrhagic shock and resuscitation. Surgery 159:1449\u20131460. \nhttps:\/\/doi.org\/10.1016\/j.surg.2015.12.013","journal-title":"Surgery"},{"key":"4555_CR15","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jss.2010.03.062","volume":"163","author":"I James","year":"2010","unstructured":"James I, Chen C, Huang G, Zhang H, Velten M, Besner G (2010) HB-EGF protects the lungs after intestinal ischemia\/reperfusion injury. J Surg Res 163:86\u201395. \nhttps:\/\/doi.org\/10.1016\/j.jss.2010.03.062","journal-title":"J Surg Res"},{"key":"4555_CR16","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.gastro.2005.05.054","volume":"129","author":"O El-Assal","year":"2005","unstructured":"El-Assal O, Besner G (2005) HB-EGF enhances restitution after intestinal ischemia\/reperfusion via PI3K\/Akt and MEK\/ERK1\/2 activation. Gastroenterology 129:609\u2013625. \nhttps:\/\/doi.org\/10.1016\/j.gastro.2005.05.054","journal-title":"Gastroenterology"},{"key":"4555_CR17","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nri2515","volume":"9","author":"J Round","year":"2009","unstructured":"Round J, Mazmanian S (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9:313\u2013323. \nhttps:\/\/doi.org\/10.1038\/nri2515","journal-title":"Nat Rev Immunol"},{"key":"4555_CR18","first-page":"1682","volume":"63","author":"Y Nezu","year":"2002","unstructured":"Nezu Y, Tagawa M, Sakaue Y, Hara Y, Tsuchida S, Ogawa R (2002) Kinetics of endotoxin concentration and tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 activities in the systemic and portal circulation during small intestinal ischemia and reperfusion in dogs. Am J Vet Res 63:1682\u20131686","journal-title":"Am J Vet Res"},{"key":"4555_CR19","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1016\/s0041-1345(97)00080-8","volume":"29","author":"L Cicalese","year":"1997","unstructured":"Cicalese L, Billiar T, Rao A, Bauer A (1997) Interaction between ischemia\/reperfusion-induced leukocyte emigration and translocating bacterial enterotoxins on enteric muscle function. Transplant Proc 29:1815. \nhttps:\/\/doi.org\/10.1016\/s0041-1345(97)00080-8","journal-title":"Transplant Proc"},{"key":"4555_CR20","doi-asserted-by":"publisher","first-page":"G479","DOI":"10.1152\/ajpgi.1999.276.2.G479","volume":"276","author":"P Bauer","year":"1999","unstructured":"Bauer P, Russell J, Granger D (1999) Role of endotoxin in intestinal reperfusion-induced expression of E-selectin. Am J Physiol 276:G479\u2013484. \nhttps:\/\/doi.org\/10.1152\/ajpgi.1999.276.2.G479","journal-title":"Am J Physiol"},{"key":"4555_CR21","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1046\/j.1365-2168.1998.00911.x","volume":"88","author":"R Hardaway","year":"1998","unstructured":"Hardaway R (1998) Traumatic and septic shock alias post-trauma critical illness. Br J Surg 88:1473\u20131479. \nhttps:\/\/doi.org\/10.1046\/j.1365-2168.1998.00911.x","journal-title":"Br J Surg"},{"key":"4555_CR22","doi-asserted-by":"publisher","first-page":"E103","DOI":"10.1111\/j.1749-6632.2010.05713.x","volume":"1207","author":"E Deitch","year":"2010","unstructured":"Deitch E (2010) Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction. Ann N Y Acad Sci 1207:E103\u2013111. \nhttps:\/\/doi.org\/10.1111\/j.1749-6632.2010.05713.x","journal-title":"Ann N Y Acad Sci"},{"key":"4555_CR23","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1053\/j.gastro.2003.10.077","volume":"126","author":"Y Tang","year":"2004","unstructured":"Tang Y, Swartz-Basile D, Swietlicki E, Yi L, Rubin D, Levin M (2004) Bax is required for resection-induced changes in apoptosis, proliferation, and members of the extrinsic cell death pathways. Gastroenterology 126:220\u2013230. \nhttps:\/\/doi.org\/10.1053\/j.gastro.2003.10.077","journal-title":"Gastroenterology"},{"key":"4555_CR24","doi-asserted-by":"publisher","first-page":"e1002785","DOI":"10.1371\/journal.ppat.1002785","volume":"8","author":"J Kubinak","year":"2012","unstructured":"Kubinak J, Round J (2012) Toll-like receptors promote mutually beneficial commensal-host interactions. PLoS Pathog 8:e1002785. \nhttps:\/\/doi.org\/10.1371\/journal.ppat.1002785","journal-title":"PLoS Pathog"},{"key":"4555_CR25","doi-asserted-by":"publisher","first-page":"G490","DOI":"10.1152\/ajpgi.00120.2012","volume":"303","author":"E Im","year":"2012","unstructured":"Im E, Riegler F, Pothoulakis C, Rhee S (2012) Elevated lipopolysaccharide in the colon evokes intestinal inflammation, aggravated in immune modulator-impaired mice. Am J Physiol Gastrointest Liver Physiol 303:G490\u2013497. \nhttps:\/\/doi.org\/10.1152\/ajpgi.00120.2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4555_CR26","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1158\/0008-5472.CAN-05-2606","volume":"66","author":"J Shao","year":"2006","unstructured":"Shao J, Sheng G, Mifflin R, Powell D, Sheng H (2006) Roles of myofibroblasts in prostaglandin E2-stimulated intestinal epithelial proliferation and angiogenesis. Cancer Res 66:846\u2013855. \nhttps:\/\/doi.org\/10.1158\/0008-5472.CAN-05-2606","journal-title":"Cancer Res"},{"key":"4555_CR27","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1124\/jpet.111.189845","volume":"340","author":"K Iwanaga","year":"2012","unstructured":"Iwanaga K, Okada M, Murata T, Hori M, Ozaki H (2012) Prostaglandin E2 promotes wound-induced migration of intestinal subepithelial myofibroblasts via EP2, EP3, and EP4 prostanoid receptor activation. J Pharmacol Exp Ther 340:604\u2013611. \nhttps:\/\/doi.org\/10.1124\/jpet.111.189845","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-019-04555-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00383-019-04555-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-019-04555-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T23:13:58Z","timestamp":1600470838000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00383-019-04555-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["4555"],"URL":"https:\/\/doi.org\/10.1007\/s00383-019-04555-5","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"type":"print","value":"0179-0358"},{"type":"electronic","value":"1437-9813"}],"subject":[],"published":{"date-parts":[[2019,9,20]]},"assertion":[{"value":"13 September 2019","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}