{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:04:44Z","timestamp":1783631084993,"version":"3.55.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00383-019-04576-0","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T13:59:24Z","timestamp":1569419964000},"page":"33-41","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tracheal cartilage growth promotion by intra-tracheal administration of basic FGF"],"prefix":"10.1007","volume":"36","author":[{"given":"Makoto","family":"Komura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Komura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Ishimaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Komuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Hoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Takato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"4576_CR1","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1634\/stemcells.2005-0415","volume":"24","author":"A Derfoul","year":"2006","unstructured":"Derfoul A, Perkins GL, Hall DJ, Tuan RS (2006) Glucocorticoids promote chondrogenic differentiation of adult human mesenchymal stem cells by enhancing expression of cartilage extracellular matrix genes. Stem Cells 24:1487\u20131495","journal-title":"Stem Cells"},{"key":"4576_CR2","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.2106\/00004623-199812000-00004","volume":"80","author":"JU Yoo","year":"1998","unstructured":"Yoo JU, Barthel TS, Nishimura K, Solchaga L, Caplan AI, Goldberg VM, Johnstone B (1998) The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells. J Bone Joint Surg Am 80:1745\u20131757","journal-title":"J Bone Joint Surg Am"},{"key":"4576_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0070-2153(06)76001-X","volume":"76","author":"R Pogue","year":"2006","unstructured":"Pogue R, Lyons K (2006) BMP signaling in the cartilage growth plate. Curr Top Dev Biol 76:1\u201348","journal-title":"Curr Top Dev Biol"},{"key":"4576_CR4","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/jcp.20238","volume":"203","author":"LA Solchaga","year":"2005","unstructured":"Solchaga LA, Penick K, Porter JD, Goldberg VM, Caplan AI, Welter JF (2005) FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. J Cell Physiol 203:398\u2013409","journal-title":"J Cell Physiol"},{"key":"4576_CR5","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1007\/s10439-009-9892-x","volume":"38","author":"C An","year":"2010","unstructured":"An C, Cheng Y, Yuan Q, Li J (2010) IGF-1 and BMP-2 induces differentiation of adipose-derived mesenchymal stem cells into chondrocytes-like cells. Ann Biomed Eng 38:1647\u20131654. \nhttps:\/\/doi.org\/10.1007\/s10439-009-9892-x","journal-title":"Ann Biomed Eng"},{"key":"4576_CR6","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3109\/17453679708996266","volume":"68","author":"S Wakitani","year":"1997","unstructured":"Wakitani S, Imoto K, Kimura T, Ochi T, Matsumoto K, Nakamura T (1997) Hepatocyte growth factor facilitates cartilage repair. Full thickness articular cartilage defect studied in rabbit knees. Acta Orthop Scand 68:474\u2013480","journal-title":"Acta Orthop Scand"},{"issue":"A Suppl 3","key":"4576_CR7","doi-asserted-by":"publisher","first-page":"116","DOI":"10.2106\/00004623-200300003-00018","volume":"85","author":"SD Cook","year":"2003","unstructured":"Cook SD, Patron LP, Salkeld SL, Rueger DC (2003) Repair of articular cartilage defects with osteogenic protein-1 (BMP-7) in dogs. J Bone Joint Surg Am 85(A Suppl 3):116\u2013123","journal-title":"J Bone Joint Surg Am"},{"key":"4576_CR8","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.2106\/00004623-199710000-00002","volume":"79","author":"RS Sellers","year":"1997","unstructured":"Sellers RS, Peluso D, Morris EA (1997) The effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the healing of full-thickness defects of articular cartilage. J Bone Joint Surg Am 79:1452\u20131463","journal-title":"J Bone Joint Surg Am"},{"key":"4576_CR9","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1046\/j.1440-169X.1997.t01-1-00003.x","volume":"39","author":"Y Otsuka","year":"1997","unstructured":"Otsuka Y, Mizuta H, Takagi K, Iyama K, Yoshitake Y, Nishikawa K, Suzuki F, Hiraki Y (1997) Requirement of fibroblast growth factor signaling for regeneration of epiphyseal morphology in rabbit full-thickness defects of articular cartilage. Dev Growth Differ 39:143\u2013156","journal-title":"Dev Growth Differ"},{"key":"4576_CR10","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1097\/01.mat.0000196513.97411.3d","volume":"52","author":"H Igai","year":"2006","unstructured":"Igai H, Chang SS, Gotoh M, Yamamoto Y, Misaki N, Okamoto T, Yamamoto M, Tabata Y, Yokomise H (2006) Regeneration of canine tracheal cartilage by slow release of basic fibroblast growth factor from gelatin sponge. ASAIO J 52:86\u201391","journal-title":"ASAIO J"},{"key":"4576_CR11","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1016\/j.jpedsurg.2008.08.038","volume":"43","author":"M Komura","year":"2008","unstructured":"Komura M, Komura H, Kanamori Y, Tanaka Y, Suzuki K, Sugiyama M, Nakahara S, Kawashima H, Hatanaka A, Hoshi K, Ikada Y, Tabata Y, Iwanaka T (2008) An animal model study for tissueengineered trachea fabricated from a biodegradable scaffold using chondrocytes to augment repair of tracheal stenosis. J Pediatr Surg 43:2141\u20132146. \nhttps:\/\/doi.org\/10.1016\/j.jpedsurg.2008.08.038","journal-title":"J Pediatr Surg"},{"key":"4576_CR12","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1586\/ers.09.29","volume":"3","author":"IB Masters","year":"2009","unstructured":"Masters IB, Chang AB (2009) Tracheobronchomalacia in children. Expert Rev Respir Med 3:425\u2013439","journal-title":"Expert Rev Respir Med"},{"key":"4576_CR13","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s00383-008-2218-5","volume":"24","author":"M Komura","year":"2008","unstructured":"Komura M, Komura H, Tanaka Y, Kanamori Y, Sugiyama M, Nakahara S, Kawashima H, Suzuki K, Hoshi K, Iwanaka T (2008) Human tracheal chondrocytes as a cell source for augmenting stenotic tracheal segments: the first feasibility study in an in vivo culture system. Pediatr Surg Int 24:1117\u20131121. \nhttps:\/\/doi.org\/10.1007\/s00383-008-2218-5","journal-title":"Pediatr Surg Int"},{"key":"4576_CR14","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1177\/039139881003301102","volume":"33","author":"M Komura","year":"2010","unstructured":"Komura M, Komura H, Kanamori Y, Tanaka Y, Ohatani Y, Ishimaru T, Sugiyama M, Hoshi K, Iwanaka T (2010) Study of mechanical properties of engineered cartilage in an in vivo culture for design of a biodegradable scaffold. Int J Artif Organs 33:775\u2013781","journal-title":"Int J Artif Organs"},{"key":"4576_CR15","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1002\/lary.23269","volume":"123","author":"M Komura","year":"2013","unstructured":"Komura M, Komura H, Otani Y, Kanamori Y, Iwanaka T, Hoshi K, Tsuyoshi T, Tabata Y (2013) The junction between hyaline cartilage and engineered cartilage in rabbits. Laryngoscope 123:1547\u20131551. \nhttps:\/\/doi.org\/10.1002\/lary.23269","journal-title":"Laryngoscope"},{"key":"4576_CR16","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.jpedsurg.2012.11.003","volume":"48","author":"T Ishimaru","year":"2013","unstructured":"Ishimaru T, Komura M, Komura H, Otani Y, Komuro H, Sugiyma M, Terawaki K, Suzuki K, Tabata Y, Iwanaka T (2013) Slow release of basic fibroblast growth factor (b-FGF) promotes growth of tracheal cartilage. J Pediatr Surg 48:288\u2013292. \nhttps:\/\/doi.org\/10.1016\/j.jpedsurg.2012.11.003","journal-title":"J Pediatr Surg"},{"key":"4576_CR17","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jpedsurg.2013.11.040","volume":"49","author":"M Komura","year":"2014","unstructured":"Komura M, Komura H, Konishi K, Ishimaru T, Hoshi K, Takato T, Tabata Y, Iwanaka T (2014) Promotion of tracheal cartilage growth by intra-tracheal injection of basic fibroblast growth factor (b-FGF). J Pediatr Surg 49:296\u2013300. \nhttps:\/\/doi.org\/10.1016\/j.jpedsurg.2013.11.040","journal-title":"J Pediatr Surg"},{"key":"4576_CR18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.prrv.2004.01.010","volume":"5","author":"VM McNamara","year":"2004","unstructured":"McNamara VM, Crabbe DC (2004) Tracheomalacia. Paediatr Respir Rev 5:147\u2013154","journal-title":"Paediatr Respir Rev"},{"key":"4576_CR19","first-page":"159","volume":"23","author":"RC Benson","year":"1978","unstructured":"Benson RC (1978) KuesHA. Fluorescence properties of indocyanine green as related to angiography Phys Med boil 23:159\u2013163","journal-title":"Fluorescence properties of indocyanine green as related to angiography Phys Med boil"},{"key":"4576_CR20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1471-2342-14-18","volume":"14","author":"Y Rino","year":"2014","unstructured":"Rino Y, Yukawa N, Sato T, Yamamoto N, Tamagawa H, Hasegawa S, Oshima T, Yoshikawa T, Masuda M, Imada T (2014) Visualization of blood supply route to the reconstructed stomach by indocyanine green fluorescence imaging during esophagectomy. BMC Med Imaging 14:18. \nhttps:\/\/doi.org\/10.1186\/1471-2342-14-18","journal-title":"BMC Med Imaging"},{"key":"4576_CR21","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.jpedsurg.2014.11.012","volume":"50","author":"T Ishimaru","year":"2015","unstructured":"Ishimaru T, Komura M, Sugiyma M, Komura H, Arai M, Fujishiro J, Uotani C, Miyakawa K, Kakihara T, Hoshi K, Takato T, Tabata Y, Komuro H, Iwanaka T (2015) Slow release of basic fibroblast growth factor (b-FGF) enhances mechanical properties of rat trachea. J Pediatr Surg 50:255\u2013259. \nhttps:\/\/doi.org\/10.1016\/j.jpedsurg.2014.11.012","journal-title":"J Pediatr Surg"},{"key":"4576_CR22","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/MAT.0b013e318197f7e3","volume":"55","author":"H Igai","year":"2009","unstructured":"Igai H, Chang SS, Gotoh M, Yamamoto Y, Yamamoto M, Tabata Y, Yokomise H (2009) Widespread and early tracheal cartilage regeneration by synchronous slow release of b-FGF and BMP-2. ASAIO J 55:266\u2013270. \nhttps:\/\/doi.org\/10.1097\/MAT.0b013e318197f7e3","journal-title":"ASAIO J"},{"key":"4576_CR23","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.gene.2008.04.019","volume":"420","author":"MB Ellman","year":"2008","unstructured":"Ellman MB, An HS, Muddasani P, Im HJ (2008) Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis. Gene 420:82\u201389. \nhttps:\/\/doi.org\/10.1016\/j.gene.2008.04.019","journal-title":"Gene"},{"key":"4576_CR24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/S0008-6363(97)00142-9","volume":"36","author":"DF Lazarous","year":"1997","unstructured":"Lazarous DF, Shou M, Stiber JA, Dadhania DM, Thirumurti V, Hodge E, Unger EF (1997) Pharmacodynamics of basic fibroblast growth factor: route of administration determines myocardial and systemic distribution. Cardiovasc Res 36:78\u201385","journal-title":"Cardiovasc Res"},{"key":"4576_CR25","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1073\/pnas.90.4.1513","volume":"90","author":"ER Edelman","year":"1993","unstructured":"Edelman ER, Nugent MA, Karnovsky MJ (1993) Perivascular and intravenous administration of basic fibroblast growth factor: vascular and solid organ deposition. Proc Natl Acad Sci USA 90:1513\u20131517","journal-title":"Proc Natl Acad Sci USA"},{"key":"4576_CR26","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/jbm.a.30343","volume":"74","author":"N Isogai","year":"2005","unstructured":"Isogai N, Morotomi T, Hayakawa S, Munakata H, Tabata Y, Ikada Y, Kamiishi H (2005) Combined chondrocyte-copolymer implantation with slow release of basic fibroblast growth factor for tissue engineering an auricular cartilage construct. J Biomed Mater Res A 74:408\u2013418","journal-title":"J Biomed Mater Res A"},{"key":"4576_CR27","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jtcvs.2007.02.022","volume":"134","author":"H Igai","year":"2007","unstructured":"Igai H, Yamamoto Y, Chang SS, Yamamoto M, Tabata Y, Yokomise H (2007) Tracheal cartilage regeneration by slow release of basic fibroblast growth factor from a gelatin sponge. J Thorac Cardiovasc Surg 134:170\u2013175","journal-title":"J Thorac Cardiovasc Surg"},{"key":"4576_CR28","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/S0022-5347(01)68090-X","volume":"162","author":"JJ Yoo","year":"1999","unstructured":"Yoo JJ, Park HJ, Lee I, Atala A (1999) Autologous engineered cartilage rods for penile reconstruction. J Urol 162:1119\u20131121","journal-title":"J Urol"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-019-04576-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00383-019-04576-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-019-04576-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T01:41:39Z","timestamp":1600911699000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00383-019-04576-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,25]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["4576"],"URL":"https:\/\/doi.org\/10.1007\/s00383-019-04576-0","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,25]]},"assertion":[{"value":"12 September 2019","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Makoto Komura received a contributed human recombinant fibroblast growth factor-2 (b-FGF) for cell culture from Kaken Pharmaceutical Co. Ltd.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}