{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:24:13Z","timestamp":1788485053567,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada","award":["UPPM\/220\/M\/05\/04\/05.17"],"award-info":[{"award-number":["UPPM\/220\/M\/05\/04\/05.17"]}]},{"name":"Faculty of Medicine, Public Health and Nursing, Universitas Gadjah MAda","award":["UPPM\/363\/M\/05\/04\/05.18"],"award-info":[{"award-number":["UPPM\/363\/M\/05\/04\/05.18"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00383-019-04582-2","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T14:03:26Z","timestamp":1569247406000},"page":"75-79","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The effect of APTR, Fn14 and CD133 expressions on liver fibrosis in biliary atresia patients"],"prefix":"10.1007","volume":"36","author":[{"given":"Akhmad","family":"Makhmudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinaldo","family":"Supanji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayu Pratama","family":"Putra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-6526","authenticated-orcid":false,"family":"Gunadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"key":"4582_CR1","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1002\/hep.21790","volume":"46","author":"RJ Sokol","year":"2007","unstructured":"Sokol RJ, Shepherd RW, Superina R, Bezerra JA, Robuck P, Hoofnagle JH (2007) Screening and outcomes in biliary atresia: summary of a National Institutes of Health workshop. Hepatology 46:566\u2013581","journal-title":"Hepatology"},{"key":"4582_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2016.06.005","volume":"73","author":"B Lakshminarayanan","year":"2016","unstructured":"Lakshminarayanan B, Davenport M (2016) Biliary atresia: a comprehensive review. J Autoimmun 73:1\u20139","journal-title":"J Autoimmun"},{"key":"4582_CR3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/lt.24640","volume":"23","author":"SS Sundaram","year":"2017","unstructured":"Sundaram SS, Mack CL, Feldman AG, Sokol RJ (2017) Biliary atresia: indications and timing of liver transplantation and optimization of pretransplant care. Liver Transpl 23:96\u2013109","journal-title":"Liver Transpl"},{"key":"4582_CR4","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1016\/j.jpedsurg.2007.08.035","volume":"42","author":"H Wada","year":"2007","unstructured":"Wada H, Muraji T, Yokoi A et al (2007) Insignificant seasonal and geographical variation in incidence of biliary atresia in Japan: a regional survey of over 20 years. J Pediatr Surg 42:2090\u20132092","journal-title":"J Pediatr Surg"},{"key":"4582_CR5","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jpeds.2012.12.085","volume":"163","author":"CY Chiu","year":"2013","unstructured":"Chiu CY, Chen PH, Chan CF, Chang MH, Wu TC, Taiwan Infant Stool Color Card Study Group et al (2013) Biliary atresia in preterm infants in Taiwan: a nationwide survey. J. Pediatr 163:100\u2013103","journal-title":"J. Pediatr"},{"key":"4582_CR6","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1186\/s13104-018-3498-z","volume":"11","author":"Gunadi","year":"2018","unstructured":"Gunadi, Gunawan TA, Widiyanto G, Yuanita A, Mulyani NS, Makhmudi A (2018) Liver transplant score for prediction of biliary atresia patients' survival following Kasai procedure. BMC Res Notes 11:381","journal-title":"BMC Res Notes"},{"key":"4582_CR7","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/j.jhep.2013.01.040","volume":"58","author":"C Chardot","year":"2013","unstructured":"Chardot C, Buet C, Serinet MO, Golmard JL, Lachaux A, Roquelaure B et al (2013) Improving outcomes of biliary atresia: French national series 1986\u20132009. J Hepatol 58:1209\u20131217","journal-title":"J Hepatol"},{"key":"4582_CR8","doi-asserted-by":"publisher","first-page":"F451","DOI":"10.1136\/adc.2009.159780","volume":"94","author":"E Livesey","year":"2009","unstructured":"Livesey E, Cortina Borja M, Sharif K et al (2009) Epidemiology of biliary atresia in England and Wales (1999\u20132006). Arch Dis Child Fetal Neonatal Ed 94:F451\u2013F455","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"4582_CR9","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jpeds.2007.05.051","volume":"151","author":"RA Schreiber","year":"2007","unstructured":"Schreiber RA, Barker CC, Roberts EA et al (2007) Biliary atresia: the Canadian experience. J Pediatr 151:659\u2013665","journal-title":"J Pediatr"},{"key":"4582_CR10","doi-asserted-by":"publisher","first-page":"21084","DOI":"10.1038\/srep21084","volume":"6","author":"R Dong","year":"2016","unstructured":"Dong R, Shen Z, Zheng C, Chen G, Zheng S (2016) Serum microRNA microarray analysis identifies miR-4429 and miR-4689 are potential diagnostic biomarkers for biliary atresia. Sci Rep 6:21084","journal-title":"Sci Rep"},{"key":"4582_CR11","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s00383-017-4068-5","volume":"33","author":"L Zheng","year":"2017","unstructured":"Zheng L, Lv Z, Gong Z, Sheng Q, Gao Z, Zhang Y, Yu S, Zhou J, Xi Z, Wang X (2017) Fn14 hepatic progenitor cells are associated with liver fibrosis in biliary atresia. Pediatr Surg Int 33:593\u2013599","journal-title":"Pediatr Surg Int"},{"key":"4582_CR12","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13104-019-4227-y","volume":"12","author":"A Makhmudi","year":"2019","unstructured":"Makhmudi A, Kalim AS, Gunadi (2019) microRNA-21 expressions impact on liver fibrosis in biliary atresia patients. BMC Res Notes 12:189","journal-title":"BMC Res Notes"},{"key":"4582_CR13","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.bbrc.2015.05.124","volume":"463","author":"F Yu","year":"2015","unstructured":"Yu F, Zheng J, Mao Y, Dong P, Li G, Lu Z, Guo C, Liu Z (2015) Fan X (2015) Long non-coding RNA APTR promotes the activation of hepatic stellate cells and the progression of liver fibrosis. Biochem Biophys Res Commun 463:679\u2013685","journal-title":"Biochem Biophys Res Commun"},{"key":"4582_CR14","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s00439-001-0651-9","volume":"110","author":"A Tajima","year":"2002","unstructured":"Tajima A, Pan IH, Fucharoen G, Fucharoen S, Matsuo M, Tokunaga K et al (2002) Three major lineages of Asian Y chromosomes: implications for the peopling of east and southeast Asia. Hum Genet 110:80\u201388","journal-title":"Hum Genet"},{"key":"4582_CR15","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s00383-016-3953-7","volume":"32","author":"Gunadi","year":"2016","unstructured":"Gunadi, Makhmudi A, Agustriani N, Rochadi  (2016) Effects of SEMA3 polymorphisms in Hirschsprung disease patients. Pediatr Surg Int 32:1025\u20131028","journal-title":"Pediatr Surg Int"},{"key":"4582_CR16","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.jhep.2012.04.029","volume":"57","author":"SU Kim","year":"2012","unstructured":"Kim SU, Oh HJ, Wanless IR, Lee S, Han KH, Park YN (2012) The Laennec staging system for histological sub-classification of cirrhosis is useful for stratification of prognosis in patients with liver cirrhosis. J Hepatol 57:556\u2013563","journal-title":"J Hepatol"},{"key":"4582_CR17","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"4582_CR18","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.bbrc.2004.09.196","volume":"324","author":"GC Huang","year":"2004","unstructured":"Huang GC, Zhang JS, Tang QQ (2004) Involvement of C\/EBP-alpha gene in in vitro activation of rat hepatic stellate cells. Biochem Biophys Res Commun 324:1309\u20131318","journal-title":"Biochem Biophys Res Commun"},{"key":"4582_CR19","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1002\/hep.25895","volume":"56","author":"SX Yuan","year":"2012","unstructured":"Yuan SX, Yang F, Yang Y, Tao QF, Zhang J, Huang G et al (2012) Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy. Hepatology 56:2231\u20132241","journal-title":"Hepatology"},{"key":"4582_CR20","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1373\/clinchem.2014.230359","volume":"61","author":"JM Lorenzen","year":"2015","unstructured":"Lorenzen JM, Schauerte C, Kielstein JT, H\u00fcbner A, Martino F, Fiedler J et al (2015) Circulating long noncoding RNATapSaki is a predictor of mortality in critically ill patients with acute kidney injury. Clin Chem 61:191\u2013201","journal-title":"Clin Chem"},{"key":"4582_CR21","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.gene.2017.12.040","volume":"645","author":"S Yu","year":"2018","unstructured":"Yu S, Qi Y, Jiang J, Wang H, Zhou Q (2018) APTR is a prognostic marker in cirrhotic patients with portal hypertension during TIPS procedure. Gene 645:30\u201333","journal-title":"Gene"},{"key":"4582_CR22","first-page":"FC08-12","volume":"8","author":"R Mannan","year":"2014","unstructured":"Mannan R, Misra V, Misra SP, Singh PA, Dwivedi M (2014) A comparative evaluation of scoring systems for assessing necro-inflammatory activity and fibrosis in liver biopsies of patients with chronic viral hepatitis. J Clin Diagn Res 8:FC08-12","journal-title":"J Clin Diagn Res"},{"key":"4582_CR23","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.arr.2019.04.001","volume":"52","author":"Z Yang","year":"2019","unstructured":"Yang Z, Jiang S, Shang J, Jiang Y, Dai Y, Xu B et al (2019) LncRNA: shedding light on mechanisms and opportunities in fibrosis and aging. Ageing Res Rev 52:17\u201331","journal-title":"Ageing Res Rev"},{"key":"4582_CR24","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3727\/105221615X14399878166078","volume":"16","author":"KY Teng","year":"2015","unstructured":"Teng KY, Ghoshal K (2015) Role of noncoding RNAs as biomarker and therapeutic targets for liver fibrosis. Gene Expr 16:155\u2013162","journal-title":"Gene Expr"},{"key":"4582_CR25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13023-018-0973-5","volume":"14","author":"Gunadi","year":"2019","unstructured":"Gunadi, Budi NYP, Kalim AS, Santiko W, Musthofa FD, Iskandar K, Makhmudi A (2019) Aberrant expressions of miRNA-206 target, FN1, in multifactorial Hirschsprung disease. Orphanet J Rare Dis 14:5","journal-title":"Orphanet J Rare Dis"},{"key":"4582_CR26","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.ajpath.2013.03.018","volume":"183","author":"K Kuramitsu","year":"2013","unstructured":"Kuramitsu K, Sverdlov DY, Liu SB, Csizmadia E, Burkly L, Schuppan D, Hanto DW, Otterbein LE, Popov Y (2013) Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation. Am J Pathol 183:182\u2013194","journal-title":"Am J Pathol"},{"key":"4582_CR27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40169-018-0198-1","volume":"7","author":"PM Glumac","year":"2018","unstructured":"Glumac PM, LeBeau AM (2018) The role of CD133 in cancer: a concise review. Clin Transl Med 7:18","journal-title":"Clin Transl Med"},{"key":"4582_CR28","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12967-018-1423-9","volume":"16","author":"X Cai","year":"2018","unstructured":"Cai X, Li J, Yuan X, Xiao J, Dooley S, Wan X, Weng H, Lu L (2018) CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma. J Transl Med 16:50","journal-title":"J Transl Med"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-019-04582-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00383-019-04582-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-019-04582-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T23:11:42Z","timestamp":1600729902000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00383-019-04582-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,23]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["4582"],"URL":"https:\/\/doi.org\/10.1007\/s00383-019-04582-2","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,23]]},"assertion":[{"value":"17 September 2019","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declared no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study has an approval from the Ethical Committee of the FK-KMK UGM\/Dr. Sardjito Hospital (KE\/FK\/1252\/EC\/2018 and KE\/FK\/1088\/EC\/2017).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from the parents\u2019 BA patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}