{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:27:07Z","timestamp":1783636027566,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s00383-020-04655-7","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T12:03:02Z","timestamp":1587384182000},"page":"735-742","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["A novel and simple machine learning algorithm for preoperative diagnosis of acute appendicitis in children"],"prefix":"10.1007","volume":"36","author":[{"given":"Emrah","family":"Aydin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130nan Utku","family":"T\u00fcrkmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6zde","family":"Namli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7i\u011fdem","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe B.","family":"Esen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Nur","family":"Eray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egemen","family":"Ero\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Akova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"4655_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-7922-9-6","author":"AH Omari","year":"2014","unstructured":"Omari AH, Khammash MR, Qasaimeh GR et al (2014) Acute appendicitis in the elderly: risk factors for perforation. World J Emerg Surg. https:\/\/doi.org\/10.1186\/1749-7922-9-6","journal-title":"World J Emerg Surg"},{"key":"4655_CR2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e8012","author":"HF Ashdown","year":"2012","unstructured":"Ashdown HF, D\u2019Souza N, Karim D et al (2012) Pain over speed bumps in diagnosis of acute appendicitis: diagnostic accuracy study. BMJ. https:\/\/doi.org\/10.1136\/bmj.e8012","journal-title":"BMJ"},{"key":"4655_CR3","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s00268-014-2821-7","volume":"39","author":"RE Andersson","year":"2015","unstructured":"Andersson RE (2015) The magic of an appendicitis score. World J Surg 39:110\u2013111","journal-title":"World J Surg"},{"key":"4655_CR4","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1002\/bjs.9835","volume":"102","author":"JJ Atema","year":"2015","unstructured":"Atema JJ, Van Rossem CC, Leeuwenburgh MM et al (2015) Scoring system to distinguish uncomplicated from complicated acute appendicitis. Br J Surg 102:979\u2013990. https:\/\/doi.org\/10.1002\/bjs.9835","journal-title":"Br J Surg"},{"key":"4655_CR5","doi-asserted-by":"publisher","DOI":"10.1089\/1096296041839480","author":"GM Davies","year":"2004","unstructured":"Davies GM, Dasbach EJ, Teutsch S (2004) The Burden of Appendicitis-Related Hospitalizations in the United States in 1997. Surg Infect (Larchmt). https:\/\/doi.org\/10.1089\/1096296041839480","journal-title":"Surg Infect (Larchmt)"},{"key":"4655_CR6","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.surg.2009.11.013","volume":"147","author":"C Simillis","year":"2010","unstructured":"Simillis C, Symeonides P, Shorthouse AJ, Tekkis PP (2010) A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon). Surgery 147:818\u2013829. https:\/\/doi.org\/10.1016\/j.surg.2009.11.013","journal-title":"Surgery"},{"key":"4655_CR7","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/bjs.9008","volume":"100","author":"CW Yu","year":"2013","unstructured":"Yu CW, Juan LI, Wu MH et al (2013) Systematic review and meta-analysis of the diagnostic accuracy of procalcitonin, C-reactive protein and white blood cell count for suspected acute appendicitis. Br J Surg 100:322\u2013329. https:\/\/doi.org\/10.1002\/bjs.9008","journal-title":"Br J Surg"},{"key":"4655_CR8","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1007\/s00464-016-5109-1","volume":"31","author":"A Acharya","year":"2017","unstructured":"Acharya A, Markar SR, Ni M, Hanna GB (2017) Biomarkers of acute appendicitis: systematic review and cost\u2013benefit trade-off analysis. Surg Endosc 31:1022\u20131031. https:\/\/doi.org\/10.1007\/s00464-016-5109-1","journal-title":"Surg Endosc"},{"key":"4655_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.5505\/1304.7361.2015.32657","volume":"15","author":"E Kucuk","year":"2015","unstructured":"Kucuk E, Kucuk I (2015) Mean platelet volume is reduced in acute appendicitis. Turk J Emerg Med 15:23\u201327. https:\/\/doi.org\/10.5505\/1304.7361.2015.32657","journal-title":"Turk J Emerg Med"},{"key":"4655_CR10","doi-asserted-by":"publisher","DOI":"10.14800\/ics.930","author":"R Aktimur","year":"2015","unstructured":"Aktimur R, Cetinkunar S (2015) Mean platelet volume is a significant biomarker in the differential diagnosis of acute appendicitis. Inflamm Cell. https:\/\/doi.org\/10.14800\/ics.930","journal-title":"Inflamm Cell"},{"key":"4655_CR11","first-page":"637","volume":"65","author":"S Bozkurt","year":"2015","unstructured":"Bozkurt S, K\u00f6se A, Erdogan S et al (2015) MPV and other inflammatory markers in diagnosing acute appendicitis. J Pak Med Assoc 65:637\u2013641","journal-title":"J Pak Med Assoc"},{"key":"4655_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/542013","author":"Z Fan","year":"2015","unstructured":"Fan Z, Pan J, Zhang Y et al (2015) Mean platelet volume and platelet distribution width as markers in the diagnosis of acute gangrenous appendicitis. Dis Markers. https:\/\/doi.org\/10.1155\/2015\/542013","journal-title":"Dis Markers"},{"key":"4655_CR13","doi-asserted-by":"publisher","first-page":"163","DOI":"10.5505\/tjtes.2015.89346","volume":"22","author":"S Yard\u0131mc\u0131","year":"2015","unstructured":"Yard\u0131mc\u0131 S (2015) Neutrophil-lymphocyte ratio and mean platelet volume can be a predictor for the severity of acute appendicitis. Turk J Trauma Emerg Surg 22:163\u2013168. https:\/\/doi.org\/10.5505\/tjtes.2015.89346","journal-title":"Turk J Trauma Emerg Surg"},{"key":"4655_CR14","doi-asserted-by":"publisher","first-page":"236","DOI":"10.5958\/2394-6792.2015.00023.X","volume":"2","author":"SVMAK Vijay Shankar","year":"2015","unstructured":"Vijay Shankar SVMAK (2015) Mean platelet volume as a diagnostic marker of acute appendicitis in children and adolescents how useful it is? Indian J Pathol Oncol 2:236\u2013239. https:\/\/doi.org\/10.5958\/2394-6792.2015.00023.X","journal-title":"Indian J Pathol Oncol"},{"key":"4655_CR15","doi-asserted-by":"publisher","DOI":"10.1101\/535377","author":"M Svanera","year":"2019","unstructured":"Svanera M, Savardi M, Benini S et al (2019) Transfer learning of deep neural network representations for fMRI decoding. bioXriv. https:\/\/doi.org\/10.1101\/535377","journal-title":"bioXriv"},{"key":"4655_CR16","doi-asserted-by":"publisher","DOI":"10.3109\/14639239209012134","author":"MS Leaning","year":"1992","unstructured":"Leaning MS, Ng KEH, Cramp DG (1992) Decision support for patient management in oncology. Inform Heal Soc Care. https:\/\/doi.org\/10.3109\/14639239209012134","journal-title":"Inform Heal Soc Care"},{"key":"4655_CR17","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.csbj.2014.11.005","volume":"13","author":"K Kourou","year":"2015","unstructured":"Kourou K, Exarchos TP, Exarchos KP et al (2015) Machine learning applications in cancer prognosis and prediction. Comput Struct Biotechnol J 13:8\u201317. https:\/\/doi.org\/10.1016\/j.csbj.2014.11.005","journal-title":"Comput Struct Biotechnol J"},{"key":"4655_CR18","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2013-001854","author":"S Mani","year":"2014","unstructured":"Mani S, Ozdas A, Aliferis C et al (2014) Medical decision support using machine learning for early detection of late-onset neonatal sepsis. J Am Med Inform Assoc. https:\/\/doi.org\/10.1136\/amiajnl-2013-001854","journal-title":"J Am Med Inform Assoc"},{"key":"4655_CR19","first-page":"261","volume":"68","author":"G Guzman-Valdivia Gomez","year":"2003","unstructured":"Guzman-Valdivia Gomez G (2003) An useful classification for acute appendicitis. Rev Gastroenterol M\u00e9xico 68:261\u2013265","journal-title":"Rev Gastroenterol M\u00e9xico"},{"key":"4655_CR20","doi-asserted-by":"publisher","first-page":"823095","DOI":"10.1155\/2012\/823095","volume":"2012","author":"B Uyanik","year":"2012","unstructured":"Uyanik B, Kavalci C, Arslan ED et al (2012) Role of mean platelet volume in diagnosis of childhood acute appendicitis. Emerg Med Int 2012:823095. https:\/\/doi.org\/10.1155\/2012\/823095","journal-title":"Emerg Med Int"},{"issue":"3","key":"4655_CR21","first-page":"427","volume":"11","author":"S Bilici","year":"2010","unstructured":"Bilici S, Sekmenli T, G\u00f6ksu M et al (2010) Mean platelet volume in diagnosis of acute appendicitis in children. Afr Health Sci 11(3):427\u2013432","journal-title":"Afr Health Sci"},{"key":"4655_CR22","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1007\/s10620-017-4722-8","volume":"62","author":"MC Hornbrook","year":"2017","unstructured":"Hornbrook MC, Goshen R, Choman E et al (2017) Early colorectal cancer detected by machine learning model using gender, age, and complete blood count data. Dig Dis Sci 62:2719\u20132727. https:\/\/doi.org\/10.1007\/s10620-017-4722-8","journal-title":"Dig Dis Sci"},{"key":"4655_CR23","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1093\/jamia\/ocv195","volume":"23","author":"V Shalev","year":"2016","unstructured":"Shalev V, Kinar Y, Kalkstein N et al (2016) Development and validation of a predictive model for detection of colorectal cancer in primary care by analysis of complete blood counts: a binational retrospective study. J Am Med Inform Assoc 23:879\u2013890. https:\/\/doi.org\/10.1093\/jamia\/ocv195","journal-title":"J Am Med Inform Assoc"},{"key":"4655_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0171759","volume":"12","author":"Y Kinar","year":"2017","unstructured":"Kinar Y, Akiva P, Choman E et al (2017) Performance analysis of a machine learning flagging system used to identify a group of individuals at a high risk for colorectal cancer. PLoS ONE 12:1\u20138. https:\/\/doi.org\/10.1371\/journal.pone.0171759","journal-title":"PLoS ONE"},{"key":"4655_CR25","doi-asserted-by":"publisher","DOI":"10.4178\/epih\/e2014025","author":"J-M Bae","year":"2014","unstructured":"Bae J-M (2014) Clinical decision analysis using decision tree. Epidemiol Health. https:\/\/doi.org\/10.4178\/epih\/e2014025","journal-title":"Epidemiol Health"},{"issue":"5","key":"4655_CR26","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1111\/j.1572-0241.2004.04129.x","volume":"99","author":"S Danese","year":"2004","unstructured":"Danese S, De La Motte C, Fiocchi C (2004) Platelets in inflammatory bowel disease: clinical, pathogenic, and therapeutic implications. Am J Gastroenterol 99(5):938\u2013945. https:\/\/doi.org\/10.1111\/j.1572-0241.2004.04129.x","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"4655_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2174\/138161211795049804","volume":"17","author":"AY Gasparyan","year":"2011","unstructured":"Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD (2011) Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 17(1):47\u201358. https:\/\/doi.org\/10.2174\/138161211795049804","journal-title":"Curr Pharm Des"},{"key":"4655_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.08.015","author":"A Zorlu","year":"2012","unstructured":"Zorlu A, Bektasoglu G, Kukul Guven FM et al (2012) Usefulness of admission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolism. Am J Cardiol. https:\/\/doi.org\/10.1016\/j.amjcard.2011.08.015","journal-title":"Am J Cardiol"},{"key":"4655_CR29","doi-asserted-by":"publisher","DOI":"10.5152\/eajm.2012.39","author":"A Kaya","year":"2012","unstructured":"Kaya A, Ayhan E, Kurt M et al (2012) Is red cell distribution width a marker for the presence and poor prognosis of cardiovascular disease? Eurasian J Med. https:\/\/doi.org\/10.5152\/eajm.2012.39","journal-title":"Eurasian J Med"},{"issue":"12","key":"4655_CR30","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1177\/000313480206801201","volume":"68","author":"DY Yoon","year":"2002","unstructured":"Yoon DY, Chu J, Chandler C et al (2002) Human cytokine levels in nonperforated versus perforated appendicitis: molecular serum markers for extent of disease? Am Surg 68(12):1033\u20131037","journal-title":"Am Surg"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-020-04655-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-020-04655-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-020-04655-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T04:00:05Z","timestamp":1696046405000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-020-04655-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,20]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["4655"],"URL":"https:\/\/doi.org\/10.1007\/s00383-020-04655-7","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,20]]},"assertion":[{"value":"7 April 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}