{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:09:38Z","timestamp":1781244578659,"version":"3.54.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The recurrence rate of gastroesophageal reflux disease (GERD) after fundoplication has been reported to be 7\u201325%. We investigated the risk factors for recurrence of GERD after Thal fundoplication (TF) in our department with the aim of further reducing the recurrence rate of GERD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We retrospectively analyzed 276 patients who underwent TF for GERD at our hospital between 2000 and 2019. Retrospectively considered variables were obtained from the medical records of patients. The variables included patient characteristics, GERD severity, surgery-related factors and postoperative course.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The postoperative GERD recurrence rate was 5.8%. In the univariate analysis, the presence of convulsive seizures (12\/4 vs. 110\/150, <jats:italic>p<\/jats:italic>\u2009=\u20090.046) and the absence of a tracheostomy (0\/16 vs. 53\/207, <jats:italic>p<\/jats:italic>\u2009=\u20090.048) at the time of TF were significantly associated with recurrence. In the multivariate analysis, the presence of convulsive seizures at the time of TF was the only factor significantly associated with recurrence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The presence of convulsive seizures and the absence of a tracheostomy at the time of TF were significantly associated with GERD recurrence after TF. Active control of seizures and consideration of surgical indications, including assessment of respiratory status, are important in preventing the recurrence of GERD after TF.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00383-021-05001-1","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T23:11:18Z","timestamp":1630019478000},"page":"1731-1735","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk factors for recurrent gastroesophageal reflux disease after Thal fundoplication"],"prefix":"10.1007","volume":"37","author":[{"given":"Daisuke","family":"Ishii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayuki","family":"Miyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Hirasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"5001_CR1","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1046\/j.1442-200X.2003.01792.x","volume":"45","author":"K Okada","year":"2003","unstructured":"Okada K, Miyako M, Honma S, Wakabayashi Y, Sugihara S, Osawa M (2003) Discharge diagnoses in infants with apparent life-threatening event. Pediatr Int 45:560\u2013563","journal-title":"Pediatr Int"},{"key":"5001_CR2","first-page":"214","volume":"27","author":"Y Ohhama","year":"1991","unstructured":"Ohhama Y, Yamamoto H, Yamada R, Nishi T, Tsunoda A (1991) Nissen fundoplication for severely retarded children suffering from gastroesophageal reflux. J Jpn Soc Pediatr Surg 27:214\u2013218","journal-title":"J Jpn Soc Pediatr Surg"},{"key":"5001_CR3","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00595-009-4149-8","volume":"40","author":"T Iwanaka","year":"2010","unstructured":"Iwanaka T, Kanamori Y, Sugiyama M, Komura M, Tanaka Y, Kodaka T, Ishimaru T (2010) Laparoscopic fundoplication for gastroesophageal reflux disease in infants and children. Surg Today 40:393\u2013397","journal-title":"Surg Today"},{"key":"5001_CR4","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/j.jpedsurg.2016.07.012","volume":"51","author":"W Ru","year":"2016","unstructured":"Ru W, Wu P, Feng S, Lai XH, Chen G (2016) Laparoscopic versus open Nissen fundoplication in children: a systematic review and meta-analysis. J Pediatr Surg 51:1731\u20131736","journal-title":"J Pediatr Surg"},{"key":"5001_CR5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00383-020-04804-y","volume":"37","author":"D Ishii","year":"2021","unstructured":"Ishii D, Miyamoto K, Hirasawa M, Miyagi H (2021) Preferential performance of Thal fundoplication for gastroesophageal reflux disease: a single institution experience. Pediatr Surg Int 37:191\u2013196","journal-title":"Pediatr Surg Int"},{"key":"5001_CR6","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0022-3468(96)90142-6","volume":"31","author":"V Ramachandran","year":"1996","unstructured":"Ramachandran V, Ashcraft KW, Sharp RJ, Murphy PJ, Snyder CL, Gittes GK, Bickler SW (1996) Thal fundoplication in neurologically impaired children. J Pediatr Surg 31:819\u2013822","journal-title":"J Pediatr Surg"},{"key":"5001_CR7","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jpedsurg.2003.11.035","volume":"39","author":"S Islam","year":"2004","unstructured":"Islam S, Teitelbaum DH, Buntain WL, Hirschl RB (2004) Esophagogastric separation for failed fundoplication in neurologically impaired children. J Pediatr Surg 39:287\u2013291","journal-title":"J Pediatr Surg"},{"key":"5001_CR8","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0022-3468(99)90194-X","volume":"34","author":"R Kubiak","year":"1999","unstructured":"Kubiak R, Spitz L, Kiely EM, Drake D, Pierro A (1999) Effectiveness of fundoplication in early infancy. J Pediatr Surg 34:295\u2013299","journal-title":"J Pediatr Surg"},{"key":"5001_CR9","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1542\/peds.61.3.503","volume":"61","author":"RG McCauley","year":"1978","unstructured":"McCauley RG, Darling DB, Leonidas JC, Schwartz AM, Leape LL (1978) Esophagrams are useful. Pediatrics 61:503\u2013504","journal-title":"Pediatrics"},{"key":"5001_CR10","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205\u2013213","journal-title":"Ann Surg"},{"key":"5001_CR11","unstructured":"Mattei P (2003) Surgical directives pediatric surgery. Philadelphia, USA"},{"key":"5001_CR12","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y (2013) Investigation of the freely available easy-to-use software \u201cezr\u201d for medical statistics. Bone Marrow Transplant 48:452\u2013458","journal-title":"Bone Marrow Transplant"},{"issue":"3 Pt 1","key":"5001_CR13","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1542\/peds.101.3.419","volume":"101","author":"EW Fonkalsrud","year":"1998","unstructured":"Fonkalsrud EW, Ashcraft KW, Coran AG, Ellis DG, Grosfeld JL, Tunell WP, Weber TR (1998) Surgical treatment of gastroesophageal reflux in children: a combined hospital study of 7467 patients. Pediatrics 101(3 Pt 1):419\u2013422","journal-title":"Pediatrics"},{"key":"5001_CR14","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1007\/s00464-002-8515-5","volume":"17","author":"K Graziano","year":"2003","unstructured":"Graziano K, Teitelbaum DH, McLean K, Hirschl RB, Coran AG, Geiger JD (2003) Recurrence after laparoscopic and open Nissen fundoplication: a comparison of the mechanisms of failure. Surg Endosc 17:704\u2013707","journal-title":"Surg Endosc"},{"key":"5001_CR15","first-page":"603","volume":"43","author":"T Ishimaru","year":"2007","unstructured":"Ishimaru T, Iwanaka T, Kawashima H, Uchida H, Yotsumoto K, Gotoh C, Hamano S (2007) Six cases of recurrence after laparoscopic Nissen fundoplication: causes of recurrence and laparoscopic reoperation. J Jpn Soc Pediatr Surg 43:603\u2013608","journal-title":"J Jpn Soc Pediatr Surg"},{"key":"5001_CR16","doi-asserted-by":"crossref","unstructured":"Dedinsky G, Vane DW, BIack T, Turner MK, West KW, Grosfeld JL (1987) Complications and reoperation after Nissen fundoplication in children. Am J Surg 153:177-183","DOI":"10.1016\/0002-9610(87)90810-5"},{"key":"5001_CR17","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1136\/adc.68.3.347","volume":"68","author":"L Spitz","year":"1993","unstructured":"Spitz L, Roth K, Kiely EM, Brereton RJ, Drake DP, Milla PJ (1993) Operation for gastro-oesophageal reflux associated with severe mental retardation. Arch Dis Child 68:347\u2013351","journal-title":"Arch Dis Child"},{"key":"5001_CR18","doi-asserted-by":"publisher","first-page":"859","DOI":"10.2214\/ajr.178.4.1780859","volume":"178","author":"B Hainaux","year":"2002","unstructured":"Hainaux B, Sattari A, El C, Sadeghi N, Cadi\u00e8re GB (2002) Intrathoracic migration of the wrap after laparoscopic Nissen fundoplication: radiologic evaluation. AJR Am J Roentgenol 178:859\u2013862","journal-title":"AJR Am J Roentgenol"},{"key":"5001_CR19","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1089\/lap.2007.0144","volume":"18","author":"T Doi","year":"2008","unstructured":"Doi T, Ichikawa S, Miyano G, Lane GJ, Miyahara K, Yamataka A (2008) A New Technique for Preventing Wrap Disruption\/Migration After Laparoscopic Nissen Fundoplication: An Experimental Study. J Laparoendosc Adv Surg Tech A 18:179\u2013182","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"5001_CR20","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/S0022-3468(88)80635-3","volume":"23","author":"D Tuggle","year":"1988","unstructured":"Tuggle D, Tunell W, Hoelzer D, Smith E (1988) The efficacy of Thal fundoplication in the treatment of gastroesophageal reflux: the influence of central nervous system impairment. J Pediatr Surg 23:638\u2013640","journal-title":"J Pediatr Surg"},{"key":"5001_CR21","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1053\/jpsu.2001.22943","volume":"36","author":"C Esposito","year":"2001","unstructured":"Esposito C, Montupet P, Reinberg O (2001) Laparoscopic surgery for gastroesophageal reflux disease during the first year of life. J Pediatr Surg 36:715\u2013717","journal-title":"J Pediatr Surg"},{"key":"5001_CR22","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0022-3468(98)90363-3","volume":"33","author":"C Kimber","year":"1998","unstructured":"Kimber C, Kiely EM, Spitz L (1998) The failure rate of surgery for gastrooesophageal reflux. J Pediatr Surg 33:64\u201366","journal-title":"J Pediatr Surg"},{"key":"5001_CR23","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1378\/chest.126.3.915","volume":"126","author":"T Kovesi","year":"2004","unstructured":"Kovesi T, Rubin S (2004) Long-term complications of congenital esophageal atresia and\/or tracheoesophageal fistula. Chest 126:915\u2013925","journal-title":"Chest"},{"key":"5001_CR24","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1089\/lap.1999.9.243","volume":"9","author":"A Voitk","year":"1999","unstructured":"Voitk A, Joffe J, Alvarez C, Rosenthal G (1999) Factors contributing to laparoscopic failure during the learning curve for laparoscopic Nissen fundoplication in a community hospital. J Laparoendosc Adv Surg Tech A 9:243\u2013248","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"5001_CR25","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1016\/j.jpedsurg.2007.04.002","volume":"42","author":"N Monawat","year":"2007","unstructured":"Monawat N, Douglas CB, Ramanath NH, Jeffrey MR, Keith EG, Carroll MH (2007) Risk factors for recurrent gastroesophageal reflux disease after fundoplication in pediatric patients: a case-control study. J Pediatr Surg 42:1478\u20131485","journal-title":"J Pediatr Surg"},{"key":"5001_CR26","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S0022-3468(99)90065-9","volume":"34","author":"EW Fonkalsrud","year":"1999","unstructured":"Fonkalsrud EW, Bustorff-Silva J, Perez CA, Quintero R, Martin L, Atkinson JB (1999) Antireflux surgery in children under 3 months of age. J Pediatr Surg 34:527\u2013531","journal-title":"J Pediatr Surg"},{"key":"5001_CR27","first-page":"997","volume":"56","author":"T Oonuma","year":"2003","unstructured":"Oonuma T (2003) Medical approach to improve QOL of children with mental and physical disabilities. Jpn J Pediat 56:997\u20131004","journal-title":"Jpn J Pediat"},{"key":"5001_CR28","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jpeds.2018.02.059","volume":"198","author":"SA Pellegrino","year":"2018","unstructured":"Pellegrino SA, King SK, McLeod E, Hawley A, Brooks J, Hutson JM, Teague WJ (2018) Impact of Esophageal Atresia on the Success of Fundoplication for Gastroesophageal Reflux. J Pediatr 198:60\u201366","journal-title":"J Pediatr"},{"key":"5001_CR29","first-page":"20","volume":"13","author":"S Takamizawa","year":"2002","unstructured":"Takamizawa S, Tsugawa C, Nishijima E, Muraji T, Satoh S, Ise K, Maekawa T (2002) Surgical approach to oropharyngeal dysphagia for neurologically impaired children: Laryngotracheal separation for aspiration pneumonia remaining after fundoplication. Jpn J Pediat Pulmonol 13:20\u201325","journal-title":"Jpn J Pediat Pulmonol"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-021-05001-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-021-05001-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-021-05001-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T17:34:14Z","timestamp":1635874454000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-021-05001-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,26]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["5001"],"URL":"https:\/\/doi.org\/10.1007\/s00383-021-05001-1","relation":{},"ISSN":["0179-0358","1437-9813"],"issn-type":[{"value":"0179-0358","type":"print"},{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,26]]},"assertion":[{"value":"1 August 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest associated with this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Asahikawa Medical University Research Ethics Committee approved this study (Permit no. 20138). All the procedures performed involving human participants were in accordance with the ethical standards of the Clinical Research Center, Asahikawa Medical University, Japan and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors hereby confirm that informed consent was obtained from all the individual patients included in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}