{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:53:09Z","timestamp":1777693989531,"version":"3.51.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s00383-022-05093-3","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T15:34:48Z","timestamp":1646408088000},"page":"657-664","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Remote ischemic conditioning causes CD4 T cells shift towards reduced cell-mediated inflammation"],"prefix":"10.1007","volume":"38","author":[{"given":"Mashriq","family":"Alganabi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Biouss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloofar","family":"Ganji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Yamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostino","family":"Pierro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"issue":"3","key":"5093_CR1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1056\/NEJMra1005408","volume":"364","author":"J Neu","year":"2011","unstructured":"Neu J, Walker WA (2011) Necrotizing enterocolitis. N Engl J Med 364(3):255\u2013264. https:\/\/doi.org\/10.1056\/NEJMra1005408","journal-title":"N Engl J Med"},{"issue":"9","key":"5093_CR2","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.2165\/00003495-200868090-00004","volume":"68","author":"AM Thompson","year":"2008","unstructured":"Thompson AM, Bizzarro MJ (2008) Necrotizing enterocolitis in newborns: pathogenesis, prevention and management. Drugs 68(9):1227\u20131238. https:\/\/doi.org\/10.2165\/00003495-200868090-00004","journal-title":"Drugs"},{"key":"5093_CR3","doi-asserted-by":"publisher","first-page":"F1000","DOI":"10.1268\/f1000research.17228.1","volume":"8","author":"M Alganabi","year":"2019","unstructured":"Alganabi M, Lee C, Bindi E, Li B, Pierro A (2019) Recent advances in understanding necrotizing enterocolitis. F1000Res J 8:F1000. https:\/\/doi.org\/10.1268\/f1000research.17228.1","journal-title":"F1000Res J"},{"issue":"4","key":"5093_CR4","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1242\/dmm.009001","volume":"5","author":"C Zhang","year":"2012","unstructured":"Zhang C, Sherman MP, Prince LS, Bader D, Weitkamp JH, Slaughter JC et al (2012) Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice. Dis Model Mech 5(4):522\u2013532. https:\/\/doi.org\/10.1242\/dmm.009001","journal-title":"Dis Model Mech"},{"issue":"1","key":"5093_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.pathophys.2013.11.009","volume":"21","author":"S Huda","year":"2014","unstructured":"Huda S, Chaudhery S, Ibrahim H, Pramanik A (2014) Neonatal necrotizing enterocolitis: clinical challenges, pathophysiology and management. Pathophysiology 21(1):3\u201312. https:\/\/doi.org\/10.1016\/j.pathophys.2013.11.009","journal-title":"Pathophysiology"},{"issue":"2","key":"5093_CR6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2174\/1573396315666190312093119","volume":"15","author":"C Bazacliu","year":"2019","unstructured":"Bazacliu C, Neu J (2019) Necrotizing enterocolitis: long term complications. Curr Pediatr Rev 15(2):115\u2013124. https:\/\/doi.org\/10.2174\/1573396315666190312093119","journal-title":"Curr Pediatr Rev"},{"issue":"6","key":"5093_CR7","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s00383-015-3697-9","volume":"31","author":"JC Lim","year":"2015","unstructured":"Lim JC, Golden JM, Ford HR (2015) Pathogenesis of neonatal necrotizing enterocolitis. Pediatr Surg Int 31(6):509\u2013518. https:\/\/doi.org\/10.1007\/s00383-015-3697-9","journal-title":"Pediatr Surg Int"},{"issue":"1","key":"5093_CR8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.pathophys.2013.11.007","volume":"21","author":"P Lu","year":"2014","unstructured":"Lu P, Sodhi CP, Hackam DJ (2014) Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis. Pathophysiology 21(1):81\u201393. https:\/\/doi.org\/10.1016\/j.pathophys.2013.11.007","journal-title":"Pathophysiology"},{"issue":"1","key":"5093_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jpedsurg.2014.10.024","volume":"50","author":"GE Besner","year":"2015","unstructured":"Besner GE (2015) A pain in the NEC: research challenges and opportunities. J Pediatr Surg 50(1):23\u201329. https:\/\/doi.org\/10.1016\/j.jpedsurg.2014.10.024","journal-title":"J Pediatr Surg"},{"issue":"3","key":"5093_CR10","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/pr.2015.97","volume":"78","author":"RM Patel","year":"2015","unstructured":"Patel RM, Denning PW (2015) Intestinal microbiota and its relationship with necrotizing enterocolitis. Pediatr Res 78(3):232\u2013238. https:\/\/doi.org\/10.1038\/pr.2015.97","journal-title":"Pediatr Res"},{"issue":"12","key":"5093_CR11","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1007\/s00383-014-3613-8","volume":"30","author":"A Yikilmaz","year":"2014","unstructured":"Yikilmaz A, Hall NJ, Daneman A, Gerstle JT, Navarro OM, Moineddin R et al (2014) Prospective evaluation of the impact of sonography on the management and surgical intervention of neonates with necrotizing enterocolitis. Pediatr Surg Int 30(12):1231\u20131240","journal-title":"Pediatr Surg Int"},{"issue":"2","key":"5093_CR12","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.jss.2014.02.055","volume":"189","author":"Y Su","year":"2014","unstructured":"Su Y, Besner GE (2014) Heparin-binding EGF-like growth factor (HB-EGF) promotes cell migration and adhesion via focal adhesion kinase. J Surg Res 189(2):222\u2013231. https:\/\/doi.org\/10.1016\/j.jss.2014.02.055","journal-title":"J Surg Res"},{"issue":"1","key":"5093_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","volume":"16","author":"K Takeda","year":"2004","unstructured":"Takeda K, Akira S (2004) TLR signaling pathways. Semin Immunol 16(1):3\u20139. https:\/\/doi.org\/10.1016\/j.smim.2003.10.003","journal-title":"Semin Immunol"},{"issue":"2","key":"5093_CR14","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","volume":"42","author":"YC Lu","year":"2008","unstructured":"Lu YC, Yeh WC, Ohashi PS (2008) LPS\/TLR4 signal transduction pathway. Cytokine 42(2):145\u2013151. https:\/\/doi.org\/10.1016\/j.cyto.2008.01.006","journal-title":"Cytokine"},{"issue":"7","key":"5093_CR15","doi-asserted-by":"publisher","first-page":"4808","DOI":"10.4049\/jimmunol.179.7.4808","volume":"179","author":"CL Leaphart","year":"2007","unstructured":"Leaphart CL, Cavallo J, Gribar SC, Cetin S, Li J, Branca MF et al (2007) A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J Immunol 179(7):4808\u20134820. https:\/\/doi.org\/10.4049\/jimmunol.179.7.4808","journal-title":"J Immunol"},{"issue":"2","key":"5093_CR16","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1172\/JCI83356","volume":"126","author":"CE Egan","year":"2016","unstructured":"Egan CE, Sodhi CP, Good M, Lin J, Jia H, Yamaguchi Y et al (2016) Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest 126(2):495\u2013508. https:\/\/doi.org\/10.1172\/JCI83356","journal-title":"J Clin Invest"},{"issue":"5","key":"5093_CR17","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1161\/01.cir.74.5.1124","volume":"74","author":"CE Murry","year":"1986","unstructured":"Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74(5):1124\u20131136. https:\/\/doi.org\/10.1161\/01.cir.74.5.1124","journal-title":"Circulation"},{"key":"5093_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fphys.2012.00027","volume":"3","author":"SY Lim","year":"2012","unstructured":"Lim SY, Hausenloy DJ (2012) Remote ischemic conditioning: from bench to bedside. Front Physiol 3:27. https:\/\/doi.org\/10.3389\/fphys.2012.00027","journal-title":"Front Physiol"},{"issue":"1","key":"5093_CR19","doi-asserted-by":"publisher","first-page":"4950","DOI":"10.1038\/s41467-020-18750-9","volume":"11","author":"Y Koike","year":"2020","unstructured":"Koike Y, Li B, Ganji N, Zhu H, Miyake H, Chen Y et al (2020) Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation. Nat Commun 11(1):4950. https:\/\/doi.org\/10.1038\/s41467-020-18750-9","journal-title":"Nat Commun"},{"issue":"2","key":"5093_CR20","first-page":"61","volume":"2","author":"J Yang","year":"2019","unstructured":"Yang J, Shakil F, Cho S (2019) Peripheral mechanisms of remote ischemic conditioning. Cond Med 2(2):61\u201368","journal-title":"Cond Med"},{"key":"5093_CR21","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1476-9255-11-16","volume":"11","author":"YH Kim","year":"2014","unstructured":"Kim YH, Yoon DW, Kim JH, Lee JH, Lim CH (2014) Effect of remote ischemic post-conditioning on systemic inflammatory response and survival rate in lipopolysaccharide-induced systemic inflammation model. J Inflamm (Lond) 11:16. https:\/\/doi.org\/10.1186\/1476-9255-11-16","journal-title":"J Inflamm (Lond)"},{"issue":"12","key":"5093_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189501","volume":"12","author":"X Zhou","year":"2017","unstructured":"Zhou X, Jiang R, Dong Y, Wang L (2017) Remote ischemic preconditioning attenuates cardiopulmonary bypass-induced lung injury. PLoS One 12(12):e0189501. https:\/\/doi.org\/10.1371\/journal.pone.0189501","journal-title":"PLoS One"},{"issue":"1","key":"5093_CR23","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1152\/physiolgenomics.00046.2004","volume":"19","author":"IE Konstantinov","year":"2004","unstructured":"Konstantinov IE, Arab S, Kharbanda RK, Li J, Cheung MM, Cherepanov V et al (2004) The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics 19(1):143\u2013150. https:\/\/doi.org\/10.1152\/physiolgenomics.00046.2004","journal-title":"Physiol Genomics"},{"issue":"10","key":"5093_CR24","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s00383-020-04724-x","volume":"36","author":"M Yamoto","year":"2020","unstructured":"Yamoto M, Alganabi M, Chusilp S, Lee D, Yazaki Y, Lee C et al (2020) Lysosomal overloading and necrotizing enterocolitis. Pediatr Surg Int 36(10):1157\u20131165. https:\/\/doi.org\/10.1007\/s00383-020-04724-x","journal-title":"Pediatr Surg Int"},{"issue":"21","key":"5093_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202000519","volume":"64","author":"B Li","year":"2020","unstructured":"Li B, Wu RY, Horne RG, Ahmed A, Lee D, Robinson SC et al (2020) Human milk oligosaccharides protect against necrotizing enterocolitis by activating intestinal cell differentiation. Mol Nutr Food Res 64(21):e2000519. https:\/\/doi.org\/10.1002\/mnfr.202000519","journal-title":"Mol Nutr Food Res"},{"issue":"2","key":"5093_CR26","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00383-019-04599-7","volume":"36","author":"H Miyake","year":"2020","unstructured":"Miyake H, Lee C, Chusilp S, Bhalla M, Li B, Pitino M et al (2020) Human breast milk exosomes attenuate intestinal damage. Pediatr Surg Int 36(2):155\u2013163. https:\/\/doi.org\/10.1007\/s00383-019-04599-7","journal-title":"Pediatr Surg Int"},{"issue":"12","key":"5093_CR27","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s00383-016-3998-7","volume":"32","author":"H Miyake","year":"2016","unstructured":"Miyake H, Chen Y, Koike Y, Hock A, Li B, Lee C et al (2016) Osmolality of enteral formula and severity of experimental necrotizing enterocolitis. Pediatr Surg Int 32(12):1153\u20131156. https:\/\/doi.org\/10.1007\/s00383-016-3998-7","journal-title":"Pediatr Surg Int"},{"issue":"12","key":"5093_CR28","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s00383-016-3997-8","volume":"32","author":"Y Chen","year":"2016","unstructured":"Chen Y, Koike Y, Miyake H, Li B, Lee C, Hock A et al (2016) Formula feeding and systemic hypoxia synergistically induce intestinal hypoxia in experimental necrotizing enterocolitis. Pediatr Surg Int 32(12):1115\u20131119","journal-title":"Pediatr Surg Int"},{"issue":"1","key":"5093_CR29","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s00383-015-3813-x","volume":"32","author":"A Zani","year":"2016","unstructured":"Zani A, Zani-Ruttenstock E, Peyvandi F, Lee C, Li B, Pierro A (2016) A spectrum of intestinal injury models in neonatal mice. Pediatr Surg Int 32(1):65\u201370. https:\/\/doi.org\/10.1007\/s00383-015-3813-x","journal-title":"Pediatr Surg Int"},{"key":"5093_CR30","first-page":"61","volume":"2","author":"J Yang","year":"2019","unstructured":"Yang J, Shakil F, Cho S (2019) Peripheral mechanisms of remote ischemic conditioning. Cond Med 2:61\u201368","journal-title":"Cond Med"},{"key":"5093_CR31","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/819467","volume":"2012","author":"JC Waite","year":"2012","unstructured":"Waite JC, Skokos D (2012) Th17 response and inflammatory autoimmune diseases. Int J Inflam 2012:819467. https:\/\/doi.org\/10.1155\/2012\/819467","journal-title":"Int J Inflam"},{"key":"5093_CR32","doi-asserted-by":"publisher","first-page":"8813558","DOI":"10.1155\/2020\/8813558","volume":"2020","author":"JB Yan","year":"2020","unstructured":"Yan JB, Luo MM, Chen ZY, He BH (2020) The function and role of the Th17\/Treg cell balance in inflammatory bowel disease. J Immunol Res 2020:8813558. https:\/\/doi.org\/10.1155\/2020\/8813558","journal-title":"J Immunol Res"},{"key":"5093_CR33","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.lfs.2017.11.026","volume":"192","author":"S Shao","year":"2018","unstructured":"Shao S, Yu X, Shen L (2018) Autoimmune thyroid diseases and Th17\/Treg lymphocytes. Life Sci 192:160\u2013165. https:\/\/doi.org\/10.1016\/j.lfs.2017.11.026","journal-title":"Life Sci"},{"key":"5093_CR34","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.3389\/fimmu.2020.01027","volume":"11","author":"J Shan","year":"2020","unstructured":"Shan J, Jin H, Xu Y (2020) T cell metabolism: a new perspective on Th17\/Treg cell imbalance in systemic lupus erythematosus. Front Immunol 11:1027. https:\/\/doi.org\/10.3389\/fimmu.2020.01027","journal-title":"Front Immunol"},{"issue":"3","key":"5093_CR35","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3390\/ijms19030730.PMID:29510522;PMCID:PMC5877591","volume":"19","author":"GR Lee","year":"2018","unstructured":"Lee GR (2018) The balance of Th17 versus Treg cells in autoimmunity. Int J Mol Sci 19(3):730. https:\/\/doi.org\/10.3390\/ijms19030730.PMID:29510522;PMCID:PMC5877591","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5093_CR36","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s11684-015-0388-9","volume":"9","author":"L Han","year":"2015","unstructured":"Han L, Yang J, Wang X, Li D, Lv L, Li B (2015) Th17 cells in autoimmune diseases. Front Med 9(1):10\u201319. https:\/\/doi.org\/10.1007\/s11684-015-0388-9","journal-title":"Front Med"},{"issue":"3","key":"5093_CR37","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.molmed.2016.01.001","volume":"22","author":"A Beringer","year":"2016","unstructured":"Beringer A, Noack M, Miossec P (2016) IL-17 in chronic inflammation: from discovery to targeting. Trends Mol Med 22(3):230\u2013241. https:\/\/doi.org\/10.1016\/j.molmed.2016.01.001","journal-title":"Trends Mol Med"},{"key":"5093_CR38","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ebiom.2019.05.042","volume":"44","author":"F Ma","year":"2019","unstructured":"Ma F, Li S, Gao X, Zhou J, Zhu X, Wang D et al (2019) Interleukin-6-mediated CCR9+ interleukin-17-producing regulatory T cells polarization increases the severity of necrotizing enterocolitis. EBioMedicine 44:71\u201385. https:\/\/doi.org\/10.1016\/j.ebiom.2019.05.042","journal-title":"EBioMedicine"},{"issue":"2","key":"5093_CR39","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1172\/JCI83356","volume":"126","author":"CE Egan","year":"2016","unstructured":"Egan CE, Sodhi CP, Good M, Lin J, Jia H, Yamaguchi Y et al (2016) Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest 126(2):495\u2013508. https:\/\/doi.org\/10.1172\/JCI83356","journal-title":"J Clin Invest"},{"issue":"1","key":"5093_CR40","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1136\/gutjnl-2011-301551","volume":"62","author":"JH Weitkamp","year":"2013","unstructured":"Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P et al (2013) Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)\/effector (CD4, CD8) T cell ratios. Gut 62(1):73\u201382. https:\/\/doi.org\/10.1136\/gutjnl-2011-301551","journal-title":"Gut"},{"issue":"12","key":"5093_CR41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082963","volume":"8","author":"BM Dingle","year":"2013","unstructured":"Dingle BM, Liu Y, Fatheree NY, Min J, Rhoads JM, Tran DQ (2013) FoxP3+ regulatory T cells attenuate experimental necrotizing enterocolitis. PLoS One 8(12):e82963. https:\/\/doi.org\/10.1371\/journal.pone.0082963","journal-title":"PLoS One"},{"issue":"9","key":"5093_CR42","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1007\/s00383-021-04929-8","volume":"37","author":"E Lau","year":"2021","unstructured":"Lau E, Lee C, Li B, Pierro A (2021) Endoplasmic reticulum stress in the acute intestinal epithelial injury of necrotizing enterocolitis. Pediatr Surg Int 37(9):1151\u20131160. https:\/\/doi.org\/10.1007\/s00383-021-04929-8","journal-title":"Pediatr Surg Int"},{"issue":"47","key":"5093_CR43","doi-asserted-by":"publisher","first-page":"15599","DOI":"10.1523\/JNEUROSCI.2544-15.2015","volume":"35","author":"MA Hamner","year":"2015","unstructured":"Hamner MA, Ye Z, Lee RV, Colman JR, Le T, Gong DC et al (2015) Ischemic preconditioning in white matter: magnitude and mechanism. J Neurosci 35(47):15599\u201315611. https:\/\/doi.org\/10.1523\/JNEUROSCI.2544-15.2015","journal-title":"J Neurosci"},{"issue":"1","key":"5093_CR44","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1471-4159.2009.05972.x","volume":"109","author":"JM Pradillo","year":"2009","unstructured":"Pradillo JM, Fern\u00e1ndez-L\u00f3pez D, Garc\u00eda-Y\u00e9benes I, Sobrado M, Hurtado O, Moro MA et al (2009) Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning. J Neurochem 109(1):287\u2013294. https:\/\/doi.org\/10.1111\/j.1471-4159.2009.05972.x","journal-title":"J Neurochem"},{"issue":"12","key":"5093_CR45","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1002\/glia.22885","volume":"63","author":"M Gliem","year":"2015","unstructured":"Gliem M, Krammes K, Liaw L, van Rooijen N, Hartung HP, Jander S (2015) Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke. Glia 63(12):2198\u20132207. https:\/\/doi.org\/10.1002\/glia.22885","journal-title":"Glia"},{"issue":"2","key":"5093_CR46","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cell.2015.08.069","volume":"163","author":"P Ejlerskov","year":"2015","unstructured":"Ejlerskov P, Hultberg JG, Wang J, Carlsson R, Ambj\u00f8rn M, Kuss M et al (2015) Lack of neuronal IFN-\u03b2-IFNAR causes lewy body- and Parkinson\u2019s disease-like dementia. Cell 163(2):324\u2013339. https:\/\/doi.org\/10.1016\/j.cell.2015.08.069","journal-title":"Cell"},{"issue":"31","key":"5093_CR47","doi-asserted-by":"publisher","first-page":"9839","DOI":"10.1523\/JNEUROSCI.2496-09.2009","volume":"29","author":"B Marsh","year":"2009","unstructured":"Marsh B, Stevens SL, Packard AE, Gopalan B, Hunter B, Leung PY et al (2009) Systemic lipopolysaccharide protects the brain from ischemic injury by reprogramming the response of the brain to stroke: a critical role for IRF3. J Neurosci 29(31):9839\u20139849. https:\/\/doi.org\/10.1523\/JNEUROSCI.2496-09.2009","journal-title":"J Neurosci"},{"issue":"23","key":"5093_CR48","doi-asserted-by":"publisher","first-page":"8456","DOI":"10.1523\/JNEUROSCI.0821-11.2011","volume":"31","author":"SL Stevens","year":"2011","unstructured":"Stevens SL, Leung PY, Vartanian KB, Gopalan B, Yang T, Simon RP et al (2011) Multiple preconditioning paradigms converge on interferon regulatory factor-dependent signaling to promote tolerance to ischemic brain injury. J Neurosci 31(23):8456\u20138463. https:\/\/doi.org\/10.1523\/JNEUROSCI.0821-11.2011","journal-title":"J Neurosci"},{"issue":"1","key":"5093_CR49","doi-asserted-by":"publisher","first-page":"116","DOI":"10.14336\/AD.2020.0320","volume":"12","author":"Y Gao","year":"2021","unstructured":"Gao Y, Ren C, Li X, Yu W, Li S, Li H et al (2021) Ischemic conditioning ameliorated hypertension and vascular remodeling of spontaneously hypertensive rat via inflammatory regulation. Aging Dis 12(1):116\u2013131. https:\/\/doi.org\/10.14336\/AD.2020.0320","journal-title":"Aging Dis"},{"issue":"3","key":"5093_CR50","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00383-019-04615-w","volume":"36","author":"M Alganabi","year":"2020","unstructured":"Alganabi M, Zhu H, O\u2019Connell JS, Biouss G, Zito A, Li B et al (2020) Calcium\/calmodulin-dependent protein kinase IV signaling pathway is upregulated in experimental necrotizing enterocolitis. Pediatr Surg Int 36(3):271\u2013277. https:\/\/doi.org\/10.1007\/s00383-019-04615-w","journal-title":"Pediatr Surg Int"},{"issue":"3","key":"5093_CR51","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00383-020-04831-9","volume":"37","author":"H Zhu","year":"2021","unstructured":"Zhu H, Li B, Bindi E, Lee C, Alganabi M, Lok MJ et al (2021) Remote ischemic conditioning avoids the development of intestinal damage after ischemia reperfusion by reducing intestinal inflammation and increasing intestinal regeneration. Pediatr Surg Int 37(3):333\u2013337. https:\/\/doi.org\/10.1007\/s00383-020-04831-9","journal-title":"Pediatr Surg Int"},{"issue":"3","key":"5093_CR52","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00383-020-04826-6","volume":"37","author":"JS O'Connell","year":"2021","unstructured":"O\u2019Connell JS, Lee C, Farhat N, Antounians L, Zani A, Li B et al (2021) Administration of extracellular vesicles derived from human amniotic fluid stem cells: a new treatment for necrotizing enterocolitis. Pediatr Surg Int 37(3):301\u2013309","journal-title":"Pediatr Surg Int"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-022-05093-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-022-05093-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-022-05093-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T11:14:27Z","timestamp":1649157267000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-022-05093-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,4]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["5093"],"URL":"https:\/\/doi.org\/10.1007\/s00383-022-05093-3","relation":{},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,4]]},"assertion":[{"value":"2 February 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was obtained from the ethical review board at The Hospital for Sick Children (#58119).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}