{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:39:27Z","timestamp":1768451967469,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"DOI":"10.1007\/s00383-022-05144-9","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T17:03:13Z","timestamp":1657818193000},"page":"1273-1281","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aberrant expression of LINC00346 regulates cell migration and proliferation via competitively binding to miRNA-148a-3p\/Dnmt1 in Hirschsprung\u2019s disease"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8208-5313","authenticated-orcid":false,"given":"Long","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongde","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"5144_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/jmg.2007.053959","volume":"45","author":"J Amiel","year":"2008","unstructured":"Amiel J, Sproat-Emison E, Garcia-Barcelo M et al (2008) Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet 45:1\u201314","journal-title":"J Med Genet"},{"key":"5144_CR2","doi-asserted-by":"publisher","first-page":"4483","DOI":"10.1172\/JCI83178","volume":"125","author":"R Soret","year":"2015","unstructured":"Soret R, Mennetrey M, Bergeron KF et al (2015) A collagen VI-dependent pathogenic mechanism for Hirschsprung\u2019s disease. J Clin Invest 125:4483\u20134496","journal-title":"J Clin Invest"},{"key":"5144_CR3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/cge.12032","volume":"83","author":"KF Bergeron","year":"2013","unstructured":"Bergeron KF, Silversides DW, Pilon N (2013) The developmental genetics of Hirschsprung\u2019s disease. Clin Genet 83:15\u201322","journal-title":"Clin Genet"},{"key":"5144_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2013.03.001","volume":"162","author":"NE Butler Tjaden","year":"2013","unstructured":"Butler Tjaden NE, Trainor PA (2013) The developmental etiology and pathogenesis of Hirschsprung disease. Transl Res 162:1\u201315","journal-title":"Transl Res"},{"key":"5144_CR5","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nature12986","volume":"505","author":"Y Tay","year":"2014","unstructured":"Tay Y, Rinn J, Pandolfi PP (2014) The multilayered complexity of ceRNA crosstalk and competition. Nature 505:344\u2013352","journal-title":"Nature"},{"key":"5144_CR6","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/nmo.12722","volume":"28","author":"Z Shen","year":"2016","unstructured":"Shen Z, Du C, Zang R et al (2016) Microarray expression profiling of dysregulated long non-coding RNAs in Hirschsprung\u2019s disease reveals their potential role in molecular diagnosis. Neurogastroenterol Motil 28:266\u2013273","journal-title":"Neurogastroenterol Motil"},{"key":"5144_CR7","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1080\/15384101.2017.1403688","volume":"17","author":"Y Su","year":"2018","unstructured":"Su Y, Wen Z, Shen Q et al (2018) Long non-coding RNA LOC100507600 functions as a competitive endogenous RNA to regulate BMI1 expression by sponging miR128-1-3p in Hirschsprung\u2019s disease. Cell Cycle 17:459\u201367","journal-title":"Cell Cycle"},{"key":"5144_CR8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bbrc.2017.07.045","volume":"491","author":"T Ye","year":"2017","unstructured":"Ye T, Ding W, Wang N et al (2017) Long noncoding RNA linc00346 promotes the malignant phenotypes of bladder cancer. Biochem Biophys Res Commun 491:79\u201384","journal-title":"Biochem Biophys Res Commun"},{"key":"5144_CR9","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.ajpath.2019.10.019","volume":"190","author":"M Piipponen","year":"2020","unstructured":"Piipponen M, Nissinen L, Riihila P et al (2020) P53-regulated long noncoding RNA PRECSIT promotes progression of cutaneous squamous cell carcinoma via STAT3 signaling. Am J Pathol 190:503\u2013517","journal-title":"Am J Pathol"},{"key":"5144_CR10","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1136\/jmedgenet-2015-103334","volume":"52","author":"X Qi","year":"2015","unstructured":"Qi X, Zhang DH, Wu N et al (2015) CeRNA in cancer: possible functions and clinical implications. J Med Genet 52:710\u2013718","journal-title":"J Med Genet"},{"key":"5144_CR11","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1089\/gtmb.2018.0285","volume":"23","author":"Y Wang","year":"2019","unstructured":"Wang Y, Hu Y, Guo J et al (2019) MiR-148a-3p suppresses the proliferation and invasion of esophageal cancer by targeting DNMT1. Genet Test Mol Biomarkers 23:98\u2013104","journal-title":"Genet Test Mol Biomarkers"},{"key":"5144_CR12","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.ydbio.2019.08.002","volume":"455","author":"J Ganz","year":"2019","unstructured":"Ganz J, Melancon E, Wilson C et al (2019) Epigenetic factors Dnmt1 and Uhrf1 coordinate intestinal development. Dev Biol 455:473\u2013484","journal-title":"Dev Biol"},{"key":"5144_CR13","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/cbf.3233","volume":"34","author":"S Jili","year":"2016","unstructured":"Jili S, Eryong L, Lijuan L et al (2016) RUNX3 inhibits laryngeal squamous cell carcinoma malignancy under the regulation of miR-148a-3p\/DNMT1 axis. Cell Biochem Funct 34:597\u2013605","journal-title":"Cell Biochem Funct"},{"key":"5144_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2020.114998","volume":"396","author":"X Li","year":"2020","unstructured":"Li X, Wang L, Cao X et al (2020) Casticin inhibits stemness of hepatocellular carcinoma cells via disrupting the reciprocal negative regulation between DNMT1 and miR-148a-3p. Toxicol Appl Pharmacol 396:114998","journal-title":"Toxicol Appl Pharmacol"},{"key":"5144_CR15","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3892\/ol.2021.12878","volume":"22","author":"Q Chen","year":"2021","unstructured":"Chen Q, Wang Y, Dang H et al (2021) MicroRNA-148a-3p inhibits the proliferation of cervical cancer cells by regulating the expression levels of DNMT1 and UTF1. Oncol Lett 22:617","journal-title":"Oncol Lett"},{"key":"5144_CR16","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nature05874","volume":"447","author":"E Birney","year":"2007","unstructured":"Consortium EP, Birney E, Stamatoyannopoulos JA et al (2007) (2012) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447:799\u2013816","journal-title":"Nature"},{"key":"5144_CR17","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1101\/gr.134767.111","volume":"22","author":"B Banfai","year":"2012","unstructured":"Banfai B, Jia H, Khatun J et al (2012) Long noncoding RNAs are rarely translated in two human cell lines. Genome Res 22:1646\u20131657","journal-title":"Genome Res"},{"key":"5144_CR18","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/nmo.12776","volume":"28","author":"JM Rogers","year":"2016","unstructured":"Rogers JM (2016) Search for the missing lncs: gene regulatory networks in neural crest development and long non-coding RNA biomarkers of Hirschsprung\u2019s disease. Neurogastroenterol Motil 28:161\u2013166","journal-title":"Neurogastroenterol Motil"},{"key":"5144_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133123","author":"A Torroglosa","year":"2019","unstructured":"Torroglosa A, Villalba-Benito L, Luzon-Toro B et al (2019) Epigenetic mechanisms in Hirschsprung disease. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20133123","journal-title":"Int J Mol Sci"},{"key":"5144_CR20","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrg3074","volume":"12","author":"M Esteller","year":"2011","unstructured":"Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12:861\u2013874","journal-title":"Nat Rev Genet"},{"key":"5144_CR21","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.devcel.2013.03.002","volume":"25","author":"Y Wang","year":"2013","unstructured":"Wang Y, Xu Z, Jiang J et al (2013) Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal. Dev Cell 25:69\u201380","journal-title":"Dev Cell"},{"key":"5144_CR22","doi-asserted-by":"publisher","first-page":"292","DOI":"10.7150\/ijms.14187","volume":"13","author":"Z Shen","year":"2016","unstructured":"Shen Z, Peng L, Zhu Z et al (2016) Downregulated expression of long non-coding RNA LOC101926975 impairs both cell proliferation and cell cycle and its clinical implication in Hirschsprung disease patients. Int J Med Sci 13:292\u2013297","journal-title":"Int J Med Sci"},{"key":"5144_CR23","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1101\/gad.947102","volume":"16","author":"A Bird","year":"2002","unstructured":"Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16:6\u201321","journal-title":"Genes Dev"},{"key":"5144_CR24","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/cbic.201000195","volume":"12","author":"RZ Jurkowska","year":"2011","unstructured":"Jurkowska RZ, Jurkowski TP, Jeltsch A (2011) Structure and function of mammalian DNA methyltransferases. ChemBioChem 12:206\u2013222","journal-title":"ChemBioChem"},{"key":"5144_CR25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/B978-0-12-387685-0.00006-8","volume":"101","author":"ZM Svedruzic","year":"2011","unstructured":"Svedruzic ZM (2011) Dnmt1 structure and function. Prog Mol Biol Transl Sci 101:221\u2013254","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"1","key":"5144_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/jmcb\/mjs049","volume":"5","author":"Q Xu","year":"2013","unstructured":"Xu Q, Jiang Y, Yin Y et al (2013) A regulatory circuit of miR-148a\/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. J Mol Cell Biol 5(1):3\u201313","journal-title":"J Mol Cell Biol"},{"key":"5144_CR27","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.tibs.2014.05.002","volume":"39","author":"A Jeltsch","year":"2014","unstructured":"Jeltsch A, Jurkowska RZ (2014) New concepts in DNA methylation. Trends Biochem Sci 39:310\u2013318","journal-title":"Trends Biochem Sci"},{"key":"5144_CR28","doi-asserted-by":"publisher","first-page":"4546","DOI":"10.1158\/0008-5472.CAN-15-3268","volume":"76","author":"S Zagorac","year":"2016","unstructured":"Zagorac S, Alcala S, Fernandez Bayon G et al (2016) DNMT1 inhibition reprograms pancreatic cancer stem cells via upregulation of the miR-17-92 cluster. Cancer Res 76:4546\u20134558","journal-title":"Cancer Res"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-022-05144-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-022-05144-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-022-05144-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T14:03:30Z","timestamp":1659708210000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-022-05144-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,14]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["5144"],"URL":"https:\/\/doi.org\/10.1007\/s00383-022-05144-9","relation":{},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,14]]},"assertion":[{"value":"17 May 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was approved by the Ethics Committee of Shandong Provincial Hospital Affiliated to Shandong University (SWYX No. 2022-016). All procedures performed in this study involving human participants were in accordance with the Declaration of Helsinki (as revised in 2013). Written informed consent was taken from Written informed consent was taken from parents\/guardians of the patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}