{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T04:34:18Z","timestamp":1785645258368,"version":"3.56.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"DOI":"10.1007\/s00383-023-05421-1","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T12:13:29Z","timestamp":1676463209000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The m6A methyltransferase METTL3 affects cell proliferation and migration by regulating YAP expression in Hirschsprung disease"],"prefix":"10.1007","volume":"39","author":[{"given":"Zhaorong","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiyue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"issue":"1","key":"5421_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/jmg.2007.053959","volume":"45","author":"J Amiel","year":"2008","unstructured":"Amiel J, Lyonnet S (2008) Hirschsprung disease, associated syndromes, and genetics: a review. J Med Genet 45(1):1\u201314","journal-title":"J Med Genet"},{"issue":"5","key":"5421_CR2","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1097\/MPG.0b013e3182a8bb50","volume":"57","author":"MG Sch\u00e4ppi","year":"2013","unstructured":"Sch\u00e4ppi MG, Staiano A, Milla PJ, Smith VV, Dias JA, Heuschkel R, Husby S, Mearin ML, Papadopoulou A, Ruemmele FM, Vandenplas Y, Koletzko S (2013) A practical guide for the diagnosis of primary enteric nervous system disorders. J Pediatr Gastroenterol Nutr 57(5):677\u2013686","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"5421_CR3","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nrn2137","volume":"8","author":"TA Heanue","year":"2007","unstructured":"Heanue TA, Pachnis V (2007) Enteric nervous system development and Hirschsprung\u2019s disease: advances in genetic and stem cell studies. Nat Rev Neurosci 8(6):466\u2013479","journal-title":"Nat Rev Neurosci"},{"issue":"9","key":"5421_CR4","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1080\/15476286.2017.1318241","volume":"14","author":"FR Traube","year":"2017","unstructured":"Traube FR, Carell T (2017) The chemistries and consequences of DNA and RNA methylation and demethylation. RNA Biol 14(9):1099\u20131107","journal-title":"RNA Biol"},{"key":"5421_CR5","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3389\/fimmu.2019.00922","volume":"10","author":"C Zhang","year":"2019","unstructured":"Zhang C, Fu J, Zhou Y (2019) A review in research progress concerning m6A methylation and Immunoregulation. Front Immunol 10:922","journal-title":"Front Immunol"},{"issue":"7397","key":"5421_CR6","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nature11112","volume":"485","author":"D Dominissini","year":"2012","unstructured":"Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, Rechavi G (2012) Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485(7397):201\u2013206","journal-title":"Nature"},{"issue":"11","key":"5421_CR7","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1038\/s41419-020-03143-z","volume":"11","author":"C Yang","year":"2020","unstructured":"Yang C, Hu Y, Zhou B, Bao Y, Li Z, Gong C, Yang H, Wang S, Xiao Y (2020) The role of m6A modification in physiology and disease. Cell Death Dis 11(11):960","journal-title":"Cell Death Dis"},{"issue":"7","key":"5421_CR8","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","volume":"169","author":"IA Roundtree","year":"2017","unstructured":"Roundtree IA, Evans ME, Pan T, He C (2017) Dynamic RNA modifications in gene expression regulation. Cell 169(7):1187\u20131200","journal-title":"Cell"},{"key":"5421_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119577","volume":"278","author":"B Wang","year":"2021","unstructured":"Wang B, Fang X, Sun X, Du C, Zhou L, Lv X, Li Y, Li H, Tang W (2021) m6A demethylase ALKBH5 suppresses proliferation and migration of enteric neural crest cells by regulating TAGLN in Hirschsprung\u2019s disease. Life Sci 278:119577","journal-title":"Life Sci"},{"issue":"1","key":"5421_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s13045-019-0830-6","volume":"12","author":"D Jin","year":"2019","unstructured":"Jin D, Guo J, Wu Y, Du J, Yang L, Wang X, Di W, Hu B, An J, Kong L, Pan L, Su G (2019) m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis. J Hematol Oncol 12(1):135","journal-title":"J Hematol Oncol"},{"issue":"10","key":"5421_CR11","doi-asserted-by":"publisher","first-page":"4087","DOI":"10.1111\/cas.15083","volume":"112","author":"J Cui","year":"2021","unstructured":"Cui J, Tian J, Wang W, He T, Li X, Gu C, Wang L, Wu J, Shang A (2021) IGF2BP2 promotes the progression of colorectal cancer through a YAP-dependent mechanism. Cancer Sci 112(10):4087\u20134099","journal-title":"Cancer Sci"},{"issue":"1","key":"5421_CR12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/s41419-020-03315-x","volume":"12","author":"Y Yuan","year":"2021","unstructured":"Yuan Y, Yan G, He M, Lei H, Li L, Wang Y, He X, Li G, Wang Q, Gao Y, Qu Z, Mei Z, Shen Z, Pu J, Wang A, Zhao W, Jiang H, Du W, Yang L (2021) ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1\/YAP signaling axis in osteosarcoma. Cell Death Dis 12(1):60","journal-title":"Cell Death Dis"},{"key":"5421_CR13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ceb.2017.12.012","volume":"49","author":"V Fu","year":"2017","unstructured":"Fu V, Plouffe SW, Guan KL (2017) The Hippo pathway in organ development, homeostasis, and regeneration. Curr Opin Cell Biol 49:99\u2013107","journal-title":"Curr Opin Cell Biol"},{"issue":"7630","key":"5421_CR14","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/nature20168","volume":"539","author":"N Gjorevski","year":"2016","unstructured":"Gjorevski N, Sachs N, Manfrin A, Giger S, Bragina ME, Ord\u00f3\u00f1ez-Mor\u00e1n P, Clevers H, Lutolf MP (2016) Designer matrices for intestinal stem cell and organoid culture. Nature 539(7630):560\u2013564","journal-title":"Nature"},{"key":"5421_CR15","doi-asserted-by":"publisher","first-page":"23208","DOI":"10.1038\/srep23208","volume":"6","author":"CJ Hindley","year":"2016","unstructured":"Hindley CJ, Condurat AL, Menon V, Thomas R, Azmitia LM, Davis JA, Pruszak J (2016) The Hippo pathway member YAP enhances human neural crest cell fate and migration. Sci Rep 6:23208","journal-title":"Sci Rep"},{"issue":"13","key":"5421_CR16","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.3390\/ijms20133123","volume":"20","author":"A Torroglosa","year":"2019","unstructured":"Torroglosa A, Villalba-Benito L, Luz\u00f3n-Toro B, Fern\u00e1ndez RM, Anti\u00f1olo G, Borrego S (2019) Epigenetic mechanisms in Hirschsprung disease. Int J Mol Sci 20(13):3123","journal-title":"Int J Mol Sci"},{"issue":"S1","key":"5421_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fasebj.2020.34.s1.09582","volume":"34","author":"J Wang","year":"2020","unstructured":"Wang J (2020) Hippo pathway interacts with Wnt pathway to regulate the neural crest cells. FASEB J 34(S1):1\u20131","journal-title":"FASEB J"},{"issue":"5","key":"5421_CR18","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00383-017-4066-7","volume":"33","author":"JC Langer","year":"2017","unstructured":"Langer JC, Rollins MD, Levitt M, Gosain A, Torre L, Kapur RP, Cowles RA, Horton J, Rothstein DH, Goldstein AM, American Pediatric Surgical Association Hirschsprung Disease Interest Group (2017) Guidelines for the management of postoperative obstructive symptoms in children with Hirschsprung disease. Pediatr Surg Int 33(5):523\u2013526","journal-title":"Pediatr Surg Int"},{"issue":"2","key":"5421_CR19","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ydbio.2016.06.017","volume":"417","author":"A Torroglosa","year":"2016","unstructured":"Torroglosa A, Alves MM, Fern\u00e1ndez RM, Anti\u00f1olo G, Hofstra RM, Borrego S (2016) Epigenetics in ENS development and Hirschsprung disease. Dev Biol 417(2):209\u2013216","journal-title":"Dev Biol"},{"issue":"4","key":"5421_CR20","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1053\/j.gastro.2008.01.028","volume":"134","author":"VC Lui","year":"2016","unstructured":"Lui VC, Cheng WW, Leon TY, Lau DK, Garcia-Barcelo MM, Miao XP, Kam MK, So MT, Chen Y, Wall NA, Sham MH, Tam PK (2016) Perturbation of hoxb5 signaling in vagal neural crests down-regulates ret leading to intestinal hypoganglionosis in mice. Gastroenterology 134(4):1104\u20131115","journal-title":"Gastroenterology"},{"issue":"9","key":"5421_CR21","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/gim.2014.17","volume":"16","author":"A Torroglosa","year":"2014","unstructured":"Torroglosa A, Enguix-Riego MV, Fern\u00e1ndez RM, Rom\u00e1n-Rodriguez FJ, Moya-Jim\u00e9nez MJ, de Agust\u00edn JC, Anti\u00f1olo G, Borrego S (2014) Involvement of DNMT3B in the pathogenesis of Hirschsprung disease and its possible role as a regulator of neurogenesis in the human enteric nervous system. Genet Med 16(9):703\u2013710","journal-title":"Genet Med"},{"issue":"5","key":"5421_CR22","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrg3724","volume":"15","author":"Y Fu","year":"2014","unstructured":"Fu Y, Dominissini D, Rechavi G, He C (2014) Gene expression regulation mediated through reversible m6A RNA methylation. Nat Rev Genet 15(5):293\u2013306","journal-title":"Nat Rev Genet"},{"issue":"2","key":"5421_CR23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/jnc.14481","volume":"147","author":"J Widagdo","year":"2018","unstructured":"Widagdo J, Anggono V (2018) The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity. J Neurochem 147(2):137\u2013152","journal-title":"J Neurochem"},{"issue":"2","key":"5421_CR24","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41593-017-0057-1","volume":"21","author":"Y Wang","year":"2018","unstructured":"Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC (2018) N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci 21(2):195\u2013206","journal-title":"Nat Neurosci"},{"issue":"8","key":"5421_CR25","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00104-21","volume":"41","author":"H Kim","year":"2021","unstructured":"Kim H, Jang S (2021) RNA m6A methyltransferase Mettl3 regulates spatial neural patterning in Xenopus laevis. Mol Cell Biol 41(8):e0010421","journal-title":"Mol Cell Biol"},{"issue":"9","key":"5421_CR26","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170166","volume":"7","author":"M Chang","year":"2017","unstructured":"Chang M, Lv H, Zhang W, Ma C, He X, Zhao S, Zhang ZW, Zeng YX, Song S, Niu Y, Tong WM (2017) Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain. Open Biol 7(9):170166","journal-title":"Open Biol"},{"issue":"8","key":"5421_CR27","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1242\/dev.102376","volume":"141","author":"X Varelas","year":"2014","unstructured":"Varelas X (2014) The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development 141(8):1614\u20131626","journal-title":"Development"},{"issue":"1","key":"5421_CR28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12964-019-0383-x","volume":"17","author":"D Kumar","year":"2019","unstructured":"Kumar D, Nitzan E, Kalcheim C (2019) YAP promotes neural crest emigration through interactions with BMP and Wnt activities. Cell Commun Signal 17(1):69","journal-title":"Cell Commun Signal"},{"issue":"5","key":"5421_CR29","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.stemcr.2019.03.009","volume":"12","author":"Y Zaltsman","year":"2019","unstructured":"Zaltsman Y, Masuko S, Bensen JJ, Kiessling LL (2019) Angiomotin regulates YAP localization during neural differentiation of human pluripotent stem cells. Stem Cell Rep 12(5):869\u2013877","journal-title":"Stem Cell Rep"},{"issue":"36","key":"5421_CR30","doi-asserted-by":"publisher","first-page":"12039","DOI":"10.1523\/JNEUROSCI.0486-14.2014","volume":"34","author":"M Yao","year":"2014","unstructured":"Yao M, Wang Y, Zhang P, Chen H, Xu Z, Jiao J, Yuan Z (2014) BMP2-SMAD signaling represses the proliferation of embryonic neural stem cells through YAP. J Neurosci 34(36):12039\u201312048","journal-title":"J Neurosci"},{"issue":"4","key":"5421_CR31","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41580-018-0086-y","volume":"20","author":"IM Moya","year":"2019","unstructured":"Moya IM, Halder G (2019) Hippo-YAP\/TAZ signalling in organ regeneration and regenerative medicine. Nat Rev Mol Cell Biol 20(4):211\u2013226","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"5421_CR32","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/s41467-022-28913-5","volume":"13","author":"S Chen","year":"2022","unstructured":"Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W (2022) Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis. Nat Commun 13(1):1248","journal-title":"Nat Commun"},{"key":"5421_CR33","doi-asserted-by":"publisher","first-page":"rbac002","DOI":"10.1093\/rb\/rbac002","volume":"9","author":"H Yu","year":"2022","unstructured":"Yu H, Hou Z, Chen N, Luo R, Yang L, Miao M, Ma X, Zhou L, He F, Shen Y, Liu X, Wang Y (2022) Yes-associated protein contributes to magnesium alloy-derivedinflammation in endothelial cells. Regen Biomater 9:rbac002","journal-title":"Regen Biomater"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-023-05421-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-023-05421-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-023-05421-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T13:16:22Z","timestamp":1702559782000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-023-05421-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,15]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["5421"],"URL":"https:\/\/doi.org\/10.1007\/s00383-023-05421-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2323729\/v1","asserted-by":"object"}]},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,15]]},"assertion":[{"value":"7 February 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The studies involving human participants were reviewed and approved by the Ethics Committee of Zhujiang Hospital of Southern Medical University. Written informed consent was obtained from patients\u2019 parents for the publication of any potentially identifiable images or data included in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"126"}}