{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:57:51Z","timestamp":1787237871328,"version":"build-2736575974"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["466815475"],"award-info":[{"award-number":["466815475"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["175300"],"award-info":[{"award-number":["175300"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SickKids Congenital Diaphragmatic Hernia Fund","award":["R00DH00000"],"award-info":[{"award-number":["R00DH00000"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"DOI":"10.1007\/s00383-023-05583-y","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:01:43Z","timestamp":1700438503000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characterization of the congenital diaphragmatic hernia model in C57BL\/6J fetal mice: a step toward lineage tracing experiments"],"prefix":"10.1007","volume":"39","author":[{"given":"Fabian","family":"Doktor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca Lopes","family":"Figueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasra","family":"Khalaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizah","family":"Ijaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matisse","family":"Blundell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Antounians","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Zani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"issue":"11","key":"5583_CR1","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1016\/j.jpedsurg.2020.06.022","volume":"55","author":"M Paoletti","year":"2020","unstructured":"Paoletti M, Raffler G, Gaffi MS, Antounians L, Lauriti G, Zani A (2020) Prevalence and risk factors for congenital diaphragmatic hernia: a global view. J Pediatr Surg 55(11):2297\u20132307. https:\/\/doi.org\/10.1016\/j.jpedsurg.2020.06.022","journal-title":"J Pediatr Surg"},{"issue":"3","key":"5583_CR2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/pd.6120","volume":"42","author":"F Russo","year":"2022","unstructured":"Russo F, Benachi A, Gratacos E et al (2022) Antenatal management of congenital diaphragmatic hernia: what\u2019s next\u202f? Prenat Diagn 42(3):291\u2013300. https:\/\/doi.org\/10.1002\/pd.6120","journal-title":"Prenat Diagn"},{"issue":"1","key":"5583_CR3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41572-022-00362-w","volume":"8","author":"A Zani","year":"2022","unstructured":"Zani A, Chung WK, Deprest J et al (2022) Congenital diaphragmatic hernia. Nat Rev Dis Prim 8(1):37. https:\/\/doi.org\/10.1038\/s41572-022-00362-w. (Published 2022 Jun 1)","journal-title":"Nat Rev Dis Prim"},{"issue":"4","key":"5583_CR4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1055\/s-0039-1693993","volume":"29","author":"L Antounians","year":"2019","unstructured":"Antounians L, Figueira RL, Sbragia L, Zani A (2019) Congenital diaphragmatic hernia: state of the art in translating experimental research to the bedside. Eur J Pediatr Surg 29(4):317\u2013327. https:\/\/doi.org\/10.1055\/s-0039-1693993","journal-title":"Eur J Pediatr Surg"},{"issue":"3","key":"5583_CR5","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1165\/rcmb.2009-0076OC","volume":"42","author":"RD Clugston","year":"2010","unstructured":"Clugston RD, Zhang W, Alvarez S, de Lera AR, Greer JJ (2010) Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia. Am J Respir Cell Mol Biol 42(3):276\u2013285. https:\/\/doi.org\/10.1165\/rcmb.2009-0076OC","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"5583_CR6","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.2353\/ajpath.2006.060445","volume":"169","author":"RD Clugston","year":"2006","unstructured":"Clugston RD, Klattig J, Englert C et al (2006) Teratogen-induced, dietary and genetic models of congenital diaphragmatic hernia share a common mechanism of pathogenesis. Am J Pathol 169(5):1541\u20131549. https:\/\/doi.org\/10.2353\/ajpath.2006.060445","journal-title":"Am J Pathol"},{"issue":"1","key":"5583_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41390-021-01409-6","volume":"91","author":"AW Rocke","year":"2022","unstructured":"Rocke AW, Clarke TG, Dalmer TRA, McCluskey SA, Rivas JFG, Clugston RD (2022) Low maternal vitamin A intake increases the incidence of teratogen induced congenital diaphragmatic hernia in mice. Pediatr Res 91(1):83\u201391. https:\/\/doi.org\/10.1038\/s41390-021-01409-6","journal-title":"Pediatr Res"},{"issue":"1","key":"5583_CR8","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/sctm.20-0199","volume":"10","author":"SM Kunisaki","year":"2021","unstructured":"Kunisaki SM, Jiang G, Biancotti JC et al (2021) Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung. Stem Cells Transl Med 10(1):98\u2013114. https:\/\/doi.org\/10.1002\/sctm.20-0199","journal-title":"Stem Cells Transl Med"},{"key":"5583_CR9","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jss.2018.06.064","volume":"231","author":"ZD Fox","year":"2018","unstructured":"Fox ZD, Jiang G, Ho KKY, Walker KA, Liu AP, Kunisaki SM (2018) Fetal lung transcriptome patterns in an ex vivo compression model of diaphragmatic hernia. J Surg Res 231:411\u2013420. https:\/\/doi.org\/10.1016\/j.jss.2018.06.064","journal-title":"J Surg Res"},{"issue":"8","key":"5583_CR10","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/0022-3468(90)90190-k","volume":"25","author":"D Kluth","year":"1990","unstructured":"Kluth D, Kangah R, Reich P, Tenbrinck R, Tibboel D, Lambrecht W (1990) Nitrofen-induced diaphragmatic hernias in rats: an animal model. J Pediatr Surg 25(8):850\u2013854. https:\/\/doi.org\/10.1016\/0022-3468(90)90190-k","journal-title":"J Pediatr Surg"},{"issue":"6","key":"5583_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.sempedsurg.2022.151228","volume":"31","author":"F Doktor","year":"2022","unstructured":"Doktor F, Antounians L, Lacher M, Zani A (2022) Congenital lung malformations: dysregulated lung developmental processes and altered signaling pathways. Semin Pediatr Surg 31(6):151228. https:\/\/doi.org\/10.1016\/j.sempedsurg.2022.151228","journal-title":"Semin Pediatr Surg"},{"issue":"8","key":"5583_CR12","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1002\/bdra.20370","volume":"79","author":"N Beurskens","year":"2007","unstructured":"Beurskens N, Klaassens M, Rottier R, de Klein A, Tibboel D (2007) Linking animal models to human congenital diaphragmatic hernia. Birth Defects Res A Clin Mol Teratol 79(8):565\u2013572. https:\/\/doi.org\/10.1002\/bdra.20370","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"9","key":"5583_CR13","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/j.jpedsurg.2017.12.002","volume":"53","author":"CM Burgos","year":"2018","unstructured":"Burgos CM, Davey MG, Riley JS, Jia H, Flake AW, Peranteau WH (2018) Lung function and pulmonary artery blood flow following prenatal maternal retinoic acid and imatinib in the nitrofen model of congenital diaphragmatic hernia. J Pediatr Surg 53(9):1681\u20131687. https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.12.002","journal-title":"J Pediatr Surg"},{"issue":"3","key":"5583_CR14","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.jpedsurg.2007.10.030","volume":"43","author":"S Montedonico","year":"2008","unstructured":"Montedonico S, Sugimoto K, Felle P, Bannigan J, Puri P (2008) Prenatal treatment with retinoic acid promotes pulmonary alveologenesis in the nitrofen model of congenital diaphragmatic hernia. J Pediatr Surg 43(3):500\u2013507. https:\/\/doi.org\/10.1016\/j.jpedsurg.2007.10.030","journal-title":"J Pediatr Surg"},{"issue":"1","key":"5583_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00383-018-4375-5","volume":"35","author":"L Montalva","year":"2019","unstructured":"Montalva L, Zani A (2019) Assessment of the nitrofen model of congenital diaphragmatic hernia and of the dysregulated factors involved in pulmonary hypoplasia. Pediatr Surg Int 35(1):41\u201361. https:\/\/doi.org\/10.1007\/s00383-018-4375-5","journal-title":"Pediatr Surg Int"},{"issue":"6","key":"5583_CR16","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/s41390-019-0345-4","volume":"85","author":"L Montalva","year":"2019","unstructured":"Montalva L, Antounians L, Zani A (2019) Pulmonary hypertension secondary to congenital diaphragmatic hernia: factors and pathways involved in pulmonary vascular remodeling. Pediatr Res 85(6):754\u2013768. https:\/\/doi.org\/10.1038\/s41390-019-0345-4","journal-title":"Pediatr Res"},{"issue":"2","key":"5583_CR17","doi-asserted-by":"publisher","first-page":"104","DOI":"10.14348\/molcells.2019.0006","volume":"42","author":"SS Wu","year":"2019","unstructured":"Wu SS, Lee JH, Koo BK (2019) Lineage tracing: computational reconstruction goes beyond the limit of imaging. Mol Cells 42(2):104\u2013112. https:\/\/doi.org\/10.14348\/molcells.2019.0006","journal-title":"Mol Cells"},{"issue":"1\u20132","key":"5583_CR18","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cell.2012.01.002","volume":"148","author":"K Kretzschmar","year":"2012","unstructured":"Kretzschmar K, Watt FM (2012) Lineage tracing. Cell 148(1\u20132):33\u201345. https:\/\/doi.org\/10.1016\/j.cell.2012.01.002","journal-title":"Cell"},{"issue":"11","key":"5583_CR19","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1007\/s00018-011-0669-7","volume":"68","author":"M Kawamata","year":"2011","unstructured":"Kawamata M, Ochiya T (2011) Gene-manipulated embryonic stem cells for rat transgenesis. Cell Mol Life Sci 68(11):1911\u20131915. https:\/\/doi.org\/10.1007\/s00018-011-0669-7","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"5583_CR20","doi-asserted-by":"publisher","first-page":"e293","DOI":"10.1038\/mtna.2016.9","volume":"5","author":"BS Pradhan","year":"2016","unstructured":"Pradhan BS, Majumdar SS (2016) An efficient method for generation of transgenic rats avoiding embryo manipulation. Mol Ther Nucleic Acids. 5(3):e293. https:\/\/doi.org\/10.1038\/mtna.2016.9. (Published 2016 Mar 8)","journal-title":"Mol Ther Nucleic Acids."},{"key":"5583_CR21","doi-asserted-by":"publisher","first-page":"867307","DOI":"10.3389\/fped.2022.867307","volume":"10","author":"F Friedmacher","year":"2022","unstructured":"Friedmacher F, Rolle U, Puri P (2022) Genetically modified mouse models of congenital diaphragmatic hernia: opportunities and limitations for studying altered lung development. Front Pediatr 10:867307. https:\/\/doi.org\/10.3389\/fped.2022.867307. (Published 2022 May 13)","journal-title":"Front Pediatr"},{"issue":"10","key":"5583_CR22","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1016\/j.ajpath.2016.07.006","volume":"186","author":"PK Donahoe","year":"2016","unstructured":"Donahoe PK, Longoni M, High FA (2016) Polygenic causes of congenital diaphragmatic hernia produce common lung pathologies. Am J Pathol 186(10):2532\u20132543. https:\/\/doi.org\/10.1016\/j.ajpath.2016.07.006","journal-title":"Am J Pathol"},{"issue":"4","key":"5583_CR23","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1164\/rccm.200809-1522ST","volume":"181","author":"CC Hsia","year":"2010","unstructured":"Hsia CC, Hyde DM, Ochs M, Weibel ER, ATS\/ERS Joint Task Force on Quantitative Assessment of Lung Structure (2010) An official research policy statement of the American Thoracic Society\/European Respiratory Society: standards for quantitative assessment of lung structure. Am J Respir Crit Care Med 181(4):394\u2013418. https:\/\/doi.org\/10.1164\/rccm.200809-1522ST","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"5583_CR24","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12890-019-0915-6","volume":"19","author":"G Crowley","year":"2019","unstructured":"Crowley G, Kwon S, Caraher EJ et al (2019) Quantitative lung morphology: semi-automated measurement of mean linear intercept. BMC Pulm Med 19(1):206. https:\/\/doi.org\/10.1186\/s12890-019-0915-6. (Published 2019 Nov 9)","journal-title":"BMC Pulm Med"},{"issue":"4","key":"5583_CR25","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","volume":"55","author":"SA Bustin","year":"2009","unstructured":"Bustin SA, Benes V, Garson JA et al (2009) The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55(4):611\u2013622. https:\/\/doi.org\/10.1373\/clinchem.2008.112797","journal-title":"Clin Chem"},{"issue":"10","key":"5583_CR26","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1093\/stcltm\/szac063","volume":"11","author":"K Khalaj","year":"2022","unstructured":"Khalaj K, Figueira RL, Antounians L et al (2022) Treatment with amniotic fluid stem cell extracellular vesicles promotes fetal lung branching and cell differentiation at canalicular and saccular stages in experimental pulmonary hypoplasia secondary to congenital diaphragmatic hernia. Stem Cells Transl Med 11(10):1089\u20131102. https:\/\/doi.org\/10.1093\/stcltm\/szac063","journal-title":"Stem Cells Transl Med"},{"issue":"3","key":"5583_CR27","doi-asserted-by":"publisher","first-page":"L317","DOI":"10.1152\/ajplung.00104.2018","volume":"317","author":"HM Kool","year":"2019","unstructured":"Kool HM, B\u00fcrgisser PE, Edel GG et al (2019) Inhibition of retinoic acid signaling induces aberrant pericyte coverage and differentiation resulting in vascular defects in congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol 317(3):L317\u2013L331. https:\/\/doi.org\/10.1152\/ajplung.00104.2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4","key":"5583_CR28","doi-asserted-by":"publisher","first-page":"L1079","DOI":"10.1152\/ajplung.00286.2007","volume":"293","author":"BR Noble","year":"2007","unstructured":"Noble BR, Babiuk RP, Clugston RD et al (2007) Mechanisms of action of the congenital diaphragmatic hernia-inducing teratogen nitrofen. Am J Physiol Lung Cell Mol Physiol 293(4):L1079\u2013L1087. https:\/\/doi.org\/10.1152\/ajplung.00286.2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"5583_CR29","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1242\/dmm.008821","volume":"6","author":"A Grzenda","year":"2013","unstructured":"Grzenda A, Shannon J, Fisher J, Arkovitz MS (2013) Timing and expression of the angiopoietin-1-Tie-2 pathway in murine lung development and congenital diaphragmatic hernia. Dis Model Mech 6(1):106\u2013114. https:\/\/doi.org\/10.1242\/dmm.008821","journal-title":"Dis Model Mech"},{"issue":"4","key":"5583_CR30","doi-asserted-by":"publisher","first-page":"e0214793","DOI":"10.1371\/journal.pone.0214793","volume":"14","author":"TM Nguyen","year":"2019","unstructured":"Nguyen TM, Jimenez J, Rendin LE et al (2019) The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs [published correction appears in PLoS One. 2019 Jul 3;14(7):e0217322]. PLoS ONE 14(4):e0214793. https:\/\/doi.org\/10.1371\/journal.pone.0214793","journal-title":"PLoS ONE"},{"issue":"6","key":"5583_CR31","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.jpedsurg.2013.03.013","volume":"48","author":"E Shue","year":"2013","unstructured":"Shue E, Wu J, Schecter S, Miniati D (2013) Aberrant pulmonary lymphatic development in the nitrofen mouse model of congenital diaphragmatic hernia. J Pediatr Surg 48(6):1198\u20131204. https:\/\/doi.org\/10.1016\/j.jpedsurg.2013.03.013","journal-title":"J Pediatr Surg"},{"issue":"7","key":"5583_CR32","doi-asserted-by":"publisher","first-page":"R82","DOI":"10.1186\/gb-2013-14-7-r82","volume":"14","author":"MM Simon","year":"2013","unstructured":"Simon MM, Greenaway S, White JK et al (2013) A comparative phenotypic and genomic analysis of C57BL\/6J and C57BL\/6N mouse strains. Genome Biol 14(7):R82. https:\/\/doi.org\/10.1186\/gb-2013-14-7-r82. (Published 2013 Jul 31)","journal-title":"Genome Biol"},{"issue":"4","key":"5583_CR33","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1136\/thx.31.4.450","volume":"31","author":"A Hislop","year":"1976","unstructured":"Hislop A, Reid L (1976) Persistent hypoplasia of the lung after repair of congenital diaphragmatic hernia. Thorax 31(4):450\u2013455. https:\/\/doi.org\/10.1136\/thx.31.4.450","journal-title":"Thorax"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-023-05583-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-023-05583-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-023-05583-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T13:33:44Z","timestamp":1702560824000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-023-05583-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["5583"],"URL":"https:\/\/doi.org\/10.1007\/s00383-023-05583-y","relation":{},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"25 October 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Cnflict of interest"}}],"article-number":"296"}}