{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T05:06:38Z","timestamp":1734152798265,"version":"3.30.2"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Japan Society for the Promotion of Science KAKENHI grants","award":["20K08216"],"award-info":[{"award-number":["20K08216"]}]},{"name":"Juntendo University Project Grant","award":["No. 2023-34"],"award-info":[{"award-number":["No. 2023-34"]}]},{"name":"President's Grant for Young Researchers Juntendo University","award":["No. 2023-03"],"award-info":[{"award-number":["No. 2023-03"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"DOI":"10.1007\/s00383-024-05867-x","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T15:03:33Z","timestamp":1730127813000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Angiopoietin-1 attenuates lipopolysaccharide-induced endotoxemia in a Hirschsprung\u2019s disease murine model by improving intestinal vascular integrity: implications for treating postoperative Hirschsprung-associated enterocolitis"],"prefix":"10.1007","volume":"40","author":[{"given":"Asuka","family":"Ishiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Suda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuxuan","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minhua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey J.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuyuki","family":"Yamataka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"issue":"1","key":"5867_CR1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s00383-024-05688-y","volume":"40","author":"W Feng","year":"2024","unstructured":"Feng W, Zhang B, Fan L et al (2024) Clinical characteristics and influence of postoperative Hirschsprung-associated enterocolitis: retrospective study at a tertiary children\u2019s hospital. Pediatr Surg Int 40(1):106. https:\/\/doi.org\/10.1007\/s00383-024-05688-y","journal-title":"Pediatr Surg Int"},{"issue":"1","key":"5867_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00383-022-05308-7","volume":"39","author":"K Suda","year":"2022","unstructured":"Suda K, Yamada S, Miyahara K et al (2022) High intestinal vascular permeability in a murine model for Hirschsprung\u2019s disease: implications for postoperative Hirschsprung-associated enterocolitis. Pediatr Surg Int 39(1):15. https:\/\/doi.org\/10.1007\/s00383-022-05308-7","journal-title":"Pediatr Surg Int"},{"issue":"5","key":"5867_CR3","doi-asserted-by":"publisher","first-page":"4602","DOI":"10.3390\/ijms24054602","volume":"24","author":"S Li","year":"2023","unstructured":"Li S, Zhang Y, Li S, Li K et al (2023) Update on the pathogenesis of the Hirschsprung-associated enterocolitis. Int J Mol Sci 24(5):4602. https:\/\/doi.org\/10.3390\/ijms24054602","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5867_CR4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00383-023-05364-7","volume":"39","author":"S Chantakhow","year":"2023","unstructured":"Chantakhow S, Tepmalai K, Singhavejsakul J, Tantraworasin A, Khorana J (2023) Prognostic factors of postoperative Hirschsprung-associated enterocolitis: a cohort study. Pediatr Surg Int 39(1):77. https:\/\/doi.org\/10.1007\/s00383-023-05364-7","journal-title":"Pediatr Surg Int"},{"issue":"6","key":"5867_CR5","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/j.jpedsurg.2013.03.025","volume":"48","author":"A Aggarwal","year":"2013","unstructured":"Aggarwal A, Jain M, Frykman PK, Xu C, Mukherjee S, Muensterer OJ (2013) Multiphoton microscopy to identify and characterize the transition zone in a mouse model of Hirschsprung disease. J Pediatr Surg 48(6):1288\u20131293","journal-title":"J Pediatr Surg"},{"issue":"2","key":"5867_CR6","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1053\/j.gastro.2008.09.064","volume":"136","author":"F Scaldaferri","year":"2009","unstructured":"Scaldaferri F, Vetrano S, Sans M et al (2009) VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis. Gastroenterology 136(2):585\u201395.e5","journal-title":"Gastroenterology"},{"issue":"6","key":"5867_CR7","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1084\/jem.20060375","volume":"203","author":"K Yano","year":"2006","unstructured":"Yano K, Liaw PC, Mullington JM et al (2006) Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med 203(6):1447\u20131458","journal-title":"J Exp Med"},{"issue":"2","key":"5867_CR8","doi-asserted-by":"publisher","first-page":"107906","DOI":"10.1016\/j.celrep.2020.107906","volume":"32","author":"K Maruyama","year":"2020","unstructured":"Maruyama K, Kidoya H, Takemura N et al (2020) Zinc finger protein St18 protects against septic death by inhibiting VEGF-A from macrophages. Cell Rep 32(2):107906","journal-title":"Cell Rep"},{"issue":"9","key":"5867_CR9","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1161\/CIRCRESAHA.116.310477","volume":"120","author":"K Heinolainen","year":"2017","unstructured":"Heinolainen K, Karaman S, D\u2019Amico G et al (2017) VEGFR3 modulates vascular permeability by controlling VEGF\/VEGFR2 signaling. Circ Res 120(9):1414\u20131425","journal-title":"Circ Res"},{"issue":"1","key":"5867_CR10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.molmed.2012.10.010","volume":"19","author":"GY Koh","year":"2013","unstructured":"Koh GY (2013) Orchestral actions of angiopoietin-1 in vascular regeneration. Trends Mol Med 19(1):31\u201339. https:\/\/doi.org\/10.1016\/j.molmed.2012.10.010","journal-title":"Trends Mol Med"},{"issue":"4","key":"5867_CR11","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1089\/sur.2016.021","volume":"17","author":"AJ Lewis","year":"2016","unstructured":"Lewis AJ, Seymour CW, Rosengart MR (2016) Current Murine Models of Sepsis. Surg Infect (Larchmt) 17(4):385\u2013393. https:\/\/doi.org\/10.1089\/sur.2016.021","journal-title":"Surg Infect (Larchmt)"},{"key":"5867_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.04.001","author":"DJ Hackam","year":"2018","unstructured":"Hackam DJ, Sodhi CP (2018) Toll-Like Receptor-Mediated Intestinal Inflammatory Imbalance in the Pathogenesis of Necrotizing Enterocolitis. Cell Mol Gastroenterol Hepatol. https:\/\/doi.org\/10.1016\/j.jcmgh.2018.04.001","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"5","key":"5867_CR13","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3390\/cells8050471","volume":"8","author":"RG Akwii","year":"2019","unstructured":"Akwii RG, Sajib MS, Zahra FT, Mikelis CM (2019) Role of angiopoietin-2 in vascular physiology and pathophysiology. Cells 8(5):471. https:\/\/doi.org\/10.3390\/cells8050471","journal-title":"Cells"},{"key":"5867_CR14","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.isci.2019.10.006","volume":"20","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Kontos CD, Annex BH, Popel AS (2019) Angiopoietin-tie signaling pathway in endothelial cells: a computational model. iScience 20:497\u2013511. https:\/\/doi.org\/10.1016\/j.isci.2019.10.006","journal-title":"iScience"},{"key":"5867_CR15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/nyas.12726","volume":"1347","author":"A Scholz","year":"2015","unstructured":"Scholz A, Plate KH, Reiss Y (2015) Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation. Ann N Y Acad Sci 1347:45\u201351. https:\/\/doi.org\/10.1111\/nyas.12726","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"5867_CR16","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1038\/s41390-021-01544-0","volume":"91","author":"U Salimi","year":"2022","unstructured":"Salimi U, Menden HL, Mabry SM, Xia S, Sampath V (2022) Angiopoietin-1 protects against endotoxin-induced neonatal lung injury and alveolar simplification in mice. Pediatr Res 91(6):1405\u20131415. https:\/\/doi.org\/10.1038\/s41390-021-01544-0","journal-title":"Pediatr Res"},{"issue":"8","key":"5867_CR17","first-page":"4557","volume":"7","author":"U Erben","year":"2014","unstructured":"Erben U, Loddenkemper C, Doerfel K et al (2014) (2014) A guide to histomorphological evaluation of intestinal inflammation in mouse models. Int J Clin Exp Pathol 7(8):4557\u20134576","journal-title":"Int J Clin Exp Pathol"},{"issue":"5","key":"5867_CR18","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.devcel.2013.08.020","volume":"26","author":"M Giannotta","year":"2013","unstructured":"Giannotta M, Trani M, Dejana E (2013) VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity. Develop cell 26(5):441\u2013454. https:\/\/doi.org\/10.1016\/j.devcel.2013.08.020","journal-title":"Develop cell"},{"issue":"1","key":"5867_CR19","doi-asserted-by":"publisher","first-page":"3528","DOI":"10.4081\/ejh.2023.3528","volume":"67","author":"J Lin","year":"2023","unstructured":"Lin J, Jiang L, Guo K, Feng N (2023) Decreased VEGFA alleviates the symptoms of LPS-induced sepsis in a mouse model by inhibiting glycolysis and thereby regulating the polarization of macrophages. Eur J Histochem 67(1):3528. https:\/\/doi.org\/10.4081\/ejh.2023.3528","journal-title":"Eur J Histochem"},{"key":"5867_CR20","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3389\/fimmu.2017.01878","volume":"19","author":"M Silva","year":"1878","unstructured":"Silva M, Videira PA (1878) Sackstein R (2018) E-selectin ligands in the human mononuclear phagocyte system: implications for infection, inflammation, and immunotherapy. Front Immunol 19:8. https:\/\/doi.org\/10.3389\/fimmu.2017.01878","journal-title":"Front Immunol"},{"issue":"2","key":"5867_CR21","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1053\/j.gastro.2008.09.064","volume":"136","author":"F Scaldaferri","year":"2009","unstructured":"Scaldaferri F, Vetrano S, Sans M et al (2009) VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis. Gastroenterology 136(2):585\u201395.e5. https:\/\/doi.org\/10.1053\/j.gastro.2008.09.064","journal-title":"Gastroenterology"},{"issue":"4","key":"5867_CR22","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1053\/j.gastro.2020.06.038","volume":"159","author":"M Rawat","year":"2020","unstructured":"Rawat M, Nighot M, Al-Sadi R et al (2020) IL1B increases intestinal tight junction permeability by up-regulation of MIR200C-3p. Which Degrades Occludin mRNA Gastroenterol 159(4):1375\u20131389. https:\/\/doi.org\/10.1053\/j.gastro.2020.06.038","journal-title":"Which Degrades Occludin mRNA Gastroenterol"},{"issue":"9","key":"5867_CR23","doi-asserted-by":"publisher","first-page":"5449","DOI":"10.1074\/jbc.M114.600692","volume":"290","author":"H Menden","year":"2015","unstructured":"Menden H, Welak S, Cossette S, Ramchandran R, Sampath V (2015) Lipopolysaccharide (LPS)-mediated angiopoietin-2-dependent autocrine angiogenesis is regulated by NADPH oxidase 2 (Nox2) in human pulmonary microvascular endothelial cells. J Biol Chem 290(9):5449\u20135461. https:\/\/doi.org\/10.1074\/jbc.M114.600692","journal-title":"J Biol Chem"},{"issue":"2","key":"5867_CR24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1164\/rccm.201708-1733OC","volume":"198","author":"B Gutbier","year":"2018","unstructured":"Gutbier B, Neuhau\u00df AK, Reppe K, et al (2018) Prognostic and pathogenic role of angiopoietin-1 and -2 in pneumonia. Am J Respir Crit Care Med 198(2):220\u2013231. https:\/\/doi.org\/10.1164\/rccm.201708-1733OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"5867_CR25","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1161\/01.RES.0000070587.79937.F0","volume":"92","author":"YD Zhao","year":"2003","unstructured":"Zhao YD, Campbell AIM, Robb M, Ng D, Stewart DJ (2003) Protective role of angiopoietin-1 in experimental pulmonary hypertension. Circ Res 92(9):984\u2013991. https:\/\/doi.org\/10.1161\/01.RES.0000070587.79937.F0","journal-title":"Circ Res"},{"issue":"6","key":"5867_CR26","doi-asserted-by":"publisher","first-page":"39400","DOI":"10.1038\/srep39400","volume":"19","author":"YC Tsai","year":"2016","unstructured":"Tsai YC, Lee CS, Chiu YW et al (2016) Angiopoietin-2, Angiopoietin-1 and subclinical cardiovascular disease in Chronic Kidney Disease. Sci Rep 19(6):39400. https:\/\/doi.org\/10.1038\/srep39400","journal-title":"Sci Rep"},{"issue":"4","key":"5867_CR27","doi-asserted-by":"publisher","first-page":"F952","DOI":"10.1152\/ajprenal.00064.2009","volume":"297","author":"YJ Jung","year":"2009","unstructured":"Jung YJ, Kim DH, Lee AS (2009) Peritubular capillary preservation with COMP-angiopoietin-1 decreases ischemia-reperfusion-induced acute kidney injury. Am J Physiol Renal Physiol 297(4):F952\u2013F960. https:\/\/doi.org\/10.1152\/ajprenal.00064.2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"5867_CR28","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000158285.57191.60","author":"SM Dallabrida","year":"2005","unstructured":"Dallabrida SM, Ismail N, Oberle JR, Himes BE, Rupnick MA (2005) Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins. Circ Res. https:\/\/doi.org\/10.1161\/01.RES.0000158285.57191.60","journal-title":"Circ Res"},{"issue":"9","key":"5867_CR29","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/nrd.2016.278","volume":"16","author":"P Saharinen","year":"2017","unstructured":"Saharinen P, Eklund L, Alitalo K (2017) Therapeutic targeting of the angiopoietin-TIE pathway. Nat Rev Drug Discov 16(9):635\u2013661. https:\/\/doi.org\/10.1038\/nrd.2016.278","journal-title":"Nat Rev Drug Discov"},{"issue":"8","key":"5867_CR30","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1097\/01.lab.0000082383.40635.fe","volume":"83","author":"N Nourhaghighi","year":"2003","unstructured":"Nourhaghighi N, Teichert-Kuliszewska K, Davis J, Stewart DJ, Nag S (2003) Altered expression of angiopoietins during blood-brain barrier breakdown and angiogenesis. Lab Invest 83(8):1211\u20131222. https:\/\/doi.org\/10.1097\/01.lab.0000082383.40635.fe","journal-title":"Lab Invest"},{"key":"5867_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.07.016","author":"AE Price","year":"2018","unstructured":"Price AE, Shamardani K, Lugo KA et al (2018) A map of toll-like receptor expression in the intestinal epithelium reveals distinct spatial, cell type-specific, and temporal patterns. Immunity. https:\/\/doi.org\/10.1016\/j.immuni.2018.07.016","journal-title":"Immunity"},{"issue":"7","key":"5867_CR32","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1002\/ibd.21527","volume":"17","author":"M Fukata","year":"2011","unstructured":"Fukata M, Shang L, Santaolalla R et al (2011) Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis. Inflamm Bowel Dis 17(7):1464\u20131473. https:\/\/doi.org\/10.1002\/ibd.21527","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"5867_CR33","doi-asserted-by":"publisher","first-page":"37877","DOI":"10.1038\/srep37877","volume":"1","author":"E Gazquez","year":"2016","unstructured":"Gazquez E, Watanabe Y, Broders-Bondon F (2016) Endothelin-3 stimulates cell adhesion and cooperates with \u03b21-integrins during enteric nervous system ontogenesis. Sci Rep 1(6):37877. https:\/\/doi.org\/10.1038\/srep37877","journal-title":"Sci Rep"},{"issue":"4","key":"5867_CR34","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1046\/j.1365-2990.2003.00472.x","volume":"29","author":"S Poncet","year":"2003","unstructured":"Poncet S, Gasc JM, Janzer RC, Meyer S, Juillerat-Jeanneret L (2003) Expression of Tie-2 in human peripheral and autonomic nervous system. Neuropathol Appl Neurobiol 29(4):361\u2013369. https:\/\/doi.org\/10.1046\/j.1365-2990.2003.00472.x","journal-title":"Neuropathol Appl Neurobiol"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-024-05867-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-024-05867-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-024-05867-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T03:02:02Z","timestamp":1734058922000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-024-05867-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5867"],"URL":"https:\/\/doi.org\/10.1007\/s00383-024-05867-x","relation":{},"ISSN":["1437-9813"],"issn-type":[{"type":"electronic","value":"1437-9813"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"18 October 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"277"}}