{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T04:39:31Z","timestamp":1771907971570,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Congenital diaphragmatic hernia (CDH) is associated with congenital heart disease (CHD) and index newborns reportedly may experience cardiac arrhythmia disorders [Tella et al.\u2014Pediatric Critical Care Medicine 2022]. This study analyses, details and reports contemporary outcome metrics of CHD and cardiac rhythm disease (CRD) in CDH babies attending a university surgical centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of medical records of all newborns undergoing Bochdalek\u00a0CDH\u00a0repair between 1999 and 2021 at a university paediatric surgical centre.\u00a0CDH\u00a0newborns with CHD and neonatal arrythmias were identified from echocardiogram and electrocardiogram (ECG) investigative studies. Operative native diaphragm and \/ or use of patch repair(s) was documented. Outcome(s) measured\u2014(i) mortality and (ii) cardiopulmonary interventions including ventilatory strategies\u2014ECMO (%), inotropes and anti-arrhythmic therapy(s).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 173\u00a0CDH neonates, 95 (55%) had CHD of which 9 babies (10%) had cardiac arrhythmias.\u00a0CDH\u00a0and co-existing CHD was linked with (a) lower infant birth weights (3130\u00a0g vs 3357\u00a0g,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05), (b) increased use of inotrope agents (48.4% vs 39.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and (c) greater use of high-frequency oscillatory ventilation (38.9% vs 23%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004).\u00a0CDH\u00a0babies experiencing arrythmias were at higher risk (%) of developing pulmonary hypertension (66.7% vs 28.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). No significant differences were observed in ECMO utilisation (12% vs 6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.46) or patch repair(s) (53% vs 46%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06) in\u00a0CDH\u00a0patients with and without CHD. CHD was not associated with increased risk(s) of mortality (OR 2.58, 95% CI 0.81\u20138.24,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.11). Of 9 index\u00a0CDH\u00a0patients with arrhythmias\u20144 babies (44%) required interventional treatments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CHD was prevalent in a high percentage (%) of CDH newborns treated at this university centre and associated with increased use (%) of cardiovascular respiratory support including patch repair. A minority of patients (2.3%) had cardiac rhythm disorders requiring treatment(s). In those developing arrhythmias pulmonary hypertension may be a risk-linked event. Optimising outcomes to offset pulmonary hypertension requires further appraisal. Future large-scale population studies may help underscore the \u2018real apparent incidence\u2019 of cardiac rhythm disorders in CDH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00383-024-05927-2","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T21:23:09Z","timestamp":1734556989000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Congenital heart disease and arrhythmia disorders in newborns with congenital diaphragmatic hernia: a 23-year experience at a UK university pediatric surgical centre"],"prefix":"10.1007","volume":"41","author":[{"given":"Wan Teng","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Sui","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Losty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"5927_CR1","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.jpedsurg.2019.01.018","volume":"54","author":"L Montalva","year":"2019","unstructured":"Montalva L, Lauriti G, Zani A (2019) Congenital heart disease associated with congenital diaphragmatic hernia: a systematic review on incidence, prenatal diagnosis, management, and outcome. 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