{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:28:49Z","timestamp":1763630929479,"version":"3.45.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study investigates risk factors and surgical outcomes in pediatric patients with congenital heart defects (CHD) who develop ischemic colitis (IC). Previous research indicates a higher IC risk in very low birth weight neonates with CHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis compared an IC-CHD group to a CHD-only group. Key variables included gestational age, birth weight, multiple pregnancies, prematurity, APGAR scores, cardiac and surgical characteristics, Aristotle-Score, and mortality rates. Surgical outcomes such as bowel resection and stoma procedures were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IC-CHD exhibited significantly lower gestational ages and birth weights, with higher rates of multiple pregnancies and prematurity. APGAR scores were notably lower. Cardiac and surgical data showed more frequent ECMO use and shorter cardiopulmonary bypass durations in the IC-CHD group. High rates of bowel resection highlighted severe gastrointestinal involvement. Mortality was significantly higher in IC-CHD with elevated Aristotle scores correlating with poorer outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Gestational age, birth weight, and initial health status are critical in predicting IC risk and surgical outcomes in pediatric patients with CHD. The significantly higher mortality and complex surgical needs in the IC-CHD group underscore the necessity for vigilant monitoring and tailored interventions. Development of targeted therapeutic strategies adjustment for confounding factors in future studies is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00383-024-05950-3","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T12:39:23Z","timestamp":1735216763000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors and surgical outcomes in pediatric patients with congenital heart disease and ischemic colitis"],"prefix":"10.1007","volume":"41","author":[{"given":"N.","family":"Mokhaberi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. P.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Aftzoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"H\u00fcners","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"K\u00f6rner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Armbrust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Biermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kozlik-Feldmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"H\u00fcbler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Reinshagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Tomuschat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"5950_CR1","first-page":"378","volume":"34","author":"W Wongtrakul","year":"2021","unstructured":"Wongtrakul W, Charoenngnam N, Ungprasert P (2021) The correlation between heart failure and the risk of ischemic colitis: a systematic review and meta-analysis. Ann Gastroenterol 34:378\u2013384","journal-title":"Ann Gastroenterol"},{"key":"5950_CR2","doi-asserted-by":"publisher","first-page":"170","DOI":"10.5005\/jp-journals-11002-0016","volume":"1","author":"S Roychaudhuri","year":"2022","unstructured":"Roychaudhuri S, Grewal G, Vijayashankar SS et al (2022) Necrotizing enterocolitis associated with congenital heart disease\u2014A review article. Newborn 1:170\u2013176. https:\/\/doi.org\/10.5005\/jp-journals-11002-0016","journal-title":"Newborn"},{"key":"5950_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/978-3-319-04340-1_19","volume":"364","author":"J Neu","year":"2011","unstructured":"Neu J, Walker WA (2011) Necrotizing enterocolitis. N Engl J Med 364:255\u2013264. https:\/\/doi.org\/10.1007\/978-3-319-04340-1_19","journal-title":"N Engl J Med"},{"key":"5950_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jpeds.2019.12.035","volume":"220","author":"C Flahive","year":"2020","unstructured":"Flahive C, Schlegel A, Mezoff EA (2020) Necrotizing enterocolitis: updates on morbidity and mortality outcomes. J Pediatr 220:7\u20139. https:\/\/doi.org\/10.1016\/j.jpeds.2019.12.035","journal-title":"J Pediatr"},{"key":"5950_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fped.2020.593926","volume":"8","author":"M Klinke","year":"2021","unstructured":"Klinke M, Wiskemann H, Bay B et al (2021) Cardiac and inflammatory necrotizing enterocolitis in newborns are not the same entity. Front Pediatr 8:1\u201310. https:\/\/doi.org\/10.3389\/fped.2020.593926","journal-title":"Front Pediatr"},{"key":"5950_CR6","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.lfs.2007.09.036","volume":"82","author":"PJ Giannone","year":"2008","unstructured":"Giannone PJ, Luce WA, Nankervis CA et al (2008) Necrotizing enterocolitis in neonates with congenital heart disease. Life Sci 82:341\u2013347. https:\/\/doi.org\/10.1016\/j.lfs.2007.09.036","journal-title":"Life Sci"},{"key":"5950_CR7","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/chd.12515","volume":"12","author":"C Pfitzer","year":"2017","unstructured":"Pfitzer C, Helm PC, Ferentzi H et al (2017) Changing prevalence of severe congenital heart disease: Results from the National Register for Congenital Heart Defects in Germany. Congenit Heart Dis 12:787\u2013793. https:\/\/doi.org\/10.1111\/chd.12515","journal-title":"Congenit Heart Dis"},{"key":"5950_CR8","doi-asserted-by":"publisher","first-page":"507","DOI":"10.4103\/apc.apc_30_21","volume":"14","author":"H Kashif","year":"2021","unstructured":"Kashif H, Abuelgasim E, Hussain N et al (2021) Necrotizing enterocolitis and congenital heart disease. Ann Pediatr Cardiol 14:507\u2013515. https:\/\/doi.org\/10.4103\/apc.apc_30_21","journal-title":"Ann Pediatr Cardiol"},{"key":"5950_CR9","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1016\/j.athoracsur.2017.04.037","volume":"104","author":"MA Raees","year":"2017","unstructured":"Raees MA, Morgan CD, Pinto VL et al (2017) Neonatal Aortic Arch Reconstruction With Direct Splanchnic Perfusion Avoids Deep Hypothermia. Ann Thorac Surg 104:2054\u20132063. https:\/\/doi.org\/10.1016\/j.athoracsur.2017.04.037","journal-title":"Ann Thorac Surg"},{"key":"5950_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-15807-6","volume":"7","author":"M Boettcher","year":"2017","unstructured":"Boettcher M, Eschenburg G, Mietzsch S et al (2017) Therapeutic targeting of extracellular DNA improves the outcome of intestinal ischemic reperfusion injury in neonatal rats. Sci Rep 7:1\u201310. https:\/\/doi.org\/10.1038\/s41598-017-15807-6","journal-title":"Sci Rep"},{"key":"5950_CR11","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1542\/peds.106.5.1080","volume":"106","author":"DB McElhinney","year":"2000","unstructured":"McElhinney DB, Hedrick HL, Bush DM et al (2000) Necrotizing Enterocolitis in Neonates With Congenital Heart Disease: Risk Factors and Outcomes. Pediatrics 106:1080\u20131087. https:\/\/doi.org\/10.1542\/peds.106.5.1080","journal-title":"Pediatrics"},{"key":"5950_CR12","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.jamcollsurg.2014.11.026","volume":"220","author":"JG Fisher","year":"2015","unstructured":"Fisher JG, Bairdain S, Sparks EA et al (2015) Serious congenital heart disease and necrotizing enterocolitis in very low birth weight neonates. J Am Coll Surg 220:1018-1026.e14. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2014.11.026","journal-title":"J Am Coll Surg"},{"key":"5950_CR13","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1007\/s00246-014-0891-9","volume":"35","author":"AC Baxi","year":"2014","unstructured":"Baxi AC, Josephson CD, Iannucci GJ, Mahle WT (2014) Necrotizing enterocolitis in infants with congenital heart disease: The role of red blood cell transfusions. Pediatr Cardiol 35:1024\u20131029. https:\/\/doi.org\/10.1007\/s00246-014-0891-9","journal-title":"Pediatr Cardiol"},{"key":"5950_CR14","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1093\/bja\/aei014","volume":"94","author":"I Malagon","year":"2005","unstructured":"Malagon I, Onkenhout W, Klok G et al (2005) Gut permeability in paediatric cardiac surgery. Br J Anaesth 94:181\u2013185. https:\/\/doi.org\/10.1093\/bja\/aei014","journal-title":"Br J Anaesth"},{"key":"5950_CR15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1053\/j.pcsu.2004.02.011","volume":"7","author":"F Lacour-Gayet","year":"2004","unstructured":"Lacour-Gayet F, Clarke D, Jacobs J et al (2004) The Aristotle score for congenital heart surgery. Pediatr Card Surg Annu 7:185\u2013191. https:\/\/doi.org\/10.1053\/j.pcsu.2004.02.011","journal-title":"Pediatr Card Surg Annu"},{"key":"5950_CR16","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.ejcts.2004.03.027","volume":"25","author":"F Lacour-Gayet","year":"2004","unstructured":"Lacour-Gayet F, Clarke D, Jacobs J et al (2004) The Aristotle score: A complexity-adjusted method to evaluate surgical results. Eur J Cardiothorac Surg 25:911\u2013924. https:\/\/doi.org\/10.1016\/j.ejcts.2004.03.027","journal-title":"Eur J Cardiothorac Surg"},{"key":"5950_CR17","first-page":"e714","volume":"118","author":"CA Warnes","year":"2008","unstructured":"Warnes CA, Williams RG, Bashore TM et al (2008) Guidelines for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines on the Management of Adults With Congenital Heart Disease): Developed in Collaboration With the American Society of Echocardiography, Heart Rhythm Society, International Society for Adult Congenital Heart Disease, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation 118:e714\u2013e833","journal-title":"Circulation"},{"key":"5950_CR18","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1093\/eurheartj\/ehx685","volume":"39","author":"R Cordina","year":"2018","unstructured":"Cordina R, Nasir Ahmad S, Kotchetkova I et al (2018) Management errors in adults with congenital heart disease: prevalence, sources, and consequences. Eur Heart J 39:982\u2013989. https:\/\/doi.org\/10.1093\/eurheartj\/ehx685","journal-title":"Eur Heart J"},{"key":"5950_CR19","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.jpedsurg.2018.02.014","volume":"53","author":"PE Lau","year":"2018","unstructured":"Lau PE, Cruz SM, Ocampo EC et al (2018) Necrotizing enterocolitis in patients with congenital heart disease: a single center experience. J Pediatr Surg 53:914\u2013917. https:\/\/doi.org\/10.1016\/j.jpedsurg.2018.02.014","journal-title":"J Pediatr Surg"},{"key":"5950_CR20","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1046\/j.1442-200x.1999.01153.x","volume":"41","author":"Y Maeno","year":"1999","unstructured":"Maeno Y, Himeno W, Fujino H et al (1999) Progression of congenital heart disease in the prenatal period. Pediatr Int 41:709\u2013715. https:\/\/doi.org\/10.1046\/j.1442-200x.1999.01153.x","journal-title":"Pediatr Int"},{"key":"5950_CR21","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s13643-020-01487-3","volume":"9","author":"F Morfaw","year":"2020","unstructured":"Morfaw F, Leenus A, Mbuagbaw L et al (2020) Outcomes after corrective surgery for congenital dextro-transposition of the arteries using the arterial switch technique: a scoping systematic review. Syst Rev 9:231. https:\/\/doi.org\/10.1186\/s13643-020-01487-3","journal-title":"Syst Rev"},{"key":"5950_CR22","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1016\/j.earlhumdev.2010.12.045","volume":"87","author":"N Zampieri","year":"2011","unstructured":"Zampieri N, Pietrobelli A, Zamboni C, Camoglio F (2011) Necrotizing enterocolitis in multiple gestations: comparison with singletons. Early Hum Dev 87:S99. https:\/\/doi.org\/10.1016\/j.earlhumdev.2010.12.045","journal-title":"Early Hum Dev"},{"key":"5950_CR23","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00431-021-04266-x","volume":"181","author":"M Kordasz","year":"2022","unstructured":"Kordasz M, Racine M, Szavay P et al (2022) Risk factors for mortality in preterm infants with necrotizing enterocolitis: a retrospective multicenter analysis. Eur J Pediatr 181:933\u2013939. https:\/\/doi.org\/10.1007\/s00431-021-04266-x","journal-title":"Eur J Pediatr"},{"key":"5950_CR24","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1213\/ANE.0000000000000531","volume":"120","author":"NA Guzzetta","year":"2015","unstructured":"Guzzetta NA, Allen NN, Wilson EC et al (2015) Excessive postoperative bleeding and outcomes in neonates undergoing cardiopulmonary bypass. Anesth Analg 120:405\u2013410. https:\/\/doi.org\/10.1213\/ANE.0000000000000531","journal-title":"Anesth Analg"},{"key":"5950_CR25","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/j.jpedsurg.2018.11.012","volume":"54","author":"JM Bubberman","year":"2019","unstructured":"Bubberman JM, van Zoonen A, Bruggink JLM et al (2019) Necrotizing enterocolitis associated with congenital heart disease: a different entity? J Pediatr Surg 54:1755\u20131760. https:\/\/doi.org\/10.1016\/j.jpedsurg.2018.11.012","journal-title":"J Pediatr Surg"},{"key":"5950_CR26","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3389\/fped.2020.00257","volume":"8","author":"S Diez","year":"2020","unstructured":"Diez S, Tielesch L, Weiss C et al (2020) Clinical characteristics of necrotizing enterocolitis in preterm patients with and without persistent ductus arteriosus and in patients with congenital heart disease. Front Pediatr 8:257. https:\/\/doi.org\/10.3389\/fped.2020.00257","journal-title":"Front Pediatr"},{"key":"5950_CR27","doi-asserted-by":"publisher","first-page":"158","DOI":"10.5090\/jcs.21.135","volume":"55","author":"S Joo","year":"2022","unstructured":"Joo S, Cho S, Lee JH et al (2022) Postcardiotomy extracorporeal membrane oxygenation support in patients with congenital heart disease. J Chest Surg 55:158\u2013167. https:\/\/doi.org\/10.5090\/jcs.21.135","journal-title":"J Chest Surg"},{"key":"5950_CR28","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1097\/PCC.0000000000002133","volume":"21","author":"JA Spinner","year":"2020","unstructured":"Spinner JA, Morris SA, Nandi D et al (2020) Necrotizing enterocolitis and associated mortality in neonates with congenital heart disease: a multi-institutional study. Pediatr Crit Care Med 21:228\u2013234. https:\/\/doi.org\/10.1097\/PCC.0000000000002133","journal-title":"Pediatr Crit Care Med"},{"key":"5950_CR29","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/jp.2015.96","volume":"35","author":"C Motta","year":"2015","unstructured":"Motta C, Scott W, Mahony L et al (2015) The association of congenital heart disease with necrotizing enterocolitis in preterm infants: a birth cohort study. J Perinatol 35:949\u2013953. https:\/\/doi.org\/10.1038\/jp.2015.96","journal-title":"J Perinatol"},{"key":"5950_CR30","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1007\/s00246-021-02691-1","volume":"42","author":"ST Kelleher","year":"2021","unstructured":"Kelleher ST, McMahon CJ, James A (2021) Necrotizing enterocolitis in children with congenital heart disease: a literature review. Pediatr Cardiol 42:1688\u20131699. https:\/\/doi.org\/10.1007\/s00246-021-02691-1","journal-title":"Pediatr Cardiol"},{"key":"5950_CR31","doi-asserted-by":"publisher","first-page":"014","DOI":"10.1055\/s-0038-1668144","volume":"29","author":"E Siano","year":"2019","unstructured":"Siano E, Lauriti G, Ceccanti S, Zani A (2019) Cardiogenic necrotizing enterocolitis: a clinically distinct entity from classical necrotizing enterocolitis. Eur J Pediatr Surg 29:014\u2013022. https:\/\/doi.org\/10.1055\/s-0038-1668144","journal-title":"Eur J Pediatr Surg"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-024-05950-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-024-05950-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-024-05950-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:24:10Z","timestamp":1763630650000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-024-05950-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5950"],"URL":"https:\/\/doi.org\/10.1007\/s00383-024-05950-3","relation":{},"ISSN":["1437-9813"],"issn-type":[{"type":"electronic","value":"1437-9813"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"16 December 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"48"}}