{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T01:37:55Z","timestamp":1776908275712,"version":"3.51.2"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Major Science and Technology Special Project of Wenzhou","award":["ZY2020021"],"award-info":[{"award-number":["ZY2020021"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300473"],"award-info":[{"award-number":["32300473"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515220053"],"award-info":[{"award-number":["2023A1515220053"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"DOI":"10.1007\/s00383-025-06025-7","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T02:20:53Z","timestamp":1746411653000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["RAS gene polymorphisms confer the risk of neuroblastoma in Chinese children from Jiangsu province"],"prefix":"10.1007","volume":"41","author":[{"given":"Lili","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"6025_CR1","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrc3526","volume":"13","author":"NK Cheung","year":"2013","unstructured":"Cheung NK, Dyer MA (2013) Neuroblastoma: developmental biology, cancer genomics and immunotherapy. Nat Rev Cancer 13:397\u2013411. https:\/\/doi.org\/10.1038\/nrc3526","journal-title":"Nat Rev Cancer"},{"key":"6025_CR2","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/s41571-022-00643-z","volume":"19","author":"B Qiu","year":"2022","unstructured":"Qiu B, Matthay KK (2022) Advancing therapy for neuroblastoma. Nat Rev Clin Oncol 19:515\u2013533. https:\/\/doi.org\/10.1038\/s41571-022-00643-z","journal-title":"Nat Rev Clin Oncol"},{"key":"6025_CR3","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1016\/S0140-6736(07)60983-0","volume":"369","author":"JM Maris","year":"2007","unstructured":"Maris JM, Hogarty MD, Bagatell R, Cohn SL (2007) Neuroblastoma. Lancet 369:2106\u20132120. https:\/\/doi.org\/10.1016\/S0140-6736(07)60983-0","journal-title":"Lancet"},{"key":"6025_CR4","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1056\/NEJMra0804577","volume":"362","author":"JM Maris","year":"2010","unstructured":"Maris JM (2010) Recent advances in neuroblastoma. N Engl J Med 362:2202\u20132211. https:\/\/doi.org\/10.1056\/NEJMra0804577","journal-title":"N Engl J Med"},{"key":"6025_CR5","first-page":"288","volume":"51","author":"PP Bao","year":"2013","unstructured":"Bao PP, Li K, Wu CX et al (2013) Recent incidences and trends of childhood malignant solid tumors in Shanghai, 2002\u20132010. Zhonghua er ke za zhi: Chin J Pediatr 51:288\u2013294","journal-title":"Zhonghua er ke za zhi: Chin J Pediatr"},{"key":"6025_CR6","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1002\/med.21750","volume":"41","author":"A Zafar","year":"2021","unstructured":"Zafar A, Wang W, Liu G et al (2021) Molecular targeting therapies for neuroblastoma: progress and challenges. Med Res Rev 41:961\u20131021. https:\/\/doi.org\/10.1002\/med.21750","journal-title":"Med Res Rev"},{"key":"6025_CR7","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1200\/JCO.2009.27.0421","volume":"28","author":"MA Smith","year":"2010","unstructured":"Smith MA, Seibel NL, Altekruse SF et al (2010) Outcomes for children and adolescents with cancer: challenges for the twenty-first century. J Clin Oncol 28:2625\u20132634. https:\/\/doi.org\/10.1200\/JCO.2009.27.0421","journal-title":"J Clin Oncol"},{"key":"6025_CR8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3322\/caac.21219","volume":"64","author":"E Ward","year":"2014","unstructured":"Ward E, DeSantis C, Robbins A, Kohler B, Jemal A (2014) Childhood and adolescent cancer statistics, 2014. CA: A Cancer J Clin 64:83\u2013103. https:\/\/doi.org\/10.3322\/caac.21219","journal-title":"CA: A Cancer J Clin"},{"key":"6025_CR9","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1001\/jama.2019.11642","volume":"322","author":"JR Park","year":"2019","unstructured":"Park JR, Kreissman SG, London WB et al (2019) Effect of tandem autologous stem cell transplant vs single transplant on event-free survival in patients with high-risk neuroblastoma: a randomized clinical trial. JAMA 322:746\u2013755. https:\/\/doi.org\/10.1001\/jama.2019.11642","journal-title":"JAMA"},{"key":"6025_CR10","doi-asserted-by":"publisher","first-page":"16078","DOI":"10.1038\/nrdp.2016.78","volume":"2","author":"KK Matthay","year":"2016","unstructured":"Matthay KK, Maris JM, Schleiermacher G et al (2016) Neuroblastoma. Nat Rev Dis Primers 2:16078. https:\/\/doi.org\/10.1038\/nrdp.2016.78","journal-title":"Nat Rev Dis Primers"},{"key":"6025_CR11","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd5750","author":"B Koneru","year":"2021","unstructured":"Koneru B, Farooqi A, Nguyen TH et al (2021) ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.abd5750","journal-title":"Sci Transl Med"},{"key":"6025_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/children5090119","author":"EK Barr","year":"2018","unstructured":"Barr EK, Applebaum MA (2018) Genetic predisposition to neuroblastoma. Children (Basel, Switzerland). https:\/\/doi.org\/10.3390\/children5090119","journal-title":"Children (Basel, Switzerland)"},{"key":"6025_CR13","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3389\/fgene.2018.00589","volume":"9","author":"X Zhong","year":"2018","unstructured":"Zhong X, Liu Y, Liu H, Zhang Y, Wang L, Zhang H (2018) Identification of potential prognostic genes for neuroblastoma. Front Genet 9:589. https:\/\/doi.org\/10.3389\/fgene.2018.00589","journal-title":"Front Genet"},{"key":"6025_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2020.101667","volume":"65","author":"J Volk","year":"2020","unstructured":"Volk J, Heck JE, Schmiegelow K, Hansen J (2020) Parental occupational organic dust exposure and selected childhood cancers in Denmark 1968\u20132016. Cancer Epidemiol 65:101667. https:\/\/doi.org\/10.1016\/j.canep.2020.101667","journal-title":"Cancer Epidemiol"},{"key":"6025_CR15","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/nature07261","volume":"455","author":"YP Mosse","year":"2008","unstructured":"Mosse YP, Laudenslager M, Longo L et al (2008) Identification of ALK as a major familial neuroblastoma predisposition gene. Nature 455:930\u2013935. https:\/\/doi.org\/10.1038\/nature07261","journal-title":"Nature"},{"key":"6025_CR16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.canlet.2005.01.055","volume":"228","author":"F Bourdeaut","year":"2005","unstructured":"Bourdeaut F, Trochet D, Janoueix-Lerosey I et al (2005) Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma. Cancer Lett 228:51\u201358. https:\/\/doi.org\/10.1016\/j.canlet.2005.01.055","journal-title":"Cancer Lett"},{"key":"6025_CR17","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1086\/424530","volume":"75","author":"YP Mosse","year":"2004","unstructured":"Mosse YP, Laudenslager M, Khazi D et al (2004) Germline PHOX2B mutation in hereditary neuroblastoma. Am J Hum Genet 75:727\u2013730. https:\/\/doi.org\/10.1086\/424530","journal-title":"Am J Hum Genet"},{"key":"6025_CR18","doi-asserted-by":"publisher","first-page":"7289","DOI":"10.2147\/OTT.S223220","volume":"12","author":"A Lin","year":"2019","unstructured":"Lin A, Hua RX, Tang J et al (2019) KRAS rs7973450 A>G increases neuroblastoma risk in Chinese children: a four-center case-control study. Onco Targets Ther 12:7289\u20137295. https:\/\/doi.org\/10.2147\/OTT.S223220","journal-title":"Onco Targets Ther"},{"key":"6025_CR19","doi-asserted-by":"publisher","first-page":"467","DOI":"10.7150\/jca.27482","volume":"10","author":"J Zhang","year":"2019","unstructured":"Zhang J, Yang Y, Li W et al (2019) TP53 gene rs1042522 allele G decreases neuroblastoma risk: a two-centre case-control study. J Cancer 10:467\u2013471. https:\/\/doi.org\/10.7150\/jca.27482","journal-title":"J Cancer"},{"key":"6025_CR20","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1111\/jcmm.14836","volume":"24","author":"M Hashemi","year":"2020","unstructured":"Hashemi M, Sarabandi S, Karami S et al (2020) LMO1 polymorphisms and the risk of neuroblastoma: assessment of meta-analysis of case-control studies. J Cell Mol Med 24:1160\u20131168. https:\/\/doi.org\/10.1111\/jcmm.14836","journal-title":"J Cell Mol Med"},{"key":"6025_CR21","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/ng.2387","volume":"44","author":"SJ Diskin","year":"2012","unstructured":"Diskin SJ, Capasso M, Schnepp RW et al (2012) Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. Nat Genet 44:1126\u20131130. https:\/\/doi.org\/10.1038\/ng.2387","journal-title":"Nat Genet"},{"key":"6025_CR22","doi-asserted-by":"publisher","first-page":"2828","DOI":"10.1002\/ijc.31822","volume":"143","author":"F Cimmino","year":"2018","unstructured":"Cimmino F, Avitabile M, Diskin SJ et al (2018) Fine mapping of 2q35 high-risk neuroblastoma locus reveals independent functional risk variants and suggests full-length BARD1 as tumor-suppressor. Int J Cancer 143:2828\u20132837. https:\/\/doi.org\/10.1002\/ijc.31822","journal-title":"Int J Cancer"},{"key":"6025_CR23","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.2147\/CMAR.S168515","volume":"10","author":"H Zhou","year":"2018","unstructured":"Zhou H, Zhuo Z, Chen S et al (2018) Polymorphisms in MYCN gene and neuroblastoma risk in Chinese children: a 3-center case-control study. Cancer Manag Res 10:1807\u20131816. https:\/\/doi.org\/10.2147\/CMAR.S168515","journal-title":"Cancer Manag Res"},{"key":"6025_CR24","doi-asserted-by":"publisher","first-page":"140","DOI":"10.21147\/j.issn.1000-9604.2023.02.05","volume":"35","author":"Q Guan","year":"2023","unstructured":"Guan Q, Lin H, Hua W et al (2023) Variant rs8400 enhances ALKBH5 expression through disrupting miR-186 binding and promotes neuroblastoma progression. Chin J Cancer Res 35:140\u2013162. https:\/\/doi.org\/10.21147\/j.issn.1000-9604.2023.02.05","journal-title":"Chin J Cancer Res"},{"key":"6025_CR25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4161\/sgtp.1.1.12178","volume":"1","author":"AD Cox","year":"2010","unstructured":"Cox AD, Der CJ (2010) Ras history: the saga continues. Small GTPases 1:2\u201327. https:\/\/doi.org\/10.4161\/sgtp.1.1.12178","journal-title":"Small GTPases"},{"key":"6025_CR26","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/nrc1097","volume":"3","author":"M Malumbres","year":"2003","unstructured":"Malumbres M, Barbacid M (2003) RAS oncogenes: the first 30 years. Nat Rev Cancer 3:459\u2013465. https:\/\/doi.org\/10.1038\/nrc1097","journal-title":"Nat Rev Cancer"},{"key":"6025_CR27","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/s41392-023-01705-z","volume":"8","author":"ME Bahar","year":"2023","unstructured":"Bahar ME, Kim HJ, Kim DR (2023) Targeting the RAS\/RAF\/MAPK pathway for cancer therapy: from mechanism to clinical studies. Signal Transduct Target Ther 8:455. https:\/\/doi.org\/10.1038\/s41392-023-01705-z","journal-title":"Signal Transduct Target Ther"},{"key":"6025_CR28","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/nrd4389","volume":"13","author":"AD Cox","year":"2014","unstructured":"Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ (2014) Drugging the undruggable RAS: mission possible? Nat Rev Drug Discovery 13:828\u2013851. https:\/\/doi.org\/10.1038\/nrd4389","journal-title":"Nat Rev Drug Discovery"},{"key":"6025_CR29","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/s41571-022-00671-9","volume":"19","author":"SR Punekar","year":"2022","unstructured":"Punekar SR, Velcheti V, Neel BG, Wong KK (2022) The current state of the art and future trends in RAS-targeted cancer therapies. Nat Rev Clin Oncol 19:637\u2013655. https:\/\/doi.org\/10.1038\/s41571-022-00671-9","journal-title":"Nat Rev Clin Oncol"},{"key":"6025_CR30","doi-asserted-by":"publisher","first-page":"8535","DOI":"10.1158\/0008-5472.CAN-08-2129","volume":"68","author":"LJ Chin","year":"2008","unstructured":"Chin LJ, Ratner E, Leng S et al (2008) A SNP in a let-7 microRNA complementary site in the KRAS 3\u2019 untranslated region increases non-small cell lung cancer risk. Cancer Res 68:8535\u20138540. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-2129","journal-title":"Cancer Res"},{"key":"6025_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/cells12151941","author":"MP Gallegos-Arreola","year":"2023","unstructured":"Gallegos-Arreola MP, Garibaldi-Rios AF, Cruz-Sanchez JI et al (2023) Association of the rs8720 and rs12587 KRAS gene variants with colorectal cancer in a Mexican population and their analysis in silico. Cells. https:\/\/doi.org\/10.3390\/cells12151941","journal-title":"Cells"},{"key":"6025_CR32","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S1470-2045(11)70044-4","volume":"12","author":"T Paranjape","year":"2011","unstructured":"Paranjape T, Heneghan H, Lindner R et al (2011) A 3\u2019-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis. Lancet Oncol 12:377\u2013386. https:\/\/doi.org\/10.1016\/S1470-2045(11)70044-4","journal-title":"Lancet Oncol"},{"key":"6025_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24806","volume":"37","author":"M Jin","year":"2023","unstructured":"Jin M, Lu F, Li X et al (2023) Association between KRAS gene polymorphisms and genetic susceptibility to breast cancer in a Chinese population. J Clin Lab Anal 37:e24806. https:\/\/doi.org\/10.1002\/jcla.24806","journal-title":"J Clin Lab Anal"},{"key":"6025_CR34","doi-asserted-by":"publisher","first-page":"6509","DOI":"10.1158\/0008-5472.CAN-10-0689","volume":"70","author":"E Ratner","year":"2010","unstructured":"Ratner E, Lu L, Boeke M et al (2010) A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk. Cancer Res 70:6509\u20136515. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-0689","journal-title":"Cancer Res"},{"key":"6025_CR35","doi-asserted-by":"publisher","first-page":"441","DOI":"10.7150\/ijms.50026","volume":"18","author":"M Jin","year":"2021","unstructured":"Jin M, Li Z, Sun Y et al (2021) Association analysis between the interaction of RAS family genes mutations and papillary thyroid carcinoma in the Han Chinese population. Int J Med Sci 18:441\u2013447. https:\/\/doi.org\/10.7150\/ijms.50026","journal-title":"Int J Med Sci"},{"key":"6025_CR36","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/ng.2529","volume":"45","author":"TJ Pugh","year":"2013","unstructured":"Pugh TJ, Morozova O, Attiyeh EF et al (2013) The genetic landscape of high-risk neuroblastoma. Nat Genet 45:279\u2013284. https:\/\/doi.org\/10.1038\/ng.2529","journal-title":"Nat Genet"},{"key":"6025_CR37","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/ng.3333","volume":"47","author":"TF Eleveld","year":"2015","unstructured":"Eleveld TF, Oldridge DA, Bernard V et al (2015) Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations. Nat Genet 47:864\u2013871. https:\/\/doi.org\/10.1038\/ng.3333","journal-title":"Nat Genet"},{"key":"6025_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.108054","volume":"236","author":"L Lin","year":"2022","unstructured":"Lin L, Miao L, Lin H et al (2022) Targeting RAS in neuroblastoma: is it possible? Pharmacol Ther 236:108054. https:\/\/doi.org\/10.1016\/j.pharmthera.2021.108054","journal-title":"Pharmacol Ther"},{"key":"6025_CR39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.omto.2020.12.004","volume":"20","author":"C Zhou","year":"2021","unstructured":"Zhou C, Wang Y, He L et al (2021) Association between NER pathway gene polymorphisms and neuroblastoma risk in an eastern Chinese population. Mol Ther Oncolytics 20:3\u201311. https:\/\/doi.org\/10.1016\/j.omto.2020.12.004","journal-title":"Mol Ther Oncolytics"},{"key":"6025_CR40","doi-asserted-by":"publisher","DOI":"10.1002\/cai2.103","author":"Q Guan","year":"2023","unstructured":"Guan Q, Zhang X, Liu J et al (2023) ALKBH5 gene polymorphisms and risk of neuroblastoma in Chinese children from Jiangsu Province. Cancer Innov. https:\/\/doi.org\/10.1002\/cai2.103","journal-title":"Cancer Innov"},{"key":"6025_CR41","doi-asserted-by":"publisher","first-page":"149","DOI":"10.14218\/csp.2023.00035","volume":"2","author":"L-L Xie","year":"2023","unstructured":"Xie L-L, Deng C-M, Chang J-M et al (2023) miR-618 rs2682818 C>A polymorphism decreases neuroblastoma risk in tumors originating from the adrenal gland. Cancer Screen Prevent 2:149\u2013153. https:\/\/doi.org\/10.14218\/csp.2023.00035","journal-title":"Cancer Screen Prevent"},{"key":"6025_CR42","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.omto.2020.12.013","volume":"20","author":"J He","year":"2021","unstructured":"He J, Yuan L, Lin H et al (2021) Genetic variants in m(6)A modification core genes are associated with glioma risk in Chinese children. Mol Ther Oncolytics 20:199\u2013208. https:\/\/doi.org\/10.1016\/j.omto.2020.12.013","journal-title":"Mol Ther Oncolytics"},{"key":"6025_CR43","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/nrc3106","volume":"11","author":"Y Pylayeva-Gupta","year":"2011","unstructured":"Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D (2011) RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer 11:761\u2013774. https:\/\/doi.org\/10.1038\/nrc3106","journal-title":"Nat Rev Cancer"},{"key":"6025_CR44","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/s41573-020-0068-6","volume":"19","author":"AR Moore","year":"2020","unstructured":"Moore AR, Rosenberg SC, McCormick F, Malek S (2020) RAS-targeted therapies: is the undruggable drugged? Nat Rev Drug Discovery 19:533\u2013552. https:\/\/doi.org\/10.1038\/s41573-020-0068-6","journal-title":"Nat Rev Drug Discovery"},{"key":"6025_CR45","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.18632\/aging.101855","volume":"11","author":"W Fu","year":"2019","unstructured":"Fu W, Zhuo Z, Hua RX et al (2019) Association of KRAS and NRAS gene polymorphisms with Wilms tumor risk: a four-center case-control study. Aging (Albany NY) 11:1551\u20131563. https:\/\/doi.org\/10.18632\/aging.101855","journal-title":"Aging (Albany NY)"},{"key":"6025_CR46","doi-asserted-by":"publisher","first-page":"4727","DOI":"10.1007\/s13277-015-4314-1","volume":"37","author":"Q Dai","year":"2016","unstructured":"Dai Q, Wei HL, Huang J, Zhou TJ, Chai L, Yang ZH (2016) KRAS polymorphisms are associated with survival of CRC in Chinese population. Tumour Biol 37:4727\u20134734. https:\/\/doi.org\/10.1007\/s13277-015-4314-1","journal-title":"Tumour Biol"},{"key":"6025_CR47","doi-asserted-by":"publisher","first-page":"579","DOI":"10.21037\/tp-20-359","volume":"10","author":"Q Guan","year":"2021","unstructured":"Guan Q, Yuan L, Lin A et al (2021) KRAS gene polymorphisms are associated with the risk of glioma: a two-center case-control study. Transl Pediatr 10:579\u2013586. https:\/\/doi.org\/10.21037\/tp-20-359","journal-title":"Transl Pediatr"},{"key":"6025_CR48","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1126\/science.aat6768","volume":"362","author":"S Ackermann","year":"2018","unstructured":"Ackermann S, Cartolano M, Hero B et al (2018) A mechanistic classification of clinical phenotypes in neuroblastoma. Science (New York, NY) 362:1165\u20131170. https:\/\/doi.org\/10.1126\/science.aat6768","journal-title":"Science (New York, NY)"},{"key":"6025_CR49","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1016\/j.celrep.2017.02.065","volume":"18","author":"X Zhang","year":"2017","unstructured":"Zhang X, Dong Z, Zhang C et al (2017) Critical role for GAB2 in neuroblastoma pathogenesis through the promotion of SHP2\/MYCN cooperation. Cell Rep 18:2932\u20132942. https:\/\/doi.org\/10.1016\/j.celrep.2017.02.065","journal-title":"Cell Rep"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-025-06025-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-025-06025-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-025-06025-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:26:21Z","timestamp":1763630781000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-025-06025-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,5]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6025"],"URL":"https:\/\/doi.org\/10.1007\/s00383-025-06025-7","relation":{},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,5]]},"assertion":[{"value":"11 April 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"130"}}