{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:27:55Z","timestamp":1790893675450,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum D\u00fcsseldorf. Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hirschsprung\u2019s disease (HD) is a rare congenital condition requiring complex corrective surgery. We reviewed available direct evidence on the volume\u2013outcome relationship for HD corrective surgery and assessed the applicability of indirect evidence based on GRADE (Grading of Recommendations Assessment, Development, and Evaluation) recommendations for rare diseases. Three retrospective cohort studies analysing the volume-outcome relationship for HD surgery met the inclusion criteria. In all studies, the high-volume threshold was below 12 HD corrective surgeries per year. No significant volume\u2013outcome relationship was found for outcomes such as readmission or intestinal perforation. Faecal incontinence was not assessed. No risk-adjustment was performed. We applied the GRADE framework and explored indirect evidence from adult colorectal surgery, which shares technical similarities and complexity with HD corrective procedures. Multiple studies in adult colorectal surgery demonstrate a clear volume\u2013outcome relationship, with improved outcomes mostly observed in centres performing more than 20 rectal resections annually. Direct evidence for a volume\u2013outcome relationship in HD surgery cannot be established or refuted due to low caseloads and decentralization. Indirect evidence from adult colorectal surgery with comparable case complexity and the same core outcome parameters suggests the presence of a volume-outcome relationship in HD corrective surgery.<\/jats:p>","DOI":"10.1007\/s00383-025-06117-4","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T14:14:13Z","timestamp":1753107253000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Volume-outcome relationship in corrective surgery for Hirschsprung\u2019s disease: a systematic literature review of direct evidence and an overview of indirect evidence"],"prefix":"10.1007","volume":"41","author":[{"given":"Valeria","family":"Solari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Boemers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Schmiedeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram Trudo","family":"Knoefel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6ttcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehart","family":"Jenetzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Wilms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"6117_CR1","unstructured":"European Platform on Rare Disease Registration (2025) EUROCAT prevalence data [website]. Joint Research Center of the European Commission. https:\/\/eu-rd-platform.jrc.ec.europa.eu\/eurocat\/eurocat-data\/prevalence_en. Accessed 18 July 2025"},{"key":"6117_CR2","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1053\/j.sempedsurg.2009.11.021","volume":"19","author":"RJ Rintala","year":"2010","unstructured":"Rintala RJ, Pakarinen MP (2010) Outcome of anorectal malformations and Hirschsprung\u2019s disease beyond childhood. Semin Pediatr Surg 19:160\u2013167. https:\/\/doi.org\/10.1053\/j.sempedsurg.2009.11.021","journal-title":"Semin Pediatr Surg"},{"key":"6117_CR3","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.jpedsurg.2016.08.027","volume":"52","author":"A Bischoff","year":"2017","unstructured":"Bischoff A, Frischer J, Knod JL et al (2017) Damaged anal canal as a cause of fecal incontinence after surgical repair for Hirschsprung disease - a preventable and under-reported complication. J Pediatr Surg 52:549\u2013553. https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.08.027","journal-title":"J Pediatr Surg"},{"key":"6117_CR4","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1016\/j.jpedsurg.2017.08.040","volume":"52","author":"L De la Torre","year":"2017","unstructured":"De la Torre L, Cogley K, Santos K et al (2017) The anal canal is the fine line between \u201cfecal incontinence and colitis\u201d after a pull-through for Hirschsprung disease. J Pediatr Surg 52:2011\u20132017. https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.08.040","journal-title":"J Pediatr Surg"},{"key":"6117_CR5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1053\/j.sempedsurg.2019.04.013","volume":"28","author":"L De La Torre","year":"2019","unstructured":"De La Torre L, Wehrli LA (2019) Error traps and culture of safety in Hirschsprung disease. Semin Pediatr Surg 28:151\u2013159. https:\/\/doi.org\/10.1053\/j.sempedsurg.2019.04.013","journal-title":"Semin Pediatr Surg"},{"key":"6117_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2024.05.004","volume":"59","author":"M Wilms","year":"2024","unstructured":"Wilms M, M\u00e3rzheuser S, Jenetzky E et al (2024) Treatment of Hirschsprung\u2019s disease in Germany: analysis of national hospital discharge data from 2016 to 2022. J Pediatr Surg 59:161574. https:\/\/doi.org\/10.1016\/j.jpedsurg.2024.05.004","journal-title":"J Pediatr Surg"},{"key":"6117_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.2338","volume":"116","author":"M Damkj\u00e6r","year":"2024","unstructured":"Damkj\u00e6r M, Tan J, Morris JK et al (2024) Children with Hirschsprung\u2019s disease have high morbidity in the first 5 years of life. Birth Defects Res 116:e2338. https:\/\/doi.org\/10.1002\/bdr2.2338","journal-title":"Birth Defects Res"},{"key":"6117_CR8","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00384-023-04495-6","volume":"38","author":"S Pietryga","year":"2023","unstructured":"Pietryga S, Lock JF, Diers J et al (2023) Nationwide volume-outcome relationship concerning in-hospital mortality and failure-to-rescue in surgery of sigmoid diverticulitis. Int J Colorectal Dis 38:203. https:\/\/doi.org\/10.1007\/s00384-023-04495-6","journal-title":"Int J Colorectal Dis"},{"key":"6117_CR9","doi-asserted-by":"publisher","first-page":"zrae025","DOI":"10.1093\/bjsopen\/zrae025","volume":"8","author":"MT Gr\u00f6nroos-Korhonen","year":"2024","unstructured":"Gr\u00f6nroos-Korhonen MT, Koskenvuo LE et al (2024) Impact of hospital volume on failure to rescue for complications requiring reoperation after elective colorectal surgery: multicentre propensity score-matched cohort study. BJS Open 8:zrae025. https:\/\/doi.org\/10.1093\/bjsopen\/zrae025","journal-title":"BJS Open"},{"key":"6117_CR10","doi-asserted-by":"publisher","first-page":"S55","DOI":"10.1016\/j.ejso.2010.06.027","volume":"36","author":"W van Gijn","year":"2010","unstructured":"van Gijn W, Gooiker GA, Wouters MW et al (2010) Volume and outcome in colorectal cancer surgery. Eur J Surg Oncol 36:S55-63. https:\/\/doi.org\/10.1016\/j.ejso.2010.06.027","journal-title":"Eur J Surg Oncol"},{"key":"6117_CR11","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ijsu.2020.12.010","volume":"86","author":"A Hendricks","year":"2021","unstructured":"Hendricks A, Diers J, Baum P et al (2021) Systematic review and meta-analysis on volume-outcome relationship of abdominal surgical procedures in Germany. Int J Surg 86:24\u201331. https:\/\/doi.org\/10.1016\/j.ijsu.2020.12.010","journal-title":"Int J Surg"},{"key":"6117_CR12","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.ejso.2020.09.024","volume":"47","author":"J Diers","year":"2021","unstructured":"Diers J, Baum P, Matthes H et al (2021) Mortality and complication management after surgery for colorectal cancer depending on the DKG minimum amounts for hospital volume. Eur J Surg 47:850\u2013857. https:\/\/doi.org\/10.1016\/j.ejso.2020.09.024","journal-title":"Eur J Surg"},{"key":"6117_CR13","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/bjs5.50254","volume":"4","author":"J Diers","year":"2020","unstructured":"Diers J, Wagner J, Baum P et al (2020) Nationwide in-hospital mortality rate following rectal resection for rectal cancer according to annual hospital volume in Germany. BJS Open 4:310\u2013319. https:\/\/doi.org\/10.1002\/bjs5.50254","journal-title":"BJS Open"},{"key":"6117_CR14","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1097\/SLA.0000000000002965","volume":"268","author":"R Vonlanthen","year":"2018","unstructured":"Vonlanthen R, Lodge P, Barkun JS et al (2018) Toward a consensus on centralization in surgery. Ann Surg 268:712\u2013724. https:\/\/doi.org\/10.1097\/SLA.0000000000002965","journal-title":"Ann Surg"},{"key":"6117_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1001\/jamapediatrics.2013.25","volume":"167","author":"JP McAteer","year":"2013","unstructured":"McAteer JP, LaRiviere CA, Drugas GT et al (2013) Influence of surgeon experience, hospital volume, and specialty designation on outcomes in pediatric surgery: a systematic review. JAMA Pediatr 167:1\u20138. https:\/\/doi.org\/10.1001\/jamapediatrics.2013.25","journal-title":"JAMA Pediatr"},{"key":"6117_CR16","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.jpedsurg.2024.01.042","volume":"59","author":"SE Peiffer","year":"2024","unstructured":"Peiffer SE, Mehl SC, Powell P et al (2024) Treatment facility case volume and disparities in outcomes of congenital diaphragmatic hernia cases. J Pediatr Surg 59:825\u2013831. https:\/\/doi.org\/10.1016\/j.jpedsurg.2024.01.042","journal-title":"J Pediatr Surg"},{"key":"6117_CR17","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1016\/j.jpedsurg.2021.02.065","volume":"56","author":"R Tamura","year":"2021","unstructured":"Tamura R, O\u2019Connor E, Jaffray B (2021) Surgeon level variation in outcome of repair of congenital diaphragmatic hernia with particular reference to the management of recurrence. J Pediatr Surg 56:2207\u20132214. https:\/\/doi.org\/10.1016\/j.jpedsurg.2021.02.065","journal-title":"J Pediatr Surg"},{"key":"6117_CR18","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1055\/s-0037-1607058","volume":"27","author":"N Durkin","year":"2017","unstructured":"Durkin N, Davenport M (2017) Centralization of pediatric surgical procedures in the United Kingdom. Eur J Pediatr Surg 27:416\u2013421. https:\/\/doi.org\/10.1055\/s-0037-1607058","journal-title":"Eur J Pediatr Surg"},{"key":"6117_CR19","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1055\/s-0041-1723994","volume":"32","author":"O Madadi-Sanjani","year":"2022","unstructured":"Madadi-Sanjani O, Fortmann D, Rolle U et al (2022) Centralization of biliary atresia: has Germany learned its lessons? Eur J Pediatr 32:233\u2013239. https:\/\/doi.org\/10.1055\/s-0041-1723994","journal-title":"Eur J Pediatr"},{"key":"6117_CR20","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.athoracsur.2025.01.007","volume":"119","author":"M Sch\u00e4fer","year":"2025","unstructured":"Sch\u00e4fer M, McFarland C, Amula V et al (2025) Volume-outcome relationship of norwood procedures: insights from the national pediatric cardiology-quality improvement collaborative database. Ann Thorac Surg 119:1045\u20131052. https:\/\/doi.org\/10.1016\/j.athoracsur.2025.01.007","journal-title":"Ann Thorac Surg"},{"key":"6117_CR21","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.jclinepi.2011.04.014","volume":"64","author":"GH Guyatt","year":"2011","unstructured":"Guyatt GH, Oxman AD, Kunz R et al (2011) GRADE guidelines: 8. rating the quality of evidence\u2013indirectness. J Clin Epidemiol 64:1303\u20131310. https:\/\/doi.org\/10.1016\/j.jclinepi.2011.04.014","journal-title":"J Clin Epidemiol"},{"key":"6117_CR22","doi-asserted-by":"publisher","DOI":"10.1080\/21675511.2015.1058463","volume":"3","author":"M Pai","year":"2015","unstructured":"Pai M, Iorio A, Meerpohl J et al (2015) Developing methodology for the creation of clinical practice guidelines for rare diseases: a report from RARE-Best practices. Rare Dis 3:e1058463. https:\/\/doi.org\/10.1080\/21675511.2015.1058463","journal-title":"Rare Dis"},{"key":"6117_CR23","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12874-019-0713-0","volume":"19","author":"M Pai","year":"2019","unstructured":"Pai M, Yeung CHT, Akl EA et al (2019) Strategies for eliciting and synthesizing evidence for guidelines in rare diseases. BMC Med Res 19:67. https:\/\/doi.org\/10.1186\/s12874-019-0713-0","journal-title":"BMC Med Res"},{"key":"6117_CR24","unstructured":"Methodological handbooks & toolkit for clinical practice guidelines and clinical decision support tools for rare or low-prevalence and complex diseases: european reference network (2020) [Available from: https:\/\/health.ec.europa.eu\/document\/download\/9d7de9a7-de0d-49b5-a297-5a0303e3059b_en?filename=ern_cpg-cdst_hb4_en.pdf. Accessed 18 July 2025"},{"key":"6117_CR25","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17594","author":"D Rossi","year":"2025","unstructured":"Rossi D, Granstr\u00f6m AL, Pakarinen M et al (2025) Defining excellence: the first core set of quality indicators for the European paediatric surgical audit on Hirschsprung\u2019s disease Care. Acta Paediatr. https:\/\/doi.org\/10.1111\/apa.17594","journal-title":"Acta Paediatr"},{"issue":"3","key":"6117_CR26","doi-asserted-by":"publisher","first-page":"CD005391","DOI":"10.1002\/14651858.CD005391.pub3","volume":"14","author":"D Archampong","year":"2012","unstructured":"Archampong D, Borowski D, Wille-J\u00f8rgensen P, Iversen LH (2012) Workload and surgeon\u2019s specialty for outcome after colorectal cancer surgery. Cochrane Database Syst Rev 14(3):CD005391. https:\/\/doi.org\/10.1002\/14651858.CD005391.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"6117_CR27","doi-asserted-by":"publisher","unstructured":"Institute for quality and efficiency in health care [Institut f\u00fcr Qualit\u00e4t und Wirtschaftlichkeit im Gesundheitswesen, IQWiG] (2024) Relationship between service volume and quality of treatment outcome in colon and rectal cancer surgery [Zusammenhang zwischen Leistungsmenge und Qualit\u00e4t des Behandlungsergebnisses bei der Chirurgie der Kolon- und der Rektumkarzinome] Update of V22\u201302), rapid report. https:\/\/doi.org\/10.60584\/V24-02","DOI":"10.60584\/V24-02"},{"key":"6117_CR28","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.jss.2020.08.014","volume":"257","author":"JC Apfeld","year":"2021","unstructured":"Apfeld JC, Wood RJ, Halleran DR et al (2021) Relationships between hospital and surgeon operative volumes and surgical outcomes in Hirschsprung\u2019s disease. J Surg Res 257:379\u2013388. https:\/\/doi.org\/10.1016\/j.jss.2020.08.014","journal-title":"J Surg Res"},{"key":"6117_CR29","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1016\/j.jpedsurg.2024.05.007","volume":"59","author":"L S\u00f6derstr\u00f6m","year":"2024","unstructured":"S\u00f6derstr\u00f6m L, Gunnarsdottir A, Oddsberg J et al (2024) National centralization of hirschsprung\u2019s disease in Sweden:a comparison of preoperative management and outcomes. J Pediatr Surg 59:1816\u20131821. https:\/\/doi.org\/10.1016\/j.jpedsurg.2024.05.007","journal-title":"J Pediatr Surg"},{"key":"6117_CR30","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1055\/s-0039-3402712","volume":"30","author":"S Giuliani","year":"2020","unstructured":"Giuliani S, Honeyford K, Chang CY et al (2020) Outcomes of Primary versus multiple-staged repair in Hirschsprung\u2019s disease in England. Eur J Pediatr Surg 30:104\u2013110. https:\/\/doi.org\/10.1055\/s-0039-3402712","journal-title":"Eur J Pediatr Surg"},{"key":"6117_CR31","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1097\/SLA.0000000000001695","volume":"265","author":"MI Neuvonen","year":"2017","unstructured":"Neuvonen MI, Kyrklund K, Rintala RJ, Pakarinen MP (2017) Bowel function and quality of life after transanal endorectal pull-through for hirschsprung disease: controlled outcomes up to adulthood. Ann Surg 265:622\u2013629. https:\/\/doi.org\/10.1097\/SLA.0000000000001695","journal-title":"Ann Surg"},{"key":"6117_CR32","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1053\/j.sempedsurg.2017.09.008","volume":"26","author":"T Wester","year":"2017","unstructured":"Wester T, Granstr\u00f6m AL (2017) Hirschsprung disease-Bowel function beyond childhood. Semin Pediatr Surg 26:322\u2013327. https:\/\/doi.org\/10.1053\/j.sempedsurg.2017.09.008","journal-title":"Semin Pediatr Surg"},{"key":"6117_CR33","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1016\/j.jpedsurg.2017.01.001","volume":"52","author":"K Bj\u00f8rnland","year":"2017","unstructured":"Bj\u00f8rnland K, Pakarinen MP, Stenstr\u00f8m P et al (2017) A Nordic multicenter survey of long-term bowel function after transanal endorectal pull-through in 200 patients with rectosigmoid Hirschsprung disease. J Pediatr Surg 52:1458\u20131464. https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.01.001","journal-title":"J Pediatr Surg"},{"key":"6117_CR34","first-page":"212","volume":"24","author":"O Swenson","year":"1948","unstructured":"Swenson O, Bill AH (1948) Resection of rectum and rectosigmoid with preservation of the sphincter for benigh spactic lesions producing megacolon: an experimenta\u00f6l study. J Surg 24:212\u2013220","journal-title":"J Surg"},{"key":"6117_CR35","first-page":"1007","volume":"56","author":"F Soave","year":"1964","unstructured":"Soave F (1964) A new surgical technique for the treatment of Hirschsprung\u2019s disease. Arch Dis Child 56:1007\u20131014","journal-title":"Arch Dis Child"},{"key":"6117_CR36","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1136\/adc.35.179.38","volume":"35","author":"B Duhamel","year":"1964","unstructured":"Duhamel B (1964) A new operation for the treatment of Hirschsprung\u2019s disease. Arch Dis Child 35:38\u20139Dam","journal-title":"Arch Dis Child"},{"key":"6117_CR37","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s00383-024-05767-0","volume":"40","author":"M Zornoza","year":"2024","unstructured":"Zornoza M, Mu\u00f1oz L, Ruiz A, De la Torre L (2024) Surgical maneuvers for long-segment Hirschsprung pull-through in unique patients. Pediatr Surg Int 40:180. https:\/\/doi.org\/10.1007\/s00383-024-05767-0","journal-title":"Pediatr Surg Int"},{"key":"6117_CR38","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1053\/j.sempedsurg.2009.11.016","volume":"19","author":"L De La Torre","year":"2010","unstructured":"De La Torre L, Langer JC (2010) Transanal endorectal pull-through for Hirschsprung disease: technique, controversies, pearls, pitfalls, and an organized approach to the management of postoperative obstructive symptoms. Semin Pediatr Surg 19:96\u2013106. https:\/\/doi.org\/10.1053\/j.sempedsurg.2009.11.016","journal-title":"Semin Pediatr Surg"},{"issue":"1","key":"6117_CR39","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s13023-020-01362-3","volume":"15","author":"K Kyrklund","year":"2020","unstructured":"Kyrklund K, Sloots CEJ, de Blaauw I et al (2020) ERNICA guidelines for the management of rectosigmoid Hirschsprung\u2019s disease. Orphanet J Rare Dis 15(1):164. https:\/\/doi.org\/10.1186\/s13023-020-01362-3","journal-title":"Orphanet J Rare Dis"},{"key":"6117_CR40","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.1607","volume":"153","author":"J Kitz","year":"2018","unstructured":"Kitz J, Fokas E, Beissbarth T et al (2018) Association of plane of total mesorectal excision with prognosis of rectal cancer: secondary analysis of the CAO\/ARO\/AIO-04 phase 3 randomized clinical trial. JAMA Surg 153:e181607. https:\/\/doi.org\/10.1001\/jamasurg.2018.1607","journal-title":"JAMA Surg"},{"key":"6117_CR41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12876-020-01208-z","volume":"20","author":"Y Dai","year":"2020","unstructured":"Dai Y, Deng Y, Lin Y et al (2020) Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis. BMC Gastroenterol 20:67. https:\/\/doi.org\/10.1186\/s12876-020-01208-z","journal-title":"BMC Gastroenterol"},{"key":"6117_CR42","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.surg.2015.09.021","volume":"159","author":"CT Aquina","year":"2016","unstructured":"Aquina CT, Probst CP, Becerra AZ et al (2016) High volume improves outcomes: the argument for centralization of rectal cancer surgery. Surgery 159:736\u2013748. https:\/\/doi.org\/10.1016\/j.surg.2015.09.021","journal-title":"Surgery"},{"key":"6117_CR43","doi-asserted-by":"publisher","first-page":"7249","DOI":"10.1007\/s00520-021-06326-2","volume":"29","author":"R Sun","year":"2021","unstructured":"Sun R, Dai Z, Zhang Y, Lu J et al (2021) The incidence and risk factors of low anterior resection syndrome (LARS) after sphincter-preserving surgery of rectal cancer: a systematic review and meta-analysis. Support Care Cancer 29:7249\u20137258. https:\/\/doi.org\/10.1007\/s00520-021-06326-2","journal-title":"Support Care Cancer"},{"key":"6117_CR44","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1002\/bjs.9264","volume":"100","author":"EM Burns","year":"2013","unstructured":"Burns EM, Bottle A, Almoudaris AM et al (2013) Hierarchical multilevel analysis of increased caseload volume and postoperative outcome after elective colorectal surgery. Br J Surg 100:1531\u20131538. https:\/\/doi.org\/10.1002\/bjs.9264","journal-title":"Br J Surg"},{"key":"6117_CR45","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1002\/bjs.11222","volume":"106","author":"S Pucciarelli","year":"2019","unstructured":"Pucciarelli S, Del Bianco P, Pace U et al (2019) Multicentre randomized clinical trial of colonic J pouch or straight stapled colorectal reconstruction after low anterior resection for rectal cancer. Br J Surg 106:1147\u20131155. https:\/\/doi.org\/10.1002\/bjs.11222","journal-title":"Br J Surg"},{"key":"6117_CR46","doi-asserted-by":"publisher","first-page":"534","DOI":"10.21037\/jgo.2017.01.25","volume":"8","author":"YR Huo","year":"2017","unstructured":"Huo YR, Phan K, Morris DL, Liauw W (2017) Systematic review and a meta-analysis of hospital and surgeon volume\/outcome relationships in colorectal cancer surgery. J Gastrointest Oncol 8:534\u2013546. https:\/\/doi.org\/10.21037\/jgo.2017.01.25","journal-title":"J Gastrointest Oncol"},{"key":"6117_CR47","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1056\/NEJM197912203012503","volume":"301","author":"HS Luft","year":"1979","unstructured":"Luft HS, Bunker JP, Enthoven AC (1979) Should operations be regionalized? The empirical relation between surgical volume and mortality. N Engl J Med 301:1364\u20131369. https:\/\/doi.org\/10.1056\/NEJM197912203012503","journal-title":"N Engl J Med"},{"key":"6117_CR48","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016184","volume":"7","author":"U Nimptsch","year":"2017","unstructured":"Nimptsch U, Mansky T (2017) Hospital volume and mortality for 25 types of inpatient treatment in German hospitals: observational study using complete national data from 2009 to 2014. BMJ Open 7:e016184. https:\/\/doi.org\/10.1136\/bmjopen-2017-016184","journal-title":"BMJ Open"},{"key":"6117_CR49","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1186\/s12893-023-02169-2","volume":"23","author":"S Zhang","year":"2023","unstructured":"Zhang S, Cai D, Zhang Y et al (2023) Comparation of robotic-assisted surgery and laparoscopic-assisted surgery in children with Hirschsprung\u2019s disease: a single-centered retrospective study. BMC Surg 23:294. https:\/\/doi.org\/10.1186\/s12893-023-02169-2","journal-title":"BMC Surg"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-025-06117-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-025-06117-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-025-06117-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:25:39Z","timestamp":1763630739000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-025-06117-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6117"],"URL":"https:\/\/doi.org\/10.1007\/s00383-025-06117-4","relation":{},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,21]]},"assertion":[{"value":"4 July 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"221"}}