{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:33:59Z","timestamp":1792017239572,"version":"4.4.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Odense University Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To systematically describe postoperative complications in surgery for HI in pediatric patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective single-center study, we systematically analyzed the rate and grade of complications according to the Comprehensive Complication Index (CCI), Clavien-Dindo Classification (CDC), and the Clavien-Madadi Classification (CMC) in 74 patients undergoing a total of 89 surgeries for CHI (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200968) or\u00a0pediatric insulinomas (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20096) at Odense University Hospital, Denmark, from 01.01.2010 until 01.10.2024.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients surgically treated for focal CHI had more favorable surgical outcomes with a mean CCI score of 10.8 vs. the diffuse CHI mean CCI of 26.3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0018). Surgical treatment for pediatric insulinomas resulted in a mean CCI of 28.9. In the total group, the most common complication was postoperative infection (29%), followed by delayed gastric emptying (20%). The rate of postoperative pancreatic fistula was 11%, but only 3.4%\u00a0were clinically relevant. Eight percent of the surgical procedures resulted in complications classified as CMD grade IIIb or higher.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite the complex nature of surgery in pediatric patients with CHI or insulinomas, the majority had an uneventful recovery. Severe complications (CMC grade IIIb\u2009+) were, however, seen in 8%. Prospective, systematic postoperative complication score evaluation is encouraged in surgery for pediatric HI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00383-025-06191-8","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T11:01:02Z","timestamp":1758106862000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Postoperative complications following surgery for congenital hyperinsulinism and insulinomas in pediatric patients"],"prefix":"10.1007","volume":"41","author":[{"given":"Gregers Gaardsk\u00e6r","family":"Boel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Thybo","family":"Christesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Bremholm","family":"Elleb\u00e6k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Bau","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"issue":"3","key":"6191_CR1","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1159\/000531766","volume":"97","author":"DD De Leon","year":"2024","unstructured":"De Leon DD, Arnoux JB, Banerjee I, Bergada I, Bhatti T, Conwell LS et al (2024) International guidelines for the diagnosis and management of hyperinsulinism. 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