{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:05:33Z","timestamp":1793196333193,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004252","name":"Qatar University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004252","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Symptomatic Meckel\u2019s diverticulum (MD) has various clinical presentations and can be easily misdiagnosed. This multicenter study examines the clinical characteristics, management, and outcomes of patients across five academic pediatric surgery centers in Bosnia &amp; Herzegovina and Serbia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively included all pediatric patients (&lt;\u200918\u00a0years) who were surgically and histopathologically confirmed to have symptomatic MD between 2011 and 2020. Demographics, clinical and radiological features, surgical treatment approaches, histopathologic findings, and outcomes were collected and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 151 patients (80.1% male), the median age was 6.7\u00a0years (IQR 1.5\u201310.8). Presentations included intestinal obstruction (38.4%), GI bleeding (37.8%), and peritonitis (23.8%); 63.6% had multiple symptoms. A technetium-99\u00a0m scan was positive in 80.7% of bleeding cases. Laparotomy was performed in 72.2%, laparoscopy in 23.2%, and conversion in 4.6%. Partial small bowel resection was required in 80.8%, versus diverticulectomy in 19.2% (p\u2009&lt;\u20090.001). Ectopic mucosa was found in 55.6% (gastric 48.3%, pancreatic 2.6%, both 4.6%; p\u2009=\u20090.05), significantly more common in males (p\u2009&lt;\u20090.001). Postoperative complications occurred in 3.2%, with no mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Symptomatic MD displays highly variable clinical presentations. It is often underdiagnosed preoperatively, particularly without GI bleeding, emphasizing the need for high clinical suspicion and tailored surgical approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00383-025-06197-2","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:16:12Z","timestamp":1759601772000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diverse clinical features of symptomatic Meckel\u2019s diverticulum: a multicenter study of 151 consecutive pediatric patients from the Western Balkans"],"prefix":"10.1007","volume":"41","author":[{"given":"Zlatan","family":"Zvizdic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blagoje","family":"Grujic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmir","family":"Jonuzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edin","family":"Husaric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlatka","family":"Martinovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Brkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Rakocevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Halilbasic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Lasic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Pasalic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emir","family":"Begagic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semir","family":"Vranic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"6197_CR1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012154","volume":"97","author":"CC Hansen","year":"2018","unstructured":"Hansen CC, Soreide K (2018) Systematic review of epidemiology, presentation, and management of Meckel\u2019s diverticulum in the 21st century. Medicine (Baltimore) 97:e12154. https:\/\/doi.org\/10.1097\/MD.0000000000012154","journal-title":"Medicine (Baltimore)"},{"key":"6197_CR2","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0002-9610(78)90238-6","volume":"136","author":"M Ymaguchi","year":"1978","unstructured":"Ymaguchi M et al (1978) Meckel\u2019s diverticulum. Investigation of 600 patients in Japanese literature. Am J Surg 136:247\u2013249. https:\/\/doi.org\/10.1016\/0002-9610(78)90238-6","journal-title":"Am J Surg"},{"key":"6197_CR3","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s00268-004-7512-3","volume":"28","author":"KE Bani-Hani","year":"2004","unstructured":"Bani-Hani KE, Shatnawi NJ (2004) Meckel\u2019s diverticulum: comparison of incidental and symptomatic cases. World J Surg 28:917\u2013920. https:\/\/doi.org\/10.1007\/s00268-004-7512-3","journal-title":"World J Surg"},{"key":"6197_CR4","first-page":"354","volume":"63","author":"JF Arnold","year":"1997","unstructured":"Arnold JF, Pellicane JV (1997) Meckel\u2019s diverticulum: a ten-year experience. Am Surg 63:354\u2013355","journal-title":"Am Surg"},{"key":"6197_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/children9010035","author":"M Nissen","year":"2022","unstructured":"Nissen M et al (2022) Meckel\u2019s diverticulum in children: a monocentric experience and mini-review of literature. Children (Basel). https:\/\/doi.org\/10.3390\/children9010035","journal-title":"Children (Basel)"},{"key":"6197_CR6","doi-asserted-by":"publisher","first-page":"170","DOI":"10.4103\/0189-6725.194671","volume":"13","author":"KN Rattan","year":"2016","unstructured":"Rattan KN et al (2016) Meckel\u2019s diverticulum in children: our 12-year experience. Afr J Paediatr Surg 13:170\u2013174. https:\/\/doi.org\/10.4103\/0189-6725.194671","journal-title":"Afr J Paediatr Surg"},{"key":"6197_CR7","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00383-007-2094-4","volume":"24","author":"M Menezes","year":"2008","unstructured":"Menezes M et al (2008) Symptomatic Meckel\u2019s diverticulum in children: a 16-year review. Pediatr Surg Int 24:575\u2013577. https:\/\/doi.org\/10.1007\/s00383-007-2094-4","journal-title":"Pediatr Surg Int"},{"key":"6197_CR8","doi-asserted-by":"publisher","first-page":"279","DOI":"10.4103\/0189-6725.91665","volume":"8","author":"E Blevrakis","year":"2011","unstructured":"Blevrakis E et al (2011) Meckel\u2019s diverticulum in paediatric practice on Crete (Greece): a 10-year review. Afr J Paediatr Surg 8:279\u2013282. https:\/\/doi.org\/10.4103\/0189-6725.91665","journal-title":"Afr J Paediatr Surg"},{"key":"6197_CR9","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.jpedsurg.2017.11.059","volume":"53","author":"Q Chen","year":"2018","unstructured":"Chen Q et al (2018) Multifaceted behavior of Meckel\u2019s diverticulum in children. J Pediatr Surg 53:676\u2013681. https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.11.059","journal-title":"J Pediatr Surg"},{"key":"6197_CR10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.5457\/p2005-114.312","volume":"18","author":"Z Zvizdic","year":"2022","unstructured":"Zvizdic Z et al (2022) Twisting of a giant cystic Meckel\u2019s diverticulum in a toddler: a case report and brief literature review. Central Eur J Paediatr 18:27\u201330. https:\/\/doi.org\/10.5457\/p2005-114.312","journal-title":"Central Eur J Paediatr"},{"key":"6197_CR11","unstructured":"(2023). NICHD. Pediatric Terminology.https:\/\/evs.nci.nih.gov\/ftp1\/Pediatric_Terminologies\/NICHD\/"},{"key":"6197_CR12","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.jpedsurg.2011.02.024","volume":"46","author":"KA Ruscher","year":"2011","unstructured":"Ruscher KA et al (2011) National trends in the surgical management of Meckel\u2019s diverticulum. J Pediatr Surg 46:893\u2013896. https:\/\/doi.org\/10.1016\/j.jpedsurg.2011.02.024","journal-title":"J Pediatr Surg"},{"key":"6197_CR13","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/s1072-7515(01)00817-1","volume":"192","author":"EK Yahchouchy","year":"2001","unstructured":"Yahchouchy EK et al (2001) Meckel\u2019s diverticulum. J Am Coll Surg 192:658\u2013662. https:\/\/doi.org\/10.1016\/s1072-7515(01)00817-1","journal-title":"J Am Coll Surg"},{"key":"6197_CR14","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/s0022-3468(97)90024-5","volume":"32","author":"J Gandy","year":"1997","unstructured":"Gandy J et al (1997) Neonatal Meckel\u2019s diverticular inflammation with perforation. J Pediatr Surg 32:750\u2013751. https:\/\/doi.org\/10.1016\/s0022-3468(97)90024-5","journal-title":"J Pediatr Surg"},{"key":"6197_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11894-019-0742-1","volume":"22","author":"RJ Lindeman","year":"2020","unstructured":"Lindeman RJ, Soreide K (2020) The many faces of Meckel\u2019s diverticulum: update on management in incidental and symptomatic patients. Curr Gastroenterol Rep 22:3. https:\/\/doi.org\/10.1007\/s11894-019-0742-1","journal-title":"Curr Gastroenterol Rep"},{"key":"6197_CR16","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/01.sla.0000154270.14308.5f","volume":"241","author":"JJ Park","year":"2005","unstructured":"Park JJ et al (2005) Meckel diverticulum: the Mayo Clinic experience with 1476 patients (1950\u20132002). Ann Surg 241:529\u2013533. https:\/\/doi.org\/10.1097\/01.sla.0000154270.14308.5f","journal-title":"Ann Surg"},{"key":"6197_CR17","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.mehy.2017.05.014","volume":"104","author":"S Celebi","year":"2017","unstructured":"Celebi S (2017) Male predominance in Meckel\u2019s diverticulum: a hyperacidity hypotheses. Med Hypotheses 104:54\u201357. https:\/\/doi.org\/10.1016\/j.mehy.2017.05.014","journal-title":"Med Hypotheses"},{"key":"6197_CR18","first-page":"537","volume":"169","author":"FE Ludtke","year":"1989","unstructured":"Ludtke FE et al (1989) Incidence and frequency or complications and management of Meckel\u2019s diverticulum. Surg Gynecol Obstet 169:537\u2013542","journal-title":"Surg Gynecol Obstet"},{"key":"6197_CR19","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1080\/11024159950189735","volume":"165","author":"PR Fa-Si-Oen","year":"1999","unstructured":"Fa-Si-Oen PR et al (1999) Complications and management of Meckel\u2019s diverticulum\u2013a review. Eur J Surg 165:674\u2013678. https:\/\/doi.org\/10.1080\/11024159950189735","journal-title":"Eur J Surg"},{"key":"6197_CR20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2147\/ceg.s3792","volume":"2","author":"JR Poley","year":"2009","unstructured":"Poley JR et al (2009) Bleeding Meckel\u2019s diverticulum in a 4-month-old infant: treatment with laparoscopic diverticulectomy. A case report and review of the literature. Clin Exp Gastroenterol 2:37\u201340. https:\/\/doi.org\/10.2147\/ceg.s3792","journal-title":"Clin Exp Gastroenterol"},{"key":"6197_CR21","doi-asserted-by":"publisher","first-page":"221","DOI":"10.4103\/0189-6725.86068","volume":"8","author":"A Pampal","year":"2011","unstructured":"Pampal A, Aksakal ED (2011) Littre hernia in childhood: a case report with a brief review of the literature. Afr J Paediatr Surg 8:221\u2013224. https:\/\/doi.org\/10.4103\/0189-6725.86068","journal-title":"Afr J Paediatr Surg"},{"key":"6197_CR22","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1007\/s00431-009-1023-z","volume":"168","author":"YY Tseng","year":"2009","unstructured":"Tseng YY, Yang YJ (2009) Clinical and diagnostic relevance of Meckel\u2019s diverticulum in children. Eur J Pediatr 168:1519\u20131523. https:\/\/doi.org\/10.1007\/s00431-009-1023-z","journal-title":"Eur J Pediatr"},{"key":"6197_CR23","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1177\/014107680609901011","volume":"99","author":"J Sagar","year":"2006","unstructured":"Sagar J et al (2006) Meckel\u2019s diverticulum: a systematic review. J R Soc Med 99:501\u2013505. https:\/\/doi.org\/10.1177\/014107680609901011","journal-title":"J R Soc Med"},{"key":"6197_CR24","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.pedneo.2013.12.005","volume":"55","author":"CC Huang","year":"2014","unstructured":"Huang CC et al (2014) Diverse presentations in pediatric Meckel\u2019s diverticulum: a review of 100 cases. Pediatr Neonatol 55:369\u2013375. https:\/\/doi.org\/10.1016\/j.pedneo.2013.12.005","journal-title":"Pediatr Neonatol"},{"key":"6197_CR25","first-page":"717","volume":"92","author":"MS Kong","year":"1993","unstructured":"Kong MS et al (1993) Technetium-99m pertechnetate scan for ectopic gastric mucosa in children with gastrointestinal bleeding. J Formos Med Assoc 92:717\u2013720","journal-title":"J Formos Med Assoc"},{"key":"6197_CR26","first-page":"318","volume":"77","author":"T Hosseinnezhad","year":"2014","unstructured":"Hosseinnezhad T et al (2014) 99mTc-pertechnetate imaging for detection of ectopic gastric mucosa: a systematic review and meta-analysis of the pertinent literature. Acta Gastroenterol Belg 77:318\u2013327","journal-title":"Acta Gastroenterol Belg"},{"key":"6197_CR27","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007760","volume":"96","author":"XK Lin","year":"2017","unstructured":"Lin XK et al (2017) Clinical characteristics of Meckel diverticulum in children: a retrospective review of a 15-year single-center experience. Medicine (Baltimore) 96:e7760. https:\/\/doi.org\/10.1097\/MD.0000000000007760","journal-title":"Medicine (Baltimore)"},{"key":"6197_CR28","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s003830100663","volume":"18","author":"M Mukai","year":"2002","unstructured":"Mukai M et al (2002) Does the external appearance of a Meckel\u2019s diverticulum assist in choice of the laparoscopic procedure? Pediatr Surg Int 18:231\u2013233. https:\/\/doi.org\/10.1007\/s003830100663","journal-title":"Pediatr Surg Int"},{"key":"6197_CR29","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6640660","volume":"2021","author":"T Fu","year":"2021","unstructured":"Fu T et al (2021) The clinical manifestation variety and management choice of Meckel\u2019s diverticulum with complication: a single center experience. Gastroenterol Res Pract 2021:6640660. https:\/\/doi.org\/10.1155\/2021\/6640660","journal-title":"Gastroenterol Res Pract"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-025-06197-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-025-06197-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-025-06197-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:26:18Z","timestamp":1763630778000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-025-06197-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,4]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6197"],"URL":"https:\/\/doi.org\/10.1007\/s00383-025-06197-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7183386\/v1","asserted-by":"object"}]},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,4]]},"assertion":[{"value":"22 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"311"}}