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Little is known about their neurodevelopmental trajectory and long-term morbidity. The aim was to determine the risk of neurodevelopmental disorders in children born with omphalocele or gastroschisis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a population-based national cohort study including children born with omphalocele or gastroschisis in Sweden 1997\u20132016. Individuals with chromosomal abnormality were excluded. Ten age and sex-matched unexposed individuals were randomly selected for every AWD case. Main outcomes were autism spectrum disorder (ASD) and attention-deficit\/hyperactivity disorder (ADHD). Data were collected from the national health registers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, 496 children were born with AWD and included in the exposed cohorts. The unexposed cohorts consisted of 4943 children. Neurodevelopmental diagnoses were found in 11 (6.1%) children\u00a0with omphalocele and 15 (4.8%) children with gastroschisis compared to 63 (3.5%) and 113 (3.6%) in the unexposed cohorts (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.096 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.275). Children with omphalocele had higher risk of ASD (HR\u2009=\u20093.51, 95% CI 1.59\u20137.78) than unexposed peers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). There was no significant difference in ADHD incidence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Children with AWD may have similar risk of ADHD as age- and sex-matched peers\n                      <jats:italic>.<\/jats:italic>\n                      While the omphalocele cohort had a higher incidence of ASD, the overall incidence remained relatively low.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>II.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00383-025-06201-9","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T18:25:24Z","timestamp":1758565524000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neurodevelopmental disorders in children with congenital abdominal wall defects: a national population-based study"],"prefix":"10.1007","volume":"41","author":[{"given":"Anna","family":"Fogelstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Skoglund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Wester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"L\u00f6f Granstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mesas-Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"issue":"2","key":"6201_CR1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1055\/s-0040-1703012","volume":"31","author":"A Raitio","year":"2021","unstructured":"Raitio A, Tauriainen A, Syvanen J, Kemppainen T, Loyttyniemi E, Sankilampi U et al (2021) Omphalocele in Finland from 1993 to 2014: trends, prevalence, mortality, and associated malformations-a population-based study. 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