{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:02:39Z","timestamp":1777982559435,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300574"],"award-info":[{"award-number":["82300574"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400592"],"award-info":[{"award-number":["82400592"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7252043"],"award-info":[{"award-number":["7252043"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangxi (Ganpo) Talent Program-Health Innovation Talent Project"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"DOI":"10.1007\/s00383-025-06258-6","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T09:26:18Z","timestamp":1766222778000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development and validation of a screening model for early diagnosis of biliary atresia in neonates with cholestasis"],"prefix":"10.1007","volume":"42","author":[{"given":"Zhaozhou","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangshuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junmin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyun","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingding","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinshi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,20]]},"reference":[{"key":"6258_CR1","doi-asserted-by":"publisher","first-page":"150950","DOI":"10.1016\/j.sempedsurg.2020.150950","volume":"29","author":"PHY Chung","year":"2020","unstructured":"Chung PHY, Zheng S, Tam PKH (2020) Biliary atresia: East versus West. Semin Pediatr Surg 29:150950","journal-title":"Semin Pediatr Surg"},{"key":"6258_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41572-024-00533-x","volume":"10","author":"PKH Tam","year":"2024","unstructured":"Tam PKH, Wells RG, Tang CSM et al (2024) Biliary Atresia. Nat Reviews Disease Primers 10:47","journal-title":"Nat Reviews Disease Primers"},{"key":"6258_CR3","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1097\/MPG.0000000000002446","volume":"69","author":"M Fanna","year":"2019","unstructured":"Fanna M, Masson G, Capito C et al (2019) Management of biliary Atresia in France 1986 to 2015: Long-term results. J Pediatr Gastroenterol Nutr 69:416\u2013424","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"6258_CR4","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1186\/s12887-025-05780-9","volume":"25","author":"C Xie","year":"2025","unstructured":"Xie C, Wang P, Wang D et al (2025) Is performing the Kasai portoenterostomy in the neonatal period associated with a better prognosis? A single-center, retrospective cohort study from China. BMC Pediatr 25:454","journal-title":"BMC Pediatr"},{"key":"6258_CR5","doi-asserted-by":"crossref","unstructured":"Hou J, Xiao W, Zhou S, Liu H (2025) Identification of biliary Atresia in infantile cholestasis: integrating radiomics with MRCP for unobservable extrahepatic biliary systems. J Comput Assist Tomogr 49:833\u2013840","DOI":"10.1097\/RCT.0000000000001729"},{"key":"6258_CR6","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s00247-013-2623-3","volume":"43","author":"HR Kianifar","year":"2013","unstructured":"Kianifar HR, Tehranian S, Shojaei P et al (2013) Accuracy of hepatobiliary scintigraphy for differentiation of neonatal hepatitis from biliary atresia: systematic review and meta-analysis of the literature. Pediatr Radiol 43:905\u2013919","journal-title":"Pediatr Radiol"},{"key":"6258_CR7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12916-025-03962-x","volume":"23","author":"Y Ma","year":"2025","unstructured":"Ma Y, Yang Y, Du Y et al (2025) Development of an artificial intelligence-based multimodal diagnostic system for early detection of biliary Atresia. BMC Med 23:127","journal-title":"BMC Med"},{"key":"6258_CR8","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00247-021-05148-y","volume":"52","author":"DD Brahee","year":"2022","unstructured":"Brahee DD, Lampl BS (2022) Neonatal diagnosis of biliary atresia: a practical review and update. Pediatr Radiol 52:685\u2013692","journal-title":"Pediatr Radiol"},{"key":"6258_CR9","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1001\/jama.2020.0837","volume":"323","author":"S Harpavat","year":"2020","unstructured":"Harpavat S, Garcia-Prats JA, Anaya C et al (2020) Diagnostic yield of newborn screening for biliary Atresia using direct or conjugated bilirubin measurements. JAMA 323:1141\u20131150","journal-title":"JAMA"},{"key":"6258_CR10","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1186\/s12887-023-04370-x","volume":"23","author":"Z Gong","year":"2023","unstructured":"Gong Z, Lin L, Lu G, Wan C (2023) Development and validation of a model for early diagnosis of biliary Atresia. BMC Pediatr 23:549","journal-title":"BMC Pediatr"},{"key":"6258_CR11","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.jss.2018.03.021","volume":"228","author":"J Golden","year":"2018","unstructured":"Golden J, Zagory JA, Fenlon M et al (2018) Liquid chromatography-mass spectroscopy in the diagnosis of biliary Atresia in children with hyperbilirubinemia. J Surg Res 228:228\u2013237","journal-title":"J Surg Res"},{"key":"6258_CR12","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1097\/HEP.0000000000000827","volume":"80","author":"S Pandurangi","year":"2024","unstructured":"Pandurangi S, Mourya R, Nalluri S et al (2024) Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary Atresia in a large North American cohort. Hepatology (Baltimore MD) 80:152\u2013162","journal-title":"Hepatology (Baltimore MD)"},{"key":"6258_CR13","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1021\/acs.jproteome.3c00873","volume":"23","author":"M Fu","year":"2024","unstructured":"Fu M, Guo Z, Chen Y et al (2024) Proteomics defines plasma biomarkers for the early diagnosis of biliary Atresia. J Proteome Res 23:1744\u20131756","journal-title":"J Proteome Res"},{"key":"6258_CR14","doi-asserted-by":"publisher","first-page":"931637","DOI":"10.3389\/fsurg.2022.931637","volume":"9","author":"H Lyu","year":"2022","unstructured":"Lyu H, Ye Y, Lui VCH et al (2022) Plasma amyloid-beta levels correlated with impaired hepatic functions: an adjuvant biomarker for the diagnosis of biliary Atresia. Front Surg 9:931637","journal-title":"Front Surg"},{"key":"6258_CR15","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1038\/s41467-021-21466-z","volume":"12","author":"W Zhou","year":"2021","unstructured":"Zhou W, Yang Y, Yu C et al (2021) Ensembled deep learning model outperforms human experts in diagnosing biliary Atresia from sonographic gallbladder images. Nat Commun 12:1259","journal-title":"Nat Commun"},{"key":"6258_CR16","doi-asserted-by":"publisher","first-page":"e0276278","DOI":"10.1371\/journal.pone.0276278","volume":"17","author":"F-R Hsu","year":"2022","unstructured":"Hsu F-R, Dai S-T, Chou C-M, Huang S-Y (2022) The application of artificial intelligence to support biliary Atresia screening by ultrasound images: A study based on deep learning models. PLoS ONE 17:e0276278","journal-title":"PLoS ONE"},{"key":"6258_CR17","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1007\/s00383-022-05148-5","volume":"38","author":"Y Sun","year":"2022","unstructured":"Sun Y, Dai S, Shen Z et al (2022) Gamma-glutamyl transpeptidase has different efficacy on biliary Atresia diagnosis in different hospital patient groups: an application of machine learning approach. Pediatr Surg Int 38:1131\u20131141","journal-title":"Pediatr Surg Int"},{"key":"6258_CR18","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00383-024-05740-x","volume":"40","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Wang A, Wang D et al (2024) Development of a diagnostic model for biliary Atresia based on MMP7 and serological tests using machine learning. Pediatr Surg Int 40:203","journal-title":"Pediatr Surg Int"},{"key":"6258_CR19","first-page":"305","volume":"12","author":"F Kong","year":"2024","unstructured":"Kong F, Dong R, Chen G et al (2024) Progress in biomarkers related to biliary Atresia. J Clin Translational Hepatol 12:305\u2013315","journal-title":"J Clin Translational Hepatol"},{"key":"6258_CR20","doi-asserted-by":"crossref","unstructured":"Hsiao Y-H, Hung W-L, Yang Y-J et al (2025) Non-invasive simple predictors of biliary Atresia in cholestatic infants - A preliminary report. Pediatr Neonatol 66(6):588-593","DOI":"10.1016\/j.pedneo.2024.11.006"},{"key":"6258_CR21","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1097\/MPG.0000000000001168","volume":"63","author":"X Chen","year":"2016","unstructured":"Chen X, Dong R, Shen Z, Yan W, Zheng S (2016) Value of Gamma-Glutamyl transpeptidase for diagnosis of biliary Atresia by correlation with age. J Pediatr Gastroenterol Nutr 63:370\u2013373","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"6258_CR22","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1007\/s12519-023-00779-7","volume":"20","author":"Y-J Han","year":"2024","unstructured":"Han Y-J, Hu S-Q, Zhu J-H et al (2024) Accurate prediction of biliary Atresia with an integrated model using MMP-7 levels and bile acids. World J Pediatrics: WJP 20:822\u2013833","journal-title":"World J Pediatrics: WJP"},{"key":"6258_CR23","doi-asserted-by":"publisher","first-page":"e819","DOI":"10.1542\/neo.22-12-e819","volume":"22","author":"AG Feldman","year":"2021","unstructured":"Feldman AG, Sokol RJ (2021) Neonatal cholestasis: updates on Diagnostics, Therapeutics, and prevention. NeoReviews 22:e819\u2013e836","journal-title":"NeoReviews"},{"key":"6258_CR24","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3346\/jkms.2017.32.4.656","volume":"32","author":"KJ Lee","year":"2017","unstructured":"Lee KJ, Kim JW, Moon JS, Ko JS (2017) Epidemiology of biliary Atresia in Korea. J Korean Med Sci 32:656\u2013660","journal-title":"J Korean Med Sci"},{"key":"6258_CR25","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jamcollsurg.2017.09.009","volume":"226","author":"M Hukkinen","year":"2018","unstructured":"Hukkinen M, Kerola A, Lohi J et al (2018) Treatment policy and liver histopathology predict biliary Atresia outcomes: results after National centralization and protocol biopsies. J Am Coll Surg 226:46\u201357e41","journal-title":"J Am Coll Surg"},{"key":"6258_CR26","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.gastha.2023.05.002","volume":"2","author":"HJ Choi","year":"2023","unstructured":"Choi HJ, Kim YE, Namgoong J-M et al (2023) Development and validation of a machine Learning-Based prediction model for detection of biliary Atresia. Gastro Hep Adv 2:778\u2013787","journal-title":"Gastro Hep Adv"},{"key":"6258_CR27","doi-asserted-by":"crossref","unstructured":"Gunda ST, Chambara N, Chen XF, Pang MYC, Ying MT-C (2022) Diagnostic efficacy of advanced ultrasonography imaging techniques in infants with biliary Atresia (BA): A systematic review and Meta-Analysis. Child (Basel Switzerland) 9:1676","DOI":"10.3390\/children9111676"},{"key":"6258_CR28","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00383-025-06118-3","volume":"41","author":"Q Yang","year":"2025","unstructured":"Yang Q, Zhang Y, Meng Y, Liu S, Zhan J (2025) The diagnostic performance of ultrasound features for biliary atresia: a systematic review and updated meta-analysis. Pediatr Surg Int 41:251","journal-title":"Pediatr Surg Int"},{"key":"6258_CR29","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1007\/s00383-021-04923-0","volume":"37","author":"G Wang","year":"2021","unstructured":"Wang G, Zhang N, Zhang X, Zhou W, Xie X, Zhou L (2021) Ultrasound characteristics combined with gamma-glutamyl transpeptidase for diagnosis of biliary Atresia in infants less than 30 days. Pediatr Surg Int 37:1175\u20131182","journal-title":"Pediatr Surg Int"},{"key":"6258_CR30","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s00383-024-05785-y","volume":"40","author":"Q Toh","year":"2024","unstructured":"Toh Q, Chen Y, Lee YY, Mali VP, Choo SC, Chiang LW (2024) Simple biliary Atresia score-a validated diagnostic aid for infantile cholestasis. Pediatr Surg Int 40:212","journal-title":"Pediatr Surg Int"},{"key":"6258_CR31","doi-asserted-by":"publisher","first-page":"108439","DOI":"10.1016\/j.compbiomed.2024.108439","volume":"174","author":"X Chen","year":"2024","unstructured":"Chen X, Zhao D, Ji H, Chen Y, Li Y, Zuo Z (2024) Predictive modeling for early detection of biliary Atresia in infants with cholestasis: insights from a machine learning study. Comput Biol Med 174:108439","journal-title":"Comput Biol Med"},{"key":"6258_CR32","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s00383-024-05730-z","volume":"40","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Li T, Wang T, Ji Q, Zhan J (2024) Comparison for the diagnostic performance of early diagnostic methods for biliary atresia: a systematic review and network meta-analysis. Pediatr Surg Int 40:146","journal-title":"Pediatr Surg Int"},{"key":"6258_CR33","doi-asserted-by":"publisher","first-page":"1581053","DOI":"10.3389\/fphar.2025.1581053","volume":"16","author":"H Wang","year":"2025","unstructured":"Wang H, Liu H, Li W et al (2025) Effect of serum MMP-7 on the diagnostic accuracy of biliary atresia: systematic review and meta-analysis. Front Pharmacol 16:1581053","journal-title":"Front Pharmacol"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-025-06258-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-025-06258-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-025-06258-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T09:26:21Z","timestamp":1766222781000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-025-06258-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,20]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6258"],"URL":"https:\/\/doi.org\/10.1007\/s00383-025-06258-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7460903\/v1","asserted-by":"object"}]},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,20]]},"assertion":[{"value":"26 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"48"}}