{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:59:21Z","timestamp":1771883961856,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"DOI":"10.1007\/s00383-026-06367-w","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T08:49:36Z","timestamp":1771836576000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Placental extracellular vesicles stimulate intestinal re-growth after massive small bowel resection in a rat model"],"prefix":"10.1007","volume":"42","author":[{"given":"Igor","family":"Sukhotnik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoav","family":"Ben-Shahar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael.","family":"Kurland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat","family":"Aharon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"issue":"1","key":"6367_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/jpen.2232","volume":"46","author":"BP Modi","year":"2022","unstructured":"Modi BP, Galloway DP, Gura K, Nucci A, Plogsted S, Tucker A, Wales PW (2022) ASPEN Definitions in Pediatric Intestinal Failure. J Parenter Enteral Nutr 46(1):42\u201359. https:\/\/doi.org\/10.1002\/jpen.2232","journal-title":"J Parenter Enteral Nutr"},{"key":"6367_CR2","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1056\/NEJMra1602650","volume":"377","author":"CP Duggan","year":"2017","unstructured":"Duggan CP, Jaksic T (2017) Pediatric Intestinal Failure. N Engl J Med 377:666\u2013675. https:\/\/doi.org\/10.1056\/NEJMra1602650","journal-title":"N Engl J Med"},{"issue":"10","key":"6367_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102341","volume":"15","author":"C Caporilli","year":"2023","unstructured":"Caporilli C, Giann\u00ec G, Grassi F, Esposito S (2023) An overview of short bowel syndrome in pediatric patients: focus on clinical management and prevention of complications. Nutrients 15(10):2341. https:\/\/doi.org\/10.3390\/nu15102341","journal-title":"Nutrients"},{"issue":"3","key":"6367_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.sempedsurg.2023.151314","volume":"32","author":"HM Phelps","year":"2023","unstructured":"Phelps HM, Warner BW (2023) Intestinal adaptation and rehabilitation. Semin Pediatr Surg 32(3):151314. https:\/\/doi.org\/10.1016\/j.sempedsurg.2023.151314","journal-title":"Semin Pediatr Surg"},{"key":"6367_CR5","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.addr.2021.03.017","volume":"173","author":"SAA Kooijmans","year":"2021","unstructured":"Kooijmans SAA, de Jong OG, Schiffelers RM (2021) Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design. Adv Drug Deliv Rev 173:252\u2013278. https:\/\/doi.org\/10.1016\/j.addr.2021.03.017","journal-title":"Adv Drug Deliv Rev"},{"issue":"12","key":"6367_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126480","volume":"23","author":"Y Matsuzaka","year":"2022","unstructured":"Matsuzaka Y, Yashiro R (2022) Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine. Int J Mol Sci 23(12):6480. https:\/\/doi.org\/10.3390\/ijms23126480","journal-title":"Int J Mol Sci"},{"key":"6367_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1563427","volume":"10","author":"M Zubair","year":"2025","unstructured":"Zubair M, Abouelnazar FA, Iqbal MA, Pan J, Zheng X, Chen T, Shen W, Yin J, Yan Y, Liu P, Mao F, Chu Y (2025) Mesenchymal stem cell-derived exosomes as a plausible immunomodulatory therapeutic tool for inflammatory diseases. Front Cell Dev Biol 10:1563427. https:\/\/doi.org\/10.3389\/fcell.2025.1563427","journal-title":"Front Cell Dev Biol"},{"issue":"9","key":"6367_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098126","volume":"24","author":"M Zavaro","year":"2023","unstructured":"Zavaro M, Dangot A, Bar-Lev TH, Amit O, Avivi I, Ram R, Aharon A (2023) The role of extracellular vesicles (EVs) in chronic graft vs. host disease, and the potential function of placental cell-derived EVs as a therapeutic tool. Int J Mol Sci 24(9):8126.9. https:\/\/doi.org\/10.3390\/ijms24098126","journal-title":"Int J Mol Sci"},{"issue":"1","key":"6367_CR9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/MPG.0000000000002876","volume":"72","author":"I Sukhotnik","year":"2021","unstructured":"Sukhotnik I, Ben-Shahar Y, Pollak Y, Cohen S, Guz-Mark A, Shamir RJ (2021) Anti-TNF-alpha therapy exerts intestinal anti-inflammatory and anti-apoptotic effects after massive bowel resection in a rat. Pediatr Gastroenterol Nutr 72(1):49\u201355. https:\/\/doi.org\/10.1097\/MPG.0000000000002876","journal-title":"Pediatr Gastroenterol Nutr"},{"issue":"23","key":"6367_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312759","volume":"22","author":"S Mecocci","year":"2021","unstructured":"Mecocci S, Pietrucci D, Milanesi M, Pascucci L, Filippi S, Rosato V (2021) Transcriptomic characterization of cow, donkey and goat milk extracellular vesicles reveals their anti-inflammatory and immunomodulatory potential. Int J Mol Sci 22(23):12759. https:\/\/doi.org\/10.3390\/ijms222312759","journal-title":"Int J Mol Sci"},{"key":"6367_CR11","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.14336\/AD.2021.0601","volume":"12","author":"H Yu","year":"2021","unstructured":"Yu H, Yang X, Xiao X, Xu M, Yang Y, Xue C et al (2021) Human adipose mesenchymal stem cell-derived exosomes protect mice from DSS-induced inflammatory bowel disease by promoting intestinalstem-cell and epithelial regeneration. Aging Dis 12:1423\u20131437. https:\/\/doi.org\/10.14336\/AD.2021.0601","journal-title":"Aging Dis"},{"issue":"1","key":"6367_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01887-1","volume":"11","author":"A Accarie","year":"2020","unstructured":"Accarie A, l\u2019Homme B, Benadjaoud MA, Lim SK, Guha C, Benderitter M, Tamarat R, S\u00e9mont A (2020) Extracellular vesicles derived from mesenchymal stromal cells mitigate intestinal toxicity in a mouse model of acute radiation syndrome. Stem Cell Res Ther 11(1):371. https:\/\/doi.org\/10.1186\/s13287-020-01887-1","journal-title":"Stem Cell Res Ther"},{"issue":"7","key":"6367_CR13","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.jpedsurg.2022.02.029","volume":"57","author":"L Wang","year":"2022","unstructured":"Wang L, Gao R, Li B, Alganabi M, He W, Shen C, Zhu H, Pierro A (2022) Human breast milk-derived exosomes protect against intestinal ischemia and reperfusion injury in neonatal rats. J Pediatr Surg 57(7):1264\u20131268. https:\/\/doi.org\/10.1016\/j.jpedsurg.2022.02.029","journal-title":"J Pediatr Surg"},{"issue":"3","key":"6367_CR14","doi-asserted-by":"publisher","first-page":"G247","DOI":"10.1152\/ajpgi.00139.2017","volume":"313","author":"I Sukhotnik","year":"2017","unstructured":"Sukhotnik I, Coran AG, Pollak Y, Kuhnreich E, Berkowitz D, Saxena AK (2017) Activated Notch signaling cascade is correlated with stem cell differentiation toward absorptive progenitors after massive small bowel resection in a rat. Am J Physiol Gastrointest Liver Physiol 313(3):G247\u2013G255. https:\/\/doi.org\/10.1152\/ajpgi.00139.2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"6367_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2024.101997","volume":"79","author":"L Zhang","year":"2025","unstructured":"Zhang L, Li J, Wan Q, Bu C, Jin W, Yuan F, Zhou W (2025) Intestinal stem cell-derived extracellular vesicles ameliorate necrotizing enterocolitis injury. Mol Cell Probes 79:101997. https:\/\/doi.org\/10.1016\/j.mcp.2024.101997","journal-title":"Mol Cell Probes"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-026-06367-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-026-06367-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-026-06367-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:02:32Z","timestamp":1771880552000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-026-06367-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6367"],"URL":"https:\/\/doi.org\/10.1007\/s00383-026-06367-w","relation":{},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]},"assertion":[{"value":"8 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"113"}}