{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:56:50Z","timestamp":1781341010999,"version":"3.54.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Tianshan Talent Training Program","award":["No.2023TSYCJC0052"],"award-info":[{"award-number":["No.2023TSYCJC0052"]}]},{"name":"Xinjiang Uygur Autonomous Region Science Foundation Projects","award":["2024D01A28"],"award-info":[{"award-number":["2024D01A28"]}]},{"name":"Tianjin Applied Basic Research Project","award":["No.22JCZDJC00290"],"award-info":[{"award-number":["No.22JCZDJC00290"]}]},{"name":"Tianjin Key Medical Discipline(Specialty) Construction Project","award":["TJYXZDXK-040A"],"award-info":[{"award-number":["TJYXZDXK-040A"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"DOI":"10.1007\/s00383-026-06501-8","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:39:20Z","timestamp":1781339960000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between post-Kasai cholangitis episodes, ursodeoxycholic acid regimen, and portal hypertension risk in biliary atresia: a multicenter cross-sectional study"],"prefix":"10.1007","volume":"42","author":[{"given":"Qianhui","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiquan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alimujiang","family":"Abudureyimu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"issue":"6","key":"6501_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1097\/mpg.0000000000002130","volume":"67","author":"M Witt","year":"2018","unstructured":"Witt M, van Wessel DBE, de Kleine RHJ, Bruggink JLM, Hulscher JBF, Verkade HJ (2018) Prognosis of Biliary atresia after 2-year survival with native liver: a Nationwide Cohort analysis. J Pediatr Gastroenterol Nutr 67(6):689\u2013694. https:\/\/doi.org\/10.1097\/mpg.0000000000002130","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"12","key":"6501_CR2","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1002\/hep4.1602","volume":"4","author":"V Venkat","year":"2020","unstructured":"Venkat V, Ng VL, Magee JC, Ye W, Hawthorne K, Harpavat S et al (2020) Modeling outcomes in children with biliary atresia with native liver after 2 years of age. Hepatol Commun 4(12):1824\u20131834. https:\/\/doi.org\/10.1002\/hep4.1602","journal-title":"Hepatol Commun"},{"issue":"12","key":"6501_CR3","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1016\/j.jpedsurg.2019.08.026","volume":"54","author":"J Liu","year":"2019","unstructured":"Liu J, Dong R, Chen G, Dong K, Zheng S (2019) Risk factors and prognostic effects of cholangitis after Kasai procedure in biliary atresia patients: a retrospective clinical study. J Pediatr Surg 54(12):2559\u20132564. https:\/\/doi.org\/10.1016\/j.jpedsurg.2019.08.026","journal-title":"J Pediatr Surg"},{"issue":"2","key":"6501_CR4","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/mpg.0000000000002555","volume":"70","author":"SH Baek","year":"2020","unstructured":"Baek SH, Kang JM, Ihn K, Han SJ, Koh H, Ahn JG (2020) The epidemiology and etiology of cholangitis after kasai portoenterostomy in patients with biliary atresia. J Pediatr Gastroenterol Nutr 70(2):171\u2013177. https:\/\/doi.org\/10.1097\/mpg.0000000000002555","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"6501_CR5","doi-asserted-by":"publisher","unstructured":"Calinescu AM, Madadi-Sanjani O, Mack C, Schreiber RA, Superina R, Kelly D et al (2022) Cholangitis definition and treatment after kasai hepatoportoenterostomy for biliary atresia: a delphi process and international expert panel. J Clin Med https:\/\/doi.org\/10.3390\/jcm11030494","DOI":"10.3390\/jcm11030494"},{"key":"6501_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2025.01.006","author":"SH Liu","year":"2025","unstructured":"Liu SH, Chen CC, Chao HC, Kong MS, Lai JY, Lai MW (2025) Annual cholangitis more than twice predicts liver transplant in biliary atresia patients who achieve jaundice-free after Kasai portoenterostomy. J Formos Med Assoc. https:\/\/doi.org\/10.1016\/j.jfma.2025.01.006","journal-title":"J Formos Med Assoc"},{"issue":"3","key":"6501_CR7","doi-asserted-by":"publisher","first-page":"102471","DOI":"10.1016\/j.jceh.2024.102471","volume":"15","author":"A Samanta","year":"2025","unstructured":"Samanta A, Sarma MS (2025) Post-Kasai portoenterostomy cholangitis: what have we learnt so far? J Clin Exp Hepatol 15(3):102471. https:\/\/doi.org\/10.1016\/j.jceh.2024.102471","journal-title":"J Clin Exp Hepatol"},{"issue":"1","key":"6501_CR8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s12887-018-1074-2","volume":"18","author":"SY Chen","year":"2018","unstructured":"Chen SY, Lin CC, Tsan YT, Chan WC, Wang JD, Chou YJ et al (2018) Number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after Kasai portoenterostomy. BMC Pediatr 18(1):119. https:\/\/doi.org\/10.1186\/s12887-018-1074-2","journal-title":"BMC Pediatr"},{"issue":"4","key":"6501_CR9","first-page":"170","volume":"71","author":"EJ Bijl","year":"2013","unstructured":"Bijl EJ, Bharwani KD, Houwen RH, de Man RA (2013) The long-term outcome of the Kasai operation in patients with biliary atresia: a systematic review. Neth J Med 71(4):170\u2013173","journal-title":"Neth J Med"},{"issue":"12","key":"6501_CR10","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.cgh.2011.07.024","volume":"9","author":"W de Vries","year":"2011","unstructured":"de Vries W, Homan-Van der Veen J, Hulscher JB, Hoekstra-Weebers JE, Houwen RH, Verkade HJ (2011) Twenty-year transplant-free survival rate among patients with biliary atresia. Clin Gastroenterol Hepatol 9(12):1086\u20131091. https:\/\/doi.org\/10.1016\/j.cgh.2011.07.024","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"6501_CR11","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s00383-024-05775-0","volume":"40","author":"PHY Chung","year":"2024","unstructured":"Chung PHY, Harumatsu T, Nakagawa Y, Tsuboi K, Chan EKW, Leung MWY et al (2024) Cholestasis after Kasai operation predicts portal hypertension in native liver survivors of biliary atresia: a multicenter study. Pediatr Surg Int 40(1):196. https:\/\/doi.org\/10.1007\/s00383-024-05775-0","journal-title":"Pediatr Surg Int"},{"issue":"1","key":"6501_CR12","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1007\/s00383-025-06222-4","volume":"41","author":"R Okubo","year":"2025","unstructured":"Okubo R, Nio M, Sasaki H, Fukuzawa T, Kudo H, Ando R et al (2025) Portal hypertension in biliary atresia: a Japanese biliary atresia registry study. Pediatr Surg Int 41(1):324. https:\/\/doi.org\/10.1007\/s00383-025-06222-4","journal-title":"Pediatr Surg Int"},{"issue":"5","key":"6501_CR13","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1097\/MPG.0b013e31826eb0cf","volume":"55","author":"BL Shneider","year":"2012","unstructured":"Shneider BL, Abel B, Haber B, Karpen SJ, Magee JC, Romero R et al (2012) Portal hypertension in children and young adults with biliary atresia. J Pediatr Gastroenterol Nutr 55(5):567\u2013573. https:\/\/doi.org\/10.1097\/MPG.0b013e31826eb0cf","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"4","key":"6501_CR14","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/mpg.0000000000002836","volume":"71","author":"K Cheng","year":"2020","unstructured":"Cheng K, Molleston JP, Bennett WE (2020) Jr. cholangitis in patients with biliary atresia receiving hepatoportoenterostomy: a National database study. J Pediatr Gastroenterol Nutr 71(4):452\u2013458. https:\/\/doi.org\/10.1097\/mpg.0000000000002836","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"6501_CR15","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1097\/mpg.0000000000003638","volume":"76","author":"M Matcovici","year":"2023","unstructured":"Matcovici M, Stoica I, Smith K, Davenport M, What Makes A (2023) Successful Kasai portoenterostomy unsuccessful? J Pediatr Gastroenterol Nutr 76(1):66\u201371. https:\/\/doi.org\/10.1097\/mpg.0000000000003638","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"6501_CR16","doi-asserted-by":"publisher","first-page":"e1236","DOI":"10.1542\/peds.2008-0986","volume":"122","author":"S Willot","year":"2008","unstructured":"Willot S, Uhlen S, Michaud L, Briand G, Bonnevalle M, Sfeir R et al (2008) Effect of ursodeoxycholic acid on liver function in children after successful surgery for biliary atresia. Pediatrics 122(6):e1236\u2013e1241. https:\/\/doi.org\/10.1542\/peds.2008-0986","journal-title":"Pediatrics"},{"issue":"8","key":"6501_CR17","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.jpedsurg.2017.08.048","volume":"53","author":"MP Pakarinen","year":"2018","unstructured":"Pakarinen MP, Johansen LS, Svensson JF, Bj\u00f8rnland K, Gatzinsky V, Stenstr\u00f6m P et al (2018) Outcomes of biliary atresia in the Nordic countries-a multicenter study of 158 patients during 2005\u20132016. J Pediatr Surg 53(8):1509\u20131515. https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.08.048","journal-title":"J Pediatr Surg"},{"issue":"2","key":"6501_CR18","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.jhep.2025.01.025","volume":"83","author":"I Nyholm","year":"2025","unstructured":"Nyholm I, Hukkinen M, Lohi J, Sj\u00f6blom N, Mutka A, Mutanen A et al (2025) Accumulation of altered serum bile acids predicts liver injury after portoenterostomy in biliary atresia. J Hepatol 83(2):440\u2013452. https:\/\/doi.org\/10.1016\/j.jhep.2025.01.025","journal-title":"J Hepatol"},{"issue":"7","key":"6501_CR19","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/j.jpedsurg.2007.11.043","volume":"43","author":"MA Kotb","year":"2008","unstructured":"Kotb MA (2008) Review of historical cohort: ursodeoxycholic acid in extrahepatic biliary atresia. J Pediatr Surg 43(7):1321\u20131327. https:\/\/doi.org\/10.1016\/j.jpedsurg.2007.11.043","journal-title":"J Pediatr Surg"},{"issue":"3","key":"6501_CR20","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/jpc.13371","volume":"53","author":"NL Webb","year":"2017","unstructured":"Webb NL, Jiwane A, Ooi CY, Nightinghale S, Adams SE, Krishnan U (2017) Clinical significance of liver histology on outcomes in biliary atresia. J Paediatr Child Health 53(3):252\u2013256. https:\/\/doi.org\/10.1111\/jpc.13371","journal-title":"J Paediatr Child Health"},{"issue":"1","key":"6501_CR21","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00383-025-06180-x","volume":"41","author":"Y Meng","year":"2025","unstructured":"Meng Y, Liu S, Yang Q, Zhao Y, Li T, Liu J et al (2025) Dosage and duration of ursodeoxycholic acid therapy Post-Kasai portoenterostomy in biliary atresia: a multicenter cross-sectional study with age stratification. Pediatr Surg Int 41(1):279. https:\/\/doi.org\/10.1007\/s00383-025-06180-x","journal-title":"Pediatr Surg Int"},{"issue":"5","key":"6501_CR22","doi-asserted-by":"publisher","first-page":"392","DOI":"10.3760\/cma.j.issn.0253-3006.2019.05.003","volume":"40","author":"Section of Hepatobiliary Surgery, B","year":"2019","unstructured":"Section of Hepatobiliary Surgery, Branch of Pediatric Surgery, Chinese Medical Association, Section of Pediatric Hepatic Transplantation, Branch of Organ Transplantation, Chinese Medical Doctor Association. Guidelines for diagnosing & treating biliary atresia (2018 Edition). Chin J Pediatr Surg 2019;40(5):392-8. https:\/\/doi.org\/10.3760\/cma.j.issn.0253-3006.2019.05.003.","journal-title":"Chin J Pediatr Surg"},{"issue":"4","key":"6501_CR23","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1097\/mpg.0000000000002243","volume":"68","author":"DA Ginstr\u00f6m","year":"2019","unstructured":"Ginstr\u00f6m DA, Hukkinen M, Kivisaari R, Pakarinen MP (2019) Biliary atresia-associated cholangitis: the central role and effective management of bile lakes. J Pediatr Gastroenterol Nutr 68(4):488\u2013494. https:\/\/doi.org\/10.1097\/mpg.0000000000002243","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"6501_CR24","doi-asserted-by":"publisher","first-page":"11207","DOI":"10.1038\/s41598-021-90860-w","volume":"11","author":"PHY Chung","year":"2021","unstructured":"Chung PHY, Chan EKW, Yeung F, Chan ACY, Mou JWC, Lee KH et al (2021) Life long follow up and management strategies of patients living with native livers after Kasai portoenterostomy. Sci Rep 11(1):11207. https:\/\/doi.org\/10.1038\/s41598-021-90860-w","journal-title":"Sci Rep"},{"issue":"6","key":"6501_CR25","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1097\/mpg.0000000000002333","volume":"68","author":"LM Bass","year":"2019","unstructured":"Bass LM, Shneider BL, Henn L, Goodrich NP, Magee JC (2019) Clinically evident portal hypertension: an operational research definition for future investigations in the pediatric population. J Pediatr Gastroenterol Nutr 68(6):763\u2013767. https:\/\/doi.org\/10.1097\/mpg.0000000000002333","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"6501_CR26","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s00383-024-05774-1","volume":"40","author":"T Harumatsu","year":"2024","unstructured":"Harumatsu T, Muraji T, Masuya R, Tsuruno Y, Iwamoto Y, Ogata M et al (2024) Inflammation patterns in early post-operative cholangitis predict long-term outcomes in biliary atresia: a potential role of non-suppurative cholangitis. Pediatr Surg Int 40(1):190. https:\/\/doi.org\/10.1007\/s00383-024-05774-1","journal-title":"Pediatr Surg Int"},{"issue":"2","key":"6501_CR27","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1093\/aje\/kwt212","volume":"179","author":"M Lunt","year":"2014","unstructured":"Lunt M (2014) Selecting an appropriate caliper can be essential for achieving good balance with propensity score matching. Am J Epidemiol 179(2):226\u2013235. https:\/\/doi.org\/10.1093\/aje\/kwt212","journal-title":"Am J Epidemiol"},{"issue":"12","key":"6501_CR28","doi-asserted-by":"publisher","first-page":"e81045","DOI":"10.1371\/journal.pone.0081045","volume":"8","author":"Y Wang","year":"2013","unstructured":"Wang Y, Cai H, Li C, Jiang Z, Wang L, Song J et al (2013) Optimal caliper width for propensity score matching of three treatment groups: a Monte Carlo study. PLoS ONE 8(12):e81045. https:\/\/doi.org\/10.1371\/journal.pone.0081045","journal-title":"PLoS ONE"},{"key":"6501_CR29","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000001592","author":"E Grimaud","year":"2025","unstructured":"Grimaud E, Gardin A, Ackermann O, Habes D, Hermeziu B, Th\u00e9baut A et al (2025) Serum bile acid levels predict the development of portal hypertension and high-risk esophageal varices following successful Kasai in biliary atresia. Hepatology. https:\/\/doi.org\/10.1097\/hep.0000000000001592","journal-title":"Hepatology"},{"issue":"2","key":"6501_CR30","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.jpedsurg.2011.11.031","volume":"47","author":"A Shalaby","year":"2012","unstructured":"Shalaby A, Makin E, Davenport M (2012) Portal venous pressure in biliary atresia. J Pediatr Surg 47(2):363\u2013366. https:\/\/doi.org\/10.1016\/j.jpedsurg.2011.11.031","journal-title":"J Pediatr Surg"},{"issue":"6","key":"6501_CR31","doi-asserted-by":"publisher","first-page":"e001098","DOI":"10.1136\/wjps-2025-001098","volume":"8","author":"M Hukkinen","year":"2025","unstructured":"Hukkinen M, Pakarinen MP (2025) Fibrotic liver injury in biliary atresia: long-term implications. World J Pediatr Surg 8(6):e001098. https:\/\/doi.org\/10.1136\/wjps-2025-001098","journal-title":"World J Pediatr Surg"},{"issue":"2","key":"6501_CR32","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/path.6273","volume":"263","author":"S Shan","year":"2024","unstructured":"Shan S, Zhao X, Wood-Trageser MA, Hu D, Liu L, Qi B et al (2024) Obliteration of portal venules contributes to portal hypertension in biliary cirrhosis. J Pathol 263(2):178\u2013189. https:\/\/doi.org\/10.1002\/path.6273","journal-title":"J Pathol"},{"issue":"1","key":"6501_CR33","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/mpg.0000000000002701","volume":"71","author":"KR Patel","year":"2020","unstructured":"Patel KR, Harpavat S, Khan Z, Dhingra S, Quintanilla N, Firan M et al (2020) Biliary atresia patients with successful Kasai portoenterostomy can present with features of obliterative portal venopathy. J Pediatr Gastroenterol Nutr 71(1):91\u201398. https:\/\/doi.org\/10.1097\/mpg.0000000000002701","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"3","key":"6501_CR34","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1148\/radiol.2021203967","volume":"299","author":"WJ Lv","year":"2021","unstructured":"Lv WJ, Zhao XY, Hu DD, Xin XH, Qin LL, Hu CH (2021) Insight into bile duct reaction to obstruction from a three-dimensional perspective using ex vivo phase-contrast CT. Radiology 299(3):597\u2013610. https:\/\/doi.org\/10.1148\/radiol.2021203967","journal-title":"Radiology"},{"issue":"4","key":"6501_CR35","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.surg.2018.10.032","volume":"165","author":"M Hukkinen","year":"2019","unstructured":"Hukkinen M, Kerola A, Lohi J, Jahnukainen T, Heikkil\u00e4 P, Pakarinen MP (2019) Very low bilirubin after portoenterostomy improves survival of the native liver in patients with biliary atresia by deferring liver fibrogenesis. Surgery 165(4):843\u2013850. https:\/\/doi.org\/10.1016\/j.surg.2018.10.032","journal-title":"Surgery"},{"key":"6501_CR36","doi-asserted-by":"publisher","first-page":"101764","DOI":"10.1016\/j.bpg.2021.101764","volume":"56\u201357","author":"M Hukkinen","year":"2022","unstructured":"Hukkinen M, Ruuska S, Pihlajoki M, Kyr\u00f6nlahti A, Pakarinen MP (2022) Long-term outcomes of biliary atresia patients surviving with their native livers. Best Pract Res Clin Gastroenterol 56\u201357:101764. https:\/\/doi.org\/10.1016\/j.bpg.2021.101764","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"11","key":"6501_CR37","doi-asserted-by":"publisher","first-page":"162505","DOI":"10.1016\/j.jpedsurg.2025.162505","volume":"60","author":"MP Pakarinen","year":"2025","unstructured":"Pakarinen MP, Hukkinen M, Nyholm I, Lohi J, Jahnukainen T (2025) Decrease of post-portoenterostomy liver fibrosis in a Nationally centralized cohort of biliary atresia patients. J Pediatr Surg 60(11):162505. https:\/\/doi.org\/10.1016\/j.jpedsurg.2025.162505","journal-title":"J Pediatr Surg"},{"issue":"4","key":"6501_CR38","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1097\/mpg.0000000000001854","volume":"66","author":"CWY Wong","year":"2018","unstructured":"Wong CWY, Chung PHY, Tam PKH, Wong KKY (2018) Long-term results and quality of life assessment in biliary atresia patients: a 35-year experience in a tertiary hospital. J Pediatr Gastroenterol Nutr 66(4):570\u2013574. https:\/\/doi.org\/10.1097\/mpg.0000000000001854","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"6501_CR39","doi-asserted-by":"publisher","unstructured":"Nyholm I, Sj\u00f6blom N, Pihlajoki M, Hukkinen M, Lohi J, Heikkil\u00e4 P et al (2023) Deep learning quantification reveals a fundamental prognostic role for ductular reaction in biliary atresia. Hepatol Commun https:\/\/doi.org\/10.1097\/hc9.0000000000000333","DOI":"10.1097\/hc9.0000000000000333"},{"issue":"3","key":"6501_CR40","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1002\/hep4.1306","volume":"3","author":"M Hukkinen","year":"2019","unstructured":"Hukkinen M, Lohi J, Heikkil\u00e4 P, Kivisaari R, Jahnukainen T, Jalanko H et al (2019) Noninvasive evaluation of liver fibrosis and portal hypertension after successful portoenterostomy for biliary atresia. Hepatol Commun 3(3):382\u2013391. https:\/\/doi.org\/10.1002\/hep4.1306","journal-title":"Hepatol Commun"},{"issue":"12","key":"6501_CR41","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/bf00311686","volume":"25","author":"M Nakada","year":"1995","unstructured":"Nakada M, Nakada K, Fujioka T, Kawaguchi F, Yamate N, Nosaka S (1995) Doppler ultrasonographic evaluation of hepatic circulation in patients following Kasai\u2019s operation for biliary atresia. Surg Today 25(12):1023\u20131026. https:\/\/doi.org\/10.1007\/bf00311686","journal-title":"Surg Today"},{"issue":"1","key":"6501_CR42","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/s0022-3468(05)80181-2","volume":"25","author":"EA Wanek","year":"1990","unstructured":"Wanek EA, Horgan JG, Karrer FM, Hall RJ, Rumack CM, Lilly JR (1990) Portal venous velocity in biliary atresia. J Pediatr Surg 25(1):146\u2013148. https:\/\/doi.org\/10.1016\/s0022-3468(05)80181-2","journal-title":"J Pediatr Surg"},{"issue":"6","key":"6501_CR43","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1053\/jpsu.2002.32892","volume":"37","author":"PL Khong","year":"2002","unstructured":"Khong PL, Ooi CG, Saing H, Chan KL, Wong WH, Tam PK et al (2002) Portal venous velocity in the follow-up of patients with biliary atresia after Kasai portoenterostomy. J Pediatr Surg 37(6):873\u2013876. https:\/\/doi.org\/10.1053\/jpsu.2002.32892","journal-title":"J Pediatr Surg"},{"issue":"4","key":"6501_CR44","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/00005176-199904000-00012","volume":"28","author":"R Kardorff","year":"1999","unstructured":"Kardorff R, Klotz M, Melter M, Rodeck B, Hoyer PF (1999) Prediction of survival in extrahepatic biliary atresia by hepatic duplex sonography. J Pediatr Gastroenterol Nutr 28(4):411\u2013417. https:\/\/doi.org\/10.1097\/00005176-199904000-00012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"6501_CR45","doi-asserted-by":"publisher","first-page":"870351","DOI":"10.3389\/fmed.2022.870351","volume":"9","author":"H Liu","year":"2022","unstructured":"Liu H, Zhang Q, Gao F, Yu H, Jiang Y, Wang X (2022) Platelet count\/spleen thickness ratio and the risk of variceal bleeding in cirrhosis with esophagogastric varices. Front Med (Lausanne) 9:870351. https:\/\/doi.org\/10.3389\/fmed.2022.870351","journal-title":"Front Med (Lausanne)"},{"issue":"7","key":"6501_CR46","doi-asserted-by":"publisher","first-page":"e9843","DOI":"10.1097\/md.0000000000009843","volume":"97","author":"Z Wang","year":"2018","unstructured":"Wang Z, Liu X, Xu H, Qu L, Zhang D, Gao P (2018) Platelet count to spleen thickness ratio is related to histologic severity of primary biliary cholangitis. Med (Baltim) 97(7):e9843. https:\/\/doi.org\/10.1097\/md.0000000000009843","journal-title":"Med (Baltim)"},{"key":"6501_CR47","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fmed.2020.00149","volume":"7","author":"A Kriegermeier","year":"2020","unstructured":"Kriegermeier A, Green R (2020) Pediatric cholestatic liver disease: review of bile acid metabolism and discussion of current and emerging therapies. Front Med (Lausanne) 7:149. https:\/\/doi.org\/10.3389\/fmed.2020.00149","journal-title":"Front Med (Lausanne)"},{"issue":"8","key":"6501_CR48","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.jpedsurg.2007.03.026","volume":"42","author":"MD Stringer","year":"2007","unstructured":"Stringer MD, Davison SM, Rajwal SR, McClean P (2007) Kasai portoenterostomy: 12-year experience with a novel adjuvant therapy regimen. J Pediatr Surg 42(8):1324\u20131328. https:\/\/doi.org\/10.1016\/j.jpedsurg.2007.03.026","journal-title":"J Pediatr Surg"},{"issue":"3","key":"6501_CR49","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1002\/hep.32800","volume":"77","author":"S Harpavat","year":"2023","unstructured":"Harpavat S, Hawthorne K, Setchell KDR, Rivas MN, Henn L, Beil CA et al (2023) Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy. Hepatology 77(3):862\u2013873. https:\/\/doi.org\/10.1002\/hep.32800","journal-title":"Hepatology"},{"issue":"7","key":"6501_CR50","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.cgh.2017.02.025","volume":"15","author":"AJ Freeman","year":"2017","unstructured":"Freeman AJ, Ng VL, Harpavat S, Hrycko A, Apted Z, Bulut P et al (2017) Level of \u03b3-glutamyltransferase in 2-year-old children with biliary atresia associates with progression of portal hypertension. Clin Gastroenterol Hepatol 15(7):1133\u20131135. https:\/\/doi.org\/10.1016\/j.cgh.2017.02.025","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"6501_CR51","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.jpedsurg.2017.10.001","volume":"53","author":"K Ihn","year":"2018","unstructured":"Ihn K, Ho IG, Chang EY, Han SJ (2018) Correlation between gamma-glutamyl transpeptidase activity and outcomes after Kasai portoenterostomy for biliary atresia. J Pediatr Surg 53(3):461\u2013467. https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.10.001","journal-title":"J Pediatr Surg"},{"issue":"7","key":"6501_CR52","doi-asserted-by":"publisher","first-page":"8882","DOI":"10.3390\/ijms13078882","volume":"13","author":"MA Kotb","year":"2012","unstructured":"Kotb MA (2012) Molecular mechanisms of ursodeoxycholic acid toxicity & side effects: ursodeoxycholic acid freezes regeneration & induces hibernation mode. Int J Mol Sci 13(7):8882\u20138914. https:\/\/doi.org\/10.3390\/ijms13078882","journal-title":"Int J Mol Sci"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-026-06501-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-026-06501-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-026-06501-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:39:22Z","timestamp":1781339962000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-026-06501-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,13]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6501"],"URL":"https:\/\/doi.org\/10.1007\/s00383-026-06501-8","relation":{},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,13]]},"assertion":[{"value":"7 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"253"}}