{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:16:12Z","timestamp":1788966972518,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K16932"],"award-info":[{"award-number":["JP21K16932"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K19565"],"award-info":[{"award-number":["JP22K19565"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"DOI":"10.1007\/s00383-026-06620-2","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:30:12Z","timestamp":1788964212000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of stem cells from exfoliated deciduous teeth from a patient with Alagille syndrome carrying a JAG1 mutation"],"prefix":"10.1007","volume":"42","author":[{"given":"Yasuyuki","family":"Uchida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Sonoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Yoshimaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruyoshi","family":"Yamaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Kosaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuro","family":"Tajiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Yamaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"6620_CR1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0022-3476(87)80153-1","volume":"110","author":"D Alagille","year":"1987","unstructured":"Alagille D, Estrada A, Hadchouel M et al (1987) Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases. J Pediatr 110:195\u2013200. https:\/\/doi.org\/10.1016\/S0022-3476(87)80153-1","journal-title":"J Pediatr"},{"key":"6620_CR2","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/J.CLD.2022.03.002","volume":"26","author":"MD Ayoub","year":"2022","unstructured":"Ayoub MD, Kamath BM (2022) Alagille syndrome: current understanding of pathogenesis, and challenges in diagnosis and management. Clin Liver Dis 26:355\u2013370. https:\/\/doi.org\/10.1016\/J.CLD.2022.03.002","journal-title":"Clin Liver Dis"},{"key":"6620_CR3","doi-asserted-by":"publisher","first-page":"726","DOI":"10.14218\/JCTH.2024.00119","volume":"12","author":"J Tidwell","year":"2024","unstructured":"Tidwell J, Wu GY (2024) Heritable chronic cholestatic liver diseases: a review. J Clin Transl Hepatol 12:726\u2013738. https:\/\/doi.org\/10.14218\/JCTH.2024.00119","journal-title":"J Clin Transl Hepatol"},{"key":"6620_CR4","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/S00383-009-2430-Y","volume":"25","author":"Y Takahashi","year":"2009","unstructured":"Takahashi Y, Nishimoto Y, Matsuura T et al (2009) Surgical complications after living donor liver transplantation in patients with biliary atresia: a relatively high incidence of portal vein complications. Pediatr Surg Int 25:745\u2013751. https:\/\/doi.org\/10.1007\/S00383-009-2430-Y","journal-title":"Pediatr Surg Int"},{"key":"6620_CR5","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/J.TRANSPROCEED.2020.05.020","volume":"53","author":"FS Alatas","year":"2021","unstructured":"Alatas FS, Matsuura T, Yoshimaru K et al (2021) Alopecia in children following living related liver transplantation. Transpl Proc 53:228\u2013232. https:\/\/doi.org\/10.1016\/J.TRANSPROCEED.2020.05.020","journal-title":"Transpl Proc"},{"key":"6620_CR6","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1080\/17474124.2023.2255518","volume":"17","author":"J Halma","year":"2023","unstructured":"Halma J, Lin HC (2023) Alagille syndrome: understanding the genotype-phenotype relationship and its potential therapeutic impact. Expert Rev Gastroenterol Hepatol 17:883\u2013892. https:\/\/doi.org\/10.1080\/17474124.2023.2255518","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"6620_CR7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/S41392-022-00934-Y","volume":"7","author":"B Zhou","year":"2022","unstructured":"Zhou B, Lin W, Long Y et al (2022) Notch signaling pathway: architecture, disease, and therapeutics. Signal Transduct Target Ther 7:95. https:\/\/doi.org\/10.1038\/S41392-022-00934-Y","journal-title":"Signal Transduct Target Ther"},{"key":"6620_CR8","doi-asserted-by":"publisher","first-page":"102302","DOI":"10.1016\/J.CEB.2023.102302","volume":"86","author":"J Ma\u0161ek","year":"2024","unstructured":"Ma\u0161ek J, Andersson ER (2024) Jagged-mediated development and disease: mechanistic insights and therapeutic implications for Alagille syndrome. Curr Opin Cell Biol 86:102302. https:\/\/doi.org\/10.1016\/J.CEB.2023.102302","journal-title":"Curr Opin Cell Biol"},{"key":"6620_CR9","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1101\/GAD.340305","volume":"19","author":"F Clotman","year":"2005","unstructured":"Clotman F, Jacquemin P, Plumb-Rudewiez N et al (2005) Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Genes Dev 19:1849\u20131854. https:\/\/doi.org\/10.1101\/GAD.340305","journal-title":"Genes Dev"},{"key":"6620_CR10","doi-asserted-by":"publisher","first-page":"5807","DOI":"10.1073\/PNAS.0937635100","volume":"100","author":"M Miura","year":"2003","unstructured":"Miura M, Gronthos S, Zhao M et al (2003) SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A 100:5807\u20135812. https:\/\/doi.org\/10.1073\/PNAS.0937635100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6620_CR11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/S13287-020-02113-8","volume":"12","author":"R Yuniartha","year":"2021","unstructured":"Yuniartha R, Yamaza T, Sonoda S et al (2021) Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells. Stem Cell Res Ther 12:57. https:\/\/doi.org\/10.1186\/S13287-020-02113-8","journal-title":"Stem Cell Res Ther"},{"key":"6620_CR12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/SCRT5","volume":"1","author":"T Yamaza","year":"2010","unstructured":"Yamaza T, Kentaro A, Chen C et al (2010) Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res Ther 1:5. https:\/\/doi.org\/10.1186\/SCRT5","journal-title":"Stem Cell Res Ther"},{"key":"6620_CR13","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/S13287-015-0154-6","volume":"6","author":"T Yamaza","year":"2015","unstructured":"Yamaza T, Alatas FS, Yuniartha R et al (2015) In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice. Stem Cell Res Ther 6:171. https:\/\/doi.org\/10.1186\/S13287-015-0154-6","journal-title":"Stem Cell Res Ther"},{"key":"6620_CR14","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1038\/S41598-018-38275-Y","volume":"9","author":"J Fujiyoshi","year":"2019","unstructured":"Fujiyoshi J, Yamaza H, Sonoda S et al (2019) Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson\u2019s disease. Sci Rep 9:1535. https:\/\/doi.org\/10.1038\/S41598-018-38275-Y","journal-title":"Sci Rep"},{"key":"6620_CR15","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/S13287-020-01630-W","volume":"11","author":"T Iwanaka","year":"2020","unstructured":"Iwanaka T, Yamaza T, Sonoda S et al (2020) A model study for the manufacture and validation of clinical-grade deciduous dental pulp stem cells for chronic liver fibrosis treatment. Stem Cell Res Ther 11:134. https:\/\/doi.org\/10.1186\/S13287-020-01630-W","journal-title":"Stem Cell Res Ther"},{"key":"6620_CR16","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1111\/ODI.12827","volume":"24","author":"H Yamaza","year":"2018","unstructured":"Yamaza H, Tomoda E, Sonoda S et al (2018) Bilirubin reversibly affects cell death and odontogenic capacity in stem cells from human exfoliated deciduous teeth. Oral Dis 24:809\u2013819. https:\/\/doi.org\/10.1111\/ODI.12827","journal-title":"Oral Dis"},{"key":"6620_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/S13287-018-1042-7","volume":"9","author":"H Yamaza","year":"2018","unstructured":"Yamaza H, Sonoda S, Nonaka K et al (2018) Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth. Stem Cell Res Ther 9:303. https:\/\/doi.org\/10.1186\/S13287-018-1042-7","journal-title":"Stem Cell Res Ther"},{"key":"6620_CR18","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1186\/S13287-021-02652-8","volume":"12","author":"S Sonoda","year":"2021","unstructured":"Sonoda S, Yoshimaru K, Yamaza H et al (2021) Biliary atresia-specific deciduous pulp stem cells feature biliary deficiency. Stem Cell Res Ther 12:582. https:\/\/doi.org\/10.1186\/S13287-021-02652-8","journal-title":"Stem Cell Res Ther"},{"key":"6620_CR19","doi-asserted-by":"publisher","first-page":"102588","DOI":"10.1016\/J.SCR.2021.102588","volume":"57","author":"D Song","year":"2021","unstructured":"Song D, Zheng YW, Hemmi Y et al (2021) Generation of human induced pluripotent stem cell lines carrying homozygous JAG1 deletions. Stem Cell Res 57:102588. https:\/\/doi.org\/10.1016\/J.SCR.2021.102588","journal-title":"Stem Cell Res"},{"key":"6620_CR20","doi-asserted-by":"publisher","first-page":"103213","DOI":"10.1016\/j.scr.2023.103213","volume":"72","author":"I Stanberry","year":"2023","unstructured":"Stanberry I, Cunningham D, Ye S et al (2023) Characterization of an induced pluripotent stem cell line NCHi011-A from a 23-year-old female with Alagille syndrome harboring a heterozygous JAG1 pathogenic variant. Stem Cell Res 72:103213. https:\/\/doi.org\/10.1016\/j.scr.2023.103213","journal-title":"Stem Cell Res"},{"key":"6620_CR21","doi-asserted-by":"publisher","first-page":"102162","DOI":"10.1016\/J.SCR.2021.102162","volume":"51","author":"B Wang","year":"2021","unstructured":"Wang B, Yang L, Li Y et al (2021) Establishment of a human induced pluripotent stem cell line (SDQLCHi037-A) from a patient with Alagille syndrome carrying heterozygous mutation in JAG1 gene. Stem Cell Res 51:102162. https:\/\/doi.org\/10.1016\/J.SCR.2021.102162","journal-title":"Stem Cell Res"},{"key":"6620_CR22","doi-asserted-by":"publisher","first-page":"102366","DOI":"10.1016\/j.scr.2021.102366","volume":"53","author":"W Zhu","year":"2021","unstructured":"Zhu W, Cheng YS, Xu M et al (2021) Generation of Alagille syndrome derived induced pluripotent stem cell line carrying heterozygous mutation in the JAGGED-1 gene at splicing site (Chr20: 10,629,709C\u2009>\u2009A) before exon 11. Stem Cell Res 53:102366. https:\/\/doi.org\/10.1016\/j.scr.2021.102366","journal-title":"Stem Cell Res"},{"key":"6620_CR23","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1089\/GTE.2006.0519","volume":"11","author":"H Samejima","year":"2007","unstructured":"Samejima H, Torii C, Kosaki R et al (2007) Screening for Alagille syndrome mutations in the JAG1 and NOTCH2 genes using denaturing high-performance liquid chromatography. Genet Test 11:216\u2013227. https:\/\/doi.org\/10.1089\/GTE.2006.0519","journal-title":"Genet Test"},{"key":"6620_CR24","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/NG0797-235","volume":"16","author":"T Oda","year":"1997","unstructured":"Oda T, Elkahloun AG, Pike BL et al (1997) Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet 16:235\u2013242. https:\/\/doi.org\/10.1038\/NG0797-235","journal-title":"Nat Genet"},{"key":"6620_CR25","doi-asserted-by":"publisher","first-page":"101386","DOI":"10.1016\/j.xpro.2022.101386","volume":"3","author":"S Sonoda","year":"2022","unstructured":"Sonoda S, Yamaza H, Yoshimaru K et al (2022) Protocol to generate xenogeneic-free\/serum-free human dental pulp stem cells. STAR Protoc 3:101386. https:\/\/doi.org\/10.1016\/j.xpro.2022.101386","journal-title":"STAR Protoc"},{"key":"6620_CR26","doi-asserted-by":"publisher","first-page":"e51777","DOI":"10.1371\/JOURNAL.PONE.0051777","volume":"7","author":"L Ma","year":"2012","unstructured":"Ma L, Makino Y, Yamaza H et al (2012) Cryopreserved dental pulp tissues of exfoliated deciduous teeth is a feasible stem cell resource for regenerative medicine. PLoS ONE 7:e51777. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0051777","journal-title":"PLoS ONE"},{"key":"6620_CR27","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I et al (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315\u2013317. https:\/\/doi.org\/10.1080\/14653240600855905","journal-title":"Cytotherapy"},{"key":"6620_CR28","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1359\/jbmr.2003.18.4.696","volume":"18","author":"S Shi","year":"2003","unstructured":"Shi S, Gronthos S (2003) Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Min Res 18:696\u2013704. https:\/\/doi.org\/10.1359\/jbmr.2003.18.4.696","journal-title":"J Bone Min Res"},{"key":"6620_CR29","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","volume":"131","author":"B Sacchetti","year":"2007","unstructured":"Sacchetti B, Funari A, Michienzi S et al (2007) Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131:324\u2013336. https:\/\/doi.org\/10.1016\/j.cell.2007.08.025","journal-title":"Cell"},{"key":"6620_CR30","doi-asserted-by":"publisher","first-page":"19286","DOI":"10.1038\/srep19286","volume":"6","author":"S Sonoda","year":"2016","unstructured":"Sonoda S, Yamaza H, Ma L et al (2016) Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells. Sci Rep 6:19286. https:\/\/doi.org\/10.1038\/srep19286","journal-title":"Sci Rep"},{"key":"6620_CR31","doi-asserted-by":"publisher","first-page":"6719","DOI":"10.1038\/S41598-024-57361-Y","volume":"14","author":"MF Zakaria","year":"2024","unstructured":"Zakaria MF, Sonoda S, Kato H et al (2024) Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease. Sci Rep 14:6719. https:\/\/doi.org\/10.1038\/S41598-024-57361-Y","journal-title":"Sci Rep"},{"key":"6620_CR32","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/S13287-026-04952-3","volume":"17","author":"S Sonoda","year":"2026","unstructured":"Sonoda S, Yu L, Dai L et al (2026) Dental pulp stem cells maintain epigenetic chromatin architecture remodeling primed by the etiological stimulus of biliary atresia. Stem Cell Res Ther 17:136. https:\/\/doi.org\/10.1186\/S13287-026-04952-3","journal-title":"Stem Cell Res Ther"},{"key":"6620_CR33","doi-asserted-by":"publisher","first-page":"1217211","DOI":"10.3389\/FBIOE.2023.1217211","volume":"11","author":"S Kaimari","year":"2023","unstructured":"Kaimari S, Kamalakar A, Goudy SL (2023) Biomedical engineering approaches for the delivery of JAGGED1 as a potential tissue regenerative therapy. Front Bioeng Biotechnol 11:1217211. https:\/\/doi.org\/10.3389\/FBIOE.2023.1217211","journal-title":"Front Bioeng Biotechnol"},{"key":"6620_CR34","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/JBM.A.34332","volume":"101","author":"T Osathanon","year":"2013","unstructured":"Osathanon T, Ritprajak P, Nowwarote N et al (2013) Surface-bound orientated Jagged-1 enhances osteogenic differentiation of human periodontal ligament-derived mesenchymal stem cells. J Biomed Mater Res A 101:358\u2013367. https:\/\/doi.org\/10.1002\/JBM.A.34332","journal-title":"J Biomed Mater Res A"},{"key":"6620_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.archoralbio.2016.01.010","volume":"65","author":"W Sukarawan","year":"2016","unstructured":"Sukarawan W, Peetiakarawach K, Pavasant P, Osathanon T (2016) Effect of Jagged-1 and Dll-1 on osteogenic differentiation by stem cells from human exfoliated deciduous teeth. Arch Oral Biol 65:1\u20138. https:\/\/doi.org\/10.1016\/j.archoralbio.2016.01.010","journal-title":"Arch Oral Biol"},{"key":"6620_CR36","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bone.2014.01.019","volume":"62","author":"CR Hill","year":"2014","unstructured":"Hill CR, Yuasa M, Schoenecker J, Goudy SL (2014) Jagged1 is essential for osteoblast development during maxillary ossification. Bone 62:10\u201321. https:\/\/doi.org\/10.1016\/j.bone.2014.01.019","journal-title":"Bone"},{"key":"6620_CR37","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bone.2016.07.006","volume":"91","author":"DW Youngstrom","year":"2016","unstructured":"Youngstrom DW, Dishowitz MI, Bales CB et al (2016) Jagged1 expression by osteoblast-lineage cells regulates trabecular bone mass and periosteal expansion in mice. Bone 91:64\u201374. https:\/\/doi.org\/10.1016\/j.bone.2016.07.006","journal-title":"Bone"},{"key":"6620_CR38","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1002\/TERM.3122","volume":"14","author":"M Zhang","year":"2020","unstructured":"Zhang M, Yuan SZ, Sun H et al (2020) miR-199b-5p promoted chondrogenic differentiation of C3H10T1\/2 cells by regulating JAG1. J Tissue Eng Regen Med 14:1618\u20131629. https:\/\/doi.org\/10.1002\/TERM.3122","journal-title":"J Tissue Eng Regen Med"},{"key":"6620_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/S12276-018-0151-9","volume":"50","author":"J Sun","year":"2018","unstructured":"Sun J, Luo Z, Wang G et al (2018) Notch ligand Jagged1 promotes mesenchymal stromal cell-based cartilage repair. Exp Mol Med 50:1\u201310. https:\/\/doi.org\/10.1038\/S12276-018-0151-9","journal-title":"Exp Mol Med"},{"key":"6620_CR40","doi-asserted-by":"publisher","first-page":"7424","DOI":"10.1038\/S41467-024-51487-3","volume":"15","author":"E Carolina","year":"2024","unstructured":"Carolina E, Kuse Y, Okumura A et al (2024) Generation of human iPSC-derived 3D bile duct within liver organoid by incorporating human iPSC-derived blood vessel. Nat Commun 15:7424. https:\/\/doi.org\/10.1038\/S41467-024-51487-3","journal-title":"Nat Commun"},{"key":"6620_CR41","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.gene.2015.10.065","volume":"576","author":"CM Grochowski","year":"2016","unstructured":"Grochowski CM, Loomes KM, Spinner NB (2016) Jagged1 (JAG1): structure, expression, and disease associations. Gene 576:381\u2013384. https:\/\/doi.org\/10.1016\/j.gene.2015.10.065","journal-title":"Gene"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-026-06620-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-026-06620-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-026-06620-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:30:12Z","timestamp":1788964212000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-026-06620-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6620"],"URL":"https:\/\/doi.org\/10.1007\/s00383-026-06620-2","relation":{},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"12 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in accordance with the Declaration of Helsinki and was approved by the Kyushu University Institutional Review Board for Human Genome\/Gene Research (protocol number 678-03) and the Kyushu University Institutional Review Board for Clinical Research (protocol number 22271-01). Written informed consent was obtained from the legal guardians of all child donors. All samples were used for research purposes only. All tissue donations were voluntary. All methods were performed according to relevant guidelines and regulations.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The guardians of all subjects involved this study signed an informed consent form.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"392"}}