{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:56:48Z","timestamp":1791197808230,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Surg Int"],"DOI":"10.1007\/s00383-026-06660-8","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:51:08Z","timestamp":1791193868000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Post-Operative Ketorolac in Children After Crohn\u2019s Ileocecectomy"],"prefix":"10.1007","volume":"42","author":[{"given":"Kara","family":"Kennedy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camryn","family":"Krumbhaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunliang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Penney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Baxelbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elana","family":"Mitchel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mattei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"6660_CR1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1136\/rapm-2021-103083","volume":"47","author":"ER Mariano","year":"2022","unstructured":"Mariano ER, Dickerson DM, Szokol JW, Harned M, Mueller JT, Philip BK et al (2022) A multisociety organizational consensus process to define guiding principles for acute perioperative pain management. Reg Anesth Pain Med 47:118\u2013127. https:\/\/doi.org\/10.1136\/rapm-2021-103083","journal-title":"Reg Anesth Pain Med"},{"key":"6660_CR2","unstructured":"Baley K, Michalov K, Kossick MA, McDowell M (2014) Intravenous acetaminophen and intravenous ketorolac for management of pediatric surgical pain: a literature review. AANA J 83:53-64"},{"key":"6660_CR3","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.jpedsurg.2019.02.044","volume":"54","author":"KJ Baxter","year":"2019","unstructured":"Baxter KJ, Short HL, Wetzel M, Steinberg RS, Heiss KF, Raval MV (2019) Decreased opioid prescribing in children using an enhanced recovery protocol. J Pediatr Surg 54:1104\u20131107. https:\/\/doi.org\/10.1016\/j.jpedsurg.2019.02.044","journal-title":"J Pediatr Surg"},{"key":"6660_CR4","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1213\/01.ANE.0000177099.28914.A7","volume":"101","author":"PF White","year":"2005","unstructured":"White PF (2005) The Changing Role of Non-Opioid Analgesic Techniques in the Management of Postoperative Pain. Anesth Analgesia 101:S5. https:\/\/doi.org\/10.1213\/01.ANE.0000177099.28914.A7","journal-title":"Anesth Analgesia"},{"key":"6660_CR5","doi-asserted-by":"publisher","unstructured":"Clarke H, Soneji N, Ko DT, Yun L, Wijeysundera DN Rates and risk factors for prolonged opioid use after major surgery: population based cohort study 2014. https:\/\/doi.org\/10.1136\/bmj.g1251","DOI":"10.1136\/bmj.g1251"},{"key":"6660_CR6","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1001\/archinternmed.2011.1827","volume":"172","author":"A Alam","year":"2012","unstructured":"Alam A, Gomes T, Zheng H, Mamdani MM, Juurlink DN, Bell CM (2012) Long-term Analgesic Use After Low-Risk Surgery: A Retrospective Cohort Study. Arch Intern Med 172:425\u2013430. https:\/\/doi.org\/10.1001\/archinternmed.2011.1827","journal-title":"Arch Intern Med"},{"key":"6660_CR7","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1017\/S104795112400091X","volume":"34","author":"J Townsend","year":"2024","unstructured":"Townsend J, Zaki H, Keesari R, Maher K, Hupp S, Branstetter JW (2024) The use of ketorolac may reduce opioid exposure in infants less than 6 months of age undergoing congenital heart surgery. Cardiol Young 34:1805\u20131808. https:\/\/doi.org\/10.1017\/S104795112400091X","journal-title":"Cardiol Young"},{"key":"6660_CR8","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1001\/jamasurg.2017.0898","volume":"152","author":"EC Wick","year":"2017","unstructured":"Wick EC, Grant MC, Wu CL (2017) Postoperative Multimodal Analgesia Pain Management With Nonopioid Analgesics and Techniques: A Review. JAMA Surg 152:691. https:\/\/doi.org\/10.1001\/jamasurg.2017.0898","journal-title":"JAMA Surg"},{"key":"6660_CR9","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1097\/PEC.0000000000003381","volume":"41","author":"MAH Alsabri","year":"2025","unstructured":"Alsabri MAH, Diab RA, Alqeeq BF, Rifai M, Abouelmagd K, Abo-elnour DE et al (2025) Ketorolac as an Analgesic in Pediatric Acute Pain Management: A Systematic Review and Meta-analysis. Pediatr Emerg Care 41:e34\u201347. https:\/\/doi.org\/10.1097\/PEC.0000000000003381","journal-title":"Pediatr Emerg Care"},{"key":"6660_CR10","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1111\/apt.14606","volume":"47","author":"OO Moninuola","year":"2018","unstructured":"Moninuola OO, Milligan W, Lochhead P, Khalili H (2018) Systematic review with meta-analysis: association between acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of Crohn\u2019s disease and ulcerative colitis exacerbation. Aliment Pharmacol Ther 47:1428\u20131439. https:\/\/doi.org\/10.1111\/apt.14606","journal-title":"Aliment Pharmacol Ther"},{"key":"6660_CR11","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ajg.2018.27","volume":"113","author":"GR Lichtenstein","year":"2018","unstructured":"Lichtenstein GR, Loftus EV, Isaacs KL, Regueiro MD, Gerson LB, Sands BE (2018) ACG Clinical Guideline: Management of Crohn\u2019s Disease in Adults. Am J Gastroenterol 113:481\u2013517. https:\/\/doi.org\/10.1038\/ajg.2018.27","journal-title":"Am J Gastroenterol"},{"key":"6660_CR12","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1097\/00054725-200411000-00009","volume":"10","author":"GF Bonner","year":"2004","unstructured":"Bonner GF, Fakhri A, Vennamaneni SR (2004) A Long-term Cohort Study of Nonsteroidal Anti-inflammatory Drug Use and Disease Activity in Outpatients with Inflammatory Bowel Disease. Inflamm Bowel Dis 10:751\u2013757. https:\/\/doi.org\/10.1097\/00054725-200411000-00009","journal-title":"Inflamm Bowel Dis"},{"key":"6660_CR13","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1097\/MCG.0000000000000421","volume":"50","author":"MD Long","year":"2016","unstructured":"Long MD, Kappelman MD, Martin CF, Chen W, Anton K, Sandler RS (2016) Role of Non-Steroidal Anti-Inflammatory Drugs in Exacerbations of Inflammatory Bowel Disease. J Clin Gastroenterol 50:152\u2013156. https:\/\/doi.org\/10.1097\/MCG.0000000000000421","journal-title":"J Clin Gastroenterol"},{"key":"6660_CR14","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1016\/j.cgh.2022.11.037","volume":"21","author":"N Narula","year":"2023","unstructured":"Narula N, Wong ECL, Pray C, Marshall JK, Rangarajan S, Islam S et al (2023) Associations of Antibiotics, Hormonal Therapies, Oral Contraceptives, and Long-Term NSAIDS With Inflammatory Bowel Disease: Results From the Prospective Urban Rural Epidemiology (PURE) Study. Clin Gastroenterol Hepatol 21:2649\u20132659e16. https:\/\/doi.org\/10.1016\/j.cgh.2022.11.037","journal-title":"Clin Gastroenterol Hepatol"},{"key":"6660_CR15","doi-asserted-by":"publisher","first-page":"101238","DOI":"10.1016\/j.ajogmf.2023.101238","volume":"6","author":"S Johnson","year":"2024","unstructured":"Johnson S, DeBolt CA, Rao MG, Berkin J, Stone J, Mella MT et al (2024) Ketorolac for postpartum pain management in patients with inflammatory bowel disease. Am J Obstet Gynecol MFM 6:101238. https:\/\/doi.org\/10.1016\/j.ajogmf.2023.101238","journal-title":"Am J Obstet Gynecol MFM"},{"key":"6660_CR16","doi-asserted-by":"publisher","first-page":"S222","DOI":"10.14309\/00000434-200609001-00528","volume":"101","author":"A-M Boller","year":"2006","unstructured":"Boller A-M, Tantitemit T, Cima RR, Larson DW, Dozois EJ, Larson D et al (2006) The Impact of Intravenous Ketorolac (Toradol\u00ae) on the Early Recurrence of Crohn\u2019s Disease: 528. Official J Am Coll Gastroenterol | ACG 101:S222","journal-title":"Official J Am Coll Gastroenterol | ACG"},{"key":"6660_CR17","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1016\/j.jpedsurg.2020.04.001","volume":"55","author":"MA Taylor","year":"2020","unstructured":"Taylor MA, West WB, Guthery SL, Deneau M, Short SS (2020) Ketorolac after colectomy for ulcerative colitis in children: An analysis of opioid utilization and postoperative complications. J Pediatr Surg 55:2393\u20132396. https:\/\/doi.org\/10.1016\/j.jpedsurg.2020.04.001","journal-title":"J Pediatr Surg"},{"key":"6660_CR18","doi-asserted-by":"publisher","unstructured":"Hutka B, L\u00e1z\u00e1r B, T\u00f3th AS, \u00c1gg B, L\u00e1szl\u00f3 SB, Makra N et al (2021) The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat. Front Pharmacol 12. https:\/\/doi.org\/10.3389\/fphar.2021.664177","DOI":"10.3389\/fphar.2021.664177"},{"key":"6660_CR19","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/S1542-3565(05)00980-8","volume":"4","author":"K Takeuchi","year":"2006","unstructured":"Takeuchi K, Smale S, Premchand P, Maiden L, Sherwood R, Thjodleifsson B et al (2006) Prevalence and Mechanism of Nonsteroidal Anti-Inflammatory Drug\u2013Induced Clinical Relapse in Patients With Inflammatory Bowel Disease. Clin Gastroenterol Hepatol 4:196\u2013202. https:\/\/doi.org\/10.1016\/S1542-3565(05)00980-8","journal-title":"Clin Gastroenterol Hepatol"},{"key":"6660_CR20","doi-asserted-by":"publisher","first-page":"652806","DOI":"10.3389\/fsurg.2022.652806","volume":"9","author":"W Chen","year":"2022","unstructured":"Chen W, Liu J, Yang Y, Ai Y, Yang Y (2022) Ketorolac Administration After Colorectal Surgery Increases Anastomotic Leak Rate: A Meta-Analysis and Systematic Review. Front Surg 9:652806. https:\/\/doi.org\/10.3389\/fsurg.2022.652806","journal-title":"Front Surg"},{"key":"6660_CR21","doi-asserted-by":"publisher","unstructured":"Evans JM, McMahon AD, Murray FE, McDevitt DG, MacDonald TM (1997) Non-steroidal anti-inflammatory drugs are associated with emergency admission to hospital for colitis due to inflammatory bowel disease. https:\/\/doi.org\/10.1136\/gut.40.5.619","DOI":"10.1136\/gut.40.5.619"},{"key":"6660_CR22","doi-asserted-by":"publisher","unstructured":"Felder JB, Korelitz BI, Rajapakse R, Schwarz S, Horatagis AP, Gleim G Effects of Nonsteroidal Antiinflammatory Drugs on Inflammatory Bowel Disease: A Case-Control Study. Official J Am Coll Gastroenterol | ACG 2000;95:1949. https:\/\/doi.org\/10.1111\/j.1572-0241.2000.02262.x","DOI":"10.1111\/j.1572-0241.2000.02262.x"},{"key":"6660_CR23","doi-asserted-by":"publisher","first-page":"513","DOI":"10.7326\/0003-4819-107-4-513","volume":"107","author":"HJ KAUFMANN","year":"1987","unstructured":"KAUFMANN HJ (1987) Nonsteroidal Anti-Inflammatory Drugs Activate Quiescent Inflammatory Bowel Disease. Ann Intern Med 107:513\u2013516. https:\/\/doi.org\/10.7326\/0003-4819-107-4-513","journal-title":"Ann Intern Med"},{"key":"6660_CR24","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s10620-006-3103-5","volume":"51","author":"AM Meyer","year":"2006","unstructured":"Meyer AM, Ramzan NN, Heigh RI, Leighton JA (2006) Relapse of Inflammatory Bowel Disease Associated With Use of Nonsteroidal Anti-Inflammatory Drugs. Dig Dis Sci 51:168\u2013172. https:\/\/doi.org\/10.1007\/s10620-006-3103-5","journal-title":"Dig Dis Sci"},{"key":"6660_CR25","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.14309\/ajg.0000000000001932","volume":"117","author":"S Cohen-Mekelburg","year":"2022","unstructured":"Cohen-Mekelburg S, Tony Van MS, Wallace B, Berinstein J, Yu X, Lewis J et al (2022) The association between non-steroidal anti-inflammatory drug use and inflammatory bowel disease exacerbations: a true association or residual bias? Am J Gastroenterol 117:1851\u20131857. https:\/\/doi.org\/10.14309\/ajg.0000000000001932","journal-title":"Am J Gastroenterol"},{"key":"6660_CR26","doi-asserted-by":"publisher","first-page":"240","DOI":"10.5863\/1551-6776-26.3.240","volume":"26","author":"SB Stone","year":"2021","unstructured":"Stone SB (2021) Ketorolac in Postoperative Neonates and Infants: A Systematic Review. J Pediatr Pharmacol Ther 26:240\u2013247. https:\/\/doi.org\/10.5863\/1551-6776-26.3.240","journal-title":"J Pediatr Pharmacol Ther"},{"key":"6660_CR27","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1097\/DCR.0000000000001244","volume":"61","author":"AT Hawkins","year":"2018","unstructured":"Hawkins AT, McEvoy MD, Wanderer JP, Ford MM, Hopkins MB, Muldoon RL et al (2018) Ketorolac Use and Anastomotic Leak in Elective Colorectal Surgery: A Detailed Analysis. Dis Colon Rectum 61:1426. https:\/\/doi.org\/10.1097\/DCR.0000000000001244","journal-title":"Dis Colon Rectum"},{"key":"6660_CR28","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1055\/a-2048-7407","volume":"34","author":"M Glenisson","year":"2023","unstructured":"Glenisson M, Bonnard A, Berrebi D, Belarbi N, Viala J, Martinez-Vinson C (2023) Complications and Disease Recurrence After Ileocecal Resection in Pediatric Crohn\u2019s Disease: A Retrospective Study. Eur J Pediatr Surg 34:253\u2013260. https:\/\/doi.org\/10.1055\/a-2048-7407","journal-title":"Eur J Pediatr Surg"},{"key":"6660_CR29","doi-asserted-by":"publisher","first-page":"862","DOI":"10.3390\/biomedicines12040862","volume":"12","author":"V Dipasquale","year":"2024","unstructured":"Dipasquale V, Milone E, Nigro S, Alibrandi A, Antonelli E, Di Fabrizio D et al (2024) Risk Factors for Complications and Disease Recurrence after Ileocecal Resection for Crohn\u2019s Disease in Children and Adults. Biomedicines 12:862. https:\/\/doi.org\/10.3390\/biomedicines12040862","journal-title":"Biomedicines"}],"container-title":["Pediatric Surgery International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-026-06660-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00383-026-06660-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00383-026-06660-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:51:10Z","timestamp":1791193870000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00383-026-06660-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6660"],"URL":"https:\/\/doi.org\/10.1007\/s00383-026-06660-8","relation":{},"ISSN":["1437-9813"],"issn-type":[{"value":"1437-9813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]},"assertion":[{"value":"11 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"428"}}