{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:56:38Z","timestamp":1773420998315,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2005,9,13]],"date-time":"2005-09-13T00:00:00Z","timestamp":1126569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1007\/s00384-005-0034-0","type":"journal-article","created":{"date-parts":[[2005,9,12]],"date-time":"2005-09-12T07:35:06Z","timestamp":1126510506000},"page":"357-364","source":"Crossref","is-referenced-by-count":16,"title":["Segmental heterogeneity of electrogenic secretions in human ascending colon and rectum"],"prefix":"10.1007","volume":"21","author":[{"given":"Jung Ho","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poong-Lyul","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Haeng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Chul","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,9,13]]},"reference":[{"issue":"3","key":"34_CR1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/BF00583600","volume":"403","author":"W Clauss","year":"1985","unstructured":"Clauss W, Schafer H, Horch I et al (1985) Segmental differences in electrical properties and Na\u2014transport of rabbit caecum, proximal and distal colon in vitro. Pflugers Arch 403(3):278\u2013282","journal-title":"Pflugers Arch"},{"issue":"9","key":"34_CR2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/gut.27.9.999","volume":"27","author":"GI Sandle","year":"1986","unstructured":"Sandle GI, Wills NK, Alles W, Binder HJ (1986) Electrophysiology of the human colon: evidence of segmental heterogeneity. Gut 27(9):999\u20131005","journal-title":"Gut"},{"issue":"1","key":"34_CR3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1152\/ajplegacy.1975.228.1.191","volume":"228","author":"WM Yau","year":"1975","unstructured":"Yau WM, Makhlouf GM (1975) Comparison of transport mechanisms in isolated ascending and descending rat colon. Am J Physiol 228(1):191\u2013195","journal-title":"Am J Physiol"},{"issue":"2 Pt 1","key":"34_CR4","first-page":"G539","volume":"276","author":"M Ikuma","year":"1999","unstructured":"Ikuma M, Kashgarian M, Binder HJ, Rajendran VM (1999) Differential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon. Am J Physiol 276(2 Pt 1):G539\u2013G549","journal-title":"Am J Physiol"},{"issue":"4","key":"34_CR5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s00424-002-0828-7","volume":"444","author":"ER Greig","year":"2002","unstructured":"Greig ER, Baker EH, Mathialahan T, Boot-Handford RP, Sandle GI (2002) Segmental variability of ENaC subunit expression in rat colon during dietary sodium depletion. Pflugers Arch 444(4):476\u2013483","journal-title":"Pflugers Arch"},{"issue":"8","key":"34_CR6","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1136\/gut.32.8.936","volume":"32","author":"GI Sandle","year":"1991","unstructured":"Sandle GI (1991) Segmental variability of glucocorticoid induced electrolyte transport in rat colon. Gut 32(8):936\u2013940","journal-title":"Gut"},{"issue":"1\u20132","key":"34_CR7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00581912","volume":"410","author":"GI Sandle","year":"1987","unstructured":"Sandle GI, McGlone F (1987) Segmental variability of membrane conductances in rat and human colonic epithelia. Implications for Na, K and Cl transport. Pflugers Arch 410(1\u20132):173\u2013180","journal-title":"Pflugers Arch"},{"issue":"3","key":"34_CR8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0016-5085(87)90904-8","volume":"93","author":"JH Sellin","year":"1987","unstructured":"Sellin JH, De Soignie R (1987) Ion transport in human colon in vitro. Gastroenterology 93(3):441\u2013448","journal-title":"Gastroenterology"},{"issue":"3","key":"34_CR9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1748-1716.1991.tb09171.x","volume":"142","author":"M Nobles","year":"1991","unstructured":"Nobles M, Diener M, Mestres P, Rummel W (1991) Segmental heterogeneity of the rat colon in the response to activators of secretion on the cAMP-, the cGMP- and the Ca2+-pathway. Acta Physiol Scand 142(3):375\u2013386","journal-title":"Acta Physiol Scand"},{"issue":"6 Pt 1","key":"34_CR10","first-page":"G1367","volume":"275","author":"S Horger","year":"1998","unstructured":"Horger S, Schultheiss G, Diener M (1998) Segment-specific effects of epinephrine on ion transport in the colon of the rat. Am J Physiol 275(6 Pt 1):G1367\u2013G1376","journal-title":"Am J Physiol"},{"key":"34_CR11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1146\/annurev.ph.55.030193.003215","volume":"55","author":"M Field","year":"1993","unstructured":"Field M, Semrad CE (1993) Toxigenic diarrheas, congenital diarrheas, and cystic fibrosis: disorders of intestinal ion transport. Annu Rev Physiol 55:631\u2013655","journal-title":"Annu Rev Physiol"},{"key":"34_CR12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.physiol.62.1.467","volume":"62","author":"R Greger","year":"2000","unstructured":"Greger R (2000) Role of CFTR in the colon. Annu Rev Physiol 62:467\u2013491","journal-title":"Annu Rev Physiol"},{"key":"34_CR13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.ph.58.030196.003155","volume":"58","author":"LS King","year":"1996","unstructured":"King LS, Agre P (1996) Pathophysiology of the aquaporin water channels. Annu Rev Physiol 58:619\u2013648","journal-title":"Annu Rev Physiol"},{"issue":"6766","key":"34_CR14","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/35003200","volume":"403","author":"BC Schroeder","year":"2000","unstructured":"Schroeder BC, Waldegger S, Fehr S et al (2000) A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403(6766):196\u2013199","journal-title":"Nature"},{"key":"34_CR15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.ph.53.030191.001541","volume":"53","author":"DC Dawson","year":"1991","unstructured":"Dawson DC (1991) Ion channels and colonic salt transport. Annu Rev Physiol 53:321\u2013339","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"34_CR16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s004240050886","volume":"438","author":"M Stockmann","year":"1999","unstructured":"Stockmann M, Gitter AH, Sorgenfrei D, Fromm M, Schulzke JD (1999) Low edge damage container insert that adjusts intestinal forceps biopsies into Ussing chamber systems. Pflugers Arch 438(1):107\u2013112","journal-title":"Pflugers Arch"},{"issue":"4","key":"34_CR17","doi-asserted-by":"crossref","first-page":"G617","DOI":"10.1152\/ajpgi.2000.278.4.G617","volume":"278","author":"M Mall","year":"2000","unstructured":"Mall M, Wissner A, Seydewitz HH et al (2000) Defective cholinergic Cl(\u2212) secretion and detection of K(+) secretion in rectal biopsies from cystic fibrosis patients. Am J Physiol Gastrointest Liver Physiol 278(4):G617\u2013G624","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"34_CR18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s004240050108","volume":"432","author":"R Warth","year":"1996","unstructured":"Warth R, Riedemann N, Bleich M, Van Driessche W, Busch AE, Greger R (1996) The cAMP-regulated and 293B-inhibited K+ conductance of rat colonic crypt base cells. Pflugers Arch 432(1):81\u201388","journal-title":"Pflugers Arch"},{"issue":"2\u20133","key":"34_CR19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0014-2999(91)90581-A","volume":"200","author":"M Diener","year":"1991","unstructured":"Diener M, Egleme C, Rummel W (1991) Phospholipase C-induced anion secretion and its interaction with carbachol in the rat colonic mucosa. Eur J Pharmacol 200(2\u20133):267\u2013276","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"34_CR20","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1172\/JCI112311","volume":"77","author":"K Dharmsathaphorn","year":"1986","unstructured":"Dharmsathaphorn K, Pandol SJ (1986) Mechanism of chloride secretion induced by carbachol in a colonic epithelial cell line. J Clin Invest 77(2):348\u2013354","journal-title":"J Clin Invest"},{"issue":"6 Pt 1","key":"34_CR21","first-page":"G1274","volume":"275","author":"M Mall","year":"1998","unstructured":"Mall M, Bleich M, Schurlein M et al (1998) Cholinergic ion secretion in human colon requires coactivation by cAMP. Am J Physiol 275(6 Pt 1):G1274\u2013G1281","journal-title":"Am J Physiol"},{"issue":"1","key":"34_CR22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00026.2001","volume":"82","author":"K Kunzelmann","year":"2002","unstructured":"Kunzelmann K, Mall M (2002) Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev 82(1):245\u2013289","journal-title":"Physiol Rev"},{"issue":"2","key":"34_CR23","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1006\/geno.1998.5562","volume":"54","author":"AD Gruber","year":"1998","unstructured":"Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU (1998) Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl-channel proteins. Genomics 54(2):200\u2013214","journal-title":"Genomics"},{"issue":"1","key":"34_CR24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0889-8553(05)70369-1","volume":"25","author":"MD O'Brien","year":"1996","unstructured":"O'Brien MD, Phillips SF (1996) Colonic motility in health and disease. Gastroenterol Clin North Am 25(1):147\u2013162","journal-title":"Gastroenterol Clin North Am"},{"issue":"2","key":"34_CR25","first-page":"G329","volume":"278","author":"IJ Cook","year":"2000","unstructured":"Cook IJ, Furukawa Y, Panagopoulos V, Collins PJ, Dent J (2000) Relationships between spatial patterns of colonic pressure and individual movements of content. Am J Physiol 278(2):G329\u2013G341","journal-title":"Am J Physiol"},{"issue":"18","key":"34_CR26","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/0024-3205(86)90408-X","volume":"38","author":"PK Rangachari","year":"1986","unstructured":"Rangachari PK, McWade D (1986) Epithelial and mucosal preparations of canine proximal colon in Ussing chambers: comparison of responses. Life Sci 38(18):1641\u20131652","journal-title":"Life Sci"},{"issue":"1","key":"34_CR27","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1172\/JCI116966","volume":"93","author":"TV Strong","year":"1994","unstructured":"Strong TV, Boehm K, Collins FS (1994) Localization of cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization. J Clin Invest 93(1):347\u2013354","journal-title":"J Clin Invest"},{"issue":"1","key":"34_CR28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0016-5085(80)90189-4","volume":"78","author":"K Bukhave","year":"1980","unstructured":"Bukhave K, Rask-Madsen J (1980) Saturation kinetics applied to in vitro effects of low prostaglandin E2 and F 2 alpha concentrations on ion transport across human jejunal mucosa. Gastroenterology 78(1):32\u201342","journal-title":"Gastroenterology"},{"issue":"Suppl","key":"34_CR29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0090-6980(81)90121-0","volume":"21","author":"M Field","year":"1981","unstructured":"Field M, Musch MW, Stoff JS (1981) Role of prostaglandins in the regulation of intestinal electrolyte transport. Prostaglandins 21(Suppl):73\u201379","journal-title":"Prostaglandins"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-005-0034-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00384-005-0034-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-005-0034-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T10:47:14Z","timestamp":1586429234000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00384-005-0034-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,13]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["34"],"URL":"https:\/\/doi.org\/10.1007\/s00384-005-0034-0","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,13]]}}}