{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:49:08Z","timestamp":1767707348176},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,4,30]],"date-time":"2005-04-30T00:00:00Z","timestamp":1114819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1007\/s00384-005-0749-y","type":"journal-article","created":{"date-parts":[[2005,4,29]],"date-time":"2005-04-29T06:31:01Z","timestamp":1114756261000},"page":"11-17","source":"Crossref","is-referenced-by-count":106,"title":["Can pathological complete response in the primary tumour following pre-operative pelvic chemoradiotherapy for T3\u2013T4 rectal cancer predict for sterilisation of pelvic lymph nodes, a low risk of local recurrence and the appropriateness of local excision?"],"prefix":"10.1007","volume":"21","author":[{"given":"R.","family":"Hughes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Glynne-Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Grainger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Richman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Makris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ashford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. I.","family":"Livingstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Meyrick Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. C.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M. A.","family":"Northover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Windsor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Novell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,4,30]]},"reference":[{"key":"749_CR1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/cncr.11075","volume":"97","author":"CH Crane","year":"2003","unstructured":"Crane CH, Skibber JM, Feig BW, Vauthey JN, Thames HD, Curley SA, Rodriguez-Bigas MA, Wolff RA, Ellis LM, Delclos ME, Lin EH, Janjan NA (2003) Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma. Cancer 97:517\u2013524","journal-title":"Cancer"},{"key":"749_CR2","first-page":"800","volume":"8","author":"S Zaheer","year":"1997","unstructured":"Zaheer S, Pemberton JH, Farouk R (1997) Surgical treatment of adenocarcinoma of the rectum. Ann Surg 8:800\u2013811","journal-title":"Ann Surg"},{"key":"749_CR3","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/BF02104451","volume":"16","author":"DA Rothenberger","year":"1992","unstructured":"Rothenberger DA, Wong WD (1992) Abdominoperitoneal resection for adenocarcinoma of the low rectum. World J Surg 16:478\u2013485","journal-title":"World J Surg"},{"key":"749_CR4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/00000658-200210000-00015","volume":"236","author":"PB Paty","year":"2002","unstructured":"Paty PB, Nash GM, Baron P, Zakowski M, Minsky B, Blumberg D, Nathansom DR, Guillem JG, Enker WE, Cohen AM, Douglas Wong W (2002) Long term results of local excision for rectal cancer. Ann Surg 236:522\u2013530","journal-title":"Ann Surg"},{"key":"749_CR5","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/archsurg.134.8.863","volume":"134","author":"MG Varma","year":"1999","unstructured":"Varma MG, Rogers SJ, Schrock TR, Welton ML (1999) Local excision of rectal carcinoma. Arch Surg 134:863\u2013866","journal-title":"Arch Surg"},{"key":"749_CR6","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00000658-200109000-00009","volume":"234","author":"CJ Kim","year":"2001","unstructured":"Kim CJ, Yeatman TJ, Coppula D, Trotti A, Williams B, Bartel JS, Dinwoodie W, Karl RC, Marcet J (2001) Local excision of T2 and T3 rectal cancers after downstaging chemoradiation. Ann Surg 234:352\u2013359","journal-title":"Ann Surg"},{"key":"749_CR7","doi-asserted-by":"crossref","unstructured":"Bonnen M, Crane C, Feig B, Skibber J, Ballo M, Brown T, Phan T, Janjan N (2001) Long term results using local excision after pre-operative chemoradiation among selected T3 rectal cancer patients. Proceedings of the 43rd Annual ASTRO meeting","DOI":"10.1016\/S0360-3016(01)01845-4"},{"key":"749_CR8","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/BF02234796","volume":"44","author":"S Sengupta","year":"2001","unstructured":"Sengupta S, Tjandra J (2001) Local excision of rectal cancer. What is the evidence? Dis Colon Rectum 44:1345\u20131361","journal-title":"Dis Colon Rectum"},{"key":"749_CR9","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/1097-0142(19890401)63:7<1421::AID-CNCR2820630732>3.0.CO;2-H","volume":"63","author":"BD Minsky","year":"1989","unstructured":"Minsky BD, Rich T, Recht A, Harvey W, Mies C (1989) Selection criteria for local excision with or without adjuvant radiotherapy for rectal cancer. Cancer 63:1421\u20131429","journal-title":"Cancer"},{"key":"749_CR10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/1097-0142(19920115)69:2<322::AID-CNCR2820690208>3.0.CO;2-B","volume":"69","author":"JT Brodsky","year":"1992","unstructured":"Brodsky JT, Richard GK, Cohen AM, Minsky BD (1992) Variables correlated with the risk of lymph node metastasis in early rectal cancer. Cancer 69:322\u2013326","journal-title":"Cancer"},{"key":"749_CR11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s10350-004-6545-x","volume":"46","author":"J Garcia-Aguilar","year":"2003","unstructured":"Garcia-Aguilar J, Hernandez de Anda E, Sirivongs P, Lee SH, Madoff RD, Rothenberger DA (2003) A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excision. Dis Colon Rectum 46:298\u2013304","journal-title":"Dis Colon Rectum"},{"key":"749_CR12","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/0959-8049(93)90012-5","volume":"29A","author":"JF Bosset","year":"1993","unstructured":"Bosset JF, Pavy JJ, Hamers HP et al (1993) Determination of the optimal dose of 5Fluorouracil when combined with low dose d,l leucovorin and irradiation in rectal cancer: results of three consecutive phase I studies. Eur J Cancer 29A:1406\u20131410","journal-title":"Eur J Cancer"},{"key":"749_CR13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0360-3016(99)00411-3","volume":"46","author":"JF Bosset","year":"2000","unstructured":"Bosset JF, Magnin V, Maignon P et al (2000) Preoperative radiochemotherapy in rectal cancer: long-term results of a phase II trial. Int J Radiat Oncol Biol Phys 46:323\u2013327","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"749_CR14","series-title":"Histopathology Reports","volume-title":"Minimum dataset for colorectal cancer","year":"1999","unstructured":"Royal College of Pathologists (1999) Minimum dataset for colorectal cancer. Histopathology Reports. Royal College of Pathologists, London"},{"key":"749_CR15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1200\/JCO.1992.10.1.79","volume":"10","author":"BD Minsky","year":"1992","unstructured":"Minsky BD, Cohen AM, Kemeny N et al (1992) Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy. J Clin Oncol 10:79\u201384","journal-title":"J Clin Oncol"},{"key":"749_CR16","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0360-3016(00)00732-X","volume":"48","author":"N Mohiuddin","year":"2000","unstructured":"Mohiuddin N, Hayne M, Regine W et al (2000) Prognostic significance of post chemoradiation stage following preoperative chemoradiotherapy and radiation for advanced\/recurrent rectal cancers. Int J Radiat Oncol Biol Phys 48:1075\u20131080","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"749_CR17","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s10434-001-0801-2","volume":"8","author":"MW Onaitis","year":"2001","unstructured":"Onaitis MW, Noone RB, Fields R, Hurwitz H, Morse M, Jowell P, McGrath K, Lee C, Anscher MS, Clary B, Mantyh C, Pappas TN, Ludwig K, Seigler HF, Tyler DS (2001) Complete response to neoadjuvant chemoradiation for rectal cancer does not influence survival. Ann Surg Oncol 8:801\u2013806","journal-title":"Ann Surg Oncol"},{"key":"749_CR18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.gassur.2003.09.019","volume":"8","author":"I Bedrosian","year":"2004","unstructured":"Bedrosian I, Rodriguez-Bigas MA, Feig B, Hunt KK, Ellis L, Curley SA, Vauthey JN, Delclos M, Crane C, Janjan N, Skibber JM (2004) Predicting the node-negative mesorectum after preoperative chemoradiation for locally advanced rectal carcinoma. J Gastrointest Surg 8:56\u201362","journal-title":"J Gastrointest Surg"},{"key":"749_CR19","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/BF02234632","volume":"44","author":"D Medich","year":"2001","unstructured":"Medich D, McGinty J, Parda D, Karlovits S, Davis C, Caushaj P, Lembersky B (2001) Preoperative chemoradiotherapy and radical surgery for locally advanced distal rectal adenocarcinoma: pathologic findings and clinical implications. Dis Colon Rectum 44:1123\u20131128","journal-title":"Dis Colon Rectum"},{"key":"749_CR20","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10350-004-0535-x","volume":"47","author":"TE Read","year":"2004","unstructured":"Read TE, Andujar JE, Caushaj FP, Johnston DR, Dietz DW, Myerson RJ, Fleshman JW, Birnbaum EH, Mutch MG, Kodner IJ (2004) Neoadjuvant therapy for rectal cancer: histologic response of the primary tumor predicts nodal status. Dis Colon Rectum 47:825\u2013831","journal-title":"Dis Colon Rectum"},{"key":"749_CR21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.radonc.2003.12.006","volume":"72","author":"K Bujko","year":"2004","unstructured":"Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Pudelko M, Kryj M, Oledzki J, Szmeja J, Sluszniak J, Serkies K, Kladny J, Pamucka M, Kukolowicz P (2004) Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. Radiother Oncol 72:15\u201324","journal-title":"Radiother Oncol"},{"key":"749_CR22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1072-7515(01)01159-0","volume":"194","author":"SP Hiotis","year":"2002","unstructured":"Hiotis SP, Weber SM, Cohen AM, Minsky BD, Paty PB, Guillem JG, Wagman R, Saltz LB, Wong WD (2002) Assessing the predictive value of clinical complete response to neoadjuvant therapy for rectal cancer: an analysis of 488 patients. J Am Coll Surg 194:131\u2013135","journal-title":"J Am Coll Surg"},{"key":"749_CR23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00000658-199907000-00008","volume":"230","author":"A Chakravarti","year":"1999","unstructured":"Chakravarti A, Compton C, Shellito P, Wood W, Landry J, Machuta S, Kaufman D, Ancukiewicz M, Willett C (1999) Long term follow up of patients with rectal cancer managed by local excision with and without adjuvant irradiation. Ann Surg 230:49\u201354","journal-title":"Ann Surg"},{"key":"749_CR24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00000658-200003000-00007","volume":"231","author":"J Garcia-Aguilar","year":"2000","unstructured":"Garcia-Aguilar J, Mellgren A, Sirivongs P, Buie D, Madoff R, Rothenberger D (2000) Local excision of rectal cancer without adjuvant therapy. A word of caution. Ann Surg 231:345\u2013351","journal-title":"Ann Surg"},{"key":"749_CR25","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/BF02237095","volume":"42","author":"D Blumberg","year":"1999","unstructured":"Blumberg D, Paty PB, Guillem JG, Picon AI, Minsky BD, Wong D, Cohen AM (1999) All patients with small intramural rectal cancers are at risk for lymph node metastasis. Dis Colon Rectum 42:881\u2013885","journal-title":"Dis Colon Rectum"},{"key":"749_CR26","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10434-999-0433-5","volume":"6","author":"Steele GD Jr","year":"1999","unstructured":"Steele GD Jr, Herndon JE, Bleday R, Russell A, Benson A III, Hussain M, Burgess A, Tepper JE, Mayer RJ (1999) Sphincter-sparing treatment for distal rectal adenocarcinoma. Ann Surg Oncol 6:433\u2013441","journal-title":"Ann Surg Oncol"},{"key":"749_CR27","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1007\/s00268-002-6359-8","volume":"26","author":"E Lezoche","year":"2002","unstructured":"Lezoche E, Guerrieri M, Paganini MA, Feliciotti F (2002) Long-term results of patients with pT2 rectal cancer treated with radiotherapy and transanal endoscopic microsurgical excision. World J Surg 26:1170\u20131174","journal-title":"World J Surg"},{"key":"749_CR28","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s10350-004-6320-z","volume":"45","author":"CM Friel","year":"2002","unstructured":"Friel CM, Cromwell JW, Marra C, Madoff RD, Rothenberger DA, Garcia-Aguilar J (2002) Salvage radical surgery after failed local excision for early rectal cancer. Dis Colon Rectum 45:875\u2013879","journal-title":"Dis Colon Rectum"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-005-0749-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00384-005-0749-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-005-0749-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T04:26:43Z","timestamp":1586233603000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00384-005-0749-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,30]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["749"],"URL":"https:\/\/doi.org\/10.1007\/s00384-005-0749-y","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,30]]}}}