{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:14:36Z","timestamp":1773148476181,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2006,10,7]],"date-time":"2006-10-07T00:00:00Z","timestamp":1160179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,10,7]],"date-time":"2006-10-07T00:00:00Z","timestamp":1160179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1007\/s00384-006-0202-x","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T10:45:57Z","timestamp":1160131557000},"page":"553-558","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hematological malignancies in chronic inflammatory bowel diseases: report of five cases and review of the literature"],"prefix":"10.1007","volume":"22","author":[{"given":"Pietro","family":"Crispino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Pica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Angelucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Consolazio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Cassieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Paoluzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,10,7]]},"reference":[{"key":"202_CR1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3109\/10428199509056830","volume":"3\u20134","author":"O Caspi","year":"1995","unstructured":"Caspi O, Polliack A, Klar R et al (1995) The association of inflammatory bowel disease and leukaemia\u2014coincidence or not? Leuk Lymphoma 3\u20134:255\u2013262","journal-title":"Leuk Lymphoma"},{"issue":"11","key":"202_CR2","first-page":"2556","volume":"57","author":"M Imagawa","year":"1999","unstructured":"Imagawa M (1999) Extra-intestinal complications of ulcerative colitis: haematological complication. Nippon Rinsho 57(11):2556\u20132561","journal-title":"Nippon Rinsho"},{"key":"202_CR3","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/0145-2126(92)90158-4","volume":"16","author":"A Cuneo","year":"1992","unstructured":"Cuneo A, Fagioli F, Pazzi I et al (1992) Morphologic, immunologic and cytogenetic studies in acute myeloid leukaemia following occupational exposure to pesticides and organic solvents. Leuk Res 16:789\u2013796","journal-title":"Leuk Res"},{"key":"202_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/ibd.3780040308","volume":"4","author":"A Ekbom","year":"1998","unstructured":"Ekbom A (1998) Risk factors and distinguishing features of cancer in IBD. Inflamm Bowel Dis 4:235\u2013243","journal-title":"Inflamm Bowel Dis"},{"key":"202_CR5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/bmj.317.7152.180","volume":"18","author":"E Baecklund","year":"1998","unstructured":"Baecklund E, Ekbom A, Sparen P et al (1998) Disease activity and risk of lymphoma in patients with rheumatoid arthritis: nested case-control study. Br Med J 18:180\u2013181","journal-title":"Br Med J"},{"issue":"Suppl 8","key":"202_CR6","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1053\/sonc.2002.33532","volume":"29","author":"T Littlewood","year":"2002","unstructured":"Littlewood T, Mandelli F (2002) The effect of anaemia in hematologic malignancies: more than a symptom. Semin Oncol 29(Suppl 8):40\u201344","journal-title":"Semin Oncol"},{"key":"202_CR7","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/S1590-8658(01)80046-3","volume":"33","author":"A Viscido","year":"2001","unstructured":"Viscido A, Bagnardi V, Sturniolo GC et al (2001) Survival and causes of death in Italian patients with ulcerative colitis. Dig Liver Dis 33:686\u2013692","journal-title":"Dig Liver Dis"},{"key":"202_CR8","doi-asserted-by":"publisher","first-page":"2914","DOI":"10.1002\/1097-0142(19851215)56:12<2914::AID-CNCR2820561232>3.0.CO;2-J","volume":"56","author":"AJ Greenstein","year":"1985","unstructured":"Greenstein AJ, Gennuso R, Sachar DB (1985) Extraintestinal cancer in inflammatory bowel disease. Cancer 56:2914\u20132991","journal-title":"Cancer"},{"key":"202_CR9","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1001\/archinte.143.2.294","volume":"143","author":"DJ Sales","year":"1983","unstructured":"Sales DJ, Kirsner JB (1983) The prognosis of inflammatory bowel disease. Arch Intern Med 143:294\u2013299","journal-title":"Arch Intern Med"},{"key":"202_CR10","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/BF01703231","volume":"66","author":"GL Castoldi","year":"1993","unstructured":"Castoldi GL, Liso V, Fenu S et al (1993) Reproducibility of the morphological diagnostic criteria for acute myeloid leukaemia: the GINEMA group experience. Ann Hematol 66:171\u2013174","journal-title":"Ann Hematol"},{"key":"202_CR11","first-page":"233","volume":"79","author":"GM Rigolin","year":"1994","unstructured":"Rigolin GM, Fagioli F, Spanedda R et al (1994) Study of prognosis in acute myeloid leukaemias (AML) by cluster analysis. Haematologica 79:233\u2013240","journal-title":"Haematologica"},{"key":"202_CR12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/canjclin.53.1.5","volume":"53","author":"A Jemal","year":"2003","unstructured":"Jemal A, Murray T, Samuels A et al (2003) Cancer statistics 2003. CA Cancer J Clin 53:5\u201326","journal-title":"CA Cancer J Clin"},{"key":"202_CR13","volume-title":"SEER cancer statistic review","author":"LAG Ries","year":"1973\u20131999","unstructured":"Ries LAG, Eisner MP, Kosary CL et al (1973\u20131999) SEER cancer statistic review. National Cancer Institute, Bethesda, MD"},{"key":"202_CR14","volume-title":"Leukemia","author":"F Groves","year":"1996","unstructured":"Groves F, Linet M, Devesa S (1996) Epidemiology of leukemia. In: Henderson ES, Lister TA, Greaves MF (eds) Leukemia, 6th edn. Saunders, Philadelphia, PA","edition":"6"},{"key":"202_CR15","first-page":"359","volume":"14","author":"DP Sandler","year":"1987","unstructured":"Sandler DP (1987) Epidemiology of acute myelogenous leukemia. Semin Oncol 14:359\u2013364","journal-title":"Semin Oncol"},{"key":"202_CR16","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/00004836-198009000-00003","volume":"2","author":"TL Fabry","year":"1980","unstructured":"Fabry TL, Sachar DB, Janowitz HD (1980) Acute myelogenous leukemia in patients with ulcerative colitis. J Clin Gastroenterol 2:225\u2013227","journal-title":"J Clin Gastroenterol"},{"key":"202_CR17","doi-asserted-by":"crossref","first-page":"864","DOI":"10.7326\/0003-4819-97-6-864","volume":"97","author":"J Cuttner","year":"1989","unstructured":"Cuttner J (1989) Increased incidence of acute promyelocytic leukemia in patients with ulcerative colitis. Ann Intern Med 97:864\u2013865","journal-title":"Ann Intern Med"},{"key":"202_CR18","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/BF01296735","volume":"27","author":"SB Hanauer","year":"1982","unstructured":"Hanauer SB, Wong KK, Frank PH et al (1982) Acute leukemia following inflammatory bowel disease. Dig Dis Sci 27:545\u2013548","journal-title":"Dig Dis Sci"},{"key":"202_CR19","first-page":"33","volume":"6","author":"EM Cohn","year":"1984","unstructured":"Cohn EM, Pearlstine B (1984) Inflammatory bowel disease and leukaemia. J Clin Gastroenterol 6:33\u201335","journal-title":"J Clin Gastroenterol"},{"key":"202_CR20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/00004836-199106000-00015","volume":"13","author":"S Orii","year":"1991","unstructured":"Orii S, Sugai T, Nakano O et al (1991) Acute promyelocytic leukaemia in Crohn\u2019s disease. Case report and review of the literature. J Clin Gastroenterol 13:325\u2013327","journal-title":"J Clin Gastroenterol"},{"key":"202_CR21","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/BF01300254","volume":"31","author":"SH Mir Madjlessi","year":"1986","unstructured":"Mir Madjlessi SH, Farmer RG, Weick JK (1986) Inflammatory bowel disease and leukaemia. A report of seven cases of leukaemia in ulcerative colitis and Crohn\u2019s disease and review of the literature. Dig Dis Sci 31:1025\u20131031","journal-title":"Dig Dis Sci"},{"key":"202_CR22","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1007\/BF01540575","volume":"35","author":"L Halme","year":"1990","unstructured":"Halme L, Von Knorring J, Elonen E (1990) Development of acute myelocytic leukaemia in patients with Crohn\u2019s disease. Dig Dis Sci 35:1553\u20131556","journal-title":"Dig Dis Sci"},{"key":"202_CR23","first-page":"193","volume":"37","author":"H Dombret","year":"1995","unstructured":"Dombret H, Marolleau JP (1995) De novo acute myeloid leukaemia in patients with Crohn\u2019s disease. Nouv Rev Fr Hematol 37:193\u2013196","journal-title":"Nouv Rev Fr Hematol"},{"key":"202_CR24","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1111\/j.1572-0241.1999.01530.x","volume":"94","author":"BI Korelitz","year":"1999","unstructured":"Korelitz BI, Mirsky FJ, Fleisher MR et al (1999) Malignant neoplasm subsequent to treatment on inflammatory bowel disease with 6-mercaptopurine. Am J Gastroenterol 94:3248\u20133253 (Nov)","journal-title":"Am J Gastroenterol"},{"key":"202_CR25","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/S0140-6736(94)92150-4","volume":"343","author":"WR Connel","year":"1994","unstructured":"Connel WR, Kamm MA, Dixon M et al (1994) Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease. Lancet 343:1249\u20131252","journal-title":"Lancet"},{"key":"202_CR26","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1136\/gut.47.4.514","volume":"47","author":"RJ Farrell","year":"2000","unstructured":"Farrell RJ, Ang Y, Kileen P et al (2000) Increased incidence of non-Hodgkin\u2019s lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low. Gut 47:514\u2013519","journal-title":"Gut"},{"key":"202_CR27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0016-5085(54)80067-9","volume":"26","author":"JA Bargen","year":"1954","unstructured":"Bargen JA, Sauer WG, Sloan WP et al (1954) The development of cancer in ulcerative colitis. Gastroenterology 26:32\u201337","journal-title":"Gastroenterology"},{"key":"202_CR28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1445-2197.1979.tb06447.x","volume":"49","author":"JCM Emanuel","year":"1979","unstructured":"Emanuel JCM, Isbister WH (1979) Chronic mucosal ulcerative colitis with malignant lymphoma: report of a case. Aust N Z J Surg 49:95\u201398","journal-title":"Aust N Z J Surg"},{"key":"202_CR29","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1182\/blood.V87.12.4990.bloodjournal87124990","volume":"87","author":"BD Cheson","year":"1996","unstructured":"Cheson BD, Bennett JM, Grever M et al (1996) National Cancer Institute-sponsored working group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 87:4990\u20134999","journal-title":"Blood"},{"key":"202_CR30","doi-asserted-by":"crossref","unstructured":"List AF, Sandberg AA, Doll DC (2004) Myelodysplastic syndromes. In: Lee RG, Bithell TC, Foerster J, Athens JW, Lukens JM (eds) Wintrobe\u2019s clinical hematology, 11th edn. Lippincott-Williams & Wilkins, pp 2207\u20132234","DOI":"10.1182\/asheducation-2004.1.297"},{"key":"202_CR31","doi-asserted-by":"crossref","first-page":"661","DOI":"10.7326\/0003-4819-117-8-661","volume":"117","author":"C Eng","year":"1992","unstructured":"Eng C, Farraje FA, Shulman LN et al (1992) The association between myelodysplastic syndrome and Crohn\u2019s disease. Ann Intern Med 117:661\u2013662","journal-title":"Ann Intern Med"},{"key":"202_CR32","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1136\/gut.34.11.1630","volume":"34","author":"R Sahay","year":"1993","unstructured":"Sahay R, Prangnell DR (1993) Inflammatory bowel disease and refractory anaemia (myelodysplasia). Gut 34:1630\u20131631","journal-title":"Gut"},{"key":"202_CR33","doi-asserted-by":"crossref","first-page":"395","DOI":"10.7326\/0003-4819-122-5-199503010-00023","volume":"122","author":"KM Boberg","year":"1995","unstructured":"Boberg KM, Brinch L, Vatn M (1995) Crohn\u2019s disease and the myelodysplastic syndrome. Ann Intern Med 122:395\u2013403","journal-title":"Ann Intern Med"},{"key":"202_CR34","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/BF02355065","volume":"31","author":"T Tani","year":"1996","unstructured":"Tani T, Sakai Y, Ohtake M, Hatakejama K (1996) Simultaneous development of Crohn\u2019s disease and myelodysplastic syndrome progressing to an acute myelocytic leukemia in a patient with normal karyotype. J Gastroenterol 31:599\u2013602","journal-title":"J Gastroenterol"},{"issue":"2","key":"202_CR35","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/ibd.3780050206","volume":"5","author":"GC Harewood","year":"1999","unstructured":"Harewood GC, Loftus EV Jr, Tefferi A et al (1999) Concurrent inflammatory bowel disease and myelodysplastic syndromes. Inflamm Bowel Dis 5(2):98\u2013103 (May)","journal-title":"Inflamm Bowel Dis"},{"key":"202_CR36","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1038\/sj.leu.2400863","volume":"11","author":"M Hebbar","year":"1997","unstructured":"Hebbar M, Kozlowski D, Wattel A et al (1997) Association between myelodysplastic syndromes and inflammatory bowel diseases. Report of seven new cases and review of the literature. Leukemia 11:2188\u20132191","journal-title":"Leukemia"},{"key":"202_CR37","first-page":"150","volume":"33","author":"TJ Hamblin","year":"1996","unstructured":"Hamblin TJ (1996) Immunologic abnormalities in myelodysplastic syndromes. Semin Hematol 33:150\u2013162","journal-title":"Semin Hematol"},{"key":"202_CR38","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/gut.39.5.684","volume":"39","author":"JM Reimund","year":"1996","unstructured":"Reimund JM, Wittersheim C, Dumont S et al (1996) Increased production of tumour necrosis factor-\u03b1, interleukin-1\u03b2, and interleukin-6 by morphologically normal intestinal biopsies from patients with Crohn\u2019s disease. Gut 39:684\u2013689","journal-title":"Gut"},{"key":"202_CR39","first-page":"693","volume":"9","author":"C Nisse","year":"1995","unstructured":"Nisse C, Lorthois C, Dorp V et al (1995) Exposure to occupational environmental factors in myelodysplastic syndromes. Preliminary results of a case control study. Leukemia 9:693\u2013699","journal-title":"Leukemia"},{"key":"202_CR40","first-page":"381","volume":"43","author":"I Koutroubakis","year":"1996","unstructured":"Koutroubakis I, Manousos ON, Meuwissen SGM, Pena AS (1996) Environmental risk factors in inflammatory bowel disease. Hepatogastroenterology 43:381\u2013393","journal-title":"Hepatogastroenterology"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-006-0202-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00384-006-0202-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-006-0202-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-006-0202-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T01:16:27Z","timestamp":1652577387000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00384-006-0202-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,7]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["202"],"URL":"https:\/\/doi.org\/10.1007\/s00384-006-0202-x","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,7]]},"assertion":[{"value":"28 July 2006","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2006","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}