{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:14:27Z","timestamp":1784034867458,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1007\/s00384-009-0643-0","type":"journal-article","created":{"date-parts":[[2009,1,28]],"date-time":"2009-01-28T11:35:36Z","timestamp":1233142536000},"page":"551-557","source":"Crossref","is-referenced-by-count":22,"title":["Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resection in a rabbit model\u2014a randomized, blinded, placebo-controlled trial"],"prefix":"10.1007","volume":"24","author":[{"given":"Heiko","family":"Neuss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieland","family":"Raue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilko","family":"Weichert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Schwenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian W.","family":"Mall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"643_CR1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s003840100313","volume":"16","author":"F Marusch","year":"2001","unstructured":"Marusch F, Koch A, Schmidt U et al (2001) Effect of caseload on the short-term outcome of colon surgery: results of a multicenter study. Int J Colorectal Dis 16:362\u2013369","journal-title":"Int J Colorectal Dis"},{"key":"643_CR2","first-page":"227","volume":"168","author":"J Tyrell","year":"1989","unstructured":"Tyrell J, Silberman H, Chandrasoma P et al (1989) Absorbable versus permanent mesh in abdominal operations. Surg Gynecol Obstet 168:227\u2013232","journal-title":"Surg Gynecol Obstet"},{"key":"643_CR3","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/art.20424","volume":"50","author":"K Brune","year":"2004","unstructured":"Brune K, Hinz B (2004) The discovery and development of antiinflammatory drugs. Arthritis Rheum 50:2391\u20132399","journal-title":"Arthritis Rheum"},{"key":"643_CR4","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1470-2045(03)01220-8","volume":"4","author":"G Gasparini","year":"2003","unstructured":"Gasparini G, Longo R, Sarmiento R et al (2003) Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents? Lancet Oncol 4:605\u2013615","journal-title":"Lancet Oncol"},{"key":"643_CR5","first-page":"728","volume":"63","author":"Y Araki","year":"2003","unstructured":"Araki Y, Okamura S, Hussain SP et al (2003) Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. Cancer Res 63:728\u2013734","journal-title":"Cancer Res"},{"key":"643_CR6","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S1470-2045(01)00488-0","volume":"2","author":"AJ Dannenberg","year":"2001","unstructured":"Dannenberg AJ, Altorki NK, Boyle JO et al (2001) Cyclo-oxygenase 2: a pharmacologicaltarget for the prevention of cancer. Lancet Oncol 2:544\u2013551","journal-title":"Lancet Oncol"},{"key":"643_CR7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/excr.1998.4050","volume":"241","author":"A Diaz","year":"1998","unstructured":"Diaz A, Chepenik KP, Korn JH et al (1998) Differential regulation of cyclooxygenases 1 and 2 by interleukin-1 beta, tumor necrosis factor-alpha, and transforming growth factor-beta 1 in human lung fibroblasts. Exp Cell Res 241:222\u2013229","journal-title":"Exp Cell Res"},{"key":"643_CR8","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hed.10108","volume":"24","author":"DT Lin","year":"2002","unstructured":"Lin DT, Subbaramaiah K, Shah JP et al (2002) Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. Head Neck 24:792\u2013799","journal-title":"Head Neck"},{"key":"643_CR9","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.ejso.2005.01.006","volume":"31","author":"C Mobius","year":"2005","unstructured":"Mobius C, Stein HJ, Spiess C et al (2005) COX2 expression, angiogenesis, proliferation and survival in Barrett\u2019s cancer. Eur J Surg Oncol 31:755\u2013759, (Cox Inhibition and Anastomotic Healing)","journal-title":"Eur J Surg Oncol"},{"key":"643_CR10","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1158\/0008-5472.664.65.2","volume":"65","author":"D Moraitis","year":"2005","unstructured":"Moraitis D, Du B, De Lorenzo MS et al (2005) Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and its ligands. Cancer Res 65:664\u2013670","journal-title":"Cancer Res"},{"key":"643_CR11","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/S0140-6736(04)17514-4","volume":"364","author":"P Juni","year":"2004","unstructured":"Juni P, Nartey L, Reichenbach S et al (2004) Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Lancet 364:2021\u20132029","journal-title":"Lancet"},{"key":"643_CR12","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/S0140-6736(04)16299-5","volume":"363","author":"M Mamdani","year":"2004","unstructured":"Mamdani M, Juurlink DN, Lee DS et al (2004) Cyclo-oxygenase-2 inhibitors versus nonselective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study. Lancet 363:1751\u20131756","journal-title":"Lancet"},{"key":"643_CR13","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/BF02051930","volume":"33","author":"T Hendriks","year":"1990","unstructured":"Hendriks T, Mastboom WJ (1990) Healing of experimental intestinal anastomoses. Parameters for repair. Dis Colon Rectum 33:891\u2013901","journal-title":"Dis Colon Rectum"},{"issue":"Suppl","key":"643_CR14","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1007\/BF00915717","volume":"8","author":"S Abramson","year":"1984","unstructured":"Abramson S, Edelson H, Kaplan H et al (1984) The inactivation of the polymorphonuclear leukocyte by non-steroidal anti-inflammatory drugs. Inflammation 8(Suppl):S103\u2013S108","journal-title":"Inflammation"},{"key":"643_CR15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0002-9343(84)80086-8","volume":"77","author":"JS Goodwin","year":"1984","unstructured":"Goodwin JS (1984) Immunologic effects of nonsteroidal anti-inflammatory drugs. Am J Med 77:7\u201315","journal-title":"Am J Med"},{"key":"643_CR16","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1073\/pnas.74.3.897","volume":"74","author":"AL Horwitz","year":"1977","unstructured":"Horwitz AL, Hance AJ, Crystal RG (1977) Granulocyte collagenase: selective digestion of type I relative to type III collagen. Proc Natl Acad Sci U S A 74:897\u2013901","journal-title":"Proc Natl Acad Sci U S A"},{"key":"643_CR17","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/BF02090163","volume":"34","author":"WJ Mastboom","year":"1991","unstructured":"Mastboom WJ, Hendriks T, van EP et al (1991) The influence of NSAIDs on experimental intestinal anastomoses. Dis Colon Rectum 34:236\u2013243","journal-title":"Dis Colon Rectum"},{"key":"643_CR18","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1084\/jem.142.2.346","volume":"142","author":"Z Werb","year":"1975","unstructured":"Werb Z, Gordon S (1975) Secretion of a specific collagenase by stimulated macrophages. J Exp Med 142:346\u2013360, (Cox Inhibition and Anastomotic Healing)","journal-title":"J Exp Med"},{"key":"643_CR19","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1046\/j.1523-1747.2002.19501.x","volume":"119","author":"K Muller-Decker","year":"2002","unstructured":"Muller-Decker K, Hirschner W, Marks F et al (2002) The effects of cyclooxygenase isozyme inhibition on incisional wound healing in mouse skin. J Invest Dermatol 119:1189\u20131195","journal-title":"J Invest Dermatol"},{"key":"643_CR20","doi-asserted-by":"crossref","first-page":"22727","DOI":"10.1074\/jbc.M314302200","volume":"279","author":"LM Szewczuk","year":"2004","unstructured":"Szewczuk LM, Forti L, Stivala LA et al (2004) Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem 279:22727\u201322737","journal-title":"J Biol Chem"},{"key":"643_CR21","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1136\/jcp.44.8.700","volume":"44","author":"DG Altman","year":"1991","unstructured":"Altman DG (1991) Statistical analysis of comparison between laboratory methods. J Clin Pathol 44:700\u2013701","journal-title":"J Clin Pathol"},{"key":"643_CR22","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/sim.4780100514","volume":"10","author":"DG Altman","year":"1991","unstructured":"Altman DG, Dore CJ (1991) Baseline comparisons in randomized clinical trials. Stat Med 10:797\u2013799","journal-title":"Stat Med"},{"key":"643_CR23","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s00268-003-7009-5","volume":"27","author":"JW Mall","year":"2003","unstructured":"Mall JW, Schwenk W, Philipp AW et al (2003) Intraperitoneal administration of the angiogenesis inhibitor thalidomide does not impair anastomotic healing following large bowel resection in a rabbit model. World J Surg 27:1119\u20131123","journal-title":"World J Surg"},{"key":"643_CR24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/sj.bjp.0703112","volume":"129","author":"MN Muscara","year":"2000","unstructured":"Muscara MN, McKnight W, Asfaha S et al (2000) Wound collagen deposition in rats: effects of an NO-NSAID and a selective COX-2 inhibitor. Br J Pharmacol 129:681\u2013686","journal-title":"Br J Pharmacol"},{"key":"643_CR25","first-page":"177","volume":"46","author":"K Zwingenberger","year":"1995","unstructured":"Zwingenberger K, Wnendt S (1995) Immunomodulation by thalidomide: systematic review of the literature and of unpublished observations. J Inflamm 46:177\u2013211","journal-title":"J Inflamm"},{"key":"643_CR26","first-page":"45","volume":"43","author":"F Nahai","year":"1977","unstructured":"Nahai F, Lamb JM, Havican RG et al (1977) Factors involved in disruption of intestinal anastomoses. Am Surg 43:45\u201351","journal-title":"Am Surg"},{"key":"643_CR27","first-page":"190","volume":"141","author":"L Wise","year":"1975","unstructured":"Wise L, McAlister W, Stein T et al (1975) Studies on the healing of anastomoses of small and large intestines. Surg Gynecol Obstet 141:190\u2013194","journal-title":"Surg Gynecol Obstet"},{"key":"643_CR28","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/bjs.4722","volume":"91","author":"RA Cahill","year":"2004","unstructured":"Cahill RA, Sheehan KM, Scanlon RW et al (2004) Effects of a selective cyclo-oxygenase 2 inhibitor on colonic anastomotic and skin wound integrity. Br J Surg 91:1613\u20131618","journal-title":"Br J Surg"},{"key":"643_CR29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/34184","volume":"391","author":"C Jiang","year":"1998","unstructured":"Jiang C, Ting AT, Seed B (1998) PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82\u201386","journal-title":"Nature"},{"key":"643_CR30","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/jlb.66.5.733","volume":"66","author":"M Ricote","year":"1999","unstructured":"Ricote M, Huang JT, Welch JS et al (1999) The peroxisome proliferator-activated receptor(PPARgamma) as a regulator of monocyte\/macrophage function. J Leukoc Biol 66:733\u2013739","journal-title":"J Leukoc Biol"},{"key":"643_CR31","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1359\/jbmr.2002.17.6.963","volume":"17","author":"AM Simon","year":"2002","unstructured":"Simon AM, Manigrasso MB, O\u2019Connor JP (2002) Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Miner Res 17:963\u2013976","journal-title":"J Bone Miner Res"},{"key":"643_CR32","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S1470-2045(01)00488-0","volume":"2","author":"AJ Dannenberg","year":"2001","unstructured":"Dannenberg AJ, Altorki NK, Boyle JO et al (2001) Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer. Lancet Oncol 2:544\u2013551","journal-title":"Lancet Oncol"},{"key":"643_CR33","first-page":"413","volume":"155","author":"P Brasken","year":"1989","unstructured":"Brasken P, Lehto M, Renvall S (1989) Changes in the connective tissue composition of the submucosal layer of colonic anastomosis. An immunohistologic study in rats. Acta Chir Scand 155:413\u2013419","journal-title":"Acta Chir Scand"},{"key":"643_CR34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF01271773","volume":"358","author":"J Lindner","year":"1982","unstructured":"Lindner J (1982) [Morphology and biochemistry of wound healing]. Langenbecks Arch Chir 358:153\u2013160","journal-title":"Langenbecks Arch Chir"},{"key":"643_CR35","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/BF02049903","volume":"34","author":"JB Sousa de","year":"1991","unstructured":"de Sousa JB, Soares EG, Aprilli F (1991) Effects of diclofenac sodium on intestinal anastomotic healing. Experimental study on the small intestine of rabbits. Dis Colon Rectum 34:613\u2013617","journal-title":"Dis Colon Rectum"},{"key":"643_CR36","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0014-2999(99)00477-X","volume":"378","author":"C Campos","year":"1999","unstructured":"Campos C, de GR, Garcia-Nieto R et al (1999) Regulation of cyclooxygenase activity by metamizol. Eur J Pharmacol 378:339\u2013347","journal-title":"Eur J Pharmacol"},{"key":"643_CR37","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.biopha.2006.06.017","volume":"60","author":"RM Langford","year":"2006","unstructured":"Langford RM, Mehta V (2006) Selective cyclooxygenase inhibition: its role in pain and anaesthesia. Biomed Pharmacother 60:323\u2013328","journal-title":"Biomed Pharmacother"},{"key":"643_CR38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0891-5849(02)00911-5","volume":"33","author":"M Asensi","year":"2002","unstructured":"Asensi M, Medina I, Ortega A et al (2002) Inhibition of cancer growth by resveratrol is related to its low bioavailability. Free Radic Biol Med 33:387\u2013398","journal-title":"Free Radic Biol Med"},{"key":"643_CR39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/abbi.1995.1130","volume":"317","author":"DK Bhattacharyya","year":"1995","unstructured":"Bhattacharyya DK, Lecomte M, Dunn J et al (1995) Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. Arch Biochem Biophys 317:19\u201324","journal-title":"Arch Biochem Biophys"},{"key":"643_CR40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/bjs.5288","volume":"93","author":"I Hingh de","year":"2006","unstructured":"de Hingh I, van Goor H, de Man BM et al (2006) Selective cyclo-oxygenase 2 inhibition affects ileal but not colonic anastomotic healing in the early postoperative period. Br J Surg 93:489\u2013497","journal-title":"Br J Surg"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-009-0643-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00384-009-0643-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-009-0643-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T19:51:24Z","timestamp":1684871484000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00384-009-0643-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,29]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["643"],"URL":"https:\/\/doi.org\/10.1007\/s00384-009-0643-0","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,29]]}}}