{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:37:03Z","timestamp":1785008223069,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1007\/s00384-012-1440-8","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T00:59:49Z","timestamp":1331081989000},"page":"1275-1283","source":"Crossref","is-referenced-by-count":8,"title":["Increased use of multidisciplinary treatment modalities adds little to the outcome of rectal cancer treated by optimal total mesorectal excision"],"prefix":"10.1007","volume":"27","author":[{"given":"Kah Hoong","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver J.","family":"McAnena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arifin S.","family":"Aprjanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe F.","family":"Dowdall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,3,8]]},"reference":[{"issue":"Suppl 3","key":"1440_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1463-1318.2006.01060.x","volume":"8","author":"J Jessop","year":"2006","unstructured":"Jessop J, Beagley C, Heald RJ (2006) The Pelican Cancer Foundation and the English National MDT-TME Development Programme. Colorectal Dis 8(Suppl 3):1\u20132. doi: 10.1111\/j.1463-1318.2006.01060.x","journal-title":"Colorectal Dis"},{"issue":"8843","key":"1440_CR2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0140-6736(93)90207-W","volume":"341","author":"JK MacFarlane","year":"1993","unstructured":"MacFarlane JK, Ryall RD, Heald RJ (1993) Mesorectal excision for rectal cancer. Lancet 341(8843):457\u2013460. doi: 0140-6736(93)90207-W","journal-title":"Lancet"},{"issue":"2","key":"1440_CR3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/bjs.4834","volume":"92","author":"A Martling","year":"2005","unstructured":"Martling A, Holm T, Rutqvist LE, Johansson H, Moran BJ, Heald RJ, Cedermark B (2005) Impact of a surgical training programme on rectal cancer outcomes in Stockholm. Br J Surg 92(2):225\u2013229. doi: 10.1002\/bjs.4834","journal-title":"Br J Surg"},{"issue":"12","key":"1440_CR4","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.ejca.2008.05.004","volume":"44","author":"M Dulk den","year":"2008","unstructured":"den Dulk M, Krijnen P, Marijnen CA, Rutten HJ, van de Poll-Franse LV, Putter H, Meershoek-Klein Kranenbarg E, Jansen-Landheer ML, Coebergh JW, van de Velde CJ (2008) Improved overall survival for patients with rectal cancer since 1990: the effects of TME surgery and pre-operative radiotherapy. Eur J Cancer 44(12):1710\u20131716. doi: 10.1016\/j.ejca.2008.05.004","journal-title":"Eur J Cancer"},{"issue":"9224","key":"1440_CR5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0140-6736(00)02469-7","volume":"356","author":"AL Martling","year":"2000","unstructured":"Martling AL, Holm T, Rutqvist LE, Moran BJ, Heald RJ, Cedemark B (2000) Effect of a surgical training programme on outcome of rectal cancer in the County of Stockholm. Stockholm Colorectal Cancer Study Group, Basingstoke Bowel Cancer Research Project. Lancet 356(9224):93\u201396","journal-title":"Lancet"},{"issue":"5","key":"1440_CR6","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/bjs.4085","volume":"90","author":"JA Smith","year":"2003","unstructured":"Smith JA, King PM, Lane RH, Thompson MR (2003) Evidence of the effect of \u2018specialization\u2019 on the management, surgical outcome and survival from colorectal cancer in Wessex. Br J Surg 90(5):583\u2013592. doi: 10.1002\/bjs.4085","journal-title":"Br J Surg"},{"issue":"8","key":"1440_CR7","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1046\/j.1365-2168.2002.02158.x","volume":"89","author":"JF Dowdall","year":"2002","unstructured":"Dowdall JF, Maguire D, McAnena OJ (2002) Experience of surgery for rectal cancer with total mesorectal excision in a general surgical practice. Br J Surg 89(8):1014\u20131019. doi: 10.1046\/j.1365-2168.2002.02158.x","journal-title":"Br J Surg"},{"issue":"2","key":"1440_CR8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2298\/ACI0602035H","volume":"53","author":"B Heald","year":"2006","unstructured":"Heald B (2006) Better surgery and better selection for adjuvants\u2014still the key to improving outcomes in rectal cancer. Acta Chir Iugosl 53(2):35\u201337","journal-title":"Acta Chir Iugosl"},{"issue":"4","key":"1440_CR9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1463-1318.2005.00791.x","volume":"7","author":"E Moore","year":"2005","unstructured":"Moore E, Heald RJ, Cecil TD, Sharpe GD, Sexton R, Moran BJ (2005) Almost all five year disease free survivors are cured following rectal cancer surgery, but longer term follow-up detects some late local and systemic recurrences. Colorectal Dis 7(4):403\u2013405. doi: 10.1111\/j.1463-1318.2005.00791.x","journal-title":"Colorectal Dis"},{"key":"1440_CR10","doi-asserted-by":"crossref","unstructured":"Wong RK, Tandan V, De Silva S, Figueredo A (2007) Pre-operative radiotherapy and curative surgery for the management of localized rectal carcinoma. Cochrane Database Syst Rev (2):CD002102. doi: 10.1002\/14651858.CD002102.pub2","DOI":"10.1002\/14651858.CD002102.pub2"},{"issue":"11","key":"1440_CR11","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00384-008-0531-z","volume":"23","author":"J Strassburg","year":"2008","unstructured":"Strassburg J, Junginger T, Trinh T, Puttcher O, Oberholzer K, Heald RJ, Hermanek P (2008) Magnetic resonance imaging (MRI)-based indication for neoadjuvant treatment of rectal carcinoma and the surrogate endpoint CRM status. Int J Colorectal Dis 23(11):1099\u20131107. doi: 10.1007\/s00384-008-0531-z","journal-title":"Int J Colorectal Dis"},{"issue":"3","key":"1440_CR12","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1463-1318.2007.01260.x","volume":"10","author":"B Moran","year":"2008","unstructured":"Moran B, Brown G, Cunningham D, Daniels I, Heald R, Quirke P, Sebag-Montefiore D (2008) Clarifying the TNM staging of rectal cancer in the context of modern imaging and neo-adjuvant treatment: \u2018y\u2019\u2018u\u2019 and \u2018p\u2019 need \u2018mr\u2019 and \u2018ct\u2019. Colorectal Dis 10(3):242\u2013243. doi: 10.1111\/j.1463-1318.2007.01260.x","journal-title":"Colorectal Dis"},{"key":"1440_CR13","doi-asserted-by":"crossref","unstructured":"Smith AJ, Driman DK, Spithoff K, Hunter A, McLeod RS, Simunovic M, Langer B Guideline for optimization of colorectal cancer surgery and pathology. J Surg Oncol 101(1):5\u201312. doi: 10.1002\/jso.21395","DOI":"10.1002\/jso.21395"},{"issue":"9604","key":"1440_CR14","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/S0140-6736(07)61866-2","volume":"370","author":"G Quasar Collaborative","year":"2007","unstructured":"Quasar Collaborative G, Gray R, Barnwell J, McConkey C, Hills RK, Williams NS, Kerr DJ (2007) Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet 370(9604):2020\u20132029. doi: 10.1016\/S0140-6736(07)61866-2","journal-title":"Lancet"},{"issue":"22 Pt 2","key":"1440_CR15","doi-asserted-by":"crossref","first-page":"6913s","DOI":"10.1158\/1078-0432.CCR-07-1188","volume":"13","author":"AB Benson 3rd","year":"2007","unstructured":"Benson AB 3rd (2007) New approaches to assessing and treating early-stage colon and rectal cancers: cooperative group strategies for assessing optimal approaches in early-stage disease. Clin Cancer Res 13(22 Pt 2):6913s\u20136920s. doi: 10.1158\/1078-0432.CCR-07-1188","journal-title":"Clin Cancer Res"},{"key":"1440_CR16","doi-asserted-by":"crossref","unstructured":"Govindarajan A, Reidy D, Weiser MR, Paty PB, Temple LK, Guillem JG, Saltz LB, Wong WD, Nash GM (2011) Recurrence rates and prognostic factors in ypN0 rectal cancer after neoadjuvant chemoradiation and total mesorectal excision. Ann Surg Oncol 18(13):3666\u20133672. doi: 10.1245\/s10434-011-1788-y","DOI":"10.1245\/s10434-011-1788-y"},{"issue":"1","key":"1440_CR17","first-page":"25","volume":"2","author":"LL Gunderson","year":"2008","unstructured":"Gunderson LL, Callister M, Marschke R, Young-Fadok T, Heppell J, Efron J (2008) Stratification of rectal cancer stage for selection of postoperative chemoradiotherapy: current status. Gastrointest Cancer Res 2(1):25\u201333","journal-title":"Gastrointest Cancer Res"},{"issue":"3","key":"1440_CR18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/sj.bjc.6602947","volume":"94","author":"S Burton","year":"2006","unstructured":"Burton S, Brown G, Daniels IR, Norman AR, Mason B, Cunningham D (2006) MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins? Br J Cancer 94(3):351\u2013357. doi: 10.1038\/sj.bjc.6602947","journal-title":"Br J Cancer"},{"issue":"17","key":"1440_CR19","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMoa040694","volume":"351","author":"R Sauer","year":"2004","unstructured":"Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351(17):1731\u20131740. doi: 10.1056\/NEJMoa040694","journal-title":"N Engl J Med"},{"issue":"8","key":"1440_CR20","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1056\/NEJM199408253310803","volume":"331","author":"MJ O\u2019Connell","year":"1994","unstructured":"O\u2019Connell MJ, Martenson JA, Wieand HS, Krook JE, Macdonald JS, Haller DG, Mayer RJ, Gunderson LL, Rich TA (1994) Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 331(8):502\u2013507","journal-title":"N Engl J Med"},{"issue":"2","key":"1440_CR21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/bjs.4821","volume":"92","author":"A Wibe","year":"2005","unstructured":"Wibe A, Eriksen MT, Syse A, Tretli S, Myrvold HE, Soreide O (2005) Effect of hospital caseload on long-term outcome after standardization of rectal cancer surgery at a national level. Br J Surg 92(2):217\u2013224. doi: 10.1002\/bjs.4821","journal-title":"Br J Surg"},{"issue":"4","key":"1440_CR22","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ejso.2007.06.007","volume":"34","author":"AJ Debes","year":"2008","unstructured":"Debes AJ, Storkson RH, Jacobsen MB (2008) Curative rectal cancer surgery in a low-volume hospital: a quality assessment. Eur J Surg Oncol 34(4):382\u2013389. doi: 10.1016\/j.ejso.2007.06.007","journal-title":"Eur J Surg Oncol"},{"issue":"22","key":"1440_CR23","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMsa035205","volume":"349","author":"JD Birkmeyer","year":"2003","unstructured":"Birkmeyer JD, Stukel TA, Siewers AE, Goodney PP, Wennberg DE, Lucas FL (2003) Surgeon volume and operative mortality in the United States. N Engl J Med 349(22):2117\u20132127. doi: 10.1056\/NEJMsa035205","journal-title":"N Engl J Med"},{"issue":"2","key":"1440_CR24","first-page":"161","volume":"238","author":"PP Goodney","year":"2003","unstructured":"Goodney PP, Stukel TA, Lucas FL, Finlayson EV, Birkmeyer JD (2003) Hospital volume, length of stay, and readmission rates in high-risk surgery. Ann Surg 238(2):161\u2013167. doi: 10.1097\/01.SLA.0000081094.66659.c3","journal-title":"Ann Surg"},{"issue":"5","key":"1440_CR25","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/00000658-200011000-00023","volume":"232","author":"JD Birkmeyer","year":"2000","unstructured":"Birkmeyer JD (2000) Relation of surgical volume to outcome. Ann Surg 232(5):724\u2013725","journal-title":"Ann Surg"},{"issue":"5","key":"1440_CR26","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1097\/SLA.0b013e31818a157d","volume":"248","author":"DW Larson","year":"2008","unstructured":"Larson DW, Marcello PW, Larach SW, Wexner SD, Park A, Marks J, Senagore AJ, Thorson AG, Young-Fadok TM, Green E, Sargent DJ, Nelson H (2008) Surgeon volume does not predict outcomes in the setting of technical credentialing: results from a randomized trial in colon cancer. Ann Surg 248(5):746\u2013750. doi: 10.1097\/SLA.0b013e31818a157d","journal-title":"Ann Surg"},{"issue":"3","key":"1440_CR27","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/1553350607307274","volume":"14","author":"BK Hollenbeck","year":"2007","unstructured":"Hollenbeck BK, Hong J, Zaojun Y, Birkmeyer JD (2007) Misclassification of hospital volume with surveillance, epidemiology, and end results medicare data. Surg Innov 14(3):192\u2013198. doi: 10.1177\/1553350607307274","journal-title":"Surg Innov"},{"issue":"19","key":"1440_CR28","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1200\/JCO.2004.01.023","volume":"22","author":"M Brink van den","year":"2004","unstructured":"van den Brink M, Stiggelbout AM, van den Hout WB, Kievit J, Klein Kranenbarg E, Marijnen CA, Nagtegaal ID, Rutten HJ, Wiggers T, van de Velde CJ (2004) Clinical nature and prognosis of locally recurrent rectal cancer after total mesorectal excision with or without preoperative radiotherapy. J Clin Oncol 22(19):3958\u20133964. doi: 10.1200\/JCO.2004.01.023","journal-title":"J Clin Oncol"},{"issue":"3","key":"1440_CR29","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0360-3016(02)02880-8","volume":"54","author":"M Dahlberg","year":"2002","unstructured":"Dahlberg M, Stenborg A, Pahlman L, Glimelius B (2002) Cost-effectiveness of preoperative radiotherapy in rectal cancer: results from the Swedish Rectal Cancer Trial. Int J Radiat Oncol Biol Phys 54(3):654\u2013660. doi: S0360301602028808","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"1440_CR30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1200\/JCO.2004.11.918","volume":"22","author":"M Simunovic","year":"2004","unstructured":"Simunovic M, Gafni A, Levine M (2004) Economics of preoperative radiotherapy with total mesorectal excision: what can we learn from the Dutch experience? J Clin Oncol 22(2):217\u2013219. doi: 10.1200\/JCO.2004.11.918","journal-title":"J Clin Oncol"},{"issue":"4","key":"1440_CR31","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1463-1318.2006.01116.x","volume":"9","author":"IR Daniels","year":"2007","unstructured":"Daniels IR, Fisher SE, Heald RJ, Moran BJ (2007) Accurate staging, selective preoperative therapy and optimal surgery improves outcome in rectal cancer: a review of the recent evidence. Colorectal Dis 9(4):290\u2013301. doi: 10.1111\/j.1463-1318.2006.01116.x","journal-title":"Colorectal Dis"},{"issue":"1","key":"1440_CR32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1463-1318.2007.01209.x","volume":"10","author":"A Sharma","year":"2008","unstructured":"Sharma A, Sharp DM, Walker LG, Monson JR (2008) Colorectal MDTs: the team\u2019s perspective. Colorectal Dis 10(1):63\u201368. doi: 10.1111\/j.1463-1318.2007.01209.x","journal-title":"Colorectal Dis"},{"issue":"11","key":"1440_CR33","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S1470-2045(06)70940-8","volume":"7","author":"A Fleissig","year":"2006","unstructured":"Fleissig A, Jenkins V, Catt S, Fallowfield L (2006) Multidisciplinary teams in cancer care: are they effective in the UK? Lancet Oncol 7(11):935\u2013943. doi: 10.1016\/S1470-2045(06)70940-8","journal-title":"Lancet Oncol"},{"key":"1440_CR34","doi-asserted-by":"crossref","unstructured":"Kusters M, Marijnen CA, van de Velde CJ, Rutten HJ, Lahaye MJ, Kim JH, Beets-Tan RG, Beets GL (2010) Patterns of local recurrence in rectal cancer; a study of the Dutch TME trial. Eur J Surg Oncol 36(5):470\u2013476. doi: 10.1016\/j.ejso.2009.11.011","DOI":"10.1016\/j.ejso.2009.11.011"},{"issue":"9","key":"1440_CR35","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1445-1433.2004.03136.x","volume":"74","author":"AL Polglase","year":"2004","unstructured":"Polglase AL, Grodski SF, Tremayne AB, Chee JB, Bhathal PS (2004) Local recurrence following surgical treatment for carcinoma of the lower rectum. ANZ J Surg 74(9):745\u2013750. doi: 10.1111\/j.1445-1433.2004.03136.x","journal-title":"ANZ J Surg"},{"issue":"8","key":"1440_CR36","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1001\/archsurg.133.8.894","volume":"133","author":"RJ Heald","year":"1998","unstructured":"Heald RJ, Moran BJ, Ryall RD, Sexton R, MacFarlane JK (1998) Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978\u20131997. Arch Surg 133(8):894\u2013899","journal-title":"Arch Surg"},{"issue":"18","key":"1440_CR37","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1200\/JCO.2001.19.18.3895","volume":"19","author":"L Stocchi","year":"2001","unstructured":"Stocchi L, Nelson H, Sargent DJ, O\u2019Connell MJ, Tepper JE, Krook JE, Beart R Jr (2001) Impact of surgical and pathologic variables in rectal cancer: a United States community and cooperative group report. J Clin Oncol 19(18):3895\u20133902","journal-title":"J Clin Oncol"},{"issue":"3","key":"1440_CR38","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00384-004-0670-9","volume":"20","author":"A Chiappa","year":"2005","unstructured":"Chiappa A, Biffi R, Zbar AP, Luca F, Crotti C, Bertani E, Biella F, Zampino G, Orecchia R, Fazio N, Venturino M, Crosta C, Pruneri GC, Grassi C, Andreoni B (2005) Results of treatment of distal rectal carcinoma since the introduction of total mesorectal excision: a single unit experience, 1994\u20132003. Int J Colorectal Dis 20(3):221\u2013230. doi: 10.1007\/s00384-004-0670-9","journal-title":"Int J Colorectal Dis"},{"issue":"2","key":"1440_CR39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00000658-199802000-00001","volume":"227","author":"GA Porter","year":"1998","unstructured":"Porter GA, Soskolne CL, Yakimets WW, Newman SC (1998) Surgeon-related factors and outcome in rectal cancer. Ann Surg 227(2):157\u2013167","journal-title":"Ann Surg"},{"issue":"5","key":"1440_CR40","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.ejso.2005.02.027","volume":"31","author":"J Engel","year":"2005","unstructured":"Engel J, Kerr J, Eckel R, Gunther B, Heiss M, Heitland W, Siewert JR, Jauch KW, Holzel D (2005) Influence of hospital volume on local recurrence and survival in a population sample of rectal cancer patients. Eur J Surg Oncol 31(5):512\u2013520. doi: 10.1016\/j.ejso.2005.02.027","journal-title":"Eur J Surg Oncol"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-012-1440-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00384-012-1440-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-012-1440-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T05:12:57Z","timestamp":1713676377000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00384-012-1440-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,8]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["1440"],"URL":"https:\/\/doi.org\/10.1007\/s00384-012-1440-8","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,8]]}}}