{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:48:39Z","timestamp":1792082919202,"version":"4.4.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T00:00:00Z","timestamp":1356652800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1007\/s00384-012-1632-2","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T01:33:09Z","timestamp":1356571989000},"page":"915-924","source":"Crossref","is-referenced-by-count":26,"title":["Role of N-acetylcysteine and GSH redox system on total and active MMP-2 in intestinal myofibroblasts of Crohn's disease patients"],"prefix":"10.1007","volume":"28","author":[{"given":"Cecilia","family":"Romagnoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Marcucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Picariello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Vincenzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Iantomasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,28]]},"reference":[{"key":"1632_CR1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.pharmthera.2006.12.004","volume":"114","author":"A Andoh","year":"2007","unstructured":"Andoh A, Bamba S, Brittan M et al (2007) Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut. Pharmacol Ther 114:94\u2013106","journal-title":"Pharmacol Ther"},{"key":"1632_CR2","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00535-005-1727-4","volume":"40","author":"A Andoh","year":"2005","unstructured":"Andoh A, Bamba S, Fujiyama Y et al (2005) Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response. J Gastroenterol 40:1089\u20131099","journal-title":"J Gastroenterol"},{"key":"1632_CR3","doi-asserted-by":"crossref","first-page":"G2","DOI":"10.1152\/ajpgi.00075.2005","volume":"289","author":"DW Powell","year":"2005","unstructured":"Powell DW, Adegboyega PA, Di Mari JF, Mifflin RC (2005) Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer. Am J Physiol Gastrointest Liver Physiol 289:G2\u2013G7","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1632_CR4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.matbio.2007.07.001","volume":"26","author":"HJ Ra","year":"2007","unstructured":"Ra HJ (2007) Parks WC Control of matrix metalloproteinase catalytic activity. Matrix Biol 26:587\u2013596","journal-title":"Matrix Biol"},{"key":"1632_CR5","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1152\/physrev.00012.2007","volume":"87","author":"FG Spinale","year":"2007","unstructured":"Spinale FG (2007) Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev 87:1285\u20131342","journal-title":"Physiol Rev"},{"key":"1632_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bdrc.20065","volume":"78","author":"V Lema\u00eetre","year":"2006","unstructured":"Lema\u00eetre V, D'Armiento J (2006) Matrix metalloproteinases in development and disease. Birth Defects Res C Embryo Today 78:1\u201310","journal-title":"Birth Defects Res C Embryo Today"},{"key":"1632_CR7","doi-asserted-by":"crossref","first-page":"10830","DOI":"10.1021\/bi901656f","volume":"48","author":"GS Butler","year":"2009","unstructured":"Butler GS, Overall CM (2009) Updated biological roles for matrix metalloproteinases and new \"intracellular\" substrates revealed by degradomics. Biochemistry 48:10830\u201310845","journal-title":"Biochemistry"},{"key":"1632_CR8","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nri1418","volume":"4","author":"WC Parks","year":"2004","unstructured":"Parks WC, Wilson CL, L\u00f3pez-Boado YS (2004) Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 4:617\u2013629","journal-title":"Nat Rev Immunol"},{"key":"1632_CR9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ibd.20011","volume":"13","author":"A Ravi","year":"2007","unstructured":"Ravi A, Garg P, Sitaraman SV (2007) Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Inflamm Bowel Dis 13:97\u2013107","journal-title":"Inflamm Bowel Dis"},{"key":"1632_CR10","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/gut.39.5.684","volume":"39","author":"JM Reimund","year":"1996","unstructured":"Reimund JM, Wittersheim C, Dumont S et al (1996) Increased production of tumour necrosis factor-alpha interleukin-1 beta, and interleukin-6 by morphologically normal intestinal biopsies from patients with Crohn's disease. Gut 39:684\u2013689","journal-title":"Gut"},{"key":"1632_CR11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.mam.2005.07.009","volume":"26","author":"Y Naito","year":"2005","unstructured":"Naito Y, Yoshikawa T (2005) Role of matrix metalloproteinases in inflammatory bowel disease. Mol Aspects Med 26:379\u2013390","journal-title":"Mol Aspects Med"},{"key":"1632_CR12","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0002-9440(10)63931-4","volume":"162","author":"BC McKaig","year":"2003","unstructured":"McKaig BC, McWilliams D, Watson SA, Mahida YR (2003) Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. Am J Pathol 162:1355\u20131360","journal-title":"Am J Pathol"},{"key":"1632_CR13","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.dld.2005.02.011","volume":"37","author":"Q Gao","year":"2005","unstructured":"Gao Q, Meijer MJ, Kubben FJ et al (2005) Expression of matrix metalloproteinases-2 and \u22129 in intestinal tissue of patients with inflammatory bowel diseases. Dig Liver Dis 37:584\u2013592","journal-title":"Dig Liver Dis"},{"key":"1632_CR14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/gut.47.1.63","volume":"47","author":"B Lampe von","year":"2000","unstructured":"von Lampe B, Barthel B, Coupland SE et al (2000) Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease. Gut 47:63\u201373","journal-title":"Gut"},{"key":"1632_CR15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/bmmb.1994.1062","volume":"53","author":"T Iantomasi","year":"1994","unstructured":"Iantomasi T, Marraccini P, Favilli F et al (1994) Glutathione metabolism in Crohn's disease. Biochem Med Metab Biol 53:87\u201391","journal-title":"Biochem Med Metab Biol"},{"key":"1632_CR16","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1002\/ibd.21552","volume":"17","author":"S Catarzi","year":"2011","unstructured":"Catarzi S, Favilli F, Romagnoli C et al (2011) Oxidative state and IL-6 production in intestinal myofibroblasts of Crohn's disease patients. Inflamm Bowel Dis 17:1674\u20131684","journal-title":"Inflamm Bowel Dis"},{"key":"1632_CR17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/jcp.21208","volume":"213","author":"MP Vincenti","year":"2007","unstructured":"Vincenti MP, Brinckerhoff CE (2007) Signal transduction and cell-type specific regulation of matrix metalloproteinase gene expression: can MMPs be good for you? J Cell Physiol 213:355\u2013364","journal-title":"J Cell Physiol"},{"key":"1632_CR18","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1053\/gast.2000.18160","volume":"119","author":"KA Papadakis","year":"2000","unstructured":"Papadakis KA, Targan SR (2000) Tumor necrosis factor: biology and therapeutic inhibitors. Gastroenterology 119:1148\u20131157","journal-title":"Gastroenterology"},{"key":"1632_CR19","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/ibd.20100","volume":"13","author":"Q Gao","year":"2007","unstructured":"Gao Q, Meijer MJ, Schl\u00fcter UG, van Hogezand RA, van der Zon JM, van den Berg M, van Duijn W, Lamers CB, Verspaget HW (2007) Infliximab treatment influences the serological expression of matrix metalloproteinase (MMP)-2 and \u22129 in Crohn's disease. Inflamm Bowel Dis 13:693\u2013702","journal-title":"Inflamm Bowel Dis"},{"key":"1632_CR20","doi-asserted-by":"crossref","first-page":"C1513","DOI":"10.1152\/ajpcell.1997.272.5.C1513","volume":"272","author":"JD Valentich","year":"1997","unstructured":"Valentich JD, Popov V, Saada JI, Powell DW (1997) Phenotypic characterization of an intestinal subepithelial myofibroblast cell line. Am J Physiol 272:C1513\u2013C1524","journal-title":"Am J Physiol"},{"key":"1632_CR21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","volume":"70","author":"WR Best","year":"1976","unstructured":"Best WR, Becktel JM, Singleton JW, Kern F Jr (1976) Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology 70:439\u2013444","journal-title":"Gastroenterology"},{"key":"1632_CR22","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1365-2249.1997.4481346.x","volume":"109","author":"YR Mahida","year":"1997","unstructured":"Mahida YR, Galvin AM, Gray T et al (1997) Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells. Clin Exp Immunol 109:377\u2013386","journal-title":"Clin Exp Immunol"},{"key":"1632_CR23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1053\/j.gastro.2007.04.069","volume":"133","author":"A Sabatino Di","year":"2007","unstructured":"Di Sabatino A, Pender SL, Jackson CL et al (2007) Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies. Gastroenterology 133:137\u2013149","journal-title":"Gastroenterology"},{"key":"1632_CR24","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0167-4889(99)00142-1","volume":"1452","author":"T Iantomasi","year":"1999","unstructured":"Iantomasi T, Favilli F, Degl'Innocenti D, Vincenzini MT (1999) Increased glutathione synthesis associated with platelet-derived growth factor stimulation of NIH3T3 fibroblasts. Biochim Biophys Acta 1452:303\u2013312","journal-title":"Biochim Biophys Acta"},{"key":"1632_CR25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","volume":"150","author":"PK Smith","year":"1985","unstructured":"Smith PK, Krohn RI, Hermanson GT et al (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150:76\u201385","journal-title":"Anal Biochem"},{"key":"1632_CR26","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.bbagen.2007.12.011","volume":"1780","author":"A Matsuzawa","year":"2008","unstructured":"Matsuzawa A, Ichijo H (2008) Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling. Biochim Biophys Acta 1780:1325\u20131336","journal-title":"Biochim Biophys Acta"},{"key":"1632_CR27","doi-asserted-by":"crossref","first-page":"G1035","DOI":"10.1152\/ajpgi.00494.2001","volume":"282","author":"K Hata","year":"2002","unstructured":"Hata K, Andoh A, Shimada M et al (2002) IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol 282:G1035\u2013G1044","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"9","key":"1632_CR28","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1093\/carcin\/bgn162","volume":"29","author":"CW Lin","year":"2008","unstructured":"Lin CW, Hou WC, Shen SC et al (2008) Quercetin inhibition of tumor invasion via suppressing PKC delta\/ERK\/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. Carcinogenesis 29(9):1807\u20131815","journal-title":"Carcinogenesis"},{"key":"1632_CR29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/molehr\/gal023","volume":"12","author":"M Cohen","year":"2006","unstructured":"Cohen M, Meisser A, Haenggeli L, Bischof P (2006) Involvement of MAPK pathway in TNF-alpha-induced MMP-9 expression in human trophoblastic cells. Mol Hum Reprod 12:225\u2013232","journal-title":"Mol Hum Reprod"},{"key":"1632_CR30","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jcp.21041","volume":"212","author":"R Kajanne","year":"2007","unstructured":"Kajanne R, Miettinen P, Mehlem A et al (2007) EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways. J Cell Physiol 212:489\u2013497","journal-title":"J Cell Physiol"},{"key":"1632_CR31","doi-asserted-by":"crossref","first-page":"47366","DOI":"10.1074\/jbc.M208284200","volume":"277","author":"H Hotokezaka","year":"2002","unstructured":"Hotokezaka H, Sakai E, Kanaoka K et al (2002) U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. J Biol Chem 277:47366\u201347372","journal-title":"J Biol Chem"},{"key":"1632_CR32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neulet.2009.10.013","volume":"467","author":"RX Guo","year":"2009","unstructured":"Guo RX, Zhang M, Liu W et al (2009) NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance. Neurosci Lett 467:95\u201399","journal-title":"Neurosci Lett"},{"key":"1632_CR33","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.matbio.2005.06.006","volume":"24","author":"C Rossa Jr","year":"2005","unstructured":"Rossa C Jr, Liu M, Patil C, Kirkwood KL (2005) MKK3\/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts. Matrix Biol 24:478\u2013488","journal-title":"Matrix Biol"},{"key":"1632_CR34","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0002-9440(10)63931-4","volume":"162","author":"BC McKaig","year":"2003","unstructured":"McKaig BC, McWilliams D, Watson SA, Mahida YR (2003) Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. Am J Pathol 162:1355\u20131360","journal-title":"Am J Pathol"},{"key":"1632_CR35","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1136\/gut.2006.093187","volume":"55","author":"G Monteleone","year":"2006","unstructured":"Monteleone G, Caruso R, Fina D et al (2006) Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut 55:1774\u20131780","journal-title":"Gut"},{"key":"1632_CR36","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/003655202317284228","volume":"37","author":"T Okuno","year":"2002","unstructured":"Okuno T, Andoh A, Bamba S et al (2002) Interleukin-1beta and tumor necrosis factor-alpha induce chemokine and matrix metalloproteinase gene expression in human colonic subepithelial myofibroblasts. Scand J Gastroenterol 37:317\u2013324","journal-title":"Scand J Gastroenterol"},{"key":"1632_CR37","doi-asserted-by":"crossref","first-page":"36099","DOI":"10.1074\/jbc.M505291200","volume":"280","author":"AL Theiss","year":"2005","unstructured":"Theiss AL, Simmons JG, Jobin C, Lund PK (2005) Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem 280:36099\u201336109","journal-title":"J Biol Chem"},{"key":"1632_CR38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1749-6632.1994.tb24723.x","volume":"732","author":"LM Matrisian","year":"1994","unstructured":"Matrisian LM (1994) Matrix metalloproteinase gene expression. Ann N Y Acad Sci 732:42\u201350","journal-title":"Ann N Y Acad Sci"},{"key":"1632_CR39","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1365-2133.1994.tb04974.x","volume":"131","author":"MS Agren","year":"1994","unstructured":"Agren MS (1994) Gelatinase activity during wound healing. Br J Dermatol 131:634\u2013640","journal-title":"Br J Dermatol"},{"key":"1632_CR40","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1136\/gut.2003.017442","volume":"53","author":"T Kirkegaard","year":"2004","unstructured":"Kirkegaard T, Hansen A, Bruun E, Brynskov J (2004) Expression and localisation of matrix metalloproteinases and their natural inhibitors in fistulae of patients with Crohn's disease. Gut 53:701\u2013709","journal-title":"Gut"},{"key":"1632_CR41","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.dld.2007.05.010","volume":"39","author":"MJ Meijer","year":"2007","unstructured":"Meijer MJ, Mieremet-Ooms MA, van der Zon AM et al (2007) Increased mucosal matrix metalloproteinase-1, -2, -3 and \u22129 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype. Dig Liver Dis 39:733\u2013739","journal-title":"Dig Liver Dis"},{"key":"1632_CR42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/gut.47.3.415","volume":"47","author":"A Stallmach","year":"2000","unstructured":"Stallmach A, Chan CC, Ecker KW et al (2000) Comparable expression of matrix metalloproteinases 1 and 2 in pouchitis and ulcerative colitis. Gut 47:415\u2013422","journal-title":"Gut"},{"key":"1632_CR43","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s005350300062","volume":"38","author":"K Matsuno","year":"2003","unstructured":"Matsuno K, Adachi Y, Yamamoto H et al (2003) The expression of matrix metalloproteinase matrilysin indicates the degree of inflammation in ulcerative colitis. J Gastroenterol 38:348\u2013354","journal-title":"J Gastroenterol"},{"key":"1632_CR44","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/03008200802143166","volume":"49","author":"G Svineng","year":"2008","unstructured":"Svineng G, Ravuri C, Rikardsen O et al (2008) The role of reactive oxygen species in integrin and matrix metalloproteinase expression and function. Connect Tissue Res 49:197\u2013202","journal-title":"Connect Tissue Res"},{"key":"1632_CR45","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1524-475X.2011.00680.x","volume":"19","author":"H Ye","year":"2011","unstructured":"Ye H, Cai PC, Zhou Q, Ma WL (2011) Transforming growth factor-\u03b21 suppresses the up-regulation of matrix metalloproteinase-2 by lung fibroblasts in response to tumor necrosis factor-\u03b1. Wound Repair Regen 19:392\u2013399","journal-title":"Wound Repair Regen"},{"key":"1632_CR46","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/hep.20683","volume":"5","author":"A Galli","year":"2005","unstructured":"Galli A, Svegliati-Baroni G, Ceni E et al (2005) Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism. Hepatology 5:1074\u20131084","journal-title":"Hepatology"},{"key":"1632_CR47","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1167\/iovs.08-3193","volume":"50","author":"CS Alge-Priglinger","year":"2009","unstructured":"Alge-Priglinger CS, Kreutzer T, Obholzer K et al (2009) Oxidative stress-mediated induction of MMP-1 and MMP-3 in human RPE cells. Invest Ophthalmol Vis Sci 50:5495\u20135503","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1632_CR48","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1089\/ars.2006.8.1775","volume":"8","author":"JA McCubrey","year":"2006","unstructured":"McCubrey JA, Lahair MM, Franklin RA (2006) Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal 8:1775\u20131789","journal-title":"Antioxid Redox Signal"},{"key":"1632_CR49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ejps.2011.06.001","volume":"43","author":"L Li","year":"2011","unstructured":"Li L, Chen P, Ling Y et al (2011) Inhibitory effects of GL-V9 on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-2\/9. Eur J Pharm Sci 43:393\u2013399","journal-title":"Eur J Pharm Sci"},{"key":"1632_CR50","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3748\/wjg.14.200","volume":"14","author":"PK Roy","year":"2008","unstructured":"Roy PK, Rashid F, Bragg J, Ibdah JA (2008) Role of the JNK signal transduction pathway in inflammatory bowel disease. World J Gastroenterol 14:200\u2013202","journal-title":"World J Gastroenterol"},{"key":"1632_CR51","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijcard.2010.12.105","volume":"158","author":"X Wu","year":"2012","unstructured":"Wu X, Li L (2012) Rosiglitazone suppresses lipopolysaccharide-induced matrix metalloproteinase-2 activity in rat aortic endothelial cells via Ras-MEK1\/2 signaling. Int J Cardiol 158:54\u201358","journal-title":"Int J Cardiol"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00384-012-1632-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-012-1632-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-012-1632-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T12:15:18Z","timestamp":1562501718000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00384-012-1632-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,28]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["1632"],"URL":"https:\/\/doi.org\/10.1007\/s00384-012-1632-2","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,28]]}}}