{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:14:16Z","timestamp":1765232056641},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2013,3,3]],"date-time":"2013-03-03T00:00:00Z","timestamp":1362268800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s00384-013-1671-3","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T12:19:50Z","timestamp":1362226790000},"page":"1351-1358","source":"Crossref","is-referenced-by-count":20,"title":["Association of PTPN22 gene (rs2488457) polymorphism with ulcerative colitis and high levels of PTPN22 mRNA in ulcerative colitis"],"prefix":"10.1007","volume":"28","author":[{"given":"Zhitao","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,3]]},"reference":[{"key":"1671_CR1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","volume":"448","author":"RJ Xavier","year":"2007","unstructured":"Xavier RJ, Podolsky DK (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature 448:427\u2013434","journal-title":"Nature"},{"key":"1671_CR2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/ng.914","volume":"43","author":"TW Behrens","year":"2011","unstructured":"Behrens TW (2011) Lyp breakdown and autoimmunity. Nat Genet 43:821\u2013822","journal-title":"Nat Genet"},{"key":"1671_CR3","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/ng.904","volume":"43","author":"J Zhang","year":"2011","unstructured":"Zhang J, Zahir N, Jiang Q et al (2011) The autoimmune disease-associated PTPN22 variant promotes calpain-mediated LYP\/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet 43:902\u2013907","journal-title":"Nat Genet"},{"key":"1671_CR4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1084\/jem.189.1.111","volume":"189","author":"JF Cloutier","year":"1999","unstructured":"Cloutier JF, Veillette A (1999) Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase. J Exp Med 189:111\u2013121","journal-title":"J Exp Med"},{"key":"1671_CR5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/cmdc.200800375","volume":"4","author":"S Wu","year":"2009","unstructured":"Wu S, Bottini M, Rickert RC et al (2009) In silico screening for PTPN22 inhibitors: active hits from an inactive phosphatase conformation. ChemMedChem 4:440\u2013444","journal-title":"ChemMedChem"},{"key":"1671_CR6","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1016\/j.bmcl.2008.03.079","volume":"18","author":"Y Xie","year":"2008","unstructured":"Xie Y, Liu Y, Gong G et al (2008) Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase. Bioorg Med Chem Lett 18:2840\u20132844","journal-title":"Bioorg Med Chem Lett"},{"key":"1671_CR7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00281-010-0201-4","volume":"32","author":"SM Stanford","year":"2010","unstructured":"Stanford SM, Mustelin TM, Bottini N (2010) Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases. Semin Immunopathol 32:127\u2013136","journal-title":"Semin Immunopathol"},{"key":"1671_CR8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/thy.2008.0301","volume":"19","author":"G Dultz","year":"2009","unstructured":"Dultz G, Matheis N, Dittmar M et al (2009) The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes. Thyroid 19:143\u2013148","journal-title":"Thyroid"},{"key":"1671_CR9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.smim.2006.03.008","volume":"18","author":"N Bottini","year":"2006","unstructured":"Bottini N, Vang T, Cucca F et al (2006) Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Semin Immunol 18:207\u2013213","journal-title":"Semin Immunol"},{"key":"1671_CR10","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1080\/08916930701510848","volume":"40","author":"SA Chung","year":"2007","unstructured":"Chung SA, Criswell LA (2007) PTPN22: its role in SLE and autoimmunity. Autoimmunity 40:582\u2013590","journal-title":"Autoimmunity"},{"key":"1671_CR11","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/ibd.21630","volume":"17","author":"LM Diaz-Gallo","year":"2011","unstructured":"Diaz-Gallo LM, Espino-Pais\u00e1n L, Fransen K et al (2011) Differential association of two PTPN22 coding variants with Crohn\u2019s disease and ulcerative colitis. Inflamm Bowel Dis 17:2287\u20132294","journal-title":"Inflamm Bowel Dis"},{"key":"1671_CR12","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/ajmg.a.31124","volume":"140","author":"E Kawasaki","year":"2006","unstructured":"Kawasaki E, Awata T, Ikegami H et al (2006) Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations. Am J Med Genet A 140:586\u2013593","journal-title":"Am J Med Genet A"},{"key":"1671_CR13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12013-011-9291-4","volume":"62","author":"F Liu","year":"2012","unstructured":"Liu F, Liu J, Zheng TS et al (2012) The \u22121123G>C variant of PTPN22 gene promoter is associated with latent autoimmune diabetes in adult Chinese Hans. Cell Biochem Biophys 62:273\u2013279","journal-title":"Cell Biochem Biophys"},{"key":"1671_CR14","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00296-010-1705-x","volume":"32","author":"JJ Huang","year":"2012","unstructured":"Huang JJ, Qiu YR, Li HX et al (2012) A PTPN22 promoter polymorphism \u22121123G>C is associated with RA pathogenesis in Chinese. Rheumatol Int 32:767\u2013771","journal-title":"Rheumatol Int"},{"key":"1671_CR15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1399-0039.2010.01521.x","volume":"76","author":"X Feng","year":"2010","unstructured":"Feng X, Li YZ, Zhang Y et al (2010) Association of the PTPN22 gene (\u22121123G>C) polymorphism with rheumatoid arthritis in Chinese patients. Tissue Antigens 76:297\u2013300","journal-title":"Tissue Antigens"},{"key":"1671_CR16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/hmg\/ddn363","volume":"18","author":"V Orr\u00fa","year":"2009","unstructured":"Orr\u00fa V, Tsai SJ, Rueda B et al (2009) A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet 18:569\u2013579","journal-title":"Hum Mol Genet"},{"key":"1671_CR17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/art.30145","volume":"63","author":"L Rodr\u00edguez-Rodr\u00edguez","year":"2011","unstructured":"Rodr\u00edguez-Rodr\u00edguez L, Taib WR, Topless R et al (2011) The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case\u2013control samples. Arthritis Rheum 63:365\u2013372","journal-title":"Arthritis Rheum"},{"key":"1671_CR18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3109\/00365528909091339","volume":"170","author":"JE Lennard-Jones","year":"1989","unstructured":"Lennard-Jones JE (1989) Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 170:2\u20136","journal-title":"Scand J Gastroenterol Suppl"},{"key":"1671_CR19","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.2005.082909","volume":"55","author":"J Satsangi","year":"2006","unstructured":"Satsangi J, Silverberg MS, Vermeire S et al (2006) The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 55:749\u2013753","journal-title":"Gut"},{"key":"1671_CR20","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1136\/bmj.2.4947.1041","volume":"2","author":"SC Truelove","year":"1955","unstructured":"Truelove SC, Witts LJ (1955) Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J 2:1041\u20131048","journal-title":"Br Med J"},{"key":"1671_CR21","doi-asserted-by":"crossref","first-page":"e33067","DOI":"10.1371\/journal.pone.0033067","volume":"7","author":"HH Chang","year":"2012","unstructured":"Chang HH, Tai TS, Lu B et al (2012) PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis. PLoS One 7:e33067","journal-title":"PLoS One"},{"key":"1671_CR22","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3:1101\u20131108","journal-title":"Nat Protoc"},{"key":"1671_CR23","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/art.21561","volume":"54","author":"A Inoue","year":"2006","unstructured":"Inoue A, Takahashi KA, Arai Y et al (2006) The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit knee. Arthritis Rheum 54:264\u2013270","journal-title":"Arthritis Rheum"},{"key":"1671_CR24","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ibd.21410","volume":"17","author":"KA Oikonomou","year":"2011","unstructured":"Oikonomou KA, Kapsoritakis AN, Kapsoritaki AI et al (2011) Angiogenin, angiopoietin-1, angiopoietin-2, and endostatin serum levels in inflammatory bowel disease. Inflamm Bowel Dis 17:963\u2013970","journal-title":"Inflamm Bowel Dis"},{"key":"1671_CR25","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1399-0039.2007.00871.x","volume":"70","author":"MK Viken","year":"2007","unstructured":"Viken MK, Olsson M, Fl\u00e5m ST et al (2007) The PTPN22 promoter polymorphism \u22121123G>C association cannot be distinguished from the 1858C>T association in a Norwegian rheumatoid arthritis material. Tissue Antigens 70:190\u2013197","journal-title":"Tissue Antigens"},{"key":"1671_CR26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","volume":"491","author":"L Jostins","year":"2012","unstructured":"Jostins L, Ripke S, Weersma RK et al (2012) Host\u2013microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491:119\u2013124","journal-title":"Nature"},{"key":"1671_CR27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s10038-005-0246-8","volume":"50","author":"M Mori","year":"2005","unstructured":"Mori M, Yamada R, Kobayashi K et al (2005) Ethnic differences in allele frequency of autoimmune-disease-associated SNPs. J Hum Genet 50:264\u2013266","journal-title":"J Hum Genet"},{"key":"1671_CR28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/gm301","volume":"4","author":"M Ronninger","year":"2012","unstructured":"Ronninger M, Guo Y, Shchetynsky K et al (2012) The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls. Genome Med 4:2","journal-title":"Genome Med"},{"key":"1671_CR29","doi-asserted-by":"crossref","first-page":"11002","DOI":"10.1074\/jbc.M600498200","volume":"281","author":"J Wu","year":"2006","unstructured":"Wu J, Katrekar A, Honigberg LA et al (2006) Identification of substrates of human protein-tyrosine phosphatase PTPN22. J Biol Chem 281:11002\u201311010","journal-title":"J Biol Chem"},{"key":"1671_CR30","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00251-002-0516-y","volume":"54","author":"S J\u00fcliger","year":"2003","unstructured":"J\u00fcliger S, Bongartz M, Luty AJ et al (2003) Functional analysis of a promoter variant of the gene encoding the interferon-gamma receptor chain I. Immunogenetics 54:675\u2013680","journal-title":"Immunogenetics"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-013-1671-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00384-013-1671-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-013-1671-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T03:49:31Z","timestamp":1595476171000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00384-013-1671-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,3]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["1671"],"URL":"https:\/\/doi.org\/10.1007\/s00384-013-1671-3","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,3]]}}}