{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:34:03Z","timestamp":1781613243226,"version":"3.54.5"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s00384-014-2012-x","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T04:01:49Z","timestamp":1411617709000},"page":"1507-1516","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The prevention of colorectal anastomotic leakage with tissue adhesives in a contaminated environment is associated with the presence of anti-inflammatory macrophages"],"prefix":"10.1007","volume":"29","author":[{"given":"Zhouqiao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos A.","family":"Vakalopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geesien S. A.","family":"Boersema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard F.","family":"Kroese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King H.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.","family":"van der Horst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M.","family":"Mulder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"M. Bastiaansen-Jenniskens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert-Jan","family":"Kleinrensink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Jeekel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan. F.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"issue":"5","key":"2012_CR1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/00005373-200105000-00001","volume":"50","author":"D Demetriades","year":"2001","unstructured":"Demetriades D, Murray JA, Chan L et al (2001) Penetrating colon injuries requiring resection: diversion or primary anastomosis? An AAST prospective multicenter study. J Trauma 50(5):765\u201375","journal-title":"J Trauma"},{"key":"2012_CR2","volume":"3","author":"R Nelson","year":"2003","unstructured":"Nelson R, Singer M (2003) Primary repair for penetrating colon injuries. Cochrane Database Syst Rev 3, CD002247","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"2012_CR3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/01.sla.0000225357.82218.ce","volume":"245","author":"VA Constantinides","year":"2007","unstructured":"Constantinides VA, Heriot A, Remzi F et al (2007) Operative strategies for diverticular peritonitis: a decision analysis between primary resection and anastomosis versus Hartmann\u2019s procedures. Ann Surg 245(1):94\u2013103","journal-title":"Ann Surg"},{"issue":"8","key":"2012_CR4","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1046\/j.1365-2168.2002.02154.x","volume":"89","author":"NY Kamwendo","year":"2002","unstructured":"Kamwendo NY, Modiba MC, Matlala NS, Becker PJ (2002) Randomized clinical trial to determine if delay from time of penetrating colonic injury precludes primary repair. Br J Surg 89(8):993\u20138","journal-title":"Br J Surg"},{"issue":"7","key":"2012_CR5","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1007\/s10350-006-0547-9","volume":"49","author":"VA Constantinides","year":"2006","unstructured":"Constantinides VA, Tekkis PP, Athanasiou T et al (2006) Primary resection with anastomosis vs. Hartmann\u2019s procedure in nonelective surgery for acute colonic diverticulitis: a systematic review. Dis Colon Rectum 49(7):966\u201381","journal-title":"Dis Colon Rectum"},{"issue":"5","key":"2012_CR6","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/bjs.4915","volume":"92","author":"T Hudolin","year":"2005","unstructured":"Hudolin T, Hudolin I (2005) The role of primary repair for colonic injuries in wartime. Br J Surg 92(5):643\u20137","journal-title":"Br J Surg"},{"issue":"4","key":"2012_CR7","first-page":"364","volume":"184","author":"R Golub","year":"1997","unstructured":"Golub R, Golub RW, Cantu R Jr, Stein HD (1997) A multivariate analysis of factors contributing to leakage of intestinal anastomoses. J Am Coll Surg 184(4):364\u201372","journal-title":"J Am Coll Surg"},{"issue":"2","key":"2012_CR8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/00000658-200108000-00007","volume":"234","author":"R Tang","year":"2001","unstructured":"Tang R, Chen HH, Wang YL et al (2001) Risk factors for surgical site infection after elective resection of the colon and rectum: a single-center prospective study of 2,809 consecutive patients. Ann Surg 234(2):181\u20139","journal-title":"Ann Surg"},{"issue":"5","key":"2012_CR9","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/DCR.0b013e3182423c0d","volume":"55","author":"SW Leichtle","year":"2012","unstructured":"Leichtle SW, Mouawad NJ, Welch KB, Lampman RM, Cleary RK (2012) Risk factors for anastomotic leakage after colectomy. Dis Colon Rectum 55(5):569\u201375","journal-title":"Dis Colon Rectum"},{"issue":"11","key":"2012_CR10","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s10350-004-0701-1","volume":"47","author":"L Salem","year":"2004","unstructured":"Salem L, Flum DR (2004) Primary anastomosis or Hartmann\u2019s procedure for patients with diverticular peritonitis? A systematic review. Dis Colon Rectum 47(11):1953\u201364","journal-title":"Dis Colon Rectum"},{"issue":"11","key":"2012_CR11","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.ejso.2012.07.111","volume":"38","author":"HS Snijders","year":"2012","unstructured":"Snijders HS, Wouters MW, van Leersum NJ et al (2012) Meta-analysis of the risk for anastomotic leakage, the postoperative mortality caused by leakage in relation to the overall postoperative mortality. Eur J Surg Oncol 38(11):1013\u20139","journal-title":"Eur J Surg Oncol"},{"issue":"1","key":"2012_CR12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0002-9610(99)80082-8","volume":"171","author":"GM Ahrendt","year":"1996","unstructured":"Ahrendt GM, Tantry US, Barbul A (1996) Intra-abdominal sepsis impairs colonic reparative collagen synthesis. Am J Surg 171(1):102\u20137, discussion 7\u20138","journal-title":"Am J Surg"},{"issue":"1","key":"2012_CR13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1006\/jsre.1997.5034","volume":"69","author":"FJ Thornton","year":"1997","unstructured":"Thornton FJ, Ahrendt GM, Schaffer MR, Tantry US, Barbul A (1997) Sepsis impairs anastomotic collagen gene expression and synthesis: a possible role for nitric oxide. J Surg Res 69(1):81\u20136","journal-title":"J Surg Res"},{"issue":"4","key":"2012_CR14","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1046\/j.1365-2168.1998.00734.x","volume":"85","author":"M Schaffer","year":"1998","unstructured":"Schaffer M, Barbul A (1998) Lymphocyte function in wound healing and following injury. Br J Surg 85(4):444\u201360","journal-title":"Br J Surg"},{"issue":"3","key":"2012_CR15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s11605-010-1370-0","volume":"15","author":"J Paral","year":"2011","unstructured":"Paral J, Subrt Z, Lochman P et al (2011) Suture-free anastomosis of the colon experimental comparison of two cyanoacrylate adhesives. J Gastrointest Surg 15(3):451\u20139","journal-title":"J Gastrointest Surg"},{"issue":"11","key":"2012_CR16","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1007\/s00464-008-9885-0","volume":"22","author":"G Silecchia","year":"2008","unstructured":"Silecchia G, Boru CE, Mouiel J et al (2008) The use of fibrin sealant to prevent major complications following laparoscopic gastric bypass: results of a multicenter, randomized trial. Surg Endosc 22(11):2492\u20137","journal-title":"Surg Endosc"},{"issue":"2","key":"2012_CR17","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jss.2013.04.015","volume":"184","author":"JC Slieker","year":"2013","unstructured":"Slieker JC, Vakalopoulos KA, Komen NA, Jeekel J, Lange JF (2013) Prevention of leakage by sealing colon anastomosis: experimental study in a mouse model. J Surg Res 184(2):819\u201324","journal-title":"J Surg Res"},{"issue":"4","key":"2012_CR18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3171\/2009.10.SPINE09537","volume":"12","author":"MC Preul","year":"2010","unstructured":"Preul MC, Campbell PK, Garlick DS, Spetzler RF (2010) Application of a new hydrogel dural sealant that reduces epidural adhesion formation: evaluation in a large animal laminectomy model. J Neurosurg Spine 12(4):381\u201390","journal-title":"J Neurosurg Spine"},{"key":"2012_CR19","doi-asserted-by":"crossref","unstructured":"Vakalopoulos KA, Daams F, Wu Z, et al. Tissue adhesives in gastrointestinal anastomosis: a systematic review. J Surg Res. 2013 Jan 16.","DOI":"10.1016\/j.jss.2012.12.043"},{"key":"2012_CR20","doi-asserted-by":"crossref","unstructured":"Wu Z, Boersema GS, Vakalopoulos KA, et al. Critical analysis of cyanoacrylate in intestinal and colorectal anastomosis. J Biomed Mater Res B Appl Biomater. 2013 Oct 24.","DOI":"10.1002\/jbm.b.33039"},{"issue":"5","key":"2012_CR21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/sur.2011.108","volume":"13","author":"EB Deerenberg","year":"2012","unstructured":"Deerenberg EB, Mulder IM, Ditzel M et al (2012) Polyvinyl alcohol hydrogel decreases formation of adhesions in a rat model of peritonitis. Surg Infect (Larchmt) 13(5):321\u20135","journal-title":"Surg Infect (Larchmt)"},{"issue":"12","key":"2012_CR22","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/bjs.8954","volume":"99","author":"EB Deerenberg","year":"2012","unstructured":"Deerenberg EB, Mulder IM, Grotenhuis N, Ditzel M, Jeekel J, Lange JF (2012) Experimental study on synthetic and biological mesh implantation in a contaminated environment. Br J Surg 99(12):1734\u201341","journal-title":"Br J Surg"},{"key":"2012_CR23","unstructured":"Zuhlke HV, Lorenz EM, Straub EM, Savvas V. Pathophysiology and classification of adhesions. Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir. 1990:1009\u201316."},{"issue":"1","key":"2012_CR24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0002-9610(92)90255-P","volume":"163","author":"JD Phillips","year":"1992","unstructured":"Phillips JD, Kim CS, Fonkalsrud EW, Zeng H, Dindar H (1992) Effects of chronic corticosteroids and vitamin A on the healing of intestinal anastomoses. Am J Surg 163(1):71\u20137","journal-title":"Am J Surg"},{"issue":"10","key":"2012_CR25","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/BF02051930","volume":"33","author":"T Hendriks","year":"1990","unstructured":"Hendriks T, Mastboom WJ (1990) Healing of experimental intestinal anastomoses parameters for repair. Dis Colon Rectum 33(10):891\u2013901","journal-title":"Dis Colon Rectum"},{"issue":"8","key":"2012_CR26","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/bjs.4146","volume":"90","author":"IH Hingh de","year":"2003","unstructured":"de Hingh IH, de Man BM, Lomme RM, van Goor H, Hendriks T (2003) Colonic anastomotic strength and matrix metalloproteinase activity in an experimental model of bacterial peritonitis. Br J Surg 90(8):981\u20138","journal-title":"Br J Surg"},{"issue":"10","key":"2012_CR27","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1161\/CIRCRESAHA.110.216523","volume":"106","author":"A Chawla","year":"2010","unstructured":"Chawla A (2010) Control of macrophage activation and function by PPARs. Circ Res 106(10):1559\u201369","journal-title":"Circ Res"},{"issue":"3","key":"2012_CR28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.niox.2003.11.001","volume":"9","author":"D Dal Secco","year":"2003","unstructured":"Dal Secco D, Paron JA, de Oliveira SH, Ferreira SH, Silva JS, Cunha FQ (2003) Neutrophil migration in inflammation: nitric oxide inhibits rolling, adhesion and induces apoptosis. Nitric Oxide 9(3):153\u201364","journal-title":"Nitric Oxide"},{"key":"2012_CR29","doi-asserted-by":"crossref","unstructured":"Vakalopoulos KA, Wu Z, Kroese L, et al. Mechanical strength and rheological properties of tissue adhesives with regard to colorectal anastomosis: an ex vivo study. Annals of surgery. 2014. doi: 10.1097\/SLA.0000000000000599","DOI":"10.1097\/SLA.0000000000000599"},{"issue":"3\u20134","key":"2012_CR30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000350383","volume":"50","author":"Z Wu","year":"2013","unstructured":"Wu Z, Vakalopoulos KA, Kroese LF et al (2013) Reducing anastomotic leakage by reinforcement of colorectal anastomosis with cyanoacrylate glue. Eur Surg Res 50(3\u20134):255\u201361","journal-title":"Eur Surg Res"},{"issue":"2","key":"2012_CR31","first-page":"65","volume":"79","author":"P Brasken","year":"1990","unstructured":"Brasken P, Lehto M, Renvall S (1990) Fibronectin, laminin, and collagen types I, III, IV and V in the healing rat colon anastomosis. Ann Chir Gynaecol 79(2):65\u201371","journal-title":"Ann Chir Gynaecol"},{"issue":"4","key":"2012_CR32","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1046\/j.1365-3083.2001.00885.x","volume":"53","author":"A Gratchev","year":"2001","unstructured":"Gratchev A, Guillot P, Hakiy N et al (2001) Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein betaIG-H3. Scand J Immunol 53(4):386\u201392","journal-title":"Scand J Immunol"},{"issue":"3","key":"2012_CR33","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.actbio.2011.11.031","volume":"8","author":"BN Brown","year":"2012","unstructured":"Brown BN, Londono R, Tottey S et al (2012) Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials. Acta Biomater 8(3):978\u201387","journal-title":"Acta Biomater"},{"issue":"1","key":"2012_CR34","first-page":"239","volume":"96","author":"PM Kou","year":"2011","unstructured":"Kou PM, Babensee JE (2011) Macrophage and dendritic cell phenotypic diversity in the context of biomaterials. J Biomed Mater Res A 96(1):239\u201360","journal-title":"J Biomed Mater Res A"},{"issue":"2","key":"2012_CR35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jss.2009.09.030","volume":"168","author":"DF Schneider","year":"2011","unstructured":"Schneider DF, Palmer JL, Tulley JM et al (2011) A novel role for NKT cells in cutaneous wound repair. J Surg Res 168(2):325\u201333, e1","journal-title":"J Surg Res"},{"issue":"12","key":"2012_CR36","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1084\/jem.185.12.2089","volume":"185","author":"DF Tough","year":"1997","unstructured":"Tough DF, Sun S, Sprent J (1997) T cell stimulation in vivo by lipopolysaccharide (LPS). J Exp Med 185(12):2089\u201394","journal-title":"J Exp Med"},{"issue":"5A","key":"2012_CR37","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1016\/S0002-9610(03)00296-4","volume":"187","author":"JE Park","year":"2004","unstructured":"Park JE, Barbul A (2004) Understanding the role of immune regulation in wound healing. Am J Surg 187(5A):11S\u20136S","journal-title":"Am J Surg"},{"issue":"4","key":"2012_CR38","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI116015","volume":"90","author":"AE Postlethwaite","year":"1992","unstructured":"Postlethwaite AE, Holness MA, Katai H, Raghow R (1992) Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. J Clin Invest 90(4):1479\u201385","journal-title":"J Clin Invest"},{"issue":"2","key":"2012_CR39","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/00000658-198802000-00016","volume":"207","author":"DG Burleson","year":"1988","unstructured":"Burleson DG, Mason AD Jr, Pruitt BA Jr (1988) Lymphoid subpopulation changes after thermal injury and thermal injury with infection in an experimental model. Ann Surg 207(2):208\u201312","journal-title":"Ann Surg"},{"issue":"3","key":"2012_CR40","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/jsre.1993.1137","volume":"55","author":"AC Ham van der","year":"1993","unstructured":"van der Ham AC, Kort WJ, Weijma IM, Jeekel H (1993) Transient protection of incomplete colonic anastomoses with fibrin sealant: an experimental study in the rat. J Surg Res 55(3):256\u201360","journal-title":"J Surg Res"},{"issue":"6","key":"2012_CR41","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/bjs.1800790617","volume":"79","author":"AC Ham van der","year":"1992","unstructured":"van der Ham AC, Kort WJ, Weijma IM, van den Ingh HF, Jeekel H (1992) Effect of antibiotics in fibrin sealant on healing colonic anastomoses in the rat. Br J Surg 79(6):525\u20138","journal-title":"Br J Surg"},{"issue":"6","key":"2012_CR42","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00384-002-0392-9","volume":"17","author":"P Mansson","year":"2002","unstructured":"Mansson P, Zhang XW, Jeppsson B, Thorlacius H (2002) Anastomotic healing in the rat colon: comparison between a radiological method, breaking strength and bursting pressure. Int J Colorectal Dis 17(6):420\u20135","journal-title":"Int J Colorectal Dis"},{"issue":"11","key":"2012_CR43","first-page":"1620","volume":"18","author":"G Bonanomi","year":"2004","unstructured":"Bonanomi G, Prince JM, McSteen F, Schauer PR, Hamad GG (2004) Sealing effect of fibrin glue on the healing of gastrointestinal anastomoses: implications for the endoscopic treatment of leaks. Surg Endosc 18(11):1620\u20134","journal-title":"Surg Endosc"},{"issue":"2","key":"2012_CR44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10151-006-0263-4","volume":"10","author":"I Kanellos","year":"2006","unstructured":"Kanellos I, Christoforidis E, Kanellos D, Pramateftakis MG, Sakkas L, Betsis D (2006) The healing of colon anastomosis covered with fibrin glue after early postoperative intraperitoneal chemotherapy. Tech Coloproctol 10(2):115\u201320","journal-title":"Tech Coloproctol"},{"issue":"3","key":"2012_CR45","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00268-008-9889-x","volume":"33","author":"P Wang","year":"2009","unstructured":"Wang P, Wang J, Zhang W, Li Y, Li J (2009) Effect of the combination of fibrin glue and growth hormone on intestinal anastomoses in a pig model of traumatic shock associated with peritonitis. World J Surg 33(3):567\u201376","journal-title":"World J Surg"},{"issue":"4","key":"2012_CR46","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1607-551X(09)70058-0","volume":"25","author":"HA Kayaoglu","year":"2009","unstructured":"Kayaoglu HA, Ersoy OF, Ozkan N, Celik A, Filiz NO (2009) Effect of n-butyl-2-cyanoacrylate on high-risk colonic anastomoses. Kaohsiung J Med Sci 25(4):177\u201383","journal-title":"Kaohsiung J Med Sci"},{"issue":"1","key":"2012_CR47","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.amjsurg.2003.02.007","volume":"187","author":"TZ Nursal","year":"2004","unstructured":"Nursal TZ, Anarat R, Bircan S, Yildirim S, Tarim A, Haberal M (2004) The effect of tissue adhesive, octyl-cyanoacrylate, on the healing of experimental high-risk and normal colonic anastomoses. Am J Surg 187(1):28\u201332","journal-title":"Am J Surg"},{"issue":"2","key":"2012_CR48","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0002-9610(80)90261-5","volume":"139","author":"P Kirkegaard","year":"1980","unstructured":"Kirkegaard P, Christensen AB, Ibsen J (1980) Experimental nonsuture colonic anastomoses. Am J Surg 139(2):233\u20136","journal-title":"Am J Surg"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-014-2012-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00384-014-2012-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-014-2012-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T10:51:52Z","timestamp":1565866312000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00384-014-2012-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,26]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["2012"],"URL":"https:\/\/doi.org\/10.1007\/s00384-014-2012-x","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,26]]}}}