{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:37:27Z","timestamp":1789994247455,"version":"4.0.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T00:00:00Z","timestamp":1415923200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s00384-014-2051-3","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T16:05:09Z","timestamp":1415981109000},"page":"237-242","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["The effect of body weight on the severity and clinical course of ulcerative colitis"],"prefix":"10.1007","volume":"30","author":[{"given":"Denia","family":"Stabroth-Akil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Leifeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Pf\u00fctzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Morgenstern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Kruis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,14]]},"reference":[{"key":"2051_CR1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","volume":"444","author":"GS Hotamisligil","year":"2006","unstructured":"Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860\u2013867","journal-title":"Nature"},{"key":"2051_CR2","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1111\/j.1365-2036.2006.02915.x","volume":"23","author":"BJ John","year":"2006","unstructured":"John BJ, Irukulla S, Abulafi AM, Kumar D, Mendall MA (2006) Systematic review: adipose tissue, obesity and gastrointestinal diseases. Aliment Pharmacol Ther 23:1511\u20131523","journal-title":"Aliment Pharmacol Ther"},{"key":"2051_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2009.07.031","volume":"314","author":"E Maury","year":"2010","unstructured":"Maury E, Brichard SM (2010) Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 314:1\u201316","journal-title":"Mol Cell Endocrinol"},{"key":"2051_CR4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1079\/BJN20041213","volume":"92","author":"P Trayhurn","year":"2004","unstructured":"Trayhurn P, Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92:347\u2013355","journal-title":"Br J Nutr"},{"key":"2051_CR5","first-page":"135","volume":"52","author":"S Bondini","year":"2006","unstructured":"Bondini S, Younossi ZM (2006) Non-alcoholic fatty liver disease and hepatitis C infection. Minerva Gastroenterol Dietol 52:135\u2013143","journal-title":"Minerva Gastroenterol Dietol"},{"key":"2051_CR6","first-page":"169","volume":"56","author":"AC Evans","year":"2010","unstructured":"Evans AC, Papachristou GI, Whitcomb DC (2010) Obesity and the risk of severe acute pancreatitis. Minerva Gastroenterol Dietol 56:169\u2013179","journal-title":"Minerva Gastroenterol Dietol"},{"key":"2051_CR7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/ncpgasthep0186","volume":"2","author":"A Sch\u00e4ffler","year":"2005","unstructured":"Sch\u00e4ffler A, Sch\u00f6lmerich J, B\u00fcchler C (2005) Mechanisms of disease: adipocytokines and visceral adipose tissue\u2014emerging role in nonalcoholic fatty liver disease. Nat Clin Pract Gastroenterol Hepatol 2:273\u2013280","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"2051_CR8","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cld.2008.07.003","volume":"12","author":"D Poorten Van der","year":"2008","unstructured":"Van der Poorten D, George J (2008) Disease-specific mechanisms of fibrosis: hepatitis C virus and nonalcoholic steatohepatitis. Clin Liver Dis 12:805\u2013824","journal-title":"Clin Liver Dis"},{"key":"2051_CR9","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s10350-007-9172-5","volume":"51","author":"A Rosemar","year":"2008","unstructured":"Rosemar A, Anger\u00e5s U, Rosengren A (2008) Body mass index and diverticular disease: a 28-year follow-up study in men. Dis Colon Rectum 51:450\u2013455","journal-title":"Dis Colon Rectum"},{"key":"2051_CR10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1053\/j.gastro.2008.09.025","volume":"136","author":"LL Strate","year":"2009","unstructured":"Strate LL, Liu YL, Aldoori WH, Syngal S, Giovannucci EL (2009) Obesity increases the risks of diverticulitis and diverticular bleeding. Gastroenterology 136:115\u2013122","journal-title":"Gastroenterology"},{"key":"2051_CR11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/01.MIB.0000200345.38837.46","volume":"12","author":"K Karmiris","year":"2006","unstructured":"Karmiris K, Koutroubakis IE, Xidakis C, Polychronaki M, Voudouri T, Kouroumalis EA (2006) Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease. Inflamm Bowel Dis 12:100\u2013105","journal-title":"Inflamm Bowel Dis"},{"key":"2051_CR12","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/MEG.0b013e3282f16251","volume":"19","author":"A Konrad","year":"2007","unstructured":"Konrad A, Lehrke M, Schachinger V et al (2007) Resistin is an inflammatory marker of inflammatory bowel disease in humans. Eur J Gastroenterol Hepatol 19:1070\u20131074","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2051_CR13","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.2174\/138161207783018635","volume":"13","author":"G Matarese","year":"2007","unstructured":"Matarese G, Mantzoros C, La Cava A (2007) Leptin and adipocytokines: bridging the gap between immunity and atherosclerosis. Curr Pharm Des 13:3676\u20133680","journal-title":"Curr Pharm Des"},{"key":"2051_CR14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.nut.2008.07.020","volume":"25","author":"L Valentini","year":"2009","unstructured":"Valentini L, Wirth EK, Schweizer U et al (2009) Circulating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease. Nutrition 25:172\u2013181","journal-title":"Nutrition"},{"key":"2051_CR15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cyto.2007.02.001","volume":"36","author":"JA Sennello","year":"2006","unstructured":"Sennello JA, Fayad R, Pini M, Gove ME, Fantuzzi G (2006) Transplantation of wild-type white adipose tissue normalizes metabolic, immune and inflammatory alterations in leptin-deficient ob\/ob mice. Cytokine 36:261\u2013266","journal-title":"Cytokine"},{"key":"2051_CR16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/gutjnl-2011-300370","volume":"61","author":"L Peyrin-Biroulet","year":"2012","unstructured":"Peyrin-Biroulet L, Gonzalez F, Dubuquoy L et al (2012) Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn\u2019s disease. Gut 61:78\u201385","journal-title":"Gut"},{"key":"2051_CR17","volume-title":"Obesity: preventing and managing the global epidemic: report of a WHO consultation","author":"WHO","year":"1998","unstructured":"WHO (1998) Obesity: preventing and managing the global epidemic: report of a WHO consultation. WHO, Geneva"},{"key":"2051_CR18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1054\/clnu.2001.0503","volume":"21","author":"A Blain","year":"2002","unstructured":"Blain A, Cattan S, Beaugerie L, Carbonnel F, Gendre JP, Cosnes J (2002) Crohn\u2019s disease clinical course and severity in obese patients. Clin Nutr 21:51\u201357","journal-title":"Clin Nutr"},{"key":"2051_CR19","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.cgh.2005.12.015","volume":"4","author":"DJ Hass","year":"2006","unstructured":"Hass DJ, Brensinger CM, Lewis JD, Lichtenstein GR (2006) The impact of increased body mass index on the clinical course of Crohn\u2019s disease. Clin Gastroenterol Hepatol 4:482\u2013488","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2051_CR20","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1055\/s-0030-1253666","volume":"135","author":"C Hemmelmann","year":"2010","unstructured":"Hemmelmann C, Brose S, Vens M, Hebebrand J, Ziegler A (2010) [Percentiles of body mass index of 18\u201380-year-old German adults based on data from the Second National Nutrition Survey] [Article in German]. Dtsch Med Wochenschr 135:848\u2013852","journal-title":"Dtsch Med Wochenschr"},{"key":"2051_CR21","unstructured":"Statistisches Bundesamt: Gesundheitswesen \u2013 Mikrozensus 2009 \u2013 Fragen zur Gesundheit \u2013 Rauchgewohnheiten der Bev\u00f6lkerung 2009. http:\/\/www-ec.destatis.de\/csp\/shop\/sfg\/bpm.html"},{"key":"2051_CR22","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000262276","volume":"2","author":"H Steed","year":"2009","unstructured":"Steed H, Walsh S, Reynolds N (2009) A brief report of the epidemiology of obesity in the inflammatory bowel disease population of Tayside, Scotland. Obes Facts 2:370\u2013372","journal-title":"Obes Facts"},{"key":"2051_CR23","unstructured":"Peppercorn MA (2008) Clinical manifestations, diagnosis, and prognosis of ulcerative colitis in adults. http:\/\/www.uptodate.com\/contents\/clinical-manifestations-diagnosis-and-prognosis-of-ulcerative-colitis-in-adults . Accessed Feb 2012"},{"key":"2051_CR24","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1365-2796.1998.00254.x","volume":"243","author":"E Capristo","year":"1998","unstructured":"Capristo E, Mingrone G, Addolorato G, Greco AV, Gasbarrini G (1998) Metabolic features of inflammatory bowel disease in a remission phase of the disease. J Intern Med 243:339\u2013347","journal-title":"J Intern Med"},{"key":"2051_CR25","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.308.6939.1259","volume":"308","author":"A Ferguson","year":"1994","unstructured":"Ferguson A, Sedgwick DM (1994) Juvenile onset inflammatory bowel disease: height and body mass index in adult life. BMJ 308:1259\u20131263","journal-title":"BMJ"},{"key":"2051_CR26","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/0148607107031004311","volume":"31","author":"K Vagianos","year":"2007","unstructured":"Vagianos K, Bector S, McConnell J, Bernstein CN (2007) Nutrition assessment of patients with inflammatory bowel disease. JPEN J Parenter Enteral Nutr 31:311\u2013319","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"2051_CR27","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1111\/j.1572-0241.2003.07520.x","volume":"98","author":"J Jahnsen","year":"2003","unstructured":"Jahnsen J, Falch JA, Mowinckel P, Aadland E (2003) Body composition in patients with inflammatory bowel disease: a population-based study. Am J Gastroenterol 98:1556\u20131562","journal-title":"Am J Gastroenterol"},{"key":"2051_CR28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00004836-198802000-00009","volume":"10","author":"S Klein","year":"1988","unstructured":"Klein S, Meyers S, O\u2019Sullivan P, Barton D, Leleiko N, Janowitz HD (1988) The metabolic impact of active ulcerative colitis. Energy expenditure and nitrogen balance. J Clin Gastroenterol 10:34\u201340","journal-title":"J Clin Gastroenterol"},{"key":"2051_CR29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1590\/S0004-28032010000100009","volume":"47","author":"J Ripoli","year":"2010","unstructured":"Ripoli J, Miszputen SJ, Ambrogini O Jr, de Carvalho L (2010) Nutritional follow-up of patients with ulcerative colitis during periods of intestinal inflammatory activity and remission. Arq Gastroenterol 47:49\u201355","journal-title":"Arq Gastroenterol"},{"key":"2051_CR30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1079\/PNS19890051","volume":"48","author":"DBA Silk","year":"1989","unstructured":"Silk DBA, Payne-James J (1989) Inflammatory bowel disease: nutritional implications and treatment. Proc Nutr Soc 48:355\u2013361","journal-title":"Proc Nutr Soc"},{"key":"2051_CR31","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/gut.2005.082925","volume":"56","author":"L Peyrin-Biroulet","year":"2007","unstructured":"Peyrin-Biroulet L, Chamaillard M, Gonzalez F et al (2007) Mesenteric fat in Crohn\u2019s disease: a pathogenetic hallmark or an innocent bystander? Gut 56:577\u2013583","journal-title":"Gut"},{"key":"2051_CR32","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ncpgasthep0528","volume":"3","author":"RB Sartor","year":"2006","unstructured":"Sartor RB (2006) Mechanisms of disease: pathogenesis of Crohn\u2019s disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 3:390\u2013407","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"2051_CR33","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1007\/s10620-009-0846-9","volume":"55","author":"MH Holtmann","year":"2010","unstructured":"Holtmann MH, Krummenauer F, Claas C et al (2010) Significant differences between Crohn\u2019s disease and ulcerative colitis regarding the impact of body mass index and initial disease activity on responsiveness to azathioprine: results from a European multicenter study in 1,176 patients. Dig Dis Sci 55:1066\u20131078","journal-title":"Dig Dis Sci"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-014-2051-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00384-014-2051-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-014-2051-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T12:06:51Z","timestamp":1559045211000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00384-014-2051-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,14]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["2051"],"URL":"https:\/\/doi.org\/10.1007\/s00384-014-2051-3","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,14]]}}}