{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:32:08Z","timestamp":1780378328898,"version":"3.54.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft (DE)"},{"name":"Sonnenfeld-Stiftung Berlin"},{"name":"Repha GmbH, Hannover, Germany"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s00384-016-2736-x","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T12:52:58Z","timestamp":1481806378000},"page":"623-634","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Myrrh exerts barrier-stabilising and -protective effects in HT-29\/B6 and Caco-2 intestinal epithelial cells"],"prefix":"10.1007","volume":"32","author":[{"given":"Rita","family":"Rosenthal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Luettig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina A.","family":"Hering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne M.","family":"Krug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fromm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg-Dieter","family":"Schulzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,15]]},"reference":[{"issue":"11","key":"2736_CR1","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nri2653","volume":"9","author":"JR Turner","year":"2009","unstructured":"Turner JR (2009) Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 9(11):799\u2013809","journal-title":"Nat Rev Immunol"},{"key":"2736_CR2","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1083\/jcb.123.6.1777","volume":"123","author":"M Furuse","year":"1993","unstructured":"Furuse M et al (1993) Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 123:1777\u20131788","journal-title":"J Cell Biol"},{"issue":"6","key":"2736_CR3","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1083\/jcb.200510043","volume":"171","author":"J Ikenouchi","year":"2005","unstructured":"Ikenouchi J et al (2005) Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol 171(6):939\u2013945","journal-title":"J Cell Biol"},{"issue":"3","key":"2736_CR4","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/cphy.c110045","volume":"2","author":"D G\u00fcnzel","year":"2012","unstructured":"G\u00fcnzel D, Fromm M (2012) Claudins and other tight junction proteins. Compr Physiol 2(3):1819\u20131852","journal-title":"Compr Physiol"},{"issue":"1","key":"2736_CR5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1083\/jcb.142.1.117","volume":"142","author":"I Martin-Padura","year":"1998","unstructured":"Martin-Padura I et al (1998) Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 142(1):117\u2013127","journal-title":"J Cell Biol"},{"issue":"1","key":"2736_CR6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1136\/gut.2006.094375","volume":"56","author":"S Zeissig","year":"2007","unstructured":"Zeissig S et al (2007) Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn\u2019s disease. Gut 56(1):61\u201372","journal-title":"Gut"},{"issue":"2","key":"2736_CR7","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.gastro.2005.05.002","volume":"129","author":"F Heller","year":"2005","unstructured":"Heller F et al (2005) Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 129(2):550\u2013564","journal-title":"Gastroenterology"},{"issue":"Suppl 2","key":"2736_CR8","doi-asserted-by":"publisher","first-page":"S146","DOI":"10.1111\/j.1440-1746.2008.05405.x","volume":"23","author":"T Oshima","year":"2008","unstructured":"Oshima T, Miwa H, Joh T (2008) Changes in the expression of claudins in active ulcerative colitis. J Gastroenterol Hepatol 23(Suppl 2):S146\u2013S150","journal-title":"J Gastroenterol Hepatol"},{"issue":"1\u20132","key":"2736_CR9","doi-asserted-by":"publisher","first-page":"e977176","DOI":"10.4161\/21688370.2014.977176","volume":"3","author":"J Luettig","year":"2015","unstructured":"Luettig J et al (2015) Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation. Tissue Barriers 3(1\u20132):e977176","journal-title":"Tissue Barriers"},{"issue":"6","key":"2736_CR10","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/jn\/138.6.1067","volume":"138","author":"M Amasheh","year":"2008","unstructured":"Amasheh M et al (2008) Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells. J Nutr 138(6):1067\u20131073","journal-title":"J Nutr"},{"issue":"5","key":"2736_CR11","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3945\/jn.108.100867","volume":"139","author":"T Suzuki","year":"2009","unstructured":"Suzuki T, Hara H (2009) Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J Nutr 139(5):965\u2013974","journal-title":"J Nutr"},{"key":"2736_CR12","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.1242\/jcs.070896","volume":"123","author":"M Amasheh","year":"2010","unstructured":"Amasheh M et al (2010) TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signaling. J Cell Sci 123:4145\u20134155","journal-title":"J Cell Sci"},{"key":"2736_CR13","doi-asserted-by":"crossref","unstructured":"Luettig J, et al. (2016) The ginger component 6-shogaol prevents TNF-alpha-induced barrier loss via inhibition of PI3K\/Akt and NF-kappaB signaling. Mol Nutr Food Res","DOI":"10.1002\/mnfr.201600274"},{"issue":"2","key":"2736_CR14","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.jep.2012.05.025","volume":"142","author":"T Shen","year":"2012","unstructured":"Shen T et al (2012) The genus Commiphora: a review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 142(2):319\u2013330","journal-title":"J Ethnopharmacol"},{"key":"2736_CR15","first-page":"1S","volume":"30 Suppl","author":"RA Ford","year":"1992","unstructured":"Ford RA, Api AM, Letizia CS (1992) Monographs on fragrance raw materials. Food Chem Toxicol 30 Suppl:1S\u2013138S","journal-title":"Food Chem Toxicol"},{"issue":"12","key":"2736_CR16","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1097\/01.mib.0000235830.94057.c6","volume":"12","author":"JH Cheon","year":"2006","unstructured":"Cheon JH et al (2006) Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis. Inflamm Bowel Dis 12(12):1152\u20131161","journal-title":"Inflamm Bowel Dis"},{"issue":"9","key":"2736_CR17","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.bcp.2009.06.026","volume":"78","author":"A Mencarelli","year":"2009","unstructured":"Mencarelli A et al (2009) The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel disease. Biochem Pharmacol 78(9):1214\u20131223","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"2736_CR18","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.intimp.2005.07.001","volume":"6","author":"N Manjula","year":"2006","unstructured":"Manjula N et al (2006) Inhibition of MAP kinases by crude extract and pure compound isolated from Commiphora mukul leads to down regulation of TNF-alpha, IL-1beta and IL-2. Int Immunopharmacol 6(2):122\u2013132","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"2736_CR19","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/apt.12397","volume":"38","author":"J Langhorst","year":"2013","unstructured":"Langhorst J et al (2013) Randomised clinical trial: a herbal preparation of myrrh, chamomile and coffee charcoal compared with mesalazine in maintaining remission in ulcerative colitis\u2014a double-blind, double-dummy study. Aliment Pharmacol Ther 38(5):490\u2013500","journal-title":"Aliment Pharmacol Ther"},{"issue":"8","key":"2736_CR20","doi-asserted-by":"publisher","first-page":"e104257","DOI":"10.1371\/journal.pone.0104257","volume":"9","author":"J Langhorst","year":"2014","unstructured":"Langhorst J et al (2014) Distinct kinetics in the frequency of peripheral CD4+ T cells in patients with ulcerative colitis experiencing a flare during treatment with mesalazine or with a herbal preparation of myrrh, chamomile, and coffee charcoal. PLoS One 9(8):e104257","journal-title":"PLoS One"},{"key":"2736_CR21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1242\/jcs.112.1.137","volume":"112","author":"H Schmitz","year":"1999","unstructured":"Schmitz H et al (1999) Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29\/B6. J Cell Sci 112:137\u2013146","journal-title":"J Cell Sci"},{"issue":"3","key":"2736_CR22","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/0016-5085(89)90897-4","volume":"96","author":"IJ Hidalgo","year":"1989","unstructured":"Hidalgo IJ, Raub TJ, Borchardt RT (1989) Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96(3):736\u2013749","journal-title":"Gastroenterology"},{"issue":"Pt 10","key":"2736_CR23","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1242\/jcs.040113","volume":"122","author":"D G\u00fcnzel","year":"2009","unstructured":"G\u00fcnzel D et al (2009) Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function. J Cell Sci 122(Pt 10):1507\u20131517","journal-title":"J Cell Sci"},{"issue":"11","key":"2736_CR24","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1242\/jcs.060665","volume":"123","author":"R Rosenthal","year":"2010","unstructured":"Rosenthal R et al (2010) Claudin-2, a component of the tight junction, forms a paracellular water channel. J Cell Sci 123(11):1913\u20131921","journal-title":"J Cell Sci"},{"issue":"11","key":"2736_CR25","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1002\/ibd.21628","volume":"17","author":"MJ Rosen","year":"2011","unstructured":"Rosen MJ et al (2011) STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction. Inflamm Bowel Dis 17(11):2224\u20132234","journal-title":"Inflamm Bowel Dis"},{"key":"2736_CR26","doi-asserted-by":"publisher","first-page":"4969","DOI":"10.1242\/jcs.00165","volume":"115","author":"S Amasheh","year":"2002","unstructured":"Amasheh S et al (2002) Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci 115:4969\u20134976","journal-title":"J Cell Sci"},{"issue":"2","key":"2736_CR27","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1083\/jcb.153.2.263","volume":"153","author":"M Furuse","year":"2001","unstructured":"Furuse M et al (2001) Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol 153(2):263\u2013272","journal-title":"J Cell Biol"},{"issue":"11","key":"2736_CR28","doi-asserted-by":"publisher","first-page":"684","DOI":"10.3858\/emm.2012.44.11.077","volume":"44","author":"N Thongon","year":"2012","unstructured":"Thongon N, Krishnamra N (2012) Apical acidity decreases inhibitory effect of omeprazole on Mg(2+) absorption and claudin-7 and -12 expression in Caco-2 monolayers. Exp Mol Med 44(11):684\u2013693","journal-title":"Exp Mol Med"},{"issue":"4","key":"2736_CR29","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1152\/ajpcell.1991.261.4.C574","volume":"261","author":"KM Kreusel","year":"1991","unstructured":"Kreusel KM et al (1991) Cl\u2212 secretion in epithelial monolayers of mucus-forming human colon cells (HT-29\/B6). Am J Phys 261(4):574\u2013582","journal-title":"Am J Phys"},{"issue":"4","key":"2736_CR30","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1590\/S0100-879X2010007500020","volume":"43","author":"W Cui","year":"2010","unstructured":"Cui W et al (2010) Tumor necrosis factor alpha increases epithelial barrier permeability by disrupting tight junctions in Caco-2 cells. Braz J Med Biol Res 43(4):330\u2013337","journal-title":"Braz J Med Biol Res"},{"key":"2736_CR31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/j.1749-6632.2000.tb05242.x","volume":"915","author":"AH Gitter","year":"2000","unstructured":"Gitter AH et al (2000) Epithelial barrier defects in HT-29\/B6 colonic cell monolayers induced by tumor necrosis factor-alpha. Ann N Y Acad Sci 915:193\u2013203","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"2736_CR32","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00441-009-0751-8","volume":"336","author":"J Mankertz","year":"2009","unstructured":"Mankertz J et al (2009) TNFalpha up-regulates claudin-2 expression in epithelial HT-29\/B6 cells via phosphatidylinositol-3-kinase signaling. Cell Tissue Res 336(1):67\u201377","journal-title":"Cell Tissue Res"},{"issue":"2","key":"2736_CR33","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1136\/gut.2008.150425","volume":"58","author":"HJ Epple","year":"2009","unstructured":"Epple HJ et al (2009) Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut 58(2):220\u2013227","journal-title":"Gut"},{"key":"2736_CR34","doi-asserted-by":"crossref","unstructured":"Schumann M, et al. (2011) Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease. Gut","DOI":"10.1136\/gutjnl-2011-300123"},{"issue":"9","key":"2736_CR35","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1038\/labinvest.3700316","volume":"85","author":"S Prasad","year":"2005","unstructured":"Prasad S et al (2005) Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab Investig 85(9):1139\u20131162","journal-title":"Lab Investig"},{"issue":"36","key":"2736_CR36","doi-asserted-by":"publisher","first-page":"31263","DOI":"10.1074\/jbc.M111.238147","volume":"286","author":"T Suzuki","year":"2011","unstructured":"Suzuki T, Yoshinaga N, Tanabe S (2011) Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem 286(36):31263\u201331271","journal-title":"J Biol Chem"},{"issue":"4","key":"2736_CR37","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.4049\/jimmunol.1201373","volume":"190","author":"MJ Rosen","year":"2013","unstructured":"Rosen MJ et al (2013) STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J Immunol 190(4):1849\u20131858","journal-title":"J Immunol"},{"issue":"29","key":"2736_CR38","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.1038\/onc.2011.43","volume":"30","author":"P Dhawan","year":"2011","unstructured":"Dhawan P et al (2011) Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene 30(29):3234\u20133247","journal-title":"Oncogene"},{"issue":"1","key":"2736_CR39","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/jcp.20189","volume":"203","author":"F Escaffit","year":"2005","unstructured":"Escaffit F, Boudreau F, Beaulieu JF (2005) Differential expression of claudin-2 along the human intestine: implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. J Cell Physiol 203(1):15\u201326","journal-title":"J Cell Physiol"},{"issue":"6","key":"2736_CR40","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.modgep.2005.12.001","volume":"6","author":"JL Holmes","year":"2006","unstructured":"Holmes JL et al (2006) Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns. Gene Expr Patterns 6(6):581\u2013588","journal-title":"Gene Expr Patterns"},{"issue":"4","key":"2736_CR41","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.bbrc.2003.12.185","volume":"314","author":"J Mankertz","year":"2004","unstructured":"Mankertz J et al (2004) Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. Biochem Biophys Res Commun 314(4):1001\u20131007","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"2736_CR42","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1016\/j.bbamem.2010.07.014","volume":"1798","author":"S Milatz","year":"2010","unstructured":"Milatz S et al (2010) Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim Biophys Acta 1798(11):2048\u20132057","journal-title":"Biochim Biophys Acta"},{"issue":"23","key":"2736_CR43","doi-asserted-by":"publisher","first-page":"3903","DOI":"10.1007\/s00018-011-0680-z","volume":"68","author":"J Piontek","year":"2011","unstructured":"Piontek J et al (2011) Elucidating the principles of the molecular organization of heteropolymeric tight junction strands. Cell Mol Life Sci 68(23):3903\u20133918","journal-title":"Cell Mol Life Sci"},{"key":"2736_CR44","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1242\/jcs.113.19.3387","volume":"113 Pt 19","author":"KM McCarthy","year":"2000","unstructured":"McCarthy KM et al (2000) Inducible expression of claudin-1-myc but not occludin-VSV-G results in aberrant tight junction strand formation in MDCK cells. J Cell Sci 113 Pt 19:3387\u20133398","journal-title":"J Cell Sci"},{"issue":"27","key":"2736_CR45","doi-asserted-by":"publisher","first-page":"6179","DOI":"10.1016\/j.febslet.2005.09.091","volume":"579","author":"SS Oliveira de","year":"2005","unstructured":"de Oliveira SS et al (2005) Claudins upregulation in human colorectal cancer. FEBS Lett 579(27):6179\u20136185","journal-title":"FEBS Lett"},{"key":"2736_CR46","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/j.1749-6632.2000.tb05259.x","volume":"915","author":"H Schmitz","year":"2000","unstructured":"Schmitz H et al (2000) Epithelial barrier and transport function of the colon in ulcerative colitis. Ann N Y Acad Sci 915:312\u2013326","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"2736_CR47","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00428-012-1195-1","volume":"460","author":"P Das","year":"2012","unstructured":"Das P et al (2012) Comparative tight junction protein expressions in colonic Crohn\u2019s disease, ulcerative colitis, and tuberculosis: a new perspective. Virchows Arch 460(3):261\u2013270","journal-title":"Virchows Arch"},{"issue":"1","key":"2736_CR48","doi-asserted-by":"publisher","first-page":"e000015","DOI":"10.1136\/bmjgast-2014-000015","volume":"1","author":"U Albrecht","year":"2014","unstructured":"Albrecht U et al (2014) Efficacy and safety of a herbal medicinal product containing myrrh, chamomile and coffee charcoal for the treatment of gastrointestinal disorders: a non-interventional study. BMJ Open Gastroenterol 1(1):e000015","journal-title":"BMJ Open Gastroenterol"},{"issue":"3","key":"2736_CR49","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.parint.2009.04.006","volume":"58","author":"RA Abdul-Ghani","year":"2009","unstructured":"Abdul-Ghani RA, Loutfy N, Hassan A (2009) Myrrh and trematodoses in Egypt: an overview of safety, efficacy and effectiveness profiles. Parasitol Int 58(3):210\u2013214","journal-title":"Parasitol Int"},{"issue":"4","key":"2736_CR50","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1527-3466.2007.00023.x","volume":"25","author":"R Deng","year":"2007","unstructured":"Deng R (2007) Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits. Cardiovasc Drug Rev 25(4):375\u2013390","journal-title":"Cardiovasc Drug Rev"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-016-2736-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00384-016-2736-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-016-2736-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T06:33:38Z","timestamp":1718951618000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00384-016-2736-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,15]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["2736"],"URL":"https:\/\/doi.org\/10.1007\/s00384-016-2736-x","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,15]]}}}