{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:21:09Z","timestamp":1786980069811,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007883","name":"Stichting Coolsingel","doi-asserted-by":"publisher","award":["191"],"award-info":[{"award-number":["191"]}],"id":[{"id":"10.13039\/501100007883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1007\/s00384-017-2839-z","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T08:03:08Z","timestamp":1498636988000},"page":"1267-1275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Nicotine chewing gum for the prevention of postoperative ileus after colorectal surgery: a multicenter, double-blind, randomised, controlled pilot study"],"prefix":"10.1007","volume":"32","author":[{"given":"Dani\u00ebl P. V.","family":"Lambrichts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geesien S. A.","family":"Boersema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buket","family":"Tas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouqiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wietske W.","family":"Vrijland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert-Jan","family":"Kleinrensink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Jeekel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan F.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand G.","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"issue":"14","key":"2839_CR1","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3748\/wjg.v16.i14.1683","volume":"16","author":"T Lubbers","year":"2010","unstructured":"Lubbers T, Buurman W, Luyer M (2010) Controlling postoperative ileus by vagal activation. World J Gastroenterol 16(14):1683\u20131687","journal-title":"World J Gastroenterol"},{"key":"2839_CR2","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00423-016-1485-1","volume":"402","author":"D Gero","year":"2016","unstructured":"Gero D, Gi\u00e9 O, H\u00fcbner M, Demartines N, Hahnloser D (2016) Postoperative ileus: in search of an international consensus on definition, diagnosis, and treatment. Langenbeck\u2019s Arch Surg 402:149\u2013158:1\u201310. doi: 10.1007\/s00423-016-1485-1","journal-title":"Langenbeck\u2019s Arch Surg"},{"issue":"4","key":"2839_CR3","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/01.sla.0000141158.27977.66","volume":"240","author":"BG Wolff","year":"2004","unstructured":"Wolff BG, Michelassi F, Gerkin TM, Techner L, Gabriel K, Du W, Wallin BA, Alvimopan Postoperative Ileus Study G (2004) Alvimopan, a novel, peripherally acting mu opioid antagonist: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus. Ann Surg 240(4):728\u2013734 discussion 734-725","journal-title":"Ann Surg"},{"issue":"7","key":"2839_CR4","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00268-008-9491-2","volume":"32","author":"A Artinyan","year":"2008","unstructured":"Artinyan A, Nunoo-Mensah JW, Balasubramaniam S, Gauderman J, Essani R, Gonzalez-Ruiz C, Kaiser AM, Beart RW Jr (2008) Prolonged postoperative ileus-definition, risk factors, and predictors after surgery. World J Surg 32(7):1495\u20131500","journal-title":"World J Surg"},{"issue":"2","key":"2839_CR5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1001\/archsurg.141.2.174","volume":"141","author":"R Schuster","year":"2006","unstructured":"Schuster R, Grewal N, Greaney GC, Waxman K (2006) Gum chewing reduces ileus after elective open sigmoid colectomy. Arch Surg 141(2):174\u2013176","journal-title":"Arch Surg"},{"issue":"2","key":"2839_CR6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1001\/archsurg.138.2.206","volume":"138","author":"A Luckey","year":"2003","unstructured":"Luckey A, Livingston E, Tache Y (2003) Mechanisms and treatment of postoperative ileus. Arch Surg 138(2):206\u2013214","journal-title":"Arch Surg"},{"issue":"Suppl 2","key":"2839_CR7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1743-3150.2004.00558.x","volume":"16","author":"AJ Bauer","year":"2004","unstructured":"Bauer AJ, Boeckxstaens GE (2004) Mechanisms of postoperative ileus. Neurogastroenterol Motil 16(Suppl 2):54\u201360","journal-title":"Neurogastroenterol Motil"},{"issue":"9","key":"2839_CR8","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1136\/gut.2008.169250","volume":"58","author":"GE Boeckxstaens","year":"2009","unstructured":"Boeckxstaens GE, de Jonge WJ (2009) Neuroimmune mechanisms in postoperative ileus. Gut 58(9):1300\u20131311","journal-title":"Gut"},{"issue":"5","key":"2839_CR9","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/00000658-199811000-00004","volume":"228","author":"JC Kalff","year":"1998","unstructured":"Kalff JC, Schraut WH, Simmons RL, Bauer AJ (1998) Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus. Ann Surg 228(5):652\u2013663","journal-title":"Ann Surg"},{"issue":"1","key":"2839_CR10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00000658-200207000-00010","volume":"236","author":"A Turler","year":"2002","unstructured":"Turler A, Moore BA, Pezzone MA, Overhaus M, Kalff JC, Bauer AJ (2002) Colonic postoperative inflammatory ileus in the rat. Ann Surg 236(1):56\u201366","journal-title":"Ann Surg"},{"issue":"4","key":"2839_CR11","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/j.gastro.2007.07.022","volume":"133","author":"GE Boeckxstaens","year":"2007","unstructured":"The FO, Boeckxstaens GE, Snoek SA, Cash JL, Bennink R, Larosa GJ, van den Wijngaard RM, Greaves DR, de Jonge WJ (2007) Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice. Gastroenterology 133(4):1219\u20131228","journal-title":"Gastroenterology"},{"issue":"3","key":"2839_CR12","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1053\/j.gastro.2009.04.057","volume":"137","author":"EP Zanden van der","year":"2009","unstructured":"van der Zanden EP, Snoek SA, Heinsbroek SE, Stanisor OI, Verseijden C, Boeckxstaens GE, Peppelenbosch MP, Greaves DR, Gordon S, De Jonge WJ (2009) Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2. Gastroenterology 137(3):1029\u20131039 1039 e1021-1024","journal-title":"Gastroenterology"},{"issue":"6921","key":"2839_CR13","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","volume":"421","author":"H Wang","year":"2003","unstructured":"Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Wang H, Yang H, Ulloa L, Al-Abed Y, Czura CJ, Tracey KJ (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421(6921):384\u2013388","journal-title":"Nature"},{"issue":"13","key":"2839_CR14","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1016\/S0028-3908(00)00139-8","volume":"39","author":"MI Damaj","year":"2000","unstructured":"Damaj MI, Meyer EM, Martin BR (2000) The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model. Neuropharmacology 39(13):2785\u20132791","journal-title":"Neuropharmacology"},{"issue":"3","key":"2839_CR15","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1213\/ane.0b013e31816f2616","volume":"107","author":"AS Habib","year":"2008","unstructured":"Habib AS, White WD, El Gasim MA, Saleh G, Polascik TJ, Moul JW, Gan TJ (2008) Transdermal nicotine for analgesia after radical retropubic prostatectomy. Anesth Analg 107(3):999\u20131004","journal-title":"Anesth Analg"},{"issue":"6","key":"2839_CR16","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1097\/00000542-200412000-00023","volume":"101","author":"P Flood","year":"2004","unstructured":"Flood P, Daniel D (2004) Intranasal nicotine for postoperative pain treatment. Anesthesiology 101(6):1417\u20131421","journal-title":"Anesthesiology"},{"issue":"2","key":"2839_CR17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1053\/cgh.2003.50012","volume":"1","author":"B Behm","year":"2003","unstructured":"Behm B, Stollman N (2003) Postoperative ileus: etiologies and interventions. Clin Gastroenterol Hepatol 1(2):71\u201380","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"2839_CR18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s11605-008-0756-8","volume":"13","author":"W Vasquez","year":"2009","unstructured":"Vasquez W, Hernandez AV, Garcia-Sabrido JL (2009) Is gum chewing useful for ileus after elective colorectal surgery? A systematic review and meta-analysis of randomized clinical trials. J Gastrointest Surg 13(4):649\u2013656","journal-title":"J Gastrointest Surg"},{"issue":"12","key":"2839_CR19","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1007\/s10350-007-9039-9","volume":"50","author":"MK Chan","year":"2007","unstructured":"Chan MK, Law WL (2007) Use of chewing gum in reducing postoperative ileus after elective colorectal resection: a systematic review. Dis Colon Rectum 50(12):2149\u20132157","journal-title":"Dis Colon Rectum"},{"issue":"8","key":"2839_CR20","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/archsurg.143.8.788","volume":"143","author":"S Purkayastha","year":"2008","unstructured":"Purkayastha S, Tilney HS, Darzi AW, Tekkis PP (2008) Meta-analysis of randomized studies evaluating chewing gum to enhance postoperative recovery following colectomy. Arch Surg 143(8):788\u2013793","journal-title":"Arch Surg"},{"issue":"7","key":"2839_CR21","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1111\/jgh.12206","volume":"28","author":"S Li","year":"2013","unstructured":"Li S, Liu Y, Peng Q, Xie L, Wang J, Qin X (2013) Chewing gum reduces postoperative ileus following abdominal surgery: a meta-analysis of 17 randomized controlled trials. J Gastroenterol Hepatol 28(7):1122\u20131132","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"2839_CR22","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ijsu.2009.01.006","volume":"7","author":"EJ Noble","year":"2009","unstructured":"Noble EJ, Harris R, Hosie KB, Thomas S, Lewis SJ (2009) Gum chewing reduces postoperative ileus? A systematic review and meta-analysis. Int J Surg 7(2):100\u2013105","journal-title":"Int J Surg"},{"key":"2839_CR23","first-page":"CD006506","volume":"2","author":"V Short","year":"2015","unstructured":"Short V, Herbert G, Perry R, Atkinson C, Ness AR, Penfold C, Thomas S, Andersen HK, Lewis SJ (2015) Chewing gum for postoperative recovery of gastrointestinal function. Cochrane Database Syst Rev 2:CD006506","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"2839_CR24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1072-7515(02)01179-1","volume":"195","author":"T Asao","year":"2002","unstructured":"Asao T, Kuwano H, Nakamura J, Morinaga N, Hirayama I, Ide M (2002) Gum chewing enhances early recovery from postoperative ileus after laparoscopic colectomy. J Am Coll Surg 195(1):30\u201332","journal-title":"J Am Coll Surg"},{"issue":"3","key":"2839_CR25","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.mehy.2014.06.011","volume":"83","author":"Z Wu","year":"2014","unstructured":"Wu Z, Boersema GS, Jeekel J, Lange JF (2014) Nicotine gum chewing: a novel strategy to shorten duration of postoperative ileus via vagus nerve activation. Med Hypotheses 83(3):352\u2013354","journal-title":"Med Hypotheses"},{"issue":"4","key":"2839_CR26","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/SLA.0b013e318293ee55","volume":"259","author":"SH Bree van","year":"2014","unstructured":"van Bree SH, Bemelman WA, Hollmann MW, Zwinderman AH, Matteoli G, El Temna S, The FO, Vlug MS, Bennink RJ, Boeckxstaens GE (2014) Identification of clinical outcome measures for recovery of gastrointestinal motility in postoperative ileus. Ann Surg 259(4):708\u2013714","journal-title":"Ann Surg"},{"issue":"11","key":"2839_CR27","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1046\/j.1365-2168.2000.01595.x","volume":"87","author":"K Holte","year":"2000","unstructured":"Holte K, Kehlet H (2000) Postoperative ileus: a preventable event. Br J Surg 87(11):1480\u20131493. doi: 10.1046\/j.1365-2168.2000.01595.x","journal-title":"Br J Surg"},{"issue":"11","key":"2839_CR28","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/nm1124","volume":"10","author":"H Wang","year":"2004","unstructured":"Wang H, Liao H, Ochani M, Justiniani M, Lin X, Yang L, Al-Abed Y, Wang H, Metz C, Miller EJ, Tracey KJ, Ulloa L (2004) Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 10(11):1216\u20131221","journal-title":"Nat Med"},{"issue":"15","key":"2839_CR29","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1056\/NEJM199504133321503","volume":"332","author":"GA Thomas","year":"1995","unstructured":"Thomas GA, Rhodes J, Mani V, Williams GT, Newcombe RG, Russell MA, Feyerabend C (1995) Transdermal nicotine as maintenance therapy for ulcerative colitis. N Engl J Med 332(15):988\u2013992","journal-title":"N Engl J Med"},{"key":"2839_CR30","first-page":"CD000146","volume":"11","author":"LF Stead","year":"2012","unstructured":"Stead LF, Perera R, Bullen C, Mant D, Hartmann-Boyce J, Cahill K, Lancaster T (2012) Nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev 11:CD000146","journal-title":"Cochrane Database Syst Rev"},{"key":"2839_CR31","doi-asserted-by":"crossref","first-page":"3786418","DOI":"10.1155\/2016\/3786418","volume":"2016","author":"CL Sparreboom","year":"2016","unstructured":"Sparreboom CL, Wu Z, Dereci A, Boersema GS, Menon AG, Ji J, Kleinrensink GJ, Lange JF (2016) Cytokines as early markers of colorectal anastomotic leakage: a systematic review and meta-analysis. Gastroenterol Res Pract 2016:3786418","journal-title":"Gastroenterol Res Pract"},{"key":"2839_CR32","unstructured":"Weiss E Cleveland clinic florida does nicotine gum enhance bowel recovery after colorectal surgery? In: In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2016 Dec 30] Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01662115 NLM Identifier: NCT01662115"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00384-017-2839-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-017-2839-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-017-2839-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T23:14:18Z","timestamp":1659136458000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00384-017-2839-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,28]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["2839"],"URL":"https:\/\/doi.org\/10.1007\/s00384-017-2839-z","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,28]]}}}