{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:10:44Z","timestamp":1781503844693,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s00384-017-2899-0","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T16:47:10Z","timestamp":1505234830000},"page":"1539-1544","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Review of local injection of anti-TNF for perianal fistulising Crohn\u2019s disease"],"prefix":"10.1007","volume":"32","author":[{"given":"Samuel O.","family":"Adegbola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapil","family":"Sahnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Tozer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin KS","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar D","family":"Faiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janindra","family":"Warusavitarne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailsa","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"2899_CR1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.dld.2007.07.154","volume":"39","author":"SB Ingle","year":"2007","unstructured":"Ingle SB, Loftus EV (2007) The natural history of perianal Crohn\u2019s disease. Dig Liver Dis 39:963\u2013969","journal-title":"Dig Liver Dis"},{"key":"2899_CR2","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.2005.082909","volume":"55","author":"J Satsangi","year":"2006","unstructured":"Satsangi J, Silverberg MS, Vermeire S, Colombel J-F (2006) The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 55:749\u2013753","journal-title":"Gut"},{"key":"2899_CR3","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/apt.12906","volume":"40","author":"NA Yassin","year":"2014","unstructured":"Yassin NA, Askari A, Warusavitarne J, Faiz OD, Athanasiou T, Phillips RKS et al (2014) Systematic review: the combined surgical and medical treatment of fistulising perianal Crohn\u2019s disease. Aliment Pharmacol Ther 40:741\u2013749","journal-title":"Aliment Pharmacol Ther"},{"key":"2899_CR4","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1002\/ibd.21940","volume":"18","author":"P Tozer","year":"2012","unstructured":"Tozer P, Ng SC, Siddiqui MR, Plamondon S, Burling D, Gupta A et al (2012) Long-term MRI-guided combined anti-TNF-\u03b1 and thiopurine therapy for Crohn\u2019s perianal fistulas. Inflamm Bowel Dis 18:1825\u20131834","journal-title":"Inflamm Bowel Dis"},{"key":"2899_CR5","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.dld.2007.07.156","volume":"39","author":"L Griggs","year":"2007","unstructured":"Griggs L, Schwartz DA (2007) Medical options for treating perianal Crohn\u2019s disease. Dig Liver Dis 39:979\u2013987","journal-title":"Dig Liver Dis"},{"key":"2899_CR6","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1056\/NEJMoa030815","volume":"350","author":"BE Sands","year":"2004","unstructured":"Sands BE, Anderson FH, Bernstein CN, Chey WY, Feagan BG, Fedorak RN et al (2004) Infliximab maintenance therapy for fistulizing Crohn\u2019s disease. N Engl J Med 350:876\u2013885","journal-title":"N Engl J Med"},{"key":"2899_CR7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.dld.2012.10.009","volume":"45","author":"G Condino","year":"2013","unstructured":"Condino G, Calabrese E, Zorzi F, Onali S, Lolli E, De Biasio F et al (2013) Anti-TNF-alpha treatments and obstructive symptoms in Crohn\u2019s disease: a prospective study. Dig Liver Dis 45:258\u2013262","journal-title":"Dig Liver Dis"},{"key":"2899_CR8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2147\/tcrm.2007.3.2.301","volume":"3","author":"G Poggioli","year":"2007","unstructured":"Poggioli G, Laureti S, Campieri M, Pierangeli F, Gionchetti P, Ugolini F et al (2007) Infliximab in the treatment of Crohn\u2019s disease. Ther Clin Risk Manag 3:301\u2013308","journal-title":"Ther Clin Risk Manag"},{"key":"2899_CR9","doi-asserted-by":"crossref","first-page":"A621","DOI":"10.1016\/S0016-5085(08)83091-0","volume":"120","author":"S Lichtiger","year":"2001","unstructured":"Lichtiger S (2001) Healing of perianal fistulae by local injection of antibody to TNF. Gastroenterology 120:A621","journal-title":"Gastroenterology"},{"key":"2899_CR10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10151-011-0759-4","volume":"15","author":"L Alessandroni","year":"2011","unstructured":"Alessandroni L, Kohn A, Cosintino R, Marrollo M, Papi C, Monterubbianesi R et al (2011) Local injection of infliximab in severe fistulating perianal Crohn\u2019s disease: an open uncontrolled study. Tech Coloproctol 15:407\u2013412","journal-title":"Tech Coloproctol"},{"key":"2899_CR11","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1080\/00365520600609941","volume":"41","author":"CR Asteria","year":"2006","unstructured":"Asteria CR, Ficari F, Bagnoli S, Milla M, Tonelli F (2006) Treatment of perianal fistulas in Crohn\u2019s disease by local injection of antibody to TNF-\u03b1 accounts for a favourable clinical response in selected cases: a pilot study. Scand J Gastroenterol 41:1064\u20131072","journal-title":"Scand J Gastroenterol"},{"key":"2899_CR12","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s10350-004-0832-4","volume":"48","author":"G Poggioli","year":"2005","unstructured":"Poggioli G, Laureti S, Pierangeli F, Rizzello F, Ugolini F, Gionchetti P et al (2005) Local injection of infliximab for the treatment of perianal Crohn\u2019s disease. Dis Colon Rectum 48:768\u2013774","journal-title":"Dis Colon Rectum"},{"key":"2899_CR13","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1097\/DCR.0b013e31825af532","volume":"55","author":"F Tonelli","year":"2012","unstructured":"Tonelli F, Giudici F, Asteria CR (2012) Effectiveness and safety of local adalimumab injection in patients with fistulizing perianal Crohn\u2019s disease. Dis Colon Rectum 55:870\u2013875","journal-title":"Dis Colon Rectum"},{"key":"2899_CR14","doi-asserted-by":"crossref","first-page":"S166","DOI":"10.1016\/S1873-9946(12)60412-7","volume":"6","author":"S Laureti","year":"2012","unstructured":"Laureti S, Coscia M, Gentilini L, Ugolini F, Vitali G, Vittori L et al (2012) P393 Combination of surgical therapy and local injections of adalimumab in treatment of complex perianal Crohn\u2019s disease. J Crohn\u2019s Colitis Eur Crohn\u2019s Colitis Organ 6:S166","journal-title":"J Crohn\u2019s Colitis Eur Crohn\u2019s Colitis Organ"},{"key":"2899_CR15","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s10151-015-1332-3","volume":"19","author":"P Tozer","year":"2015","unstructured":"Tozer P, Borowski DW, Gupta A, Yassin N, Phillips R, Hart A (2015) Managing perianal Crohn\u2019s fistula in the anti-TNF\u03b1 era. Tech Coloproctol Springer Milan 19:673\u2013678","journal-title":"Tech Coloproctol Springer Milan"},{"key":"2899_CR16","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1056\/NEJM199905063401804","volume":"340","author":"DH Present","year":"1999","unstructured":"Present DH, Rutgeerts P, Targan S, Hanauer SB, Mayer L, van Hogezand RA et al (1999) Infliximab for the treatment of fistulas in patients with Crohn\u2019s disease. N Engl J Med 340:1398\u20131405","journal-title":"N Engl J Med"},{"key":"2899_CR17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.gastro.2006.11.041","volume":"132","author":"JF Colombel","year":"2007","unstructured":"Colombel JF, Sandborn WJ, Rutgeerts P, Enns R, Hanauer SB, Panaccione R et al (2007) Adalimumab for maintenance of clinical response and remission in patients with Crohn\u2019s disease: the CHARM trial. Gastroenterology 132:52\u201365","journal-title":"Gastroenterology"},{"key":"2899_CR18","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/gut.2008.159251","volume":"58","author":"J-F Colombel","year":"2009","unstructured":"Colombel J-F, Schwartz DA, Sandborn WJ, Kamm MA, D\u2019Haens G, Rutgeerts P et al (2009) Adalimumab for the treatment of fistulas in patients with Crohn\u2019s disease. Gut 58:940\u2013948","journal-title":"Gut"},{"key":"2899_CR19","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1111\/j.1572-0241.2002.07093.x","volume":"97","author":"WJ Sandborn","year":"2002","unstructured":"Sandborn WJ, Hanauer SB (2002) Infliximab in the treatment of Crohn\u2019s disease: a user\u2019s guide for clinicians. Am J Gastroenterol 97:2962\u20132972","journal-title":"Am J Gastroenterol"},{"key":"2899_CR20","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1136\/gutjnl-2013-306709","volume":"63","author":"KB Gecse","year":"2014","unstructured":"Gecse KB, Bemelman W, Kamm MA, Stoker J, Khanna R, Ng SC et al (2014) A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn\u2019s disease. Gut 63:1381\u20131392","journal-title":"Gut"},{"key":"2899_CR21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/07388551.2014.992388","volume":"0","author":"RG Jones","year":"2015","unstructured":"Jones RG, Martino A (2015) Targeted localized use of therapeutic antibodies: a review of non-systemic, topical and oral applications. Crit Rev Biotechnol 0:1\u201315","journal-title":"Crit Rev Biotechnol"},{"key":"2899_CR22","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1177\/2050640614547805","volume":"2","author":"J Hendel","year":"2014","unstructured":"Hendel J, Karstensen JG, Vilmann P (2014) Serial intralesional injections of infliximab in small bowel Crohn\u2019s strictures are feasible and might lower inflammation. United Eur Gastroenterol J 2:406\u2013412","journal-title":"United Eur Gastroenterol J"},{"key":"2899_CR23","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1038\/ajg.2009.509","volume":"104","author":"SC Ng","year":"2009","unstructured":"Ng SC, Plamondon S, Gupta A, Burling D, Swatton A, Vaizey CJ et al (2009) Prospective evaluation of anti-tumor necrosis factor therapy guided by magnetic resonance imaging for Crohn\u2019s perineal fistulas. Am J Gastroenterol Nat Publ Group 104:2973\u20132986","journal-title":"Am J Gastroenterol Nat Publ Group"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00384-017-2899-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-017-2899-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-017-2899-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:50:59Z","timestamp":1507596659000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00384-017-2899-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,12]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["2899"],"URL":"https:\/\/doi.org\/10.1007\/s00384-017-2899-0","relation":{},"ISSN":["0179-1958","1432-1262"],"issn-type":[{"value":"0179-1958","type":"print"},{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,12]]}}}