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Therapy consisted of surgical ablation and topic treatment. QoL was analyzed using the SF-36 and the CECA questionnaires.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Fifty-two of 67 patients (77.6%) were successfully contacted and 29\/52 provided full information. The mean age was 43.8\u2009\u00b1\u200912.8\u00a0years. The median follow-up from treatment to answering of the questionnaire was 34\u00a0months. Twenty-one percent (6\/29) of the patients reported suffering from recurrence of condyloma acuminata, three patients from anal dysplasia (10.3%). In the SF-36, HIV+ patients did not rate their QoL as significantly different over all items after successful treatment of HPV-associated anal lesions. In the CECA questionnaire, patients with persisting HPV-associated anal lesions reported significantly higher emotional stress levels and disturbance of everyday life compared to patients who had successful treatment (71.9\/100\u2009\u00b1\u200918.7 vs. 40.00\/100\u2009\u00b1\u200927.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). Importantly, the sexuality of patients with anal lesions was significantly impaired (59.8\/100\u2009\u00b1\u200930.8 vs. 27.5\/100\u2009\u00b1\u200912.2, <jats:italic>p<\/jats:italic>\u2009=\u20090.032).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>HPV-associated anal lesions impact significantly negative on QoL in HIV+ patients. Successful treatment of HPV-associated anal lesions in HIV+ patients improved QoL. Specific questionnaires, such as CECA, seem to be more adequate than the SF-36 in this setting.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00384-020-03567-1","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T04:33:52Z","timestamp":1585197232000},"page":"1103-1110","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life"],"prefix":"10.1007","volume":"35","author":[{"given":"Paul","family":"Wesselmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolynne","family":"Schwarze-Zander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Boesecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Rockstroh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Stoffels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim O.","family":"Vilz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim R.","family":"Glowka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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