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Approval was obtained from the ethics committee of University of Leuven (S53684).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All patients had consented for their data to be analyzed through the VLECC Biobank (Vlaamse Erfelijkheidsstudie Crohn\u2019s en Colitis Ulcerosa, of Flemish Study for Genetics Research on Crohn\u2019s Disease and Ulcerative Colitis).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. Further, all the possible conflicts of interest are now disclosed:Marc Ferrante:Research grant: Amgen, Biogen, Janssen, Pfizer, TakedaConsultancy: Abbvie, Boehringer-Ingelheim, Janssen, MSD, Pfizer, Sandoz, Takeda, ThermofisherSpeakers fee: Abbvie, Amgen, Biogen, Boehringer-Ingelheim, Falk, Ferring, Janssen, Lamepro, MSD, Mylan, Pfizer, Sandoz, TakedaSeverine Vermeire:Receipt of grants\/research supports: MSD, Abbvie, Takeda, Janssen, PfizerReceipt of honoraria or consultation fees: AbbVie, MSD, Takeda, Ferring, Genentech\/Roche, Shire, Pfizer Inc, Galapagos, Mundipharma, Hospira, Celgene, Second Genome, Progenity, Lilly, Arena, Gilead and JanssenParticipation in a company sponsored speaker\u2019s bureau: AbbVie, MSD, Takeda, Ferring, Hospira, Pfizer, Janssen, and Tillots","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}