{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T22:56:27Z","timestamp":1770677787939,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s00384-022-04123-9","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T01:03:15Z","timestamp":1648170195000},"page":"983-988","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Do immune inflammatory markers correlate with anal dysplasia and anal cancer risk in patients living with HIV?"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1556-7072","authenticated-orcid":false,"given":"Jonathan","family":"Stem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-7761","authenticated-orcid":false,"given":"Evie","family":"Carchman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0454-895X","authenticated-orcid":false,"given":"Robert","family":"Striker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0308-6308","authenticated-orcid":false,"given":"Cristina B.","family":"Sanger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"4123_CR1","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1056\/NEJM200003163421107","volume":"342","author":"DP Ryan","year":"2000","unstructured":"Ryan DP, Compton CC, Mayer RJ (2000) Carcinoma of the anal canal. N Engl J Med 342:792\u2013800. https:\/\/doi.org\/10.1056\/NEJM200003163421107","journal-title":"N Engl J Med"},{"key":"4123_CR2","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s10552-019-01209-8","volume":"30","author":"AM Koskan","year":"2019","unstructured":"Koskan AM, Brennhofer SA, Helitzer DL (2019) Screening for anal cancer precursors among patients living with HIV in the absence of national guidelines: practitioners\u2019 perspectives. Cancer Causes Control 30:989\u2013996. https:\/\/doi.org\/10.1007\/s10552-019-01209-8","journal-title":"Cancer Causes Control"},{"key":"4123_CR3","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1007\/s10900-018-0486-0","volume":"43","author":"KZ Apaydin","year":"2018","unstructured":"Apaydin KZ, Fontenot HB, Shtasel DL, Mayer KH, Keuroghlian AS (2018) Primary care provider practices and perceptions regarding HPV vaccination and anal cancer screening at a boston community health center. J Community Health 43:792\u2013801. https:\/\/doi.org\/10.1007\/s10900-018-0486-0","journal-title":"J Community Health"},{"key":"4123_CR4","doi-asserted-by":"publisher","unstructured":"Templeton AJ, McNamara MG, \u0160eruga B et al (2014) Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis.\u00a0J Natl Cancer Inst\u00a0106:dju124. https:\/\/doi.org\/10.1093\/jnci\/dju124","DOI":"10.1093\/jnci\/dju124"},{"key":"4123_CR5","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1007\/s00432-014-1714-3","volume":"140","author":"K Sun","year":"2014","unstructured":"Sun K, Chen S, Xu J, Li G, He Y (2014) The prognostic significance of the prognostic nutritional index in cancer: a systematic review and meta-analysis. J Cancer Res Clin Oncol 140:1537\u20131549. https:\/\/doi.org\/10.1007\/s00432-014-1714-3","journal-title":"J Cancer Res Clin Oncol"},{"key":"4123_CR6","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.2147\/CMAR.S197349","volume":"11","author":"A Casadei-Gardini","year":"2019","unstructured":"Casadei-Gardini A, Montagnani F, Casadei C et al (2019) Immune inflammation indicators in anal cancer patients treated with concurrent chemoradiation: training and validation cohort with online calculator (ARC: Anal Cancer Response Classifier). Cancer Manag Res 11:3631\u20133642. https:\/\/doi.org\/10.2147\/CMAR.S197349","journal-title":"Cancer Manag Res"},{"key":"4123_CR7","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s00384-018-03225-7","volume":"34","author":"F De Felice","year":"2019","unstructured":"De Felice F, Rubini FL, Romano L et al (2019) Prognostic significance of inflammatory-related parameters in patients with anal canal cancer. Int J Colorectal Dis 34:519\u2013525. https:\/\/doi.org\/10.1007\/s00384-018-03225-7","journal-title":"Int J Colorectal Dis"},{"key":"4123_CR8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.radonc.2016.12.009","volume":"122","author":"A Schernberg","year":"2017","unstructured":"Schernberg A, Escande A, Rivin Del Campo E et al (2017) Leukocytosis and neutrophilia predicts outcome in anal cancer. Radiother Oncol 122:137\u2013145. https:\/\/doi.org\/10.1016\/j.radonc.2016.12.009","journal-title":"Radiother Oncol"},{"key":"4123_CR9","doi-asserted-by":"publisher","first-page":"O90","DOI":"10.1111\/codi.12467","volume":"16","author":"E Toh","year":"2014","unstructured":"Toh E, Wilson J, Sebag-Montefiore D, Botterill I (2014) Neutrophil:lymphocyte ratio as a simple and novel biomarker for prediction of locoregional recurrence after chemoradiotherapy for squamous cell carcinoma of the anus. Colorectal Dis 16:O90\u2013O97. https:\/\/doi.org\/10.1111\/codi.12467","journal-title":"Colorectal Dis"},{"key":"4123_CR10","doi-asserted-by":"publisher","unstructured":"Knight K, Choong JX, McKee RF et al (2021) The influence of systemic inflammation on treatment response and survival in anal squamous cell cancer. Clin Oncol (R Coll Radiol)\u00a033:e22\u2013e30. https:\/\/doi.org\/10.1016\/j.clon.2020.06.010","DOI":"10.1016\/j.clon.2020.06.010"},{"key":"4123_CR11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s11605-019-04456-x","volume":"24","author":"VJ Campos","year":"2020","unstructured":"Campos VJ, Mazzini GS, Juchem JF, Gurski RR (2020) Neutrophil-lymphocyte ratio as a marker of progression from non-dysplastic Barrett\u2019s esophagus to esophageal adenocarcinoma: a cross-sectional retrospective study. J Gastrointest Surg 24:8\u201318. https:\/\/doi.org\/10.1007\/s11605-019-04456-x","journal-title":"J Gastrointest Surg"},{"key":"4123_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154900","volume":"11","author":"E Quiros-Roldan","year":"2016","unstructured":"Quiros-Roldan E, Raffetti E, Donato F et al (2016) Neutrophil to lymphocyte ratio and cardiovascular disease incidence in HIV-infected patients: a population-based cohort study. PLoS One 11:e0154900. https:\/\/doi.org\/10.1371\/journal.pone.0154900","journal-title":"PLoS ONE"},{"key":"4123_CR13","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.4314\/ahs.v19i1.35","volume":"19","author":"TT Duman","year":"2019","unstructured":"Duman TT, Aktas G, Atak BM, Kocak MZ, Erkus E, Savli H (2019) Neutrophil to lymphocyte ratio as an indicative of diabetic control level in type 2 diabetes mellitus. Afr Health Sci 19:1602\u20131606. https:\/\/doi.org\/10.4314\/ahs.v19i1.35","journal-title":"Afr Health Sci"},{"key":"4123_CR14","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/S1470-2045(12)70080-3","volume":"13","author":"DA Machalek","year":"2012","unstructured":"Machalek DA, Poynten M, Jin F et al (2012) Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis. Lancet Oncol 13:487\u2013500. https:\/\/doi.org\/10.1016\/S1470-2045(12)70080-3","journal-title":"Lancet Oncol"},{"key":"4123_CR15","first-page":"638","volume":"12","author":"AJ Durante","year":"2003","unstructured":"Durante AJ, Williams AB, Da Costa M, Darragh TM, Khoshnood K (2003) Palefsky JM (2003) Incidence of anal cytological abnormalities in a cohort of human immunodeficiency virus-infected women. Cancer Epidemiol Biomarkers Prev 12:638\u2013642","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"4123_CR16","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s11904-014-0224-x","volume":"11","author":"MF Schim van der Loeff","year":"2014","unstructured":"Schim van der Loeff MF, Mooij SH, Richel O, de Vries HJC, Prins JM (2014) HPV and anal cancer in HIV-infected individuals: a review. Curr HIV\/AIDS Rep 11:250\u2013262. https:\/\/doi.org\/10.1007\/s11904-014-0224-x","journal-title":"Curr HIV\/AIDS Rep"},{"key":"4123_CR17","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/QAI.0b013e3181b033ab","volume":"52","author":"RJ Bedimo","year":"2009","unstructured":"Bedimo RJ, McGinnis KA, Dunlap M, Rodriguez-Barradas MC, Justice AC (2009) Incidence of non-AIDS-defining malignancies in HIV-infected versus noninfected patients in the HAART era: impact of immunosuppression. J Acquir Immune Defic Syndr 52:203\u2013208. https:\/\/doi.org\/10.1097\/QAI.0b013e3181b033ab","journal-title":"J Acquir Immune Defic Syndr"},{"key":"4123_CR18","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1093\/jnci\/djp205","volume":"101","author":"AK Chaturvedi","year":"2009","unstructured":"Chaturvedi AK, Madeleine MM, Biggar RJ, Engels EA (2009) Risk of human papillomavirus-associated cancers among persons with AIDS. J Natl Cancer Inst 101:1120\u20131130. https:\/\/doi.org\/10.1093\/jnci\/djp205","journal-title":"J Natl Cancer Inst"},{"key":"4123_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/CEJ.0000000000000507","volume":"29","author":"A Vanhaesebrouck","year":"2020","unstructured":"Vanhaesebrouck A, Pernot S, Pavie J et al (2020) Factors associated with anal cancer screening uptake in men who have sex with men living with HIV: a cross-sectional study. Eur J Cancer Prev 29:1\u20136. https:\/\/doi.org\/10.1097\/CEJ.0000000000000507","journal-title":"Eur J Cancer Prev"},{"key":"4123_CR20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1136\/sextrans-2017-053515","volume":"95","author":"KZ Apaydin","year":"2019","unstructured":"Apaydin KZ, Nguyen A, Borba CPC et al (2019) Factors associated with anal cancer screening follow-up by high-resolution anoscopy. Sex Transm Infect 95:83\u201386. https:\/\/doi.org\/10.1136\/sextrans-2017-053515","journal-title":"Sex Transm Infect"},{"key":"4123_CR21","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1097\/NCC.0000000000000524","volume":"41","author":"JS Wells","year":"2018","unstructured":"Wells JS, Holstad MM, Watkins BD (2018) Sociodemographic predictors of anal cancer screening and follow-up in human immunodeficiency virus-infected individuals. Cancer Nurs 41:424\u2013430. https:\/\/doi.org\/10.1097\/NCC.0000000000000524","journal-title":"Cancer Nurs"},{"key":"4123_CR22","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1093\/cid\/cit369","volume":"57","author":"EL Yanik","year":"2013","unstructured":"Yanik EL, Napravnik S, Cole SR, Incidence and timing of cancer in HIV-infected individuals following initiation of combination antiretroviral therapy, et al (2013) Clin Infect Dis 57:756\u2013764. https:\/\/doi.org\/10.1093\/cid\/cit369","journal-title":"Clin Infect Dis"},{"key":"4123_CR23","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1200\/JCO.2017.74.9291","volume":"36","author":"V Col\u00f3n-L\u00f3pez","year":"2018","unstructured":"Col\u00f3n-L\u00f3pez V, Shiels MS, Machin M et al (2018) Anal cancer risk among people with HIV infection in the United States. J Clin Oncol 36:68\u201375. https:\/\/doi.org\/10.1200\/JCO.2017.74.9291","journal-title":"J Clin Oncol"},{"key":"4123_CR24","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1097\/DCR.0000000000001763","volume":"63","author":"CB Geltzeiler","year":"2020","unstructured":"Geltzeiler CB, Xu Y, Carchman E et al (2020) CD4\/CD8 ratio as a novel marker for increased risk of high-grade anal dysplasia and anal cancer in HIV+ patients: a retrospective cohort study. Dis Colon Rectum 63:1585\u20131592. https:\/\/doi.org\/10.1097\/DCR.0000000000001763","journal-title":"Dis Colon Rectum"},{"key":"4123_CR25","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/DCR.0000000000001231","volume":"62","author":"JCN Gon\u00e7alves","year":"2019","unstructured":"Gon\u00e7alves JCN, Macedo ACL, Madeira K et al (2019) Accuracy of anal cytology for diagnostic of precursor lesions of anal cancer: systematic review and meta-analysis. Dis Colon Rectum 62:112\u2013120. https:\/\/doi.org\/10.1097\/DCR.0000000000001231","journal-title":"Dis Colon Rectum"},{"key":"4123_CR26","doi-asserted-by":"crossref","unstructured":"Basim P, Yuksel M (2020) Peripheral inflammatory biomarkers as predictors of recurrence in surgically-treated anogenital condylomata acuminata patients. Int J STD AIDS 31:1380\u20131388. https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462420950562","DOI":"10.1177\/0956462420950562"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-022-04123-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00384-022-04123-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-022-04123-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T12:12:35Z","timestamp":1651752755000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00384-022-04123-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,25]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["4123"],"URL":"https:\/\/doi.org\/10.1007\/s00384-022-04123-9","relation":{},"ISSN":["1432-1262"],"issn-type":[{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,25]]},"assertion":[{"value":"2 March 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}