{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:10Z","timestamp":1791229450526,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"name":"The Key R&D Projects in the Tianjin Science and Technology Pillar Program","award":["19YFZCSY00420"],"award-info":[{"award-number":["19YFZCSY00420"]}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"],"award-info":[{"award-number":["21JCZDJC00060, 21JCYBJC00180 and 21JCYBJC00340"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-044A"],"award-info":[{"award-number":["TJYXZDXK-044A"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]},{"name":"Tianjin Hospital Association Hospital Management Research Project","award":["2019ZZ07"],"award-info":[{"award-number":["2019ZZ07"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Aim<\/jats:title>\n                <jats:p>Both the clinical manifestation and molecular characteristics of colorectal cancer (CRC) vary according to the anatomical site. We explored the risk factors for four groups of colorectal neoplasms (CRN) at different anatomical sites.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We extracted data from the database of Tianjin Colorectal Cancer Screening Program from 2010 to 2020. According to the CRN anatomical sites, patients were divided into four groups: the proximal colon group, the distal colon group, the rectum group, and the multiple colorectal sites. Binary logistic regression analysis was used to explore the differences in risk factors of CRN at different anatomical sites.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The numbers of patients with CRN in the proximal colon, distal colon, rectum, and multiple colorectal sites were 4023, 6920, 3657, and 7938, respectively. Male sex was associated with a higher risk from the proximal colon to the rectum. Advanced age and obesity were also significantly associated with overall colorectal CRN risk, but there were some differences between men and women. Smoking was associated with CRN risk only in the distal colon and rectum in both men and women. Frequent alcohol consumption and family history of CRC in first-degree relatives (FDRs) were associated with the risk of multisite colorectal CRN only in males.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We observed differences in advanced age, obesity, smoking, alcohol consumption, and family history of colorectal cancer at different anatomical sites of colorectal neoplasms. These factors vary by gender.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00384-022-04296-3","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T10:03:15Z","timestamp":1675159395000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The comparison of risk factors for colorectal neoplasms at different anatomical sites"],"prefix":"10.1007","volume":"38","author":[{"given":"Huaqing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiurong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xipeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"issue":"3","key":"4296_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"4296_CR2","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","volume":"135","author":"C Xia","year":"2022","unstructured":"Xia C, Dong X, Li H, Cao M, Sun D, He S, Yang F, Yan X, Zhang S, Li N, Chen W (2022) Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J (Engl) 135(5):584\u2013590","journal-title":"Chin Med J (Engl)"},{"issue":"4","key":"4296_CR3","doi-asserted-by":"publisher","first-page":"973","DOI":"10.3892\/ijo.2013.2041","volume":"43","author":"V Conteduca","year":"2013","unstructured":"Conteduca V, Sansonno D, Russi S, Dammacco F (2013) Precancerous colorectal lesions (Review). Int J Oncol 43(4):973\u2013984","journal-title":"Int J Oncol"},{"issue":"9150","key":"4296_CR4","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0140-6736(98)07127-X","volume":"353","author":"R Midgley","year":"1999","unstructured":"Midgley R, Kerr D (1999) Colorectal cancer. The Lancet 353(9150):391\u2013399","journal-title":"The Lancet"},{"issue":"7","key":"4296_CR5","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1046\/j.1365-2168.2002.02120.x","volume":"89","author":"A Leslie","year":"2002","unstructured":"Leslie A, Carey FA, Pratt NR, Steele RJ (2002) The colorectal adenoma-carcinoma sequence. Br J Surg 89(7):845\u2013860","journal-title":"Br J Surg"},{"issue":"3","key":"4296_CR6","doi-asserted-by":"publisher","first-page":"458","DOI":"10.14309\/ajg.0000000000001122","volume":"116","author":"A Shaukat","year":"2021","unstructured":"Shaukat A, Kahi CJ, Burke CA, Rabeneck L, Sauer BG, Rex DK (2021) ACG clinical guidelines: colorectal cancer screening 2021. Am J Gastroenterol 116(3):458\u2013479","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"4296_CR7","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.ejso.2014.11.001","volume":"41","author":"GH Lee","year":"2015","unstructured":"Lee GH, Malietzis G, Askari A, Bernardo D, Al-Hassi HO, Clark SK (2015) Is right-sided colon cancer different to left-sided colorectal cancer? - a systematic review. Eur J Surg Oncol 41(3):300\u2013308","journal-title":"Eur J Surg Oncol"},{"issue":"10","key":"4296_CR8","doi-asserted-by":"publisher","first-page":"779","DOI":"10.7326\/0003-4819-113-10-779","volume":"113","author":"JA Bufill","year":"1990","unstructured":"Bufill JA (1990) Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med 113(10):779\u2013788","journal-title":"Ann Intern Med"},{"key":"4296_CR9","doi-asserted-by":"crossref","unstructured":"Wang L, Lo CH, He X, Hang D, Wang M, Wu K, Chan AT, Ogino S, Giovannucci EL, Song M (2020) Risk factor profiles differ for cancers of different regions of the colorectum. Gastroenterology 159(1):241\u2013256 e13","DOI":"10.1053\/j.gastro.2020.03.054"},{"issue":"11","key":"4296_CR10","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1007\/s00384-010-1030-6","volume":"25","author":"L Huang","year":"2010","unstructured":"Huang L, Wang X, Gong W, Huang Y, Jiang B (2010) The comparison of the clinical manifestations and risk factors of colorectal cancer and adenomas: results from a colonoscopy-based study in southern Chinese. Int J Colorectal Dis 25(11):1343\u20131351","journal-title":"Int J Colorectal Dis"},{"issue":"9403","key":"4296_CR11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","volume":"363","author":"WHOE Consultation","year":"2004","unstructured":"Consultation WHOE (2004) Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363(9403):157\u2013163","journal-title":"Lancet"},{"key":"4296_CR12","doi-asserted-by":"crossref","unstructured":"Park SH, Hong KI, Park HC, Kim YS, Bok GH, Kim KH, Shin DS, Han JY, Kim YK, Choi YJ, Eun SH, Lim BH, Kwack KK, Korean Society of Digestive Endoscopy Polyp Study W (2021) Colon polyp detection in primary health care institutions of Korea: detection rate and issues with following the guidelines. Korean J Gastroenterol 78(6):328\u2013336","DOI":"10.4166\/kjg.2021.123"},{"issue":"4","key":"4296_CR13","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.stemcr.2020.08.001","volume":"15","author":"X Yu","year":"2020","unstructured":"Yu X, Li S, Xu Y, Zhang Y, Ma W, Liang C, Lu H, Ji Y, Liu C, Chen D, Li J (2020) Androgen maintains intestinal homeostasis by inhibiting bmp signaling via intestinal stromal cells. Stem Cell Reports 15(4):912\u2013925","journal-title":"Stem Cell Reports"},{"issue":"17","key":"4296_CR14","doi-asserted-by":"publisher","first-page":"5167","DOI":"10.3748\/wjg.v21.i17.5167","volume":"21","author":"SE Kim","year":"2015","unstructured":"Kim SE, Paik HY, Yoon H, Lee JE, Kim N, Sung MK (2015) Sex- and gender-specific disparities in colorectal cancer risk. World J Gastroenterol 21(17):5167\u20135175","journal-title":"World J Gastroenterol"},{"issue":"8","key":"4296_CR15","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1055\/s-0042-105436","volume":"48","author":"IJ Je","year":"2016","unstructured":"Je IJ, de Wit K, van der Vlugt M, Bastiaansen BA, Fockens P, Dekker E (2016) Prevalence, distribution and risk of sessile serrated adenomas\/polyps at a center with a high adenoma detection rate and experienced pathologists. Endoscopy 48(8):740\u2013746","journal-title":"Endoscopy"},{"issue":"7","key":"4296_CR16","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1093\/aje\/kws282","volume":"177","author":"AN Burnett-Hartman","year":"2013","unstructured":"Burnett-Hartman AN, Passarelli MN, Adams SV, Upton MP, Zhu LC, Potter JD, Newcomb PA (2013) Differences in epidemiologic risk factors for colorectal adenomas and serrated polyps by lesion severity and anatomical site. Am J Epidemiol 177(7):625\u2013637","journal-title":"Am J Epidemiol"},{"issue":"6","key":"4296_CR17","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1002\/cncr.2820360944","volume":"36","author":"T Muto","year":"1975","unstructured":"Muto T, Bussey HJ, Morson BC (1975) The evolution of cancer of the colon and rectum. Cancer 36(6):2251\u20132270","journal-title":"Cancer"},{"issue":"9","key":"4296_CR18","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1056\/NEJM198809013190901","volume":"319","author":"B Vogelstein","year":"1988","unstructured":"Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM, Bos JL (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319(9):525\u2013532","journal-title":"N Engl J Med"},{"key":"4296_CR19","doi-asserted-by":"publisher","first-page":"15065","DOI":"10.1038\/nrdp.2015.65","volume":"1","author":"EJ Kuipers","year":"2015","unstructured":"Kuipers EJ, Grady WM, Lieberman D, Seufferlein T, Sung JJ, Boelens PG, van de Velde CJ, Watanabe T (2015) Colorectal cancer. Nat Rev Dis Primers 1:15065","journal-title":"Nat Rev Dis Primers"},{"issue":"7\u20138","key":"4296_CR20","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/0959-8049(95)00213-3","volume":"31","author":"JH Bond","year":"1995","unstructured":"Bond JH (1995) Interference with the adenoma-carcinoma sequence. Eur J Cancer 31(7\u20138):1115\u20131117","journal-title":"Eur J Cancer"},{"issue":"6","key":"4296_CR21","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1093\/annonc\/mdx080","volume":"28","author":"S Schlesinger","year":"2017","unstructured":"Schlesinger S, Aleksandrova K, Abar L, Vieria AR, Vingeliene S, Polemiti E, Stevens CAT, Greenwood DC, Chan DSM, Aune D, Norat T (2017) Adult weight gain and colorectal adenomas-a systematic review and meta-analysis. Ann Oncol 28(6):1217\u20131229","journal-title":"Ann Oncol"},{"issue":"6","key":"4296_CR22","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1158\/1055-9965.EPI-09-0813","volume":"19","author":"I Laake","year":"2010","unstructured":"Laake I, Thune I, Selmer R, Tretli S, Slattery ML, Veierod MB (2010) A prospective study of body mass index, weight change, and risk of cancer in the proximal and distal colon. Cancer Epidemiol Biomarkers Prev 19(6):1511\u20131522","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"4296_CR23","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1093\/aje\/kws431","volume":"178","author":"R Nishihara","year":"2013","unstructured":"Nishihara R, Morikawa T, Kuchiba A, Lochhead P, Yamauchi M, Liao X, Imamura Y, Nosho K, Shima K, Kawachi I, Qian ZR, Fuchs CS, Chan AT, Giovannucci E, Ogino S (2013) A prospective study of duration of smoking cessation and colorectal cancer risk by epigenetics-related tumor classification. Am J Epidemiol 178(1):84\u2013100","journal-title":"Am J Epidemiol"},{"issue":"6","key":"4296_CR24","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1136\/gutjnl-2011-300865","volume":"61","author":"M Yamauchi","year":"2012","unstructured":"Yamauchi M, Morikawa T, Kuchiba A, Imamura Y, Qian ZR, Nishihara R, Liao X, Waldron L, Hoshida Y, Huttenhower C, Chan AT, Giovannucci E, Fuchs C, Ogino S (2012) Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 61(6):847\u2013854","journal-title":"Gut"},{"key":"4296_CR25","doi-asserted-by":"crossref","unstructured":"Murphy N, Ward HA, Jenab M, Rothwell, JA Boutron-Ruault MC, Carbonnel F, Kvaskoff M, Kaaks R, Kuhn T, Boeing H, Aleksandrova K, Weiderpass E, Skeie G, Borch KB, Tjonneland A, Kyro C, Overvad K, Dahm CC, Jakszyn P, Sanchez MJ, Gil L, Huerta JM, Barricarte A, Quiros JR, Khaw KT, Wareham N, Bradbury KE, Trichopoulou A, La Vecchia C, Karakatsani A, Palli D, Grioni S, Tumino R, Fasanelli F, Panico S, Bueno-de-Mesquita B, Peeters PH, Gylling B, Myte R, Jirstrom K, Berntsson J, Xue X, Riboli E, Cross AJ, Gunter MJ (2019) Heterogeneity of colorectal cancer risk factors by anatomical subsite in 10 European countries: a multinational cohort study. Clin Gastroenterol Hepatol 17(7):1323\u20131331 e6","DOI":"10.1016\/j.cgh.2018.07.030"},{"issue":"1","key":"4296_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/ijc.11533","volume":"108","author":"EW Tiemersma","year":"2004","unstructured":"Tiemersma EW, Bunschoten A, Kok FJ, Glatt H, de Boer SY, Kampman E (2004) Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas. Int J Cancer 108(1):97\u2013103","journal-title":"Int J Cancer"},{"issue":"6","key":"4296_CR27","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1093\/aje\/kwaa005","volume":"189","author":"IT Gram","year":"2020","unstructured":"Gram IT, Park SY, Wilkens LR, Haiman CA, Le Marchand L (2020) Smoking-related risks of colorectal cancer by anatomical subsite and sex. Am J Epidemiol 189(6):543\u2013553","journal-title":"Am J Epidemiol"},{"issue":"10","key":"4296_CR28","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nrc1190","volume":"3","author":"SS Hecht","year":"2003","unstructured":"Hecht SS (2003) Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer 3(10):733\u2013744","journal-title":"Nat Rev Cancer"},{"key":"4296_CR29","doi-asserted-by":"crossref","unstructured":"Bai X, Wei H, Liu W, Coker OO, Gou H, Liu C, Zhao L, Li C, Zhou Y, Wang G, Kang W, Ng EK, Yu J (2022) Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites. Gut","DOI":"10.1136\/gutjnl-2021-325021"},{"key":"4296_CR30","doi-asserted-by":"crossref","unstructured":"Johnson CH, Golla JP, Dioletis E, Singh S, Ishii M, Charkoftaki G, Thompson DC, Vasiliou V (2021) Molecular mechanisms of alcohol-induced colorectal carcinogenesis. Cancers (Basel) 13(17)","DOI":"10.3390\/cancers13174404"},{"issue":"6","key":"4296_CR31","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1097\/DCR.0b013e31824e612a","volume":"55","author":"N Kontou","year":"2012","unstructured":"Kontou N, Psaltopoulou T, Soupos N, Polychronopoulos E, Xinopoulos D, Linos A, Panagiotakos D (2012) Alcohol consumption and colorectal cancer in a Mediterranean population: a case-control study. Dis Colon Rectum 55(6):703\u2013710","journal-title":"Dis Colon Rectum"},{"issue":"3","key":"4296_CR32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1097\/00001648-199605000-00010","volume":"7","author":"MP Longnecker","year":"1996","unstructured":"Longnecker MP, Chen M-J, Probst-Hensch NM, Harper JM, Lee ER, Frankl HD, Haile RW (1996) Alcohol and smoking in relation to the prevalence of adenomatous colorectal polyps detected at sigmoidoscopy. Epidemiology 7(3):275\u2013280","journal-title":"Epidemiology"},{"issue":"1","key":"4296_CR33","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s003940200004","volume":"41","author":"JG Erhardt","year":"2002","unstructured":"Erhardt JG, Kreichgauer HP, Meisner C, Bode JC, Bode C (2002) Alcohol, cigarette smoking, dietary factors and the risk of colorectal adenomas and hyperplastic polyps\u2013a case control study. Eur J Nutr 41(1):35\u201343","journal-title":"Eur J Nutr"},{"key":"4296_CR34","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n877","volume":"373","author":"M Song","year":"2021","unstructured":"Song M, Emilsson L, Roelstraete B, Ludvigsson JF (2021) Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden. BMJ 373:n877","journal-title":"BMJ"},{"key":"4296_CR35","doi-asserted-by":"crossref","unstructured":"Quintero E, Carrillo M, Leoz ML, Cubiella J, Gargallo C, Lanas A, Bujanda L, Gimeno-Garcia AZ, Hernandez-Guerra M, Nicolas-Perez D, Alonso-Abreu I, Morillas JD, Balaguer F, Muriel A, de Oncology Group of the Asociacion Espanola de G (2016) Risk of advanced neoplasia in first-degree relatives with colorectal cancer: a large multicenter cross-sectional study. PLoS Med 13(5):e1002008","DOI":"10.1371\/journal.pmed.1002008"},{"issue":"2","key":"4296_CR36","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1136\/gut.50.2.228","volume":"50","author":"G Lindgren","year":"2002","unstructured":"Lindgren G, Liljegren A, Jaramillo E, Rubio C, Lindblom A (2002) Adenoma prevalence and cancer risk in familial non-polyposis colorectal cancer. Gut 50(2):228\u2013234","journal-title":"Gut"},{"issue":"3","key":"4296_CR37","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1053\/j.gastro.2012.11.011","volume":"144","author":"SC Ng","year":"2013","unstructured":"Ng SC, Lau JY, Chan FK, Suen BY, Leung WK, Tse YK, Ng SS, Lee JF, To KF, Wu JC, Sung JJ (2013) Increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer. Gastroenterology 144(3):544\u2013550","journal-title":"Gastroenterology"},{"key":"4296_CR38","doi-asserted-by":"crossref","unstructured":"Samadder NJ, Valentine JF, Guthery S, Singh H, Bernstein CN, Leighton JA, Wan Y, Wong J, Boucher K, Pappas L, Rowe K, Burt RW, Curtin K, Smith KR (2019) Family history associates with increased risk of colorectal cancer in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 17(9):1807\u20131813 e1","DOI":"10.1016\/j.cgh.2018.09.038"},{"key":"4296_CR39","doi-asserted-by":"crossref","unstructured":"Armelao F, Paternolli C, Franceschini G, Franch R, Orlandi PG, Miori G, Avancini I, Togni M, Rossi M, Meggio A, Tasini E, Manfrini R, Giacomin D, Fasoli R, Faitini K, Mastromauro M, Costa S, Ridolfi F, Rosi P, de Pretis G (2011) Colonoscopic findings in first-degree relatives of patients with colorectal cancer: a population-based screening program. Gastrointest Endosc 73(3):527\u2013534 e2","DOI":"10.1016\/j.gie.2010.12.025"},{"issue":"2","key":"4296_CR40","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1093\/jnci\/djs482","volume":"105","author":"S Ogino","year":"2013","unstructured":"Ogino S, Nishihara R, Lochhead P, Imamura Y, Kuchiba A, Morikawa T, Yamauchi M, Liao X, Qian ZR, Sun R, Sato K, Kirkner GJ, Wang M, Spiegelman D, Meyerhardt JA, Schernhammer ES, Chan AT, Giovannucci E, Fuchs CS (2013) Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level. J Natl Cancer Inst 105(2):130\u2013140","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"4296_CR41","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1158\/1055-9965.EPI-08-0878","volume":"18","author":"B Bapat","year":"2009","unstructured":"Bapat B, Lindor NM, Baron J, Siegmund K, Li L, Zheng Y, Haile R, Gallinger S, Jass JR, Young JP, Cotterchio M, Jenkins M, Grove J, Casey G, Thibodeau SN, Bishop DT, Hopper JL, Ahnen D, Newcomb PA, Le Marchand L, Potter JD, Seminara DR, Family CC (2009) The association of tumor microsatellite instability phenotype with family history of colorectal cancer. Cancer Epidemiol Biomarkers Prev 18(3):967\u2013975","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-022-04296-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00384-022-04296-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-022-04296-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T11:08:11Z","timestamp":1703156891000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00384-022-04296-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["4296"],"URL":"https:\/\/doi.org\/10.1007\/s00384-022-04296-3","relation":{},"ISSN":["1432-1262"],"issn-type":[{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,31]]},"assertion":[{"value":"23 December 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Tianjin Union Medical Center. This trial was conducted following the Declaration of Helsinki guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all participants before entering the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"26"}}