{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:19:07Z","timestamp":1785777547201,"version":"3.56.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"DOI":"10.1007\/s00384-023-04366-0","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T05:02:27Z","timestamp":1680152547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Incidence and risk outcomes of second primary malignancy of patients with post-operative colorectal cancer"],"prefix":"10.1007","volume":"38","author":[{"given":"Jiahui","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjin","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huatian","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"4366_CR1","doi-asserted-by":"crossref","unstructured":"Siegel RL, Miller KD, Jemal A et al (2019) Cancer statistics.\u00a0CA: Cancer J Clin 69(1):7\u201334","DOI":"10.3322\/caac.21551"},{"key":"4366_CR2","doi-asserted-by":"crossref","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J Clin 71(3):209\u2013249","DOI":"10.3322\/caac.21660"},{"key":"4366_CR3","doi-asserted-by":"crossref","unstructured":"Siegel RL, Miller KD, Goding Sauer A et al (2020) Colorectal cancer statistics, 2020. CA: Cancer J Clin 70(3):145\u2013164","DOI":"10.3322\/caac.21601"},{"key":"4366_CR4","doi-asserted-by":"crossref","unstructured":"Miller KD, Nogueira L, Devasia T et al (2022) Cancer treatment and survivorship statistics, 2022. CA: Cancer J Clin 72(5):409\u2013436","DOI":"10.3322\/caac.21731"},{"issue":"2","key":"4366_CR5","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/jgh.13476","volume":"32","author":"H Jayasekara","year":"2017","unstructured":"Jayasekara H, Reece JC, Buchanan DD et al (2017) Risk factors for metachronous colorectal cancer or polyp: a systematic review and meta-analysis. J Gastroenterol Hepatol 32(2):301\u2013326","journal-title":"J Gastroenterol Hepatol"},{"issue":"5","key":"4366_CR6","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1002\/ijc.30153","volume":"139","author":"H Jayasekara","year":"2016","unstructured":"Jayasekara H, Reece JC, Buchanan DD et al (2016) Risk factors for metachronous colorectal cancer following a primary colorectal cancer: a prospective cohort study. Int J Cancer 139(5):1081\u20131090","journal-title":"Int J Cancer"},{"issue":"11","key":"4366_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143067","volume":"10","author":"X Guan","year":"2015","unstructured":"Guan X, Jin Y, Chen Y et al (2015) The incidence characteristics of second primary malignancy after diagnosis of primary colon and rectal cancer: a population based study. PLoS ONE 10(11):e0143067","journal-title":"PLoS ONE"},{"issue":"4","key":"4366_CR8","doi-asserted-by":"publisher","first-page":"e651","DOI":"10.1634\/theoncologist.2019-0266","volume":"25","author":"H Jia","year":"2020","unstructured":"Jia H, Li Q, Yuan J, Sun X, Wu Z (2020) Second primary malignancies in patients with colorectal cancer: a population-based analysis. Oncologist 25(4):e651\u2013e658","journal-title":"Oncologist"},{"key":"4366_CR9","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1245\/s10434-019-07326-7","volume":"26","author":"KK Broman","year":"2019","unstructured":"Broman KK, Bailey CE, Parikh AA (2019) Sidedness of colorectal cancer impacts risk of second primary gastrointestinal malignancy. Ann Surg Oncol 26:2037\u20132043","journal-title":"Ann Surg Oncol"},{"key":"4366_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.650937","volume":"11","author":"M Wu","year":"2021","unstructured":"Wu M, Huang M, He C et al (2021) Risk of second primary malignancies based on the histological subtypes of colorectal cancer. Front Oncol 11:650937","journal-title":"Front Oncol"},{"key":"4366_CR11","doi-asserted-by":"crossref","unstructured":"Tiritilli A, Ko C (2022) Patients with early-onset colorectal cancer have an increased risk of second primary malignancy. Dig Dis Sci 1\u20139","DOI":"10.1007\/s10620-021-06971-x"},{"issue":"1","key":"4366_CR12","doi-asserted-by":"publisher","first-page":"e2031661","DOI":"10.1001\/jamanetworkopen.2020.31661","volume":"4","author":"X Guan","year":"2021","unstructured":"Guan X, Wei R, Yang R et al (2021) Association of radiotherapy for rectal cancer and second gynecological malignant neoplasms. JAMA Netw Open 4(1):e2031661\u2013e2031661","journal-title":"JAMA Netw Open"},{"issue":"4","key":"4366_CR13","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1002\/cam4.1437","volume":"7","author":"X He","year":"2018","unstructured":"He X, Wu W, Ye D, Li Y, Si J, Sun L (2018) Excessive risk of second primary cancers in young-onset colorectal cancer survivors. Cancer Med 7(4):1201\u20131210","journal-title":"Cancer Med"},{"issue":"S5","key":"4366_CR14","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1002\/cncr.22013","volume":"107","author":"F Ahmed","year":"2006","unstructured":"Ahmed F, Goodman MT, Kosary C et al (2006) Excess risk of subsequent primary cancers among colorectal carcinoma survivors, 1975\u20132001. Cancer 107(S5):1162\u20131171","journal-title":"Cancer"},{"key":"4366_CR15","unstructured":"Jack A, Percy CL, Sobin L, Whelan S (2000) International classification of diseases for oncology: ICD-O: World Health Organization"},{"issue":"25","key":"4366_CR16","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1200\/JCO.2017.72.4203","volume":"35","author":"SS Han","year":"2017","unstructured":"Han SS, Rivera GA, Tammem\u00e4gi MC et al (2017) Risk stratification for second primary lung cancer. J Clin Oncol 35(25):2893","journal-title":"J Clin Oncol"},{"key":"4366_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2020.106123","volume":"97","author":"Q Li","year":"2020","unstructured":"Li Q, Lin J, Chi A, Davies S (2020) Practical considerations of utilizing propensity score methods in clinical development using real-world and historical data. Contemp Clin Trials 97:106123","journal-title":"Contemp Clin Trials"},{"issue":"446","key":"4366_CR18","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","volume":"94","author":"JP Fine","year":"1999","unstructured":"Fine JP, Gray RJ (1999) A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 94(446):496\u2013509","journal-title":"J Am Stat Assoc"},{"issue":"6","key":"4366_CR19","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1158\/1055-9965.EPI-09-0186","volume":"18","author":"RL Siegel","year":"2009","unstructured":"Siegel RL, Jemal A, Ward EM (2009) Increase in incidence of colorectal cancer among young men and women in the United States. Cancer Epidemiol Biomark Prev 18(6):1695\u20131698","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"2","key":"4366_CR20","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1053\/j.gastro.2019.04.049","volume":"157","author":"AJ Dwyer","year":"2019","unstructured":"Dwyer AJ, Murphy CC, Boland CR et al (2019) A summary of the fight colorectal cancer working meeting: exploring risk factors and etiology of sporadic early-age onset colorectal cancer. Gastroenterology 157(2):280\u2013288","journal-title":"Gastroenterology"},{"key":"4366_CR21","doi-asserted-by":"crossref","unstructured":"George A, Stead TS, Ganti L (2020) What\u2019s the risk: differentiating risk ratios, odds ratios, and hazard ratios? Cureus 12(8)","DOI":"10.7759\/cureus.10047"},{"key":"4366_CR22","doi-asserted-by":"crossref","unstructured":"Doubeni CA (2014) The impact of colorectal cancer screening on the US population: is it time to celebrate? (Vol. 120, pp. 2810\u20132813): Wiley Online Library","DOI":"10.1002\/cncr.28789"},{"key":"4366_CR23","doi-asserted-by":"crossref","unstructured":"Kim TJ, Kim ER, Hong SN, Chang DK, Kim Y-H (2016) Long-term outcome and prognostic factors of sporadic colorectal cancer in young patients: a large institutional-based retrospective study. Medicine 95(19)","DOI":"10.1097\/MD.0000000000003641"},{"key":"4366_CR24","doi-asserted-by":"crossref","unstructured":"Enwerem N, Cho MY, Demb J et al (2021) Systematic review of prevalence, risk factors, and risk for metachronous advanced neoplasia in patients with young-onset colorectal adenoma.\u00a0Clin Gastroenterol Hepatol\u00a019(4):680\u2013689.e612","DOI":"10.1016\/j.cgh.2020.04.092"},{"key":"4366_CR25","doi-asserted-by":"crossref","unstructured":"Chen FW, Yang L, Cusumano VT et al (2021) Early-onset colorectal cancer is associated with a lower risk of metachronous advanced neoplasia than traditional-onset colorectal cancer. Dig Dis Sci\u00a01\u20139","DOI":"10.1007\/s10620-021-06902-w"},{"issue":"11","key":"4366_CR26","doi-asserted-by":"publisher","first-page":"O386","DOI":"10.1111\/codi.13874","volume":"19","author":"V Kozak","year":"2017","unstructured":"Kozak V, Kalady M, Gamaleldin M, Liang J, Church J (2017) Colorectal surveillance after segmental resection for young-onset colorectal cancer: is there evidence for extended resection? Colorectal Dis 19(11):O386\u2013O392","journal-title":"Colorectal Dis"},{"issue":"4","key":"4366_CR27","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S1470-2045(11)70061-4","volume":"12","author":"AB De Gonzalez","year":"2011","unstructured":"De Gonzalez AB, Curtis RE, Kry SF et al (2011) Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries. Lancet Oncol 12(4):353\u2013360","journal-title":"Lancet Oncol"},{"issue":"16","key":"4366_CR28","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1093\/jnci\/djm081","volume":"99","author":"C Schairer","year":"2007","unstructured":"Schairer C, Hisada M, Chen BE et al (2007) Comparative mortality for 621 second cancers in 29356 testicular cancer survivors and 12420 matched first cancers. J Natl Cancer Inst 99(16):1248\u20131256","journal-title":"J Natl Cancer Inst"},{"issue":"34","key":"4366_CR29","doi-asserted-by":"publisher","first-page":"3212","DOI":"10.1200\/JCO.19.00308","volume":"37","author":"E Fokas","year":"2019","unstructured":"Fokas E, Allg\u00e4uer M, Polat B et al (2019) Randomized phase II trial of chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: CAO\/ARO\/AIO-12. J Clin Oncol 37(34):3212\u20133222","journal-title":"J Clin Oncol"},{"issue":"4","key":"4366_CR30","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1093\/annonc\/mdu560","volume":"26","author":"A Breugom","year":"2015","unstructured":"Breugom A, Van Gijn W, Muller E et al (2015) Adjuvant chemotherapy for rectal cancer patients treated with preoperative (chemo) radiotherapy and total mesorectal excision: a Dutch Colorectal Cancer Group (DCCG) randomized phase III trial. Ann Oncol 26(4):696\u2013701","journal-title":"Ann Oncol"},{"issue":"1","key":"4366_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-82248-7","volume":"11","author":"J Halamkova","year":"2021","unstructured":"Halamkova J, Kazda T, Pehalova L et al (2021) Second primary malignancies in colorectal cancer patients. Sci Rep 11(1):1\u201312","journal-title":"Sci Rep"},{"issue":"1","key":"4366_CR32","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1186\/s12967-022-03544-y","volume":"20","author":"X Zhu","year":"2022","unstructured":"Zhu X, Zhou J, Zhou L, Zhang M, Gao C, Tao L (2022) Association between postoperative radiotherapy for young-onset head and neck cancer and long-term risk of second primary malignancy: a population-based study. J Transl Med 20(1):405","journal-title":"J Transl Med"},{"issue":"10","key":"4366_CR33","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1056\/NEJM199203053261001","volume":"326","author":"JV Selby","year":"1992","unstructured":"Selby JV, Friedman GD, Quesenberry CP Jr, Weiss NS (1992) A case\u2013control study of screening sigmoidoscopy and mortality from colorectal cancer. N Engl J Med 326(10):653\u2013657","journal-title":"N Engl J Med"},{"issue":"4","key":"4366_CR34","doi-asserted-by":"publisher","first-page":"261","DOI":"10.7326\/0003-4819-136-4-200202190-00005","volume":"136","author":"RJ Green","year":"2002","unstructured":"Green RJ, Metlay JP, Propert K et al (2002) Surveillance for second primary colorectal cancer after adjuvant chemotherapy: an analysis of Intergroup 0089. Ann Intern Med 136(4):261\u2013269","journal-title":"Ann Intern Med"},{"issue":"4","key":"4366_CR35","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.clcc.2022.07.002","volume":"21","author":"A Teufel","year":"2022","unstructured":"Teufel A, Li M, Gerken M et al (2022) Second cancer after additive chemotherapy in patients with colon cancer. Clin Colorectal Cancer 21(4):354\u2013361","journal-title":"Clin Colorectal Cancer"},{"issue":"1","key":"4366_CR36","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.beha.2019.02.012","volume":"32","author":"GSG Murthy","year":"2019","unstructured":"Murthy GSG, Abedin S (2019) Myeloid malignancies after treatment for solid tumours. Best Pract Res Clin Haematol 32(1):40\u201346","journal-title":"Best Pract Res Clin Haematol"},{"key":"4366_CR37","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.2147\/OTT.S129220","volume":"10","author":"J Yang","year":"2017","unstructured":"Yang J, Li S, Lv M et al (2017) Risk of subsequent primary malignancies among patients with prior colorectal cancer: a population-based cohort study. Onco Targets Ther 10:1535","journal-title":"Onco Targets Ther"},{"key":"4366_CR38","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.3389\/fonc.2020.01154","volume":"10","author":"B Zhang","year":"2020","unstructured":"Zhang B, Guo K, Zheng X, Sun L, Shen M, Ruan S (2020) Risk of second primary malignancies in colon cancer patients treated with colectomy. Front Oncol 10:1154","journal-title":"Front Oncol"},{"issue":"19","key":"4366_CR39","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1002\/cncr.30164","volume":"122","author":"N Donin","year":"2016","unstructured":"Donin N, Filson C, Drakaki A et al (2016) Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008. Cancer 122(19):3075\u20133086","journal-title":"Cancer"},{"key":"4366_CR40","first-page":"1097","volume":"10","author":"MV Papageorge","year":"2022","unstructured":"Papageorge MV, Woods AP, de Geus SW et al (2022) The persistence of poverty and its impact on cancer diagnosis, treatment and survival. Ann Surg 10.1097","journal-title":"Ann Surg"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-023-04366-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00384-023-04366-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-023-04366-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T11:16:27Z","timestamp":1703157387000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00384-023-04366-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["4366"],"URL":"https:\/\/doi.org\/10.1007\/s00384-023-04366-0","relation":{},"ISSN":["1432-1262"],"issn-type":[{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]},"assertion":[{"value":"3 March 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"88"}}