{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:56:07Z","timestamp":1792670167751,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:00:00Z","timestamp":1699056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:00:00Z","timestamp":1699056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"DOI":"10.1007\/s00384-023-04558-8","type":"journal-article","created":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T12:02:22Z","timestamp":1699099342000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparing neoadjuvant therapy followed by local excision to total mesorectal excision in the treatment of early stage rectal cancer: a systematic review and meta-analysis of randomised clinical trials"],"prefix":"10.1007","volume":"38","author":[{"given":"Paul","family":"Lynch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odhr\u00e1n K.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2609-0836","authenticated-orcid":false,"given":"\u00c9anna J.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Davey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Creavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hanly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Kennelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u00e1n T.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Des C.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,4]]},"reference":[{"issue":"2","key":"4558_CR1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/imj.12916","volume":"46","author":"S Ananda","year":"2016","unstructured":"Ananda S, Wong H, Faragher I, Jones IT, Steele M, Kosmider S, Desai J, Tie J, Field K, Wong R, Tran B, Bae S, Gibbs P (2016) Survival impact of the Australian National Bowel Cancer Screening Programme. Intern Med J 46(2):166\u2013171","journal-title":"Intern Med J"},{"key":"4558_CR2","doi-asserted-by":"crossref","unstructured":"Ryan OK, Ryan \u00c9J, Creavin B, Rausa E, Kelly ME, Petrelli F, Bonitta G, Kennelly R, Hanly A, Martin ST, Winter DC\u00a0(2021) Winter, Surgical approach for rectal cancer: a network meta-analysis comparing open, laparoscopic, robotic and transanal TME approaches. Eur J Surg Oncol 47(2):285\u2013295","DOI":"10.1016\/j.ejso.2020.06.037"},{"issue":"2","key":"4558_CR3","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ejso.2017.11.024","volume":"44","author":"RCH Stijns","year":"2018","unstructured":"Stijns RCH, Tromp MSR, Hugen N, de Wilt JHW (2018) Advances in organ preserving strategies in rectal cancer patients. Eur J Surg Oncol 44(2):209\u2013219","journal-title":"Eur J Surg Oncol"},{"issue":"11","key":"4558_CR4","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1007\/s10350-004-0678-9","volume":"47","author":"D Gopaul","year":"2004","unstructured":"Gopaul D, Belliveau P, Vuong T, Trudel J, Vasilevsky CA, Corns R, Gordon PH (2004) Outcome of local excision of rectal carcinoma. Dis Colon Rectum 47(11):1780\u20131788","journal-title":"Dis Colon Rectum"},{"issue":"8","key":"4558_CR5","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1007\/s00464-002-8814-x","volume":"17","author":"W Lee","year":"2003","unstructured":"Lee W, Lee D, Choi S, Chun H (2003) Transanal endoscopic microsurgery and radical surgery for T1 and T2 rectal cancer. Surg Endosc 17(8):1283\u20131287","journal-title":"Surg Endosc"},{"issue":"9","key":"4558_CR6","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1007\/BF02234796","volume":"44","author":"S Sengupta","year":"2001","unstructured":"Sengupta S, Tjandra JJ (2001) Local excision of rectal cancer. Dis Colon Rectum 44(9):1345\u20131361","journal-title":"Dis Colon Rectum"},{"issue":"6","key":"4558_CR7","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S1470-2045(11)70097-3","volume":"12","author":"W Van Gijn","year":"2011","unstructured":"Van Gijn W, Marijnen CAM, Nagtegaal ID, Kranenbarg EMK, Putter H, Wiggers T, Rutten HJT, P\u00e5hlman L, Glimelius B, Van de Velde CJH (2011) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol 12(6):575\u2013582","journal-title":"Lancet Oncol"},{"issue":"16","key":"4558_CR8","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1200\/JCO.2011.40.1836","volume":"30","author":"R Sauer","year":"2012","unstructured":"Sauer R, Liersch T, Merkel S, Fietkau R, Hohenberger W, Hess C, Becker H, Raab HR, Villanueva MT, Witzigmann H, Wittekind C, Beissbarth T, Rodel C (2012) Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO\/ARO\/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol 30(16):1926\u20131933","journal-title":"J Clin Oncol"},{"issue":"12","key":"4558_CR9","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1002\/bjs.7251","volume":"97","author":"FM Smith","year":"2010","unstructured":"Smith FM, Waldron D, Winter DC (2010) Rectum-conserving surgery in the era of chemoradiotherapy. Br J Surg 97(12):1752\u20131764","journal-title":"Br J Surg"},{"issue":"2","key":"4558_CR10","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/bjc.2016.417","volume":"116","author":"B Creavin","year":"2017","unstructured":"Creavin B, Ryan \u00c9J, Martin ST, Hanly A, O\u2019Connell PR, Sheahan K, Winter DC (2017) Organ preservation with local excision or active surveillance following chemoradiotherapy for rectal cancer. Br J Cancer 116(2):169\u2013174","journal-title":"Br J Cancer"},{"issue":"5","key":"4558_CR11","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/S2468-1253(20)30001-7","volume":"5","author":"F Dossa","year":"2020","unstructured":"Dossa F, Acuna SA, Baxter NN (2020) Local excision after preoperative chemoradiation for T2 and T3 rectal cancers: is the wait over? The Lancet Gastroenterology & Hepatology 5(5):422\u2013424","journal-title":"The Lancet Gastroenterology & Hepatology"},{"key":"4558_CR12","doi-asserted-by":"crossref","unstructured":"Thomas F, Menahem B, Lebreton G, Bouhier-Leporrier K, Dejardin O, Alves\u00a0A (2022)\u00a0Permanent stoma after sphincter preservation for rectal cancer. A situation that occurs more often than you might think. Front Oncol 12:1056314","DOI":"10.3389\/fonc.2022.1056314"},{"key":"4558_CR13","doi-asserted-by":"crossref","unstructured":"Lossius WJ, Stornes T, Myklebust TA, Endreseth BH, Wibe\u00a0A (2022)\u00a0Completion surgery vs. primary TME for early rectal cancer: a national study. Int J Colorectal Dis 37(2):429\u2013435","DOI":"10.1007\/s00384-021-04083-6"},{"issue":"15","key":"4558_CR14","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/S1470-2045(15)00215-6","volume":"16","author":"J Garcia-Aguilar","year":"2015","unstructured":"Garcia-Aguilar J, Renfro LA, Chow OS, Shi Q, Carrero XW, Lynn PB, Thomas CR Jr, Chan E, Cataldo PA, Marcet JE, Medich DS, Johnson CS, Oommen SC, Wolff BG, Pigazzi A, McNevin SM, Pons RK, Bleday R (2015) Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial. Lancet Oncol 16(15):1537\u20131546","journal-title":"Lancet Oncol"},{"issue":"7","key":"4558_CR15","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/bjs.9809","volume":"102","author":"Verseveld, M., E.J. de Graaf, C. Verhoef, E. van Meerten, C.J. Punt, I.H. de Hingh, I.D. Nagtegaal, J.J. Nuyttens, C.A. Marijnen, J.H. de Wilt, and C.S. Group","year":"2015","unstructured":"Verseveld, M., E.J. de Graaf, C. Verhoef, E. van Meerten, C.J. Punt, I.H. de Hingh, I.D. Nagtegaal, J.J. Nuyttens, C.A. Marijnen, J.H. de Wilt, and C.S. Group (2015) Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery (CARTS study). Br J Surg 102(7):853\u2013860","journal-title":"Br J Surg"},{"issue":"9","key":"4558_CR16","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1093\/ptj\/89.9.873","volume":"89","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Reprint\u2014Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement. Phys Ther 89(9):873\u2013880","journal-title":"Phys Ther"},{"issue":"15","key":"4558_CR17","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","volume":"283","author":"DF Stroup","year":"2000","unstructured":"Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 283(15):2008\u20132012","journal-title":"JAMA"},{"key":"4558_CR18","doi-asserted-by":"crossref","unstructured":"Higgins JP, Altman DG, G\u00f8tzsche PC, J\u00fcni P, Moher D, Oxman AD, Savovi\u0107 J, Schulz KF, Weeks L, Sterne JA (2011)\u00a0The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials. Bmj 343","DOI":"10.1136\/bmj.d5928"},{"key":"4558_CR19","doi-asserted-by":"crossref","unstructured":"Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, Norris S, Falck-Ytter Y, Glasziou P, DeBeer H, Jaeschke R\u00a0(2011)\u00a0GRADE guidelines: 1. Introduction\u2014GRADE evidence profiles and summary of findings tables. J Clin Epidemiol 64(4):383\u2013394","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"4558_CR20","unstructured":"Wells GA, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M, Tugwell P (2000)\u00a0The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Oxford"},{"issue":"1","key":"4558_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2288-5-13","volume":"5","author":"SP Hozo","year":"2005","unstructured":"Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5(1):1\u201310","journal-title":"BMC Med Res Methodol"},{"issue":"6","key":"4558_CR22","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1177\/0962280216669183","volume":"27","author":"D Luo","year":"2018","unstructured":"Luo D, Wan X, Liu J, Tong T (2018) Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range. Stat Methods Med Res 27(6):1785\u20131805","journal-title":"Stat Methods Med Res"},{"issue":"1","key":"4558_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2288-14-135","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol 14(1):1\u201313","journal-title":"BMC Med Res Methodol"},{"issue":"9","key":"4558_CR24","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1002\/bjs.8821","volume":"99","author":"E Lezoche","year":"2012","unstructured":"Lezoche E, Baldarelli M, Lezoche G, Paganini AM, Gesuita R, Guerrieri M (2012) Randomized clinical trial of endoluminal locoregional resection versus laparoscopic total mesorectal excision for T2 rectal cancer after neoadjuvant therapy. Br J Surg 99(9):1211\u20131218","journal-title":"Br J Surg"},{"issue":"5","key":"4558_CR25","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S2468-1253(19)30410-8","volume":"5","author":"E Rullier","year":"2020","unstructured":"Rullier E, Vendrely V, Asselineau J, Rouanet P, Tuech JJ, Valverde A, de Chaisemartin C, Rivoire M, Trilling B, Jafari M et al (2020) Organ preservation with chemoradiotherapy plus local excision for rectal cancer: 5-year results of the GRECCAR 2 randomised trial. The lancet Gastroenterology & hepatology 5(5):465\u2013474","journal-title":"The lancet Gastroenterology & hepatology"},{"issue":"2","key":"4558_CR26","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S2468-1253(20)30333-2","volume":"6","author":"SP Bach","year":"2021","unstructured":"Bach SP, Gilbert A, Brock K, Korsgen S, Geh I, Hill J, Gill T, Hainsworth P, Tutton MG, Khan J, Robinson J, Steward M, Cunningham C, Levy B, Beveridge A, Handley K, Kaur M, Marchevsky N, Magill L, Russell A, Quirke P, West NP, Sebag-Montefiore D (2021) Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study. Lancet Gastroenterol Hepatol 6(2):92\u2013105","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"1","key":"4558_CR27","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.annonc.2022.09.160","volume":"34","author":"X Serra-Aracil","year":"2023","unstructured":"Serra-Aracil X, Pericay C, Badia-Closa J, Golda T, Biondo S, Hernandez P, Targarona E, Borda-Arrizabalaga N, Reina A, Delgado S, Vallribera F, Caro A, Gallego-Plazas J, Pascual M, Alvarez-Laso C, Guadalajara-Labajo HG, Mora-Lopez L (2023) Short-term outcomes of chemoradiotherapy and local excision versus total mesorectal excision in T2\u2013T3ab, N0, M0 rectal cancer: a multicentre randomised, controlled, phase III trial (the TAU-TEM study). Ann Oncol 34(1):78\u201390","journal-title":"Ann Oncol"},{"issue":"7","key":"4558_CR28","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1186\/2047-783X-15-7-292","volume":"15","author":"T Herzog","year":"2010","unstructured":"Herzog T, Belyaev O, Chromik AM, Weyhe D, Mueller CA, Munding J, Tannapfel A, Uhl W, Seelig MH (2010) TME quality in rectal cancer surgery. Eur J Med Res 15(7):292\u2013296","journal-title":"Eur J Med Res"},{"key":"4558_CR29","doi-asserted-by":"crossref","unstructured":"Serra-Aracil X, Pericay C, Badia-Closa J, Golda T, Biondo S, Hern\u00e1ndez P, Tarragona E, Borda-Arrizabalaga N, Reina \u00c1, Delgado S (2022)\u00a0Noninferiority multicenter prospective randomized controlled study of rectal cancer T2\u2013T3s (superficial) N0, M0 (T2T3sN0M0) undergoing neoadjuvant treatment and local excision (TEM) versus total mesorectal excision (TME): preoperative, surgical, and pathological outcomes\u2014The TAUTEM-study. Am Soc Clin Oncol","DOI":"10.1200\/JCO.2022.40.16_suppl.3501"},{"key":"4558_CR30","doi-asserted-by":"crossref","unstructured":"You YN, Hardiman KM, Bafford A, Poylin V, Francone TD, Davis K, Paquette IM, Steele SR, Feingold DL\u00a0(2020) The American society of colon and rectal surgeons clinical practice guidelines for the management of rectal cancer. Dis Colon Rectum 63(9):1191\u20131222","DOI":"10.1097\/DCR.0000000000001762"},{"issue":"8","key":"4558_CR31","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1245\/s10434-019-07328-5","volume":"26","author":"AL Halverson","year":"2019","unstructured":"Halverson AL, Morris AM, Cleary RK, Chang GJ (2019) For patients with early rectal cancer, does local excision have an impact on recurrence, survival, and quality of life relative to radical resection? Ann Surg Oncol 26(8):2497\u20132506","journal-title":"Ann Surg Oncol"},{"key":"4558_CR32","doi-asserted-by":"crossref","unstructured":"Fernandez LM, S\u00e3o Juli\u00e3o GP, Renehan AG, Beets GL, Papoila AL, Vailati BB, Bahadoer RR, Kranenbarg EM, Roodvoets AG, Figueiredo NL, Van De Velde CJ (2023)\u00a0The risk of distant metastases in patients with clinical complete response managed by watch and wait after neoadjuvant therapy for Rectal cancer: the influence of local regrowth in the International Watch and Wait Database. Dis Colon Rectum 66(1):41\u201349","DOI":"10.1097\/DCR.0000000000002494"},{"key":"4558_CR33","doi-asserted-by":"crossref","unstructured":"Cunningham C (2023)\u00a0Local excision for early rectal cancer. Clin Oncol (Royal College of Radiologists (Great Britain))\u00a035(2):82\u201386","DOI":"10.1016\/j.clon.2022.08.030"},{"key":"4558_CR34","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3389\/fonc.2019.00318","volume":"9","author":"C Gani","year":"2019","unstructured":"Gani C, Gani N, Zschaeck S, Eberle F, Schaeffeler N, Hehr T, Berger B, Fischer SG, Cla\u00dfen J, Zipfel S, R\u00f6del C, Teufel M, Zips D (2019) Organ preservation in rectal cancer: the patients\u2019 perspective. Front Oncol 9:318","journal-title":"Front Oncol"},{"issue":"1","key":"4558_CR35","doi-asserted-by":"publisher","first-page":"e96","DOI":"10.1097\/SLA.0000000000005052","volume":"277","author":"PB Lynn","year":"2023","unstructured":"Lynn PB, Van der Valk MJM, Claassen YHM, Shi Q, Widmar M, Bastiaannet E, Van de Velde CJH, Garcia-Aguilar J (2023) Chemoradiation and local excision versus total mesorectal excision for T2N0 rectal cancer: comparison of short- and long-term outcomes from 2 prospective studies. Ann Surg 277(1):e96\u2013e102","journal-title":"Ann Surg"},{"key":"4558_CR36","doi-asserted-by":"crossref","unstructured":"Schrag D, Shi Q, Weiser MR, Gollub MJ, Saltz LB, Musher BL, Goldberg J, Al Baghdadi T, Goodman KA, McWilliams RR, Farma JM (2023)\u00a0Preoperative treatment of locally advanced rectal cancer. N Engl J Med","DOI":"10.1056\/NEJMoa2303269"},{"key":"4558_CR37","doi-asserted-by":"crossref","unstructured":"Kennecke HF, O'Callaghan CJ, Loree JM, Moloo H, Auer R, Jonker DJ, Raval M, Musselman R, Ma G, Caycedo-Marulanda A, Simianu VV (2023)\u00a0Neoadjuvant chemotherapy, excision, and observation for early rectal cancer: the phase II NEO trial (CCTG CO.28) primary end point results. J Clin Oncol\u00a041(2):233\u2013242","DOI":"10.1200\/JCO.22.00184"},{"issue":"10","key":"4558_CR38","doi-asserted-by":"publisher","first-page":"e576","DOI":"10.1111\/codi.12381","volume":"15","author":"R Hompes","year":"2013","unstructured":"Hompes R, McDonald R, Buskens C, Lindsey I, Armitage N, Hill J, Scott A, Mortensen NJ, Cunningham C (2013) Completion surgery following transanal endoscopic microsurgery: assessment of quality and short- and long-term outcome. Colorectal Dis 15(10):e576\u2013e581","journal-title":"Colorectal Dis"},{"issue":"7","key":"4558_CR39","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1111\/codi.14962","volume":"22","author":"SHEM Clermonts","year":"2020","unstructured":"Clermonts SHEM, K\u00f6eter T, Pottel H, Stassen LPS, Wasowicz DK, Zimmerman DDE (2020) Outcomes of completion total mesorectal excision are not compromised by prior transanal minimally invasive surgery. Colorectal Dis 22(7):790\u2013798","journal-title":"Colorectal Dis"},{"key":"4558_CR40","unstructured":"Habr-Gama A, Perez RO, Kiss DR, Rawet V, Scanavini A, Santinho PM, Nadalin W (2004)\u00a0Preoperative chemoradiation therapy for low rectal cancer. Impact on downstaging and sphincter-saving operations. Hepato-Gastroenterol\u00a051(60):1703\u20131707"},{"key":"4558_CR41","doi-asserted-by":"crossref","unstructured":"Dattani M, Heald RJ, Goussous G, Broadhurst J, Sao Juliao GP, Habr-Gama A, Perez RO, Moran BJ (2018)\u00a0Oncological and survival outcomes in watch and wait patients with a clinical complete response after neoadjuvant chemoradiotherapy for rectal cancer: a systematic review and pooled analysis. Ann Surg 268(6):955\u2013967","DOI":"10.1097\/SLA.0000000000002761"},{"key":"4558_CR42","doi-asserted-by":"crossref","unstructured":"van der Valk MJ, Hilling DE, Bastiaannet E, Kranenbarg EM, Beets GL, Figueiredo NL, Habr-Gama A, Perez RO, Renehan AG, van de Velde CJ, Ahlberg M (2018)\u00a0Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study. Lancet\u00a0391(10139):2537\u20132545","DOI":"10.1016\/S0140-6736(18)31078-X"},{"issue":"10","key":"4558_CR43","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1002\/bjs.11220","volume":"106","author":"EJ Ryan","year":"2019","unstructured":"Ryan EJ, O\u2019Sullivan DP, Kelly ME, Syed AZ, Neary PC, O\u2019Connell PR, Kavanagh DO, Winter DC, O\u2019Riordan JM (2019) Meta-analysis of the effect of extending the interval after long-course chemoradiotherapy before surgery in locally advanced rectal cancer. Br J Surg 106(10):1298\u20131310","journal-title":"Br J Surg"},{"issue":"1","key":"4558_CR44","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/SLA.0b013e3182196e1f","volume":"254","author":"J Garcia-Aguilar","year":"2011","unstructured":"Garcia-Aguilar J, Smith DD, Avila K, Bergsland EK, Chu P, Krieg RM (2011) Optimal timing of surgery after chemoradiation for advanced rectal cancer: preliminary results of a multicenter, nonrandomized phase II prospective trial. Ann Surg 254(1):97\u2013102","journal-title":"Ann Surg"},{"key":"4558_CR45","doi-asserted-by":"crossref","unstructured":"Ryan \u00c9J, O'Riordan JM, Winter DC (2020)\u00a0Author response to: should a minimum 8-week interval between preoperative radiotherapy and surgery become the standard of care? No, it shouldn\u2019t. Br J Surg","DOI":"10.1002\/bjs.11574"},{"key":"4558_CR46","doi-asserted-by":"crossref","unstructured":"Temmink SJ, Peeters KC, Bahadoer RR, Kranenbarg EM, Roodvoets AG, Melenhorst J, Burger JW, Wolthuis A, Renehan AG, Figueiredo NL, Pares O ( 2023)\u00a0Watch and wait after neoadjuvant treatment in rectal cancer: comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD). Br J Surg 110(6):676\u2013684","DOI":"10.1093\/bjs\/znad186"},{"key":"4558_CR47","doi-asserted-by":"crossref","unstructured":"Martens MH, Maas M, Heijnen LA, Lambregts DM, Leijtens JW, Stassen LP, Breukink SO, Hoff C, Belgers EJ, Melenhorst J, Jansen R (2016)\u00a0Long-term outcome of an organ preservation program after neoadjuvant treatment for rectal cancer. J Natl Cancer Inst\u00a0108(12)","DOI":"10.1093\/jnci\/djw171"},{"key":"4558_CR48","doi-asserted-by":"crossref","unstructured":"Habr-Gama A, S\u00e3o Juli\u00e3o GP, Fernandez LM, Vailati BB, Andrade A, Ara\u00fajo SE, Gama-Rodrigues J, Perez RO (2019)\u00a0Achieving a complete clinical response after neoadjuvant chemoradiation that does not require surgical resection: it may take longer than you think!. Dis Colon Rectum 62(7):802\u2013808","DOI":"10.1097\/DCR.0000000000001338"},{"issue":"4","key":"4558_CR49","doi-asserted-by":"publisher","first-page":"513","DOI":"10.6004\/jnccn.2014.0056","volume":"12","author":"A Cercek","year":"2014","unstructured":"Cercek A, Goodman KA, Hajj C, Weisberger E, Segal NH, Reidy-Lagunes DL, Stadler ZK, Wu AJ, Weiser MR, Paty PB, Guillem JG, Nash GM, Temple LK, Garcia-Aguilar J, Saltz LB (2014) Neoadjuvant chemotherapy first, followed by chemoradiation and then surgery, in the management of locally advanced rectal cancer. J Natl Compr Canc Netw 12(4):513\u2013519","journal-title":"J Natl Compr Canc Netw"},{"key":"4558_CR50","doi-asserted-by":"crossref","unstructured":"Conroy T, Bosset JF, Etienne PL, Rio E, Fran\u00e7ois \u00c9, Mesgouez-Nebout N, Vendrely V, Artignan X, Bouch\u00e9 O, Gargot D, Boige V. Unicancer Gastrointestinal Group and Partenariat de Recherche en Oncologie Digestive (PRODIGE) Group (2021)\u00a0Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol\u00a022(5):702\u2013715","DOI":"10.1016\/S1470-2045(21)00079-6"},{"key":"4558_CR51","doi-asserted-by":"crossref","unstructured":"Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CA, Putter H, Kranenbarg EM, Roodvoets AG, Nagtegaal ID, Beets-Tan RG, Blomqvist LK, Fokstuen T (2021)\u00a0Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial. Lancet Oncol\u00a022(1):29\u201342","DOI":"10.1016\/S1470-2045(20)30555-6"},{"key":"4558_CR52","doi-asserted-by":"crossref","unstructured":"Donnelly M, Ryan OK, Ryan \u00c9J, Creavin B, O\u2019Reilly M, McDermott R, Kennelly R, Hanly A, Martin ST, Winter DC (2023)\u00a0Total neoadjuvant therapy versus standard neoadjuvant treatment strategies for the management of locally advanced rectal cancer: network meta-analysis of randomized clinical trials. Brit J Surg","DOI":"10.1093\/bjs\/znad177"},{"issue":"23","key":"4558_CR53","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1200\/JCO.22.00032","volume":"40","author":"J Garcia-Aguilar","year":"2022","unstructured":"Garcia-Aguilar J, Patil S, Gollub MJ, Kim JK, Yuval JB, Thompson HM, Verheij FS, Omer DM, Lee M, Dunne RF, Marcet J, Cataldo P, Polite B, Herzig DO, Liska D, Oommen S, Friel CM, Ternent C, Coveler AL, Hunt S, Gregory A, Varma MG, Bello BL, Carmichael JC, Krauss J, Gleisner A, Paty PB, Weiser MR, Nash GM, Pappou E, Guillem JG, Temple L, Wei IH, Widmar M, Lin S, Segal NH, Cercek A, Yaeger R, Smith JJ, Goodman KA, Wu AJ, Saltz LB (2022) Organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy. J Clin Oncol 40(23):2546\u20132556","journal-title":"J Clin Oncol"},{"issue":"7","key":"4558_CR54","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1002\/bjs.8702","volume":"99","author":"ST Martin","year":"2012","unstructured":"Martin ST, Heneghan HM, Winter DC (2012) Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer. Br J Surg 99(7):918\u2013928","journal-title":"Br J Surg"},{"key":"4558_CR55","doi-asserted-by":"publisher","first-page":"S486","DOI":"10.1016\/S0167-8140(21)06977-2","volume":"161","author":"A Garant","year":"2021","unstructured":"Garant A, Vasilevsky C, Boutros M, Khosrow-Khavar F, Kavan P, Diec H, Desgroseilliers S, Faria J, Ferland E, Pelsser V (2021) OC-0621 interim safety analysis and preliminary results of the morpheus phase III study. Radiother Oncol 161:S486\u2013S487","journal-title":"Radiother Oncol"},{"key":"4558_CR56","doi-asserted-by":"crossref","unstructured":"Gerard JP, Barbet N, Schiappa R (2022)\u00a0Contact X-ray brachytherapy with chemoradiotherapy is improving organ preservation in early cT2-T3 rectal adenocarcinoma. Three-year results of the phase 3 randomized OPRA trial (NCT02505750). J Clin Oncol\u00a040","DOI":"10.1200\/JCO.2022.40.16_suppl.3512"},{"key":"4558_CR57","doi-asserted-by":"crossref","unstructured":"George TJ, Yothers G, Rahma OE, Hong TS, Russell MM, You YN, Parker W, Jacobs SA, Lucas PC, Colangelo LH, Gollub MJ (2023)\u00a0Long-term results from NRG-GI002: a phase II clinical trial platform using total neoadjuvant therapy (TNT) in locally advanced rectal cancer (LARC). J Clin Oncol\u00a041(4_suppl):7\u20137","DOI":"10.1200\/JCO.2023.41.4_suppl.7"},{"key":"4558_CR58","doi-asserted-by":"crossref","unstructured":"Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, R\u00f6del CD, Cervantes A, Arnold D (2017)\u00a0Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol\u00a028(suppl_4):iv22-iv40","DOI":"10.1093\/annonc\/mdx224"},{"key":"4558_CR59","doi-asserted-by":"crossref","unstructured":"Bach SP, Hill J, Monson JR, Simson JN, Lane L, Merrie A, Warren B, Mortensen NM,\u00a0Association of Coloproctology of Great, and C. Ireland Transanal Endoscopic Microsurgery (2009)\u00a0A predictive model for local recurrence after transanal endoscopic microsurgery for rectal cancer. Br J Surg 96(3):280\u2013290","DOI":"10.1002\/bjs.6456"},{"key":"4558_CR60","doi-asserted-by":"crossref","unstructured":"Bahadoer RR, Peeters KC, Beets GL, Figueiredo NL, Bastiaannet E, Vahrmeijer A, Temmink SJ, Meershoek-Klein Kranenbarg WE, Roodvoets AG, Habr-Gama A, Perez RO (2021)\u00a0Watch and wait after a clinical complete response in rectal cancer patients younger than 50 years. Br J Surg\u00a0109(1):114\u2013120","DOI":"10.1093\/bjs\/znab372"},{"key":"4558_CR61","doi-asserted-by":"crossref","unstructured":"Ryan \u00c9J, Creavin B, Sheahan K (2020)\u00a0Delivery of personalized care for locally advanced rectal cancer: incorporating pathological, molecular genetic, and immunological biomarkers into the multimodal paradigm. Front Oncol 10","DOI":"10.3389\/fonc.2020.01369"},{"issue":"25","key":"4558_CR62","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1056\/NEJMoa2201445","volume":"386","author":"A Cercek","year":"2022","unstructured":"Cercek A, Lumish M, Sinopoli J, Weiss J, Shia J, Lamendola-Essel M, El Dika IH, Segal N, Shcherba M, Sugarman R, Stadler Z, Yaeger R, Smith JJ, Rousseau B, Argiles G, Patel M, Desai A, Saltz LB, Widmar M, Iyer K, Zhang J, Gianino N, Crane C, Romesser PB, Pappou EP, Paty P, Garcia-Aguilar J, Gonen M, Gollub M, Weiser MR, Schalper KA, Diaz LA Jr (2022) PD-1 blockade in mismatch repair-deficient, locally advanced rectal cancer. N Engl J Med 386(25):2363\u20132376","journal-title":"N Engl J Med"},{"key":"4558_CR63","doi-asserted-by":"crossref","unstructured":"Smith JJ, Chow OS, Gollub MJ, Nash GM, Temple LK, Weiser MR, Guillem JG, Paty PB, Avila K, Garcia-Aguilar J, Rectal Cancer Consortium (2015)\u00a0Organ preservation in rectal adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy, and total mesorectal excision or nonoperative management. BMC Cancer\u00a015(1):767","DOI":"10.1186\/s12885-015-1632-z"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-023-04558-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00384-023-04558-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-023-04558-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T11:39:37Z","timestamp":1703158777000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00384-023-04558-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,4]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["4558"],"URL":"https:\/\/doi.org\/10.1007\/s00384-023-04558-8","relation":{},"ISSN":["1432-1262"],"issn-type":[{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,4]]},"assertion":[{"value":"26 October 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This review was registered prospectively with PROSPERO (CRD42022368100).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Preregistration"}},{"value":"This article is an original work, has not been published before, and is not being considered for publication elsewhere in its final form, in either printed or electronic media.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Originality"}}],"article-number":"263"}}