{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:21:09Z","timestamp":1786980069748,"version":"build-2736575974"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Tattoo markings are often used as preoperative markers for colorectal cancer. However, scattered ink markings adversely affect tumor site recognition intraoperatively; therefore, interventions for rectal cancer may lead to an inaccurate distal resection margin (DRM) and incomplete total mesorectal excision (TME). This is the first case series of fluorescence-guided robotic rectal surgery in which near-infrared fluorescence clips (NIRFCs) were used to localize rectal cancer lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 20 consecutive patients who underwent robotic surgery for rectal cancer between December 2022 and December 2023 in the current study. The primary endpoints were the rate of intraoperative clip detection and its usefulness for marking the tumor site. Secondary endpoints were oncological assessments, including DRM and the number of lymph nodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clip locations were confirmed in 17 of 20 (85%) patients. NIRFCs were not detected in 3 out of 7 patients who underwent preoperative chemoradiation therapy. No adverse events, including bleeding or perforation, were observed at the time of clipping, and no clips were lost. The median DRM was 55\u00a0mm (range, 22\u201386\u00a0mm) for rectosigmoid (Rs), 33\u00a0mm (range, 16\u201360\u00a0mm) for upper rectum (Ra), and 20\u00a0mm (range, 17\u201330\u00a0mm) for low rectum (Rb). The median number of lymph nodes was 13 (range, 10\u201321).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The rate of intraoperative clip detection, oncological assessment, including DRM, and the number of lymph nodes indicate that the utility of fluorescence-guided methods with NIRFCs is feasible for rectal cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00384-024-04615-w","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T03:13:35Z","timestamp":1711163615000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fluorescence guidance using near-infrared fluorescent clips in robotic rectal surgery: a case series"],"prefix":"10.1007","volume":"39","author":[{"given":"Satoshi","family":"Narihiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syunsuke","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsumi","family":"Kazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomotaka","family":"Kumamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Toya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Eto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"4615_CR1","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1007\/s10350-004-6355-1","volume":"45","author":"GJ Harris","year":"2002","unstructured":"Harris GJ, Church JM, Senagore AJ et al (2002) Factors affecting local recurrence of colonic adenocarcinoma. Dis Colon Rectum 45:1029\u20131034. https:\/\/doi.org\/10.1007\/s10350-004-6355-1","journal-title":"Dis Colon Rectum"},{"key":"4615_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10147-019-01485-z","volume":"25","author":"Y Hashiguchi","year":"2020","unstructured":"Hashiguchi Y, Muro K, Saito Y et al (2020) Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol 25:1\u201342. https:\/\/doi.org\/10.1007\/s10147-019-01485-z","journal-title":"Int J Clin Oncol"},{"key":"4615_CR3","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1007\/s11605-010-1165-3","volume":"14","author":"IJ Park","year":"2010","unstructured":"Park IJ, Kim JC (2010) Adequate length of the distal resection margin in rectal cancer: from the oncological point of view. J Gastrointest Surg 14:1331\u20131337. https:\/\/doi.org\/10.1007\/s11605-010-1165-3","journal-title":"J Gastrointest Surg"},{"key":"4615_CR4","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/j.1463-1318.2008.01735.x","volume":"11","author":"W Hohenberger","year":"2009","unstructured":"Hohenberger W, Weber K, Matzel K, Papadopoulos T, Merkel S (2009) Standardized surgery for colonic cancer: complete mesocolic excision and central ligation \u2013 technical notes and outcome. Colorectal Dis 11:354\u2013364. https:\/\/doi.org\/10.1111\/j.1463-1318.2008.01735.x","journal-title":"Colorectal Dis"},{"key":"4615_CR5","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1001\/jamaoncol.2022.2831","volume":"8","author":"HF Kennecke","year":"2022","unstructured":"Kennecke HF, Bahnson HT, Lin B et al (2022) Patterns of practice and improvements in survival among patients with stage 2\/3 rectal cancer treated with trimodality therapy. JAMA Oncol 8:1466\u20131470. https:\/\/doi.org\/10.1001\/jamaoncol.2022.2831","journal-title":"JAMA Oncol"},{"key":"4615_CR6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ijsu.2020.06.014","volume":"80","author":"S Narihiro","year":"2020","unstructured":"Narihiro S, Yoshida M, Ohdaira H et al (2020) Effectiveness and safety of tumor site marking with near-infrared fluorescent clips in colorectal laparoscopic surgery: a case series study. Int J Surg 80:74\u201378. https:\/\/doi.org\/10.1016\/j.ijsu.2020.06.014","journal-title":"Int J Surg"},{"key":"4615_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s40792-023-01666-z","volume":"9","author":"S Narihiro","year":"2023","unstructured":"Narihiro S, Nakashima S, Kazi M, Yoshioka S, Kitagawa K, Toya N, Eto K (2023) Effectiveness of fluorescence-guided methods using near-infrared fluorescent clips of robotic colorectal surgery: a case report. Surg Case Rep 9:81. https:\/\/doi.org\/10.1186\/s40792-023-01666-z","journal-title":"Surg Case Rep"},{"key":"4615_CR8","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1056\/NEJMoa040694","volume":"351","author":"R Sauer","year":"2004","unstructured":"Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731\u20131740. https:\/\/doi.org\/10.1056\/NEJMoa040694","journal-title":"N Engl J Med"},{"key":"4615_CR9","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/S0140-6736(09)60484-0","volume":"373","author":"D Sebag-Montefiore","year":"2009","unstructured":"Sebag-Montefiore D, Stephens RJ, Steele R et al (2009) Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet 373:811\u2013820. https:\/\/doi.org\/10.1016\/S0140-6736(09)60484-0","journal-title":"Lancet"},{"key":"4615_CR10","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4103\/0972-9941.158969","volume":"12","author":"JR Lue","year":"2016","unstructured":"Lue JR, Pyrzak A, Allen J (2016) Improving accuracy of intraoperative diagnosis of endometriosis: role of firefly in minimal access robotic surgery. J Minim Access Surg 12:186\u2013189. https:\/\/doi.org\/10.4103\/0972-9941.158969","journal-title":"J Minim Access Surg"},{"key":"4615_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.21037\/ls-20-98","volume":"5","author":"YJ Lee","year":"2021","unstructured":"Lee YJ, van den Berg NS, Orosco RK, Rosenthal EL, Sorger JM (2021) A narrative review of fluorescence imaging in robotic-assisted surgery. Laparosc Surg 5:31. https:\/\/doi.org\/10.21037\/ls-20-98","journal-title":"Laparosc Surg"},{"key":"4615_CR12","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1080\/17434440.2020.1851191","volume":"17","author":"A Ghuman","year":"2020","unstructured":"Ghuman A, Kavalukas S, Sharp SP, Wexner SD (2020) Clinical role of fluorescence imaging in colorectal surgery \u2013 an updated review. Expert Rev Med Devices 17:1277\u20131283. https:\/\/doi.org\/10.1080\/17434440.2020.1851191","journal-title":"Expert Rev Med Devices"},{"key":"4615_CR13","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ijsu.2020.07.048","volume":"81","author":"DE Messenger","year":"2020","unstructured":"Messenger DE (2020) Commentary: Effectiveness and safety of tumor site marking with near-infrared fluorescent clips in colorectal laparoscopic surgery: a case series study. Int J Surg 81:84. https:\/\/doi.org\/10.1016\/j.ijsu.2020.07.048","journal-title":"Int J Surg"},{"key":"4615_CR14","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.humpath.2011.07.026","volume":"43","author":"C Du","year":"2012","unstructured":"Du C, Xue W, Li J, Cai Y, Gu J (2012) Morphology and prognostic value of tumor budding in rectal cancer after neoadjuvant radiotherapy. Hum Pathol 43:1061\u20131067. https:\/\/doi.org\/10.1016\/j.humpath.2011.07.026","journal-title":"Hum Pathol"},{"key":"4615_CR15","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.5754\/hge12165","volume":"59","author":"CT Lee","year":"2012","unstructured":"Lee CT, Chow NH, Liu YS et al (2012) Computed tomography with histological correlation for evaluating tumor regression of rectal carcinoma after preoperative chemoradiation therapy. Hepatogastroenterol 59:2484\u20132489. https:\/\/doi.org\/10.5754\/hge12165","journal-title":"Hepatogastroenterol"},{"key":"4615_CR16","doi-asserted-by":"publisher","first-page":"5964","DOI":"10.3748\/wjg.v19.i36.5964","volume":"19","author":"P De Nardi","year":"2013","unstructured":"De Nardi P, Carvello M (2013) How reliable is current imaging in restaging rectal cancer after neoadjuvant therapy? World J Gastroenterol 19:5964\u20135972. https:\/\/doi.org\/10.3748\/wjg.v19.i36.5964","journal-title":"World J Gastroenterol"},{"key":"4615_CR17","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1245\/s10434-012-2722-7","volume":"20","author":"A Trakarnsanga","year":"2013","unstructured":"Trakarnsanga A, Gonen M, Shia J et al (2013) What is the significance of the circumferential margin in locally advanced rectal cancer after neoadjuvant chemoradiotherapy? Ann Surg Oncol 20:1179\u20131184. https:\/\/doi.org\/10.1245\/s10434-012-2722-7","journal-title":"Ann Surg Oncol"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-024-04615-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00384-024-04615-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-024-04615-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T14:03:36Z","timestamp":1736345016000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00384-024-04615-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,23]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4615"],"URL":"https:\/\/doi.org\/10.1007\/s00384-024-04615-w","relation":{},"ISSN":["1432-1262"],"issn-type":[{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,23]]},"assertion":[{"value":"16 March 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted following the ethical principles of the Declaration of Helsinki (Edinburgh 2000) and obtained approval from the Institutional Review Board [no. 30-249(9270)] prior to patient enrolment. Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41"}}