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This cross-sectional cohort study evaluated long-term effect of anastomotic leakage on urinary and sexual function in male patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients operated with anterior resection for rectal cancer in 15 Swedish hospitals 2007\u20132013 were identified. Anastomotic leakage and other clinical variables were retrieved from the Swedish Colorectal Cancer Registry and medical records. Urinary and sexual dysfunction were evaluated at 4 to 11\u00a0years after surgery using the International Prostate Symptom Score, International Index of Erectile Function, and European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire CR29. The effect of anastomotic leakage on average scores of urinary and sexual dysfunction was evaluated as a primary outcome, and the single items permanent urinary catheter and sexual inactivity as secondary outcomes. The association of anastomotic leakage and functional outcomes was analyzed using regression models with adjustment for confounders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After a median follow-up of 84\u00a0months (interquartile range: 67\u2013110), 379 out of 864 eligible men were included. Fifty-nine (16%) patients had anastomotic leakage. Urinary incontinence was more common in the leakage group, with an adjusted mean score difference measured by EORTC QLQ ColoRectal\u201329 of 8.69 (95% confidence interval: 0.72\u201316.67). The higher risks of urinary frequency, permanent urinary catheter, and sexual inactivity did not reach significance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Anastomotic leakage after anterior resection had a minor negative impact on urinary and sexual function in men.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00384-024-04626-7","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T01:01:43Z","timestamp":1712624503000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Minor impact of anastomotic leakage in anterior resection for rectal cancer on long-term male urinary and sexual function"],"prefix":"10.1007","volume":"39","author":[{"given":"Martin","family":"Ruteg\u00e5rd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Jutesten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Buchwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Angenete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Louise","family":"Lydrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"4626_CR1","doi-asserted-by":"crossref","unstructured":"Pachler J, Wille-Jorgensen P (2012) Quality of life after rectal resection for cancer, with or without permanent colostomy. 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